Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4IgG and loxP

Human Gene Therapy

Volumn 12, Issue 4, 2001, Pages 415-426

  Takehara, M ^a,b   Murakami, M ^a   Inobe, M ^a   Tanaka, K ^a   Chikuma, S ^a   Saito, I ^c   Kanegae, Y ^c   Yasunami, Y ^d   Nakano, M ^d   Yamashita, K ^b   Todo, S ^b   Uede, T ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c THE UNIVERSITY OF TOKYO   (Japan)

^d FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; COMPLEMENTARY DNA; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; RECOMBINASE; VIRUS VECTOR;

ADENOVIRUS; ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TRANSFER; GENETIC RECOMBINATION; GENETIC TRANSDUCTION; GRAFT REJECTION; IMMUNE RESPONSE; IMMUNITY; KNOCKOUT MOUSE; MALE; MOLECULAR CLONING; NONHUMAN; PROMOTER REGION; T LYMPHOCYTE ACTIVATION;

ADENOVIRIDAE; ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; COS CELLS; DNA NUCLEOTIDYLTRANSFERASES; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, VIRAL; GENETIC VECTORS; IMMUNOCONJUGATES; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS TRANSPLANTATION; LIVER; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; POLYMERASE CHAIN REACTION; SKIN TRANSPLANTATION; SURVIVAL; TRANSPLANTATION, HOMOLOGOUS;

ADENOVIRIDAE; ANIMALIA;

EID: 0035114921     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340150504037     Document Type: Article

References (33)

1. CTLA4Ig prolongs allograft survival while suppressing cell-mediated immunity
2. Skeletal muscle as a privileged site for orthotopic skin allografts
3. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance
4. Immunomodulation of pancreatic islet allografts in mice with CTLA4IgG secreting muscle cells
5. Prolonged xenograft survival of islets infected with small doses of adenovirus expressing CTLA4Ig
6. Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet allograft survival
7. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
8. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
9. Application of Cre/Lox P system to adenovirus vector
10. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4IgG administration
11. CTLA4-Ig and anti-CD40 ligands prevent renal allograft rejection in primates
12. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
13. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig
14. Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation
15. Immunosuppression in vivo by a soluble form of the CTLA-4, T cell activation molecules
16. Interferon gamma plays a critical role in induced cell death of effector T cell: A possible third mechanism of self-tolerance
17. Identification and characterization of an alternative cytotoxic T lymphocyte-associated protein 4 binding molecule on B cells
18. Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG
19. Efficient selection for high expression transfectants with a novel eukaryotic vector
20. Transplantation tolerance induced by CTLA4-Ig
21. Constitutive expression of murine CTLA4Ig from recombinant adenovirus vector results in prolonged transgene expression
22. A cell culture model for T lymphocyte clonal anergy
23. Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
24. Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance
25. CTLA4IgG gene delivery prevents autoantibody production and lupus nephritis in MRL/lpr mice
26. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1
27. CTLA4IgG treatment induces long-term acceptance of rat small bowel allografts
28. Asialo GM1+CD81+ T cells play a critical role in costimulation blockade-resistant allograft rejection
29. Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment
30. A major costimulatory molecule on antigen-presenting cells, a CTLA4 ligand, is distinct from B7
31. Long-term acceptance of major histocompatibility complex-mismatched cardiac allograft induced by a low dose of CTLA4IgM plus FK506
32. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis
33. Prolongation of islet xenograft survival (rat to mouse) by in vitro culture at 37°C