68Ga-labelled recombinant antibody variants for immuno-PET imaging of solid tumours

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 37, Issue 7, 2010, Pages 1397-1407

  Eder, Matthias ^a   Knackmuss, Stefan ^b   Le Gall, Fabrice ^b   Reusch, Uwe ^b   Rybin, Vladimir ^c   Little, Melvyn ^b   Haberkorn, Uwe ^d   Mier, Walter ^d   Eisenhut, Michael ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Affimed GmbH   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

68Ga; EpCAM; HBED CC; PET imaging; Recombinant antibody fragments

Indexed keywords

CHELATING AGENT; EPITHELIAL CELL ADHESION MOLECULE; EPITHELIAL CELL ADHESION MOLECULE ANTIBODY; GALLIUM 68; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; METAL COMPLEX; N,N' BIS[2 HYDROXY 5 (CARBOXYETHYL)BENZYL]ETHYLENEDIAMINE N,N' DIACETIC ACID; N,N' BIS[2 HYDROXY 5 (CARBOXYETHYL)BENZYL]ETHYLENEDIAMINE N,N' DIACETIC ACID HUMAN IMMUNOGLOBULIN G ANTIBODY CONJUGATE GA 68; N,N' BIS[2 HYDROXY 5 (CARBOXYETHYL)BENZYL]ETHYLENEDIAMINE N,N' DIACETIC ACID SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY CONJUGATE GA 68; RADIOPHARMACEUTICAL AGENT; RECOMBINANT ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; CELL ADHESION MOLECULE; DIAGNOSTIC AGENT; GALLIUM; IMMUNOGLOBULIN FRAGMENT; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY ISOLATION; ANTIBODY LABELING; ANTIBODY LIBRARY; ANTIBODY SPECIFICITY; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; BIOACCUMULATION; COLON CARCINOMA; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; DNA MODIFICATION; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG UPTAKE; EMBRYO; ENVIRONMENTAL TEMPERATURE; EXPERIMENTAL NEOPLASM; FEMALE; HAIRY CELL LEUKEMIA; HODGKIN DISEASE; HUMAN; HUMAN CELL; ISOTOPE LABELING; MOLECULAR WEIGHT; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN DOMAIN; PROTEIN VARIANT; ROOM TEMPERATURE; SOLID TUMOR; SQUAMOUS CELL CARCINOMA; T CELL LYMPHOMA; TUMOR; ANIMAL; CHEMISTRY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; METHODOLOGY; NEOPLASM; SCINTISCANNING; TUMOR CELL LINE;

ANIMALS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; EPITHELIAL CELLS; FEMALE; GALLIUM RADIOISOTOPES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOGLOBULIN FRAGMENTS; MICE; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RECOMBINANT PROTEINS;

EID: 77954955682     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-010-1392-6     Document Type: Article

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