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Volumn 21, Issue 1, 2010, Pages 181-192

Systemic immune responses in Alzheimer's disease: In vitro mononuclear cell activation and cytokine production

Author keywords

Alzheimer's disease; chemokine; cytokine; PBMC; rA 42

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CD36 ANTIGEN; CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; EOTAXIN; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES; TUMOR NECROSIS FACTOR ALPHA; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); CYTOKINE; PEPTIDE FRAGMENT;

EID: 77954977892     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-091714     Document Type: Article
Times cited : (74)

References (43)
  • 1
    • 64049098761 scopus 로고    scopus 로고
    • Neuropathology and cognitive impairment in Alzheimer disease: A complex but coherent relationship
    • Nelson PT, Braak H, Markesbery WR (2009) Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J Neuropathol Exp Neurol 68, 1-14.
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 1-14
    • Nelson, P.T.1    Braak, H.2    Markesbery, W.R.3
  • 2
    • 61849185913 scopus 로고    scopus 로고
    • Recent developments in Alzheimer's disease therapeutics
    • Rafili MS, Aisen PS (2009) Recent developments in Alzheimer's disease therapeutics. BMC Med 7, 7.
    • (2009) BMC Med , vol.7 , pp. 7
    • Rafili, M.S.1    Aisen, P.S.2
  • 6
    • 59349100950 scopus 로고    scopus 로고
    • Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: Underlying mechanisms
    • Teeling JL, Perry VH (2009) Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms. Neuroscience 158, 1062-1073.
    • (2009) Neuroscience , vol.158 , pp. 1062-1073
    • Teeling, J.L.1    Perry, V.H.2
  • 8
    • 77049112046 scopus 로고    scopus 로고
    • Role of COX-2 and 5-LO polymorphisms in Alzheimer's disease in a population from Northern Italy: Implication for pharmacogenomics
    • Listi F, Caruso C, Lio D, Colonna-Romano G, Chiappelli M, Licastro F, Candore G (2010) Role of COX-2 and 5-LO polymorphisms in Alzheimer's disease in a population from Northern Italy: implication for pharmacogenomics. J Alzheimers Dis 19, 551-557.
    • (2010) J Alzheimers Dis , vol.19 , pp. 551-557
    • Listi, F.1    Caruso, C.2    Lio, D.3    Colonna-Romano, G.4    Chiappelli, M.5    Licastro, F.6    Candore, G.7
  • 9
  • 11
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer Disease: Driving force, bystander or beneficial response?
    • Wyss-Coray T (2006) Inflammation in Alzheimer Disease: Driving force, bystander or beneficial response? Nat Med 12, 1005-1015.
    • (2006) Nat Med , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 12
    • 34547281067 scopus 로고    scopus 로고
    • Systemic and acquired immune responses in Alzheimer's disease
    • Britschgi M, Wyss-Coray T (2007) Systemic and acquired immune responses in Alzheimer's disease. Int Rev Neurobiol 82, 205-233.
    • (2007) Int Rev Neurobiol , vol.82 , pp. 205-233
    • Britschgi, M.1    Wyss-Coray, T.2
  • 13
    • 0024157709 scopus 로고    scopus 로고
    • Expression of immune system associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease
    • Rogers J, Luber-Narod J, Styren SD, Civin WH (1998) Expression of immune system associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease. Neurobiol Aging 9, 339-349.
    • (1998) Neurobiol Aging , vol.9 , pp. 339-349
    • Rogers, J.1    Luber-Narod, J.2    Styren, S.D.3    Civin, W.H.4
  • 16
    • 0036085702 scopus 로고    scopus 로고
    • Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals
    • Weksler ME, Relkin N, Turkenich R, LaRusse S, Zhou L, Szabo P (2002) Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals. Exp Gerontol 37, 943-948.
    • (2002) Exp Gerontol , vol.37 , pp. 943-948
    • Weksler, M.E.1    Relkin, N.2    Turkenich, R.3    Larusse, S.4    Zhou, L.5    Szabo, P.6
  • 17
    • 14844322281 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients
    • Reale M, Iarlori C, Gambi F, Lucci I, Salvatore M, Gambi D (2005) Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients. Exp Gerontol 40, 165-171.
    • (2005) Exp Gerontol , vol.40 , pp. 165-171
    • Reale, M.1    Iarlori, C.2    Gambi, F.3    Lucci, I.4    Salvatore, M.5    Gambi, D.6
  • 18
  • 19
    • 47849132772 scopus 로고    scopus 로고
    • Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease
    • Reale M, Iarlori C, Feliciani C, Gambi D (2008) Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease. J Alzheimers Dis 14, 147-159.
    • (2008) J Alzheimers Dis , vol.14 , pp. 147-159
    • Reale, M.1    Iarlori, C.2    Feliciani, C.3    Gambi, D.4
  • 21
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Service Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Service Task Force on Alzheimer's Disease. Neurology 34, 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 22
    • 0004235298 scopus 로고
    • American Psychiatric Association 3rd revised ed Washington (DC), American Psychiatric Association
    • American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders: DSM-III-R, 3rd revised ed. Washington (DC), American Psychiatric Association.
    • (1987) Diagnostic and Statistical Manual of Mental Disorders: DSM-III-R
  • 23
    • 10744222732 scopus 로고    scopus 로고
    • Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines
    • Reale M, Iarlori C, Gambi F, Feliciani C, Salone A, Toma L, DeLuca G, Salvatore M, Conti P, Gambi D (2004) Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines. J Neuroim-munol 148, 162-171.
    • (2004) J Neuroim-munol , vol.148 , pp. 162-171
    • Reale, M.1    Iarlori, C.2    Gambi, F.3    Feliciani, C.4    Salone, A.5    Toma, L.6    Deluca, G.7    Salvatore, M.8    Conti, P.9    Gambi, D.10
  • 24
    • 33845566340 scopus 로고    scopus 로고
    • Toxicity ofrecombinant beta-amyloid prefibrillar oligomers on the morphogenesis of the sea urchin Paracentrotus lividus
    • Carrotta R, Di Carlo M, Manno M, Montana G, Picone P, Romancino D, San Biagio PL (2006) Toxicity ofrecombinant beta-amyloid prefibrillar oligomers on the morphogenesis of the sea urchin Paracentrotus lividus. FASEBJ 20, 1916-1917.
    • (2006) FASEBJ , vol.20 , pp. 1916-1917
    • Carrotta, R.1    Di Carlo, M.2    Manno, M.3    Montana, G.4    Picone, P.5    Romancino, D.6    San Biagio, P.L.7
  • 25
    • 0036141148 scopus 로고    scopus 로고
    • CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production ofreactive oxygen species in response to beta-amyloid fibrils
    • Coraci IS, Husemann J, Berman JW, Hulette C, Dufour JH, Campanella GK, Luster AD, Silverstein SC, El-Khoury JB (2002) CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production ofreactive oxygen species in response to beta-amyloid fibrils. Am J Pathol 160, 101-112.
    • (2002) Am J Pathol , vol.160 , pp. 101-112
    • Coraci, I.S.1    Husemann, J.2    Berman, J.W.3    Hulette, C.4    Dufour, J.H.5    Campanella, G.K.6    Luster, A.D.7    Silverstein, S.C.8    El-Khoury, J.B.9
  • 27
    • 68249133572 scopus 로고    scopus 로고
    • Alterations in lymphocyte subset patterns and co-stimulatory molecules in patients with Alzheimer disease
    • Xue S, Xu D, Yang X, Dong W (2009) Alterations in lymphocyte subset patterns and co-stimulatory molecules in patients with Alzheimer disease. Chin Med J122, 1469-1472.
    • (2009) Chin Med J , vol.122 , pp. 1469-1472
    • Xue, S.1    Xu, D.2    Yang, X.3    Dong, W.4
  • 32
    • 0027410894 scopus 로고
    • Human antibodies reactive with beta-amyloid protein in Alzheimer's disease
    • Gaskin F, Finley J, Fang Q, Xu S, Fu SM (1993) Human antibodies reactive with beta-amyloid protein in Alzheimer's disease. JExpMed 177, 1181-1186.
    • (1993) J Exp Med , vol.177 , pp. 1181-1186
    • Gaskin, F.1    Finley, J.2    Fang, Q.3    Xu, S.4    Fu, S.M.5
  • 33
    • 34447629515 scopus 로고    scopus 로고
    • Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration
    • Rosenkranz D, Weyer S, Tolosa E, Gaenslen A, Berg D, Leyhe T, Gasser T, Stoltze L (2007) Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration. J Neuroimmunol 188, 117-127.
    • (2007) J Neuroimmunol , vol.188 , pp. 117-127
    • Rosenkranz, D.1    Weyer, S.2    Tolosa, E.3    Gaenslen, A.4    Berg, D.5    Leyhe, T.6    Gasser, T.7    Stoltze, L.8
  • 35
    • 0028803845 scopus 로고
    • An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogene-sis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis
    • Karpus WJ, Lukacs NW, McRae BL, Strieter RM, Kunkel SL, Miller SD (1995) An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogene-sis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J Immunol 155, 5003-5010.
    • (1995) J Immunol , vol.155 , pp. 5003-5010
    • Karpus, W.J.1    Lukacs, N.W.2    McRae, B.L.3    Strieter, R.M.4    Kunkel, S.L.5    Miller, S.D.6
  • 36
    • 0027202363 scopus 로고
    • T-cell autoimmunity in the central nervous system
    • Wekerle H (1993) T-cell autoimmunity in the central nervous system. Intervirology 35, 95-100.
    • (1993) Intervirology , vol.35 , pp. 95-100
    • Wekerle, H.1
  • 37
    • 0344465840 scopus 로고    scopus 로고
    • Potential role of MCP-1 in endothelial cell tight junction 'opening': Signaling via Rho and Rho kinase
    • Stamatovic SM, Keep RF, Kunkel SL, Andjelkovic AV (2003) Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. J Cell Sci 116, 4615-4628.
    • (2003) J Cell Sci , vol.116 , pp. 4615-4628
    • Stamatovic, S.M.1    Keep, R.F.2    Kunkel, S.L.3    Andjelkovic, A.V.4
  • 38
    • 23044465288 scopus 로고    scopus 로고
    • Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer's disease
    • Iarlori C, Gambi D, Gambi F, Lucci I, Feliciani C, Salvatore M, Reale M (2005) Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer's disease. Exp Gerontol 40, 605-611.
    • (2005) Exp Gerontol , vol.40 , pp. 605-611
    • Iarlori, C.1    Gambi, D.2    Gambi, F.3    Lucci, I.4    Feliciani, C.5    Salvatore, M.6    Reale, M.7
  • 42
    • 68949169046 scopus 로고    scopus 로고
    • IV im-munoglobulin is associated with a reduced risk of Alzheimer disease and related disorders
    • Fillit H, Hess G, Hill J, Bonnet P, Toso C (2009) IV im-munoglobulin is associated with a reduced risk of Alzheimer disease and related disorders. Neurology 73, 180-185.
    • (2009) Neurology , vol.73 , pp. 180-185
    • Fillit, H.1    Hess, G.2    Hill, J.3    Bonnet, P.4    Toso, C.5


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