Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation

Gene Therapy

Volumn 6, Issue 5, 1999, Pages 816-822

  Shinozaki, K ^a   Yahata, H ^a   Tanji, H ^a   Sakaguchi, T ^a   Ito, H ^b   Dohi, K ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

Gene transfer; Immunosuppression; Interleukin 10; Liver transplantation; Recombinant adenoviruses

Indexed keywords

BETA GALACTOSIDASE; INTERLEUKIN 10; VIRUS VECTOR;

ADENOVIRUS; ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; GRAFT SURVIVAL; LIVER TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOVIRIDAE; ANIMALS; GENE EXPRESSION; GENETIC VECTORS; GRAFT SURVIVAL; IMMUNOSUPPRESSION; INTERLEUKIN-10; LIVER TRANSPLANTATION; MALE; RATS; RATS, INBRED LEW; RATS, INBRED STRAINS; TRANSFECTION; TRANSPLANTATION, HOMOLOGOUS;

ADENOVIRIDAE; ANIMALIA;

EID: 0032981047     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300881     Document Type: Article

References (48)

1. Gruber SA. The case for local immunosuppression. Transplantation 1992; 54: 1-11.
2. O'Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998; 8: 275-283.
3. Schwartz RH. Models of T cell anergy: is there a common molecular mechanism? J Exp Med 1996; 184: 1-8.
4. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse helper T cells. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170: 2081-2095.
5. de Waal Malefyt R et al. Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-1220.
6. + T cell clones and peripheral blood T cells. J Immunol 1992; 149: 2378-2384.
7. de Waal Malefyt R et al. Interleukin-10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991; 174: 915-924.
8. + T-cells clones and T cells: specific inhibition of IL-2 production and proliferation. J Immunol 1993; 150: 4754-4765.
9. Bejarano MT et al. Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures. Int Immunol 1992; 4: 1389-1397.
10. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389: 737-742.
11. Buer J et al. Interleukin-10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J Exp Med 1998; 187: 177-183.
12. Ding L, Shevach EM. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J Immunol 1992; 148: 3133-3139.
13. Fiorentino DF et al. IL-10 inhibits cytokine production of activated macrophage. J Immunol 1991; 147: 3815-3822.
14. Cassatella MA et al. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide. J Exp Med 1993; 178: 2207-2211.
15. Wissing KM et al. A pilot trial of recombinant human interleukin-10 in kidney transplant recipients receiving OKT3 induction therapy. Transplantation 1997; 64: 999-1006.
16. Chernoff AE et al. A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses. J Immunol 1995; 154: 5492-5499.
17. Ettinghausen SE, Rosenberg SA. Immunotherapy of murine sarcomas using lymphokine activated killer cells: optimization of the schedule and route of administration of recombinant interleukin-2. Cancer Res 1986; 46: 2784-2792.
18. Blazar BR, Taylor PA, Smith S, Vallera DA. Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts. Blood 1995; 85: 842-851.
19. Shaked A et al. Adenovirus-mediated gene transfer in the transplant setting. II. Successful expression of transferred cDNA in syngeneic liver grafts. Transplantation 1994; 57: 1508-1511.
20. Drazan KE et al. Adenovirus-mediated gene transfer in the transplant setting. Part III. Variables affecting gene transfer in liver grafts. Transplantation 1995; 59: 670-673.
21. Roos WK et al. Isolated-organ perfusion for local gene delivery: efficient adenovirus-mediated gene transfer into the liver. Gene Therapy 1997; 4: 55-62.
22. Chapelier A et al. Gene therapy in lung transplantation: feasibility of ex vivo adenovirus-mediated gene transfer to the grafts. Hum Gene Ther 1996; 7: 1837-1845.
23. Qin L et al. Adenovirus-mediated gene transfer of viral interleukin-10 inhibits the immune response to both alloantigen and adenoviral antigen. Hum Gene Ther 1997; 8: 1365-1374.
24. Xing Z et al. Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reaction. J Clin Invest 1996; 97: 1102-1110.
25. Xing Z et al. Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia. Gene Therapy 1997; 4: 140-149.
26. Boehler A et al. Adenovirus-mediated interleukin-10 gene transfer inhibits post-transplant fibrous airway obliteration in an animal model of bronchiolitis obliterans. Hum Gene Ther 1998; 9: 541-551.
27. Hayashi A et al. Frequent occurrence of hepatocytic apoptosis in acute rejection of the grafted rat liver. Pathol Int 1997; 47: 518-524.
28. Kamada N et al. Liver transplantation in the rat: biochemical and histological evidence of complete tolerance induction in nonrejection strains. Transplantation 1983; 35: 304-311.
29. Goode HF et al. Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplantation. Hepatology 1994; 19: 354-359.
30. Olthoff KM et al. Adenovirus-mediated gene transfer into cold-preserved liver allografts: survival pattern and unresponsiveness following transduction with CTLA4Ig. Nature Med 1998; 4: 194-200.
31. Zwacka RA et al. Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation. Nature Med 1998; 4: 194-200.
32. Qin L et al. Retrovirus-mediated transfer of viral interleukin-10 gene prolongs murine cardiac allograft survival. J Immunol 1996; 156: 2316-2323.
33. Sykes M et al. Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene. Transplantation 1993; 55: 197-202.
34. Moore KW et al. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 1990; 248: 1230-1234.
35. Drazan KE et al. Transduction of hepatic allografts achieves local levels of viral IL-10 which suppress alloreactivity in vitro. J Surg Res 1995; 59: 219-223.
36. Huh RD et al. Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human IL-10 in healthy volunteers. Blood 1996; 87: 699-705.
37. Pescovitz MD, Sachs DH, Lunney JK, Hsu SM. Localization of class II MHC antigens on porcine renal vascular endothelium. Transplantation 1984; 37: 627-630.
38. Daar AS et al. The detailed distribution of MHC class II antigens in normal human organs. Transplantation 1984; 38: 293-298.
39. Herz J, Gerard RD. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 1993; 90: 2812-2816.
40. Huard J et al. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Therapy 1995; 2: 107-115.
41. Holler E et al. Systemic and cellular-release of IL-10 in human BMT. Eur J Cancer 1995; 31: 39-45.
42. Cantwell MJ et al. Adenovirus vector infection of chronic lymphocytic leukemia B cells. Blood 1996; 88: 4676-4683.
43. Graham FL, Prevec L. Manipulation of adenovirus vectors. In: Murray EJ (ed). Gene Transfer and Expression Protocols. Humana Press: Clifton, NJ, 1991, pp 109-128.
44. Graham FL, Van Der Eb EJ. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973; 52: 456-467.
45. Tashiro H et al. Monitoring for rejection and engraftment following rat orthotopic liver transplantation by polymerase chain reaction. Transplantation 1994; 58: 745-748.
46. Tashiro H et al. Assessment of microchimerism in rat liver transplantation by polymerase chain reaction. Hepatology 1996; 23: 828-834.
47. Kamada N, Calne RY. Orthotopic liver transplantation in the rat: technique using cuff for portal vein anastomosis and biliary drainage. Transplantation 1979; 28: 47-50.
48. Kamada N, Sumimoto R, Kaneda K. The value of hepatic artery reconstruction as a technique in rat liver transplantation. Surgery 1992; 111: 195-200.