High-glucose condition reduces cardioprotective effects of insulin against mechanical stress-induced cell injury

Life Sciences

Volumn 87, Issue 5-6, 2010, Pages 154-161

  Teshima, Yasushi ^a   Takahashi, Naohiko ^a   Thuc, Luong Cong ^a   Nishio, Satoru ^a   Nagano Torigoe, Yasuko ^a   Miyazaki, Hiroko ^a   Ezaki, Kaori ^a   Yufu, Kunio ^a   Hara, Masahide ^a   Nakagawa, Mikiko ^a   Saikawa, Tetsunori ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cardiomyocyte; Cardioprotection; Hyperglycemia; Insulin; Mechanical stretch

Indexed keywords

GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SILICONE; TENSIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CHROMOSOME 10; CONTROLLED STUDY; DRUG EFFECT; HEART FAILURE; HEART MUSCLE CELL; HEART PROTECTION; HYPERGLYCEMIA; MECHANICAL STRESS; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CARDIOTONIC AGENTS; GLUCOSE; INSULIN; MEMBRANE POTENTIAL, MITOCHONDRIAL; MYOCYTES, CARDIAC; NECROSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; STRESS, MECHANICAL;

RATTUS;

EID: 77954955923     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.06.006     Document Type: Article

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