GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2

Immunology

Volumn 131, Issue 1, 2010, Pages 50-58

  Hwang, Soo Seok ^a   Lee, Sumin ^a   Lee, Wonyong ^a   Lee, Gap Ryol ^a  

^a Sogang University   (South Korea)

Author keywords

chromatin remodelling; differentiation; GATA 3; interaction; metastasis associated protein 2; T helper type 2

Indexed keywords

CALCIUM BINDING PROTEIN; GAMMA INTERFERON; INTERLEUKIN 4; METASTASIS ASSOCIATED PROTEIN 2; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMATIN; GENE EXPRESSION; GENE LOCUS; GENE REPRESSION; GENETIC TRANSFECTION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TH2 CELL; TRANSACTIVATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL LINE, TUMOR; CHROMATIN ASSEMBLY AND DISASSEMBLY; CYTOKINES; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; MICE; MICE, INBRED C57BL; S100 PROTEINS; TH2 CELLS; TRANSFECTION;

EID: 77955127618     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2010.03271.x     Document Type: Article

References (35)

1. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996 383 : 787 793.
2. Dong C, Flavell RA. Th1 and Th2 cells. Curr Opin Hematol 2001 8 : 47 51.
3. Glimcher LH, Murphy KM. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev 2000 14 : 1693 1711.
4. Stockinger B, Veldhoen M. Differentiation and function of Th17 T cells. Curr Opin Immunol 2007 19 : 281 286.
5. Weaver CT, Hatton RD, Mangan PR et al. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007 25 : 821 852.
6. Lee GR, Kim ST, Spilianakis CG et al. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity 2006 24 : 369 379.
7. Ansel KM, Djuretic IM, Tanasa B et al. Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol 2006 24 : 607 656.
8. Lee GR, Fields PE, Griffin IVTJ et al. Regulation of the Th2 cytokine locus by a Locus Control Region. Immunity 2003 19 : 145 153.
9. Fields PE, Lee GR, Kim ST et al. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 2004 21 : 865 876.
10. Lee GR, Spilianakis C, Flavell RA. Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol 2005 6 : 42 8.
11. Spilianakis C, Flavell RA. Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat Immunol 2004 5 : 1017 1027.
12. Zheng WP, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997 89 : 587 596.
13. Zhu J, Min B, Hu-Li J et al. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol 2004 5 : 1157 1165.
14. Pai SY, Truitt ML, Ho IC. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci USA 2004 101 : 1993 1998.
15. Ouyang W, Ranganath SH, Weindel K et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 1998 9 : 745 755.
16. Ouyang W, Lohning M, Gao Z et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 2000 12 : 27 37.
17. Lee BH, Takemoto N, Kurata H et al. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J Exp Med 2000 192 : 105 115.
18. Toh Y, Nicolson GL. The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications. Clin Exp Metastasis 2009 26 : 215 227.
19. Luo J, Su F, Chen D et al. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 2000 408 : 377 381.
20. Cui Y, Niu A, Pestell R et al. Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells. Mol Endocrinol 2006 20 : 2020 2035.
21. Manavathi B, Singh K, Kumar R. MTA family of coregulators in nuclear receptor biology and pathology. Nucl Recept Signal 2007 5 : e010.
22. Lu X, Kovalev GI, Chang H et al. Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice. J Biol Chem 2008 283 : 13825 13833.
23. Yamagata T, Mitani K, Oda H et al. Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs. EMBO J 2000 19 : 4676 4687.
24. Miccio A, Wang Y, Hong W et al. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J 2010 29 : 442 456.
25. Rylski M, Welch JJ, Chen YY et al. GATA-1-mediated proliferation arrest during erythroid maturation. Mol Cell Biol 2003 23 : 5031 5042.
26. Miaw SC, Choi A, Yu E et al. ROG, repressor of GATA, regulates the expression of cytokine genes. Immunity 2000 12 : 323 333.
27. + T cells. J Exp Med 2001 194 : 1461 1471.
28. Chang HC, Zhang S, Thieu VT et al. PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity 2005 22 : 693 703.
29. Hwang ES, Szabo SJ, Schwartzberg PL et al. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 2005 307 : 430 433.
30. Hossain MB, Hosokawa H, Hasegawa A et al. Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells. Immunology 2008 125 : 377 386.
31. Zhao X, Zheng B, Huang Y et al. Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses. J Immunol 2007 179 : 8297 8304.
32. Tsang AP, Visvader JE, Turner CA et al. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell 1997 90 : 109 119.
33. Fox AH, Liew C, Holmes M et al. Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers. EMBO J 1999 18 : 2812 2822.
34. Hong W, Nakazawa M, Chen YY et al. FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J 2005 24 : 2367 2378.
35. Gao Z, Huang Z, Olivey HE et al. FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. EMBO J 2010 29 : 457 468.