Guanosine triphosphatases as novel therapeutic targets in tuberculosis

International Journal of Infectious Diseases

Volumn 14, Issue 8, 2010, Pages

  Rajni, ^a   Meena, Laxman S ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

Author keywords

GTPase; Mycobacterium; Prokaryotes; Signaling transduction; Tuberculosis; Virulence factor

Indexed keywords

BCG VACCINE; GUANOSINE TRIPHOSPHATE; ISONIAZID; LYSOZYME; RIFAMPICIN; VIRULENCE FACTOR; GUANOSINE TRIPHOSPHATASE; TUBERCULOSTATIC AGENT;

BACTERIAL SURVIVAL; CELL WALL; DISEASE SEVERITY; DRUG TARGETING; EXTENSIVELY DRUG RESISTANT TUBERCULOSIS; HUMAN; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PHAGOSOME; REVIEW; TUBERCULOSIS; VIRULENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIOLOGY; PATHOGENICITY; TUBERCULOSIS, MULTIDRUG-RESISTANT; TUBERCULOSIS, PULMONARY;

ANIMALS; ANTITUBERCULAR AGENTS; GTP PHOSPHOHYDROLASES; HUMANS; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; TUBERCULOSIS, MULTIDRUG-RESISTANT; TUBERCULOSIS, PULMONARY; VIRULENCE FACTORS;

EID: 77954957897     PISSN: 12019712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijid.2009.11.016     Document Type: Review

References (49)

1. Kumar V., Abbas A.K., Fausto N., Mitchell R.N. Robbins basic pathology 2007, Saunders Elsevier, 516-522, ISBN 978-1-4160-2973-1. 8th ed.
2. World Health Organization. Tuberculosis fact sheet No. 104. Global and regional incidence. Geneva: WHO; 2006.
3. Alderwick L.J., Birch H.L., Mishra A.K., Eggeling L., Besra G.S. Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets. Biochem Soc Trans 2007, 35:1325-1328.
4. Brennan P.J. Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis. Tuberculosis (Edinb) 2003, 83:91-97.
5. Belisle J.T., Vissa V.D., Sievert T., Takayama K., Brennan P.J., Besra G.S. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997, 276:1420-1422.
6. Fratti R.A., Chua J., Vergne I., Deretic V. Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest. Proc Natl Acad Sci U S A 2003, 100:5437-5442.
7. Kartmann B., Stengler S., Niederweis M. Porins in the cell wall of Mycobacterium tuberculosis. J Bacteriol 1999, 181:6543-6546.
8. Velmurugan K., Chen B., Miller J.L., Azogue S., Gurses S., Hsu T., et al. Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells. PLoS Pathog 2007, 3:e110.
9. Berthet F.X., Lagranderie M., Gounon P., Winter C.L., Ensergueix D., Chavarot P., et al. Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene. Science 1998, 282:759-762.
10. Magallanes V.R., Gomez G.S., Rauzier J., Barreiro L.B., Tailleux L., Boudou F., et al. Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages. Infect Immun 2007, 75:504-507.
11. Rindi L., Lari N., Garzelli C. Search for genes potentially involved in Mycobacterium tuberculosis virulence by mRNA differential display. Biochem Biophys Res Commun 1999, 258:94-101.
12. Movahedzadeh F., Smith D.A., Norman R.A., Dinadayala P., Murray-Rust J., Russell D.G., et al. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol Microbiol 2004, 51:1003-1014.
13. Raynaud C., Guilhot C., Rauzier J., Bordat Y., Pelicic V., Manganelli R., et al. Phospholipases C are involved in the virulence of Mycobacterium tuberculosis. Mol Microbiol 2002, 45:203-217.
14. Lam T.H., Yuen K.Y., Ho P.L., Wong K.C., Leong W.M., Law H.K., et al. Differential fadE28 expression associated with phenotypic virulence of Mycobacterium tuberculosis. Microb Pathog 2008, 45:12-17.
15. Bourne H.R., Sanders D.A., McCormick F. The GTPase superfamily: conserved structure and molecular mechanism. Nature 1991, 349:117-127.
16. Leipe D.D., Wolf Y.I., Koonin E.V., Aravind L. Classification and evolution of P-loop GTPases and related ATPases. J Mol Bio 2002, 317:41-72.
17. Hauryliuk V.V. GTPases of prokaryotic translational apparatus. Mol Biol (Mosk) 2006, 40:769-783.
18. Rodnina M.V., Stark H., Savelsbergh A., Wieden H.J., Mohr D., Matassova N.B., et al. GTPases mechanisms and functions of translation factors on the ribosome. Biol Chem 2000, 381:377-387.
19. Caldon C.E., March P.E. Function of the universally conserved bacterial GTPases. Curr Opinion Microbiol 2003, 6:135-139.
20. Vergne I., Chua J., Deretic V. Mycobacterium tuberculosis phagosome maturation arrest: selective targeting of PI3P-dependent membrane trafficking. Traffic 2003, 4:600-606.
21. Roberts E.A., Chua J., Kyei G.B., Deretic V. Higher order Rab programming in phagolysosome biogenesis. J Cell Biol 2006, 174:923-929.
22. Kyei G.B., Vergne I., Chua J., Roberts E., Harris J., Junutula J.R., et al. Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest. EMBO J 2006, 25:5250-5259.
23. Golden M.P., Vikram H.R. Extrapulmonary tuberculosis: an overview. Am Fam Physician 2005, 72:1761-1768.
24. Mutlu G., Mutlu E., Bellmeyer A., Rubinstein I. Pulmonary adverse events of anti-tumor necrosis factor-alpha antibody therapy. Am J Med 2006, 119:639-646.
25. Ramaswamy S., Musser J.M. Molecular genetic basis of anti-microbial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber Lung Dis 1998, 79:3-29.
26. Sharma S.K., Mohan A. Extrapulmonary tuberculosis. Ind J Med Res 2004, 316-353.
27. Jain A., Dixit P. Multidrug resistant to extensively drug resistant tuberculosis: what is next?. J Biosci 2008, 33:605-616.
28. Spigelman M.K. New tuberculosis therapeutics: a growing pipeline. J Infect Dis 2007, 196:28-34.
29. Holtz T.H., Cegielski J.P. Origin of the term XDR-TB. Eur Respir J 2007, 30:396.
30. Migliori G.B., Loddenkemper R., Blasi F., Raviglione M.C. 125 years after Robert Koch's discovery of the tubercle bacillus: the new XDR-TB threat. Is " science" enough to tackle the epidemic?. Eur Respir J 2007, 29:423-427.
31. Cardona P.J., Ruiz-Manzano J. On the nature of Mycobacterium tuberculosis-latent bacilli. Eur Respir J 2004, 24:1044-1051.
32. Zhang Y., Yang Y., Woods A., Cotter R.J., Sun Z. Resuscitation of dormant Mycobacterium tuberculosis by phospholipids or specific peptides. Biochem Biophys Res Commun 2001, 284:542-547.
33. Voskuil M.I., Schnappinger D., Visconti K.C., Harrell M.I., Dolganov G.M., Sherman D.R., et al. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. Exp Med 2003, 198:705-713.
34. Bourne H.R. GTPases: a family of molecular switches and clocks. Phil Trans R Soc London 1995, 349:283-289.
35. Sprang S.R. G-protein mechanisms: insights from structural analysis. Annu Rev Biochem 1997, 66:639-678.
36. Caldon C.E., Yoong P., March P.E. Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function. Mol Microbiol 2001, 41:289-297.
37. Kok J., Trach K.A., Hoch J.A. Effects on Bacillus subtilis of a conditional lethal mutation in the essential GTP-binding protein Obg. J Bacteriol 1994, 176:7155-7160.
38. Gualerzi C.O., Pon C.L. Initiation of mRNA translation in prokaryotes. Biochem 1990, 29:5881-5889.
39. Brock S., Szkaradkiewicz K., Sprinzi M. Initiation factors of protein biosynthesis in bacteria and their structural relationship to elongation and termination factors. Mol Microbiol 1998, 29:409-417.
40. Wilson K.S., Noller H.F. Molecular movement inside the translational engine. Cell 1998, 92:337-349.
41. Rodnina M.V., Savelsbergh A., Wintermeyer W. Dynamics of translation on the ribosome: molecular mechanics of translocation. FEMS Microbiol Rev 1999, 23:317-333.
42. 37Rv. Enzyme Microb Tech 2008, 42:138-144.
43. Minkovsky N., Zariman A., Chary V.K., Johnstone B.H., Powell B.S., Torrance P.D., et al. Bex, the Bacillus subtilis homolog of the essential E. coli GTPase Era, is required for normal cell division and spore formation. J Bacteriol 2002, 184:6389-6394.
44. Morimoto T., Chin L.P., Hirai T., Asai K., Kobayashi K., Moriya S., et al. Six GTP- binding proteins of the Era/Obg family are essential for cell growth in Bacillus subtilis. Microbiol 2002, 148:3539-3552.
45. Mittenhuber G. Comparative genomics of prokaryotic GTP-binding proteins (the Era, Obg, EngA, ThdF (TrmE), YchF and YihA families) and their relationship to eukaryotic GTP-binding proteins (the DRG, ARF, RAB, RAN, RAS, and RHO families). J Mol Microbiol Biotechnol 2001, 3:21-35.
46. Via L.E., Deretic D., Ulmer R.J., Hibler N.S., Huber L.A., Deretic V. Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7. J Biol Chem 1997, 272:13326-13331.
47. Vergne I., Chua J., Lee H., Lucas M., Belisle J., Deretic V. Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 2005, 102:4033-4038.
48. Margalit D.N., Romberg L., Mets R.B., Hebert A.M., Mitchison T.J., Kirschner M.W., et al. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A 2004, 101:11821-11826.
49. Lamb H.K., Thompson P., Elliott C., Charles I.G., Richards J., Lockyer M., et al. Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium. Protein Sci 2007, 16:2391-2402.