In vitro cellular accumulation of gadolinium incorporated into chitosan nanoparticles designed for neutron-capture therapy of cancer

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 53, Issue 1, 2002, Pages 57-63

  Shikata, F ^a   Tokumitsu, H ^a   Ichikawa, H ^a   Fukumori, Y ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Cell accumulation of particles; Chitosan; Endocytosis; Gadolinium; Neutron capture therapy

Indexed keywords

CHITOSAN; GADOLINIUM; GADOLINIUM PENTETATE; NANOPARTICLE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LEVEL; CELL TYPE; CONTROLLED STUDY; DRUG ACCUMULATION; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; MELANOMA; MOUSE; NEUTRON CAPTURE THERAPY; NONHUMAN; SQUAMOUS CELL CARCINOMA; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; BIOCOMPATIBLE MATERIALS; CHITIN; CHITOSAN; GADOLINIUM; GADOLINIUM DTPA; L CELLS (CELL LINE); MELANOMA, EXPERIMENTAL; MICE; NANOTECHNOLOGY; NEOPLASMS; NEUTRON CAPTURE THERAPY; TUMOR CELLS, CULTURED;

EID: 0036138541     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(01)00198-9     Document Type: Article

References (20)

1. Suppression of rabbit VX-2 subcutaneous tumor growth by gadolinium neutron capture therapy
2. Gadolinium neutron capture therapy of melanoma cells and solid tumors with the magnetic resonance imaging contrast agent gadobutrol
3. Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: preparation by novel emulsion-droplet coalescence technique and characterization
4. Chitosan, a drug carrier for the 21st century: a review
5. Optimized formulation of magnetic chitosan microparticles containing the anticancer agent, oxantrazole
6. Evaluation of process parameters involved in chitosan microsphere preparation by the o/w/o multiple emulsion method
7. Chitosan and chondroitin microspheres for oral-administration controlled release of metoclopramide
8. Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
9. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines
10. Gadolinium neutron-capture therapy using novel gadopentetic acid-chitosan complex nanoparticles: in vivo growth suppression of experimental melanoma solid tumor
11. Chitosans as absorption enhancers for poorly absorbable drugs 2: Mechanism of absorption enhancement
12. Chitosan: properties, preparations and application to microparticulate systems
13. Influence of the degree of acetylation on some biological properties of chitosan films
14. In vitro cytotoxicity of macromolecules in different cell culture systems
15. Surface-modified biodegradable albumin nano- and microspheres. II: effect of surface charge on in vitro phagocytosis and biodistribution in rats
16. Polyethylene particles of a 'critical size' are necessary for the induction of cytokines by macrophage in vitro
17. Recognition of liposomes by cells: in vitro binding and endocytosis mediated by specific lipid headgroups and surface charge density
18. Radiation effect of gadolinium-neutron capture reactions on the survival of Chinese hamster cells
19. Comparison of radiation effects of gadolinium and boron neutron capture reactions