Regulatory cells potentiate the efficacy of IL-4 gene transfer by up- regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients

Journal of Immunology

Volumn 164, Issue 11, 2000, Pages 5739-5745

  Ke, Bibo ^a   Ritter, Thomas ^b   Kato, Hirohisa ^a   Zhai, Yuan ^a   Li, Jiye ^a   Lehmann, Manfred ^b,c   Busuttil, Ronald W ^a   Volk, Hans Dieter ^b   Kupiec Weglinski, Jerzy W ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF ROSTOCK   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CD4 ANTIGEN; GAMMA INTERFERON; INHIBITOR OF APOPTOSIS PROTEIN; INTERLEUKIN 10; INTERLEUKIN 4; PROTEIN BCL X;

ADENOVIRUS; ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; GENE TRANSFER; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; MALE; NONHUMAN; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; RAT; SPLEEN CELL; TH2 CELL;

EID: 0034120177     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.11.5739     Document Type: Article

References (41)

1. Zhai, Y., R. M. Ghobrial, R. W. Busuttil, and J. W. Kupiec-Weglinski. 1999. Th1 and Th2 cytokines in organ transplantation: paradigm lost? Crit. Rev. Immunol. 19:155.
2. Nickerson, P., J. Steiger, X. X. Zheng, A. W. Steele, W. Steurer, P. Roy-Chaudhury, and T. B. Strom. 1997. Manipulation of cytokine networks in transplantation: false hope or realistic opportunity for tolerance? Transplantation 63:489.
3. Onodera, K., M. Lehmann, E. Akalin, H. D. Volk, M. H. Sayegh, and J. W. Kupiec-Weglinski. 1996. Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients. J. Immunol. 157:1944.
4. Onodera, K., W. W. Hancock, E. Graser, M. Lehmann, M. H. Sayegh, T. B. Strom, H. D. Volk, and J. W. Kupiec-Weglinski. 1997. Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients. J. Immunol. 158:1572.
5. Onodera, K., H. D. Volk, T. Ritter, and J. W. Kupiec-Weglinski. 1998. Thymus requirement and antigen dependency in the "infectious" tolerance pathway in transplant recipients. J. Immunol. 160:5765.
6. Takeuchi, T., R. P. Lowry, and B. Konieczny. 1992. Heart allografts in murine systems: the differential activation of Th2-like effector cells in peripheral tolerance. Transplantation 53:1281.
7. Mottram, P. L., W. R. Han, L. J. Purcell, I. F. C. McKenzie, and W. W. Hancock. 1995. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-γ in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy. Transplantation 59:559.
8. Chen, N., and E. H. Field. 1995. Enhanced type 2 diminished type 1 cytokines in neonatal tolerance. Transplantation 59:993.
9. Donckier, V., M. Wissing, C. Bruyns, D. Abramowicz, M. Lybin, M. L. Vanderhaeghen, and M. Goldman. 1995. Critical role of interleukin 4 in the induction of neonatal transplantation tolerance. Transplantation 59:1571.
10. Vossen, A., G. Tibbe, R. Benner, and H. Savelkoul. 1995. T-lymphocyte and cytokine-directed strategies for inhibiting skin allograft rejection in mice. Transplant. Proc. 27:380.
11. Zheng, X. X., A. W. Steele, P. W. Nickerson, W. Steurer, J. Steiger, and T. B. Strom. 1995. Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J. Immunol. 154:5590.
12. Steiger, J., P. W. Nickerson, W. Steurer, M. Moscovitch-Lopatin, and T. B. Strom. 1995. IL-2 knockout recipient mice reject islet cell allografts. J. Immunol. 155:489.
13. + T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 59:1155.
14. Mosmann, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
15. Waldmann, H., and S. Cobbold. 1998. How do monoclonal antibodies induce tolerance? A role for infectious tolerance? Annu. Rev. Immunol. 16:619.
16. Qin, S., S. P. Cobbold, H. Pope, J. Elliott, D. Kioussis, J. Davies, and H. Waldmann. 1993. "Infectious" transplantation tolerance. Science 259:974.
17. Lehmann, M., F. Sternkopf, F. Metz, and H. D. Volk. 1992. Induction of long-term survival of rat skin allografts by a novel, highly efficient anti-CD4 monoclonal antibody. Transplantation 54:959.
18. Ritter, T., K. Risch, G. Schroder, J. Kolls, A. Siegling, E. Graser, P. Reinke, J. Brock, M. Lehmann, and H. D. Volk. 1999. Intragraft overexpression of interleukin-4 is neither sufficient nor essential for tolerance induction to cardiac allografts in a high-responder strain combination. Transplantation 68:1427.
19. Kolls, J., K. Peppel, M. Silva, and B, Beutler. 1994. Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. Proc. Natl. Acad. Sci. USA 91:215.
20. Siegling, A., M. Lehmann, C. Platzer, F. Emmrich, and H. D. Volk. 1994. A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats. J. Immunol. Methods 177:23.
21. Bach, F. H., C. Ferran, P. Hechenleitner, W. Mark, N. Koyamada, T. Miyatake, H. Winkler, A. Badrichani, D. Candinas, and W. W. Hancock. 1997. Accommodation of vascularized xenografts: expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment. Nat. Med. 3:196.
22. Soares, M. P., Y Lin, K. Sato, K. M. Stuhlmeier, and F. H. Bach. 1999. Accommodation. Immunol. Today 20:434.
23. Davis, J. D., G. Martin, J. Phillips, S. E. Marshall, S. P. Cobbold, and H. Waldmann. 1996. T cell regulation in adult transplantation tolerance. J. Immunoi. 157:529.
24. Punch, J. D., T. Tono, L. H. Qin, D. K. Bishop, and J. S. Bromberg. 1998. Tolerance induction by anti-CD2 plus anti-CD3 monoclonal antibodies: evidence for an IL-4 requirement. J. Immunol. 161:1156.
25. + T cells in the infectious tolerance pathway: IL-4 dependent and independent mechanisms and differential chemokine and chemokine receptor expression. Transplantation 67:S241.
26. Qin, L., Y. Z. Ding, D. R. Pahud, E. Chang, M. J. Imperiale, and J. S. Bromberg. 1997. Promoter attenuation in gene therapy: interferon-γ and tumor necrosis factor-α inhibit transgene expression. Hum. Gene Ther. 8:2019.
27. Chan, S. Y., K. W. Li, J. R. Piccotti, M. C. Louie, T. A. Judge, L. A. Turka, E. J. Eichwald, and D. K. Bishop. 1999. Tissue specific consequences of the anti-adenoviral immune response: implications for cardiac transplants. Nat. Med. 5:1143.
28. Lei, D., M. Lehmann, J. Shellito, S. Nelson, A. Siegling, H. D. Volk, and J. L. Kolls. 1996. Non-depleting anti-CD4 mAb treatment prolongs lung-directed El-deleted adenoviral-mediated gene expression in rats. Hum. Gene Ther. 7:2272.
29. Arnold, B., G. Schonrich, and G. J. Hammerling. 1993. Multiple levels of peripheral tolerance. Immunol. Today 14:12.
30. Zhai, Y., and J. W. Kupiec-Weglinski. 1999. What is the role of regulatory T cells in transplantation tolerance? Curr. Opin. Immunol. 11:497.
31. Chen, Z. K., S. P. Cobbold, H. Waldmann, and S. Metcalfe. 1996. Amplification of natural regulatory immune mechanisms for transplantation tolerance. Transplantation 62:1200.
32. Marshall, S. E., S. P. Cobbold, J. D. Davies, G. M. Martin, J. M. Philips, and H. Waldmann. 1996. Tolerance and suppression in a primed immune system. Transplantation 62:1614.
33. Yamada, K, P. R. Gianello, F. L. Ierino, T. Loft, A. Shimizu, S. Meehan, R. B. Colvin, and D. H. Sachs. 1997. Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts. J. Exp. Med. 186: 497.
34. L serve as anti-inflammatory function in endothelial cells through inhibition of NFκB. J. Clin. Invest. 103:543.
35. Amersi, F., R. Buelow, H. Kato, B. Ke, A. J. Coito, X. D. Shen, D. Zhao, J. Zaky, J. Melinek, C. R. Lassman, et al. 1999. Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. J. Clin. Invest. 104:1631.
36. Soares, M. P., Y. L. Csizmadia, K. Takigami, K. Sat, S.T. Grey, R. B. Colvin, A. M. Choi, K. D. Poss, and F. H. Bach. 1998. Expression of HO-1 can determine cardiac xenograft survival. Nat. Med. 4:1073.
37. Woo, J., S. Iyer, M. C. Cornejo, N. Mori, L. Gao, I. Sipos, M. Maines, and R. Buelow. 1998. Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32). Transplant. Immunol. 6:84.
38. Hancock, W. W., R. Buelow, M. H. Sayegh, and L. A. Turka. 1998. Antibody induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat. Med. 12:1392.
39. Ke, B., A. J. Coito, H. Kato, Y. Zhai, T. Wang, B. Sawitzki, P. Seu, R. W. Busuttil, and J. W. Kupiec-Weglinski. 2000. Fas ligand gene transfer prolongs rat renal allograft survival and downregulates anti-apoptotic Bag-1 in parallel with enhanced Th2-type cytokine expression. Transplantation. 69:1690.
40. Takayama, S., T. Sato, S. Krajewski, K. Kochel, S. Irie, J. A. Millan, and J. C. Reed. 1995. Cloning and functional analysis of Bag-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 80:279.
41. L and Mcl-1. Blood 89:4415.