Protein expression changes in human monocytic THP-1 cells treated with lipoteichoic acid from Lactobacillus plantarum and Staphylococcus aureus

Molecules and Cells

Volumn 29, Issue 6, 2010, Pages 585-594

  Zeng, Ri Zhong ^a,b   Kim, Han Geun ^a   Kim, Na Ra ^a   Lee, Hae Young ^a   Jung, Bong Jun ^a   Ko, Mi Yeon ^a   Lee, Seung Yeon ^a   Chung, Dae Kyun ^a  

^a Kyung Hee University   (South Korea)

^b INSTITUTE OF TROPICAL BIOSCIENCE AND BIOTECHNOLOGY   (China)

Author keywords

2 DE; gram positive bacteria; lipoteichoic acid; proteome analysis; THP 1 cells

Indexed keywords

CYCLOPHILIN A; DOPACHROME TAUTOMERASE; HLA B27 ANTIGEN; LIPOTEICHOIC ACID; MANGANESE SUPEROXIDE DISMUTASE;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; LACTOBACILLUS PLANTARUM; MASS SPECTROMETRY; MONOCYTE; MONOCYTIC LEUKEMIA; PROTEIN EXPRESSION; PROTEOMICS; RNA PROCESSING; STAPHYLOCOCCUS AUREUS;

BIOLOGICAL MARKERS; CELL LINE, TUMOR; CYCLOPHILIN A; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HLA-B27 ANTIGEN; HUMANS; IMMUNOMODULATION; IMP DEHYDROGENASE; LACTOBACILLUS PLANTARUM; LIPOPOLYSACCHARIDES; MASS SPECTROMETRY; MONOCYTES; PROTEOME; SEPSIS; STAPHYLOCOCCUS AUREUS; TEICHOIC ACIDS;

LACTOBACILLUS PLANTARUM; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 77955055072     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10059-010-0073-4     Document Type: Article

References (76)

1. A. Bevilacqua M.C. Ceriani S. Capaccioli A. Nicolin 2003 Posttranscriptional regulation of gene expression by degradation of messenger RNAs J. Cell Physiol. 195 356 372 10.1002/jcp.10272 12704645 (Pubitemid 36529864)
2. N. Bloksma E. de Heer H. van Dijk J.M. Willers 1979 Adjuvanticity of lactobacilli. I. Differential effects of viable and killed bacteria Clin. Exp. Immunol. 37 367 375 387312
3. nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor α J. Biol. Chem. 283 57 65 10.1074/jbc.M705286200 17965020
4. C.Y. Chen A.B. Shyu 1995 AU-rich elements: characterization and importance in mRNA degradation Trends Biochem. Sci. 20 465 470 10.1016/S0968-0004(00)89102-1 8578590
5. C.Y. Chen R. Gherzi S.E. Ong E.L. Chan R. Raijmakers G.J. Pruijn G. Stoecklin C. Moroni M. Mann M. Karin 2001 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs Cell 107 451 464 10.1016/S0092-8674(01) 00578-5 11719186 (Pubitemid 33152781)
6. N.H. Cho C.Y. Choi S.Y. Seong 2004 Down-regulation of gp96 by Orientia tsutsugamushi Microbiol. Immunol. 48 297 305 15107540
7. A.M. Coleman B.E. Rendon M. Zhao M.W. Qian R. Bucala D. Xin R.A. Mitchell 2008 Cooperative regulation of NSCLC angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase J. Immunol. 181 2330 2337 18684922
8. D.J. Diekema M.A. Pfaller F.J. Schmitz J. Smayevsky J. Bell R.N. Jones M. Beach SENTRY Partcipants Group 2001 Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999 Clin. Infect. Dis. 32 114 132 10.1086/320184
9. E. Ellingsen S. Morath T. Flo A. Schromm T. Hartung C. Thiemermann T. Espevik D. Golenbock D. Foster R. Solberg, et al. 2002 Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14 Med. Sci. Monit. 8 149 156
10. W. Fischer 1988 Physiology of lipoteichoic acids in bacteria Adv. Microb. Physiol. 29 233 302 10.1016/S0065-2911(08)60349-5 3289326
11. N.L. Garneau J. Wilusz C.J. Wilusz 2007 The highways and byways of mRNA decay Nat. Rev. Mol. Cell Biol. 8 113 126 10.1038/nrm2104 17245413 (Pubitemid 46432531)
12. I. Ginsburg S.E. Fligiel P.A. Ward J. Varani 1988 Lipoteichoic acid-antilipoteichoic acid complexes induce superoxide generation by human neutrophils Inflammation 12 525 548 10.1007/BF00914316 2851550
13. C. Grangette S. Nutten E. Palumbo S. Morath C. Hermann J. Dewulf B. Pot T. Hartung P. Hols A. Mercenier 2005 Enhanced antiinflammatory capacity of Lactobacillus plantarum mutant synthesizing modified teichoic acids Proc. Natl. Acad. Sci. USA 102 10321 10326 10.1073/pnas.0504084102 15985548 (Pubitemid 41023369)
14. C.G. Ha J.K. Cho C.H. Lee Y.G. Chai Y.A. Ha S.H. Shin 2006 Cholesterol lowering effect of Lactobacillus plantarum isolated from human feces J. Microbiol. Biotechnol. 16 1201 1209
15. P. Heiduschka P. Blitgen-Heinecke A. Tura D. Kokkinou S. Julien S. Hofmeister K.U. Bartz-Schmidt U. Schraermeyer 2007 Melanin precursor 5,6-dihydroxyindol: protective effectes and cytotoxicity on retinal cells in vitro and in vivo Toxicol. Pathol. 35 1030 1038 10.1080/01926230701831358 18098047
16. H. Hemmi O. Takeuchi T. Kawai T. Kaisho S. Sato H. Sanjo M. Matsumoto K. Hoshino H. Wagner K. Takeda, et al. 2000 A Toll-like receptor recognizes bacterial DNA Nature 408 740 745 10.1038/35047123 11130078 (Pubitemid 32015992)
17. M. Hiyoshi H. Konishi H. Uemura H. Matsuzaki H. Tsukamoto R. Sugimoto H. Takeda S. Dakeshita A. Kitayama H. Takami, et al. 2009 D-dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride Toxicology 255 6 14 10.1016/j.tox.2008.09.016 18930782
18. B.A. Howard Z. Zheng M.J. Campa M.Z. Wang A. Sharma E. Haura J.E. 2nd. Herndon M.C. Fitzgerald G. Bepler E.F. Patz Jr. 2004 Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer Lung Cancer 46 313 323 10.1016/j.lungcan.2004.05.013 15541816 (Pubitemid 39487306)
19. W. Hu A. Hasan A. Wilson M.R. Stanford Y. Li-Yang S. Todryk R. Whiston T. Shinnick Y. Mizushima R. van der Zee, et al. 1998 Experimental mucosal induction of uveitis with the 60-kDa heat shock protein-derived peptide 336-351 Eur. J. Immunol. 28 2444 2455 10.1002/(SICI)1521-4141(199808)28:08<2444::AID- IMMU2444>3.0.CO;2-N 9710222 (Pubitemid 28362719)
20. T.L. Hwang Y. Liang K.Y. Chien J.S. Yu 2006 Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma Proteomics 6 2259 2272 10.1002/pmic.200500345 16493704
21. C.H. Jang I.A. Lee Y.R. Ha J.K. Lim M.K. Sung S.J. Lee J.S. Kim 2008 PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells Biosci. Biotechnol. Biochem. 72 1799 1808 10.1271/bbb.80079 18603805
22. Z.G. Jin A.O. Lungu L. Xie M. Wang C. Wong B.C. Berk 2004 Cyclophilin A is a proinflammatory cytokine that activates endothelial cells Arterioscler. Thromb. Vasc. Biol. 24 1186 1191 10.1161/01.ATV.0000130664.51010.28 15130913 (Pubitemid 38880006)
23. G. Karupiah N.H. Hunt N.J. King G. Chaudhri 2000 NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response Rev. Immunogenet. 2 387 415 11256747
24. T. Kawai S. Akira 2007 Signaling to NF-κB by Toll-like receptors Trends Mol. Med. 13 460 469 10.1016/j.molmed.2007.09.002 18029230 (Pubitemid 350086981)
25. H.G. Kim M.G. Gim J.Y. Kim H.J. Hwang M.S. Ham J.M. Lee T. Hartung J.W. Park S.H. Han D.K. Chung 2007 Lipoteichoic acid from Lactobacillus plantarum elicits both the production of Interleukin-23p19 and suppression of pathogenmediated Interleukin-10 in THP-1 cells FEMS Immunol. Med. Microbiol. 49 205 214 10.1111/j.1574-695X.2006.00175.x 17328754
26. H.G. Kim N.R. Kim M.G. Gim J.M. Lee S.Y. Lee M.Y. Ko J.Y. Kim S.H. Han D.K. Chung 2008 Lipoteichoic acid isolated from Lactobacillus plantarum inhibits lipopolysaccharide-induced TNF-α production in THP-1 cells and endotoxin shock in Mice J. Immunol. 180 2553 2561 18250466
27. H.G. Kim S.Y. Lee N.R. Kim M.Y. Ko J.M. Lee T.H. Yi S.K. Chung D.K. Chung 2008 Inhibitory effects of Lactobacillus plantarum lipoteichoic acid (LTA) on Staphylococcus aureus LTA-induced tumor necrosis factor-alpha production J. Microbiol. Biotechnol. 18 1191 1196 18600067
28. A. King M.A. Selak E. Gottlieb 2006 Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer Oncogene 25 4675 4682 10.1038/sj.onc.1209594 16892081 (Pubitemid 44187617)
29. C.C. Kuo C.W. Kuo C.M. Liang S.M. Liang 2005 A transcriptomic and proteomic analysis of the effect of CpG-ODN on human THP-1 monocytic leukemia cells Proteomics 5 894 906 10.1002/pmic.200401144 15693060 (Pubitemid 40469020)
30. W. Lam S. Bussom Y.C. Cheng 2009 Effect of hypoxia on the expression of phosphoglycerate kinase and antitumor activity of troxacitabine and gemcitabine in non-small cell lung carcinoma Mol. Cancer Ther. 8 415 423 10.1158/1535-7163.MCT-08-0692 19208827
31. H.M. Lee Y.H. Lee 2006 Isolation of Lactobacillus plantarum from kimchi and its inhibitory activity on the adherence and growth of Helicobacter pylori J. Microbiol. Biotechnol. 16 1513 1517
32. R. Levy M. Kotb O. Nagauker G. Majumdar M. Alkan I. Ofek E.H. Beachey 1990 Stimulation of oxidative burst in human monocytes by lipoteichoic acids Infect. Immun. 58 566 568 2153634
33. Z.Y. Li X. Zhao S.J. Bai Z. Wang L.J. Chen Y.Q. Wei C. Huang 2008 Proteomics identification of cyclophilin A as a potential prognostic factor and therapeutic target in endometrial carcinoma Mol. Cell. Proteomics 7 1810 1823 10.1074/mcp.M700544-MCP200 18421009
34. M.Y. Lin C.L. Yen 1999 Antioxidative ability of lactic acid bacteria J. Agric. Food Chem. 47 1460 1466 10.1021/jf981149l 10563999 (Pubitemid 29217139)
35. J. Liu J.D. Farmer Jr. W.S. Lane J. Friekman I. Weissman S.L. Schreiber 1991 Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP- FK506 complexes Cell 66 807 815 10.1016/0092-8674(91)90124-H 1715244
36. H. Liu T.D. Qiao Y. Han S. Han X.Y. Zhang T. Lin J. Gao P. Zhao Z. Chen D. Fan 2006 ZNRD1 mediates resistance of gastric cancer cells to methotrexate by regulation of IMPDH2 and Bcl-2 Biochem. Cell Biol. 84 199 206 10.1139/O05-173 (Pubitemid 43946031)
37. M. Mathur P.W. Tucker H.H. Samuels 2001 PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors Mol. Cell Biol. 21 2298 2311 10.1128/MCB.21.7.2298-2311.2001 11259580 (Pubitemid 32222084)
38. E. Mattsson L. Verhage J. Rollof A. Fleer J. Verhoef H. van Dijk 1993 Peptidoglycan and teichoic acid from Staphylococcus epidermidis stimulate human monocytes to release tumour necrosis factor-alpha, interleukin-1β and interleukin-6 FEMS Immunol. Med. Microbiol. 7 281 287 8275059
39. M. Mohamadzadeh S. Olson W.V. Kalina G. Ruthel G.L. Demmin K.L. Warfield S. Bavari T.R. Klaenhammer 2005 Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization Proc. Natl. Acad. Sci. USA 102 2880 2885 10.1073/pnas.0500098102 15710900 (Pubitemid 40299885)
40. F. Mor I.R. Cohen 1992 T cells in the lesion of experimental autoimmune encephalomyelitis: enrichment for reactivities to myelin basic protein and to heat shock proteins J. Clin. Invest. 90 2447 2455 10.1172/JCI116136 1281835
41. D.C. Morrison J.L. Ryan 1987 Endotoxins and disease mechanisms Annu. Rev. Med. 38 417 432 3555304
42. F.C. Neuhaus J. Baddiley 2003 A continuum of anionic charge: structures and functions of D-alanyl-teichoic acids in Gram-positive bacteria Microbiol. Mol. Biol. Rev. 67 686 723 10.1128/MMBR.67.4.686-723.2003 14665680 (Pubitemid 37549774)
43. K. Ohashi V. Burkart S. Flohe H. Kolb 2000 Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex J. Immunol. 164 558 561 10623794
44. M.P. Panchenko N. Silva J.R. Stone 2009 Up-regulation of a hydrogen peroxide-responsive pre-mRNA binding protein in atherosclerosis and intimal hyperplasia Cardiovasc. Pathol. 18 167 172 10.1016/j.carpath.2008.03.008 18508286
45. S. Paris H. Denis E. Delaive M. Dieu V. Dumont N. Ninane M. Raes C. Michiels 2005 Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia FEBS Lett. 579 105 114 10.1016/j.febslet.2004.11.055 15620698 (Pubitemid 40023381)
46. R. Rakkola S. Matikainen T.A. Nyman 2007 Proteome analysis of human macrophages reveals the upregulation of manganese-containing superoxide dismutase after toll-like receptor activation Proteomics 7 378 384 10.1002/pmic.200600582 17211829 (Pubitemid 46293981)
47. B.E. Rendon T. Roger I. Teneng M. Zhao Y. Al Abed T. Calandra R.A. Mitchell 2007 Regulation of human lung adenocarcinoma cell migration and invasion by macro-phage migration inhibitory factor J. Biol. Chem. 282 29910 29918 10.1074/jbc.M704898200 17709373 (Pubitemid 350035289)
48. Y.H. Ryu J.E. Baik J.S. Yang S.S. Kang J. Im C.H. Yun D.W. Kim K. Lee D.K. Chung H.R. Ju, et al. 2009 Differential immunostimulatory effects of Gram-positive bacteria due to their lipoteichoic acids Int. Immunopharmacol. 9 127 133 10.1016/j.intimp.2008.10.014 19013542
49. H. Schild H.G. Rammensee 2000 Gp96-the immune system's Swiss army knife Nat. Immunol. 1 100 101 10.1038/77770 11248798
50. M. Schroder R.J. Kaufman 2005 The mammalian unfolded protein response Annu. Rev. Biochem. 74 739 789 10.1146/annurev.biochem.73.011303.074134 15952902 (Pubitemid 40995523)
51. N.W.J. Schroder S. Morath C. Alexander L. Hamann T. Hartung U. Zähringer U.B. Göbel J.R. Weber R.R. Schumann 2003 Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved J. Biol. Chem. 278 15587 15594 10.1074/jbc.M212829200 12594207 (Pubitemid 36799667)
52. H.S. Seo S.M. Michalek M.H. Nahm 2008 Lipoteichoic acid is important in innate immune responses to Gram-positive bacteria Infect. Immun. 76 206 213 10.1128/IAI.01140-07 17954723
53. Y. Shav-Tal D. Zipori 2002 PSF and p54(nrb)/NonO - multifunctional nuclear proteins FEBS Lett. 531 109 114 10.1016/S0014-5793(02)03447-6 12417296 (Pubitemid 35341179)
54. B. Sherry N. Yarlett A. Strupp A. Cerami 1992 Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide- activated macrophages Proc. Natl. Acad. Sci. USA 89 3511 3515 10.1073/pnas.89.8.3511 1565646
55. P.K. Sorger H.R. Pelham 1987 The glucose-regulated protein grp94 is related to heat shock protein hsp90 J. Mol. Biol. 194 341 344 10.1016/0022-2836(87)90380-9 3612810
56. T.J. Standiford D.A. Arenberg J.M. Danforth S.L. Kunkel G.M. Van Otteren R.M. Strieter 1994 Lipoteichoic acid induces secretion of interleukin-8 from human blood monocytes: a cellular and molecular analysis Infect. Immun. 62 119 125 8262617
57. H. Sugimoto M. Taniguchi A. Nakagawa I. Tanaka M. Suzuki J. Nishihira 1999 Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 Å resolution Biochemistry 38 3268 3279 10.1021/bi982184o 10079069 (Pubitemid 29148901)
58. O. Takeuchi K. Hoshino S. Akira 2000 Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection J. Immunol. 165 5392 5396 11067888
59. M.J. Turner D.P. Sowders M.L. DeLay R. Mohapatra S. Bai J.A. Smith J.R. Brandewie J.D. Taurog R.A. Colbert 2005 HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response J. Immunol. 175 2438 2448 16081815
60. M.J. Turner M.L. DeLay S. Bai E. Klenk R.A. Colbert 2007 HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats Implications for the pathogenesis of spondylarthritis-like disease. Arthritis Rheuma. 56 215 223
61. M.P. Velez T.L.A. Verhoeven C. Draing S.V. Aulock M. Pfitzenmaier A. Geyer I. Lambrichts C. Grangette B. Pot J. Vanderleyden, et al. 2007 Functional analysis of D-alanylation of lipoteichoic acid in the probiotic strain Lactobacillus rhamnosus GG Appl. Environ. Microbiol. 73 3595 3604 10.1128/AEM.02083-06 (Pubitemid 46871449)
62. R.P. Wallin A. Lundqvist S.H. More A. von Bonin R. Kiessling H.G. Ljunggren 2002 Heat-shock proteins as activators of the innate immune system Trends Immunol. 23 130 135 10.1016/S1471-4906(01)02168-8 11864840 (Pubitemid 34178294)
63. Z. Wang J. Dillon E.R. Gaillard 2006 Antioxidant properties of melanin in retinal pigment epithelial cells Photochem. Photobiol. 82 474 479 10.1562/2005-10-21-RA-725 16613501
64. J. Wang J. Wang J. Dai Y. Jung C.L. Wei Y. Wang A.M. Havens P.J. Hogg E.T. Keller K.J. Pienta, et al. 2007 A glycolytic mechanism regulating an angiogenic switch in prostate cancer Cancer Res. 67 149 159 10.1158/0008-5472. CAN-06-2971 17210694 (Pubitemid 46142770)
65. T. Warger N. Hilf G. Rechtsteiner P. Haselmayer D.M. Carrick H. Jonuleit P. von Landenberg H.G. Rammensee C.V. Nicchitta M.P. Radsak, et al. 2006 Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses J. Biol. Chem. 281 22545 22553 10.1074/jbc.M502900200 16754684
66. T. Weiler Q. Du O. Krokhin W. Ens K. Standing H. EI-Gabalawy J.A. Wilkins 2007 The identification and characterization of a novel protein, c19orf10, in the synovium Arthritis Res. Ther. 9 1 9 10.1186/ar2145 (Pubitemid 46592227)
67. R. Winzen B.K. Thakur O. Dittrich-Breiholz M. Shah N. Redich S. Dhamija M. Kracht H. Holtmann 2007 Functional analysis of KSRP interaction with the AU-Rich element of interleukin-8 and identification of inflammatory mRNA targets Mol. Cell Biol. 27 8388 8400 10.1128/MCB.01493-07 17908789 (Pubitemid 350234249)
68. B. Wu R.C. Wilmouth 2008 Proteomics analysis of immuno-precipitated proteins associated with the oncogenic kinase cot Mol. Cells 25 43 49 18319612
69. Q. Xu M.C. Leiva S.A. Fischkoff R.E. Handschumacher C.R. Lyttle 1992 Leukocyte chemotactic activity of cyclophilin J. Biol. Chem. 267 11968 11971 1601866
70. Z. Yasukawa C. Sato K. Kitajima 2007 Identification of an inflammation-inducible serum protein recognized by anti-disialic acid antibodies as carbonic anhydrase II J. Biochem. 141 429 441 10.1093/jb/mvm047 17298961 (Pubitemid 46770395)
71. K. Yoshiura T. Nakaoka T. Nishishita K. Sato A. Yamamoto S. Shimada T. Saida Y. Kawakami T.A. Takahashi H. Fukuda, et al. 2005 Carbonic anhydrase II is a tumor vessel endothelium-associated antigen targeted by dendritic cell therapy Clin. Cancer Res. 11 8201 8207 10.1158/1078-0432.CCR-05-0816 16299253 (Pubitemid 41698765)
72. A. Zanin-Zhorov G. Nussbaum S. Franitza I.R. Cohen O. Lider 2003 T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors FASEB J. 17 1567 1569 12824285
73. A. Zanin-Zhorov R. Bruck G. Tal S. Oren H. Aeed R. Hershkoviz I.R. Cohen O. Lider 2005 Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines J. Immunol. 174 3227 3236 15749853
74. A. Zanin-Zhorov G. Tal S. Shivtiel M. Cohen T. Lapidot G. Nussbaum R. Margalit I.R. Cohen O. Lider 2005 Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T Cells: effects on signaling, chemotaxis, and inflammation J. Immunol. 175 276 285 15972659
75. D. Zhang L.K. Tai L.L. Wong L.L. Chiu S.K. Sethi E.S. Koay 2005 Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer Mol. Cell. Proteomics 4 1686 1696 10.1074/mcp.M400221-MCP200 16048908 (Pubitemid 41749262)
76. D. Zieker I. Konigsrainer F. Traub K. Nieselt B. Knapp C. Schillinger C. Stirnkorb F. Fend H. Northoff S. Kupka, et al. 2008 PGK1 a potential marker for peritoneal dissemination in gastric cancer Cell Physiol. Biochem. 21 429 436 10.1159/000129635 18453750 (Pubitemid 351620296)