Understanding variation in roller compaction through finite element-based process modeling

Computers and Chemical Engineering

Volumn 34, Issue 7, 2010, Pages 1058-1071

  Cunningham, John C ^a,b   Winstead, Denita ^b   Zavaliangos, Antonios ^a  

^a Drexel University   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Dry granulation; Finite element; Process modeling; Roller compaction

Indexed keywords

2-D MODEL; 3D MODELS; ADAPTIVE MESHING; COMPACTED MATERIALS; COUNTER ROTATING; DESIGN IMPROVEMENTS; DRY GRANULATION; EULERIAN; EXPLICIT FINITE ELEMENTS; FEED SYSTEMS; FINITE ELEMENT; FINITE-ELEMENT PROCESS MODELING; FRICTIONAL COEFFICIENTS; LAGRANGIAN; LOCAL STRESS; MANUFACTURING PROCESS; MECHANICAL BEHAVIOR; MICROCRYSTALLINE CELLULOSE; MODEL PREDICTION; PERIODIC VARIATION; PHARMACEUTICAL INDUSTRY; PROCESS MODELING; PRODUCT QUALITY; QUALITY BY DESIGNS; REDUCE VARIATION; RELATIVE DENSITY; ROLL FORCE; ROLL SURFACE PRESSURE; ROLLER COMPACTION; STRESS CONDITION;

CHEMICAL CONTAMINATION; COMPACTION; DESIGN; DRUG PRODUCTS PLANTS; FRICTION; GRANULATION; POWDERS; QUALITY CONTROL; ROLLERS (MACHINE COMPONENTS); SEALS; SHEAR STRESS; STRENGTH OF MATERIALS; THREE DIMENSIONAL; TRIBOLOGY; TWO DIMENSIONAL;

FINITE ELEMENT METHOD;

EID: 77954863372     PISSN: 00981354     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compchemeng.2010.04.008     Document Type: Article

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