Nondestructive Measurements of the Compact Strength and the Particle-Size Distribution after Milling of Roller Compacted Powders by Near-Infrared Spectroscopy

Journal of Pharmaceutical Sciences

Volumn 93, Issue 4, 2004, Pages 1047-1053

  Gupta, Abhay ^a   Peck, Garnet E ^a   Miller, Ronald W ^b   Morris, Kenneth R ^a  

^a PURDUE UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Compact strength; Compaction; Dry granulation; Granulation; Milling; Near infrared spectroscopy; Particle size; Process Analytical Technology (PAT); Roller compaction; Three point beam bending method

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; MICROCRYSTALLINE CELLULOSE; TOLMETIN;

ARTICLE; DRUG GRANULATION; DRUG MANUFACTURE; DRUG MIXTURE; FILM COATING; NEAR INFRARED SPECTROSCOPY; PARTICLE SIZE; POWDER; QUALITY CONTROL;

EID: 1842482367     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20003     Document Type: Article

References (12)

1. Prebble KA, MacDonald BF. 1993. Some applications of near-infrared reflectance analysis in the pharmaceutical industry. J Pharm Biomed Anal 11:1077-1085.
2. Kirsch JD, Drennen JK. 1995. Near-infrared spectroscopy: Applications in the analysis of tablets and solid pharmaceutical dosage. Appl Spectrosc Rev 30:139-174.
3. Blanco M, Coello J, Iturriaga H, Maspoch S, de la Pesuela C. 1998. Near-infrared spectroscopy in the pharmaceutical industry. Analyst 123:135R-150R.
4. Ufret C, Morris KR. 2001. Modeling of powder blending using on-line near-infrared measurements. Drug Dev Ind Pharm 27:719-729.
5. Trafford AD, Jee RD, Moffat AC, Grahm P. 1999. A Rapid quantitative assay of intact paracetamol tablets by reflectance near-infrared spectroscopy. Analyst 124:163-167.
6. Lunar PL, Majuru S, Seyer JJ, Kemper MS. 2000. Quantifying crystalline form composition in binary powder mixtures using near-infrared reflectance spectroscopy. Pharm Dev Technol 5:231-246.
7. Buice RG, Gold TB, Lodder RA, Digenis GA. 1995. Determination of moisture in intact gelatin capsules by near-infrared spectrophotometry. Pharm Res 12:161-163.
8. Kirsch JD, Drennen JK. 1996. Near-infrared spectroscopic monitoring of the film coating process. Pharm Res 13:234-237.
9. Morris KR, Stowell JG, Byrn SR, Placette AW, Davis TD, Peck GE. 2000. Accelerated fluid bed drying using NIR monitoring and phenomenological modeling. Drug Dev Ind Pharm 26:985-988.
10. Wildfong PLD, Samy AS, Corfa J, Peck GE, Morris KR. 2002. Accelerated fluid bed drying using NIR monitoring and phenomenological modeling: Method assessment and formulation suitability. J Pharm Sci 91:631-639.
11. Miller RW. 1999. Roller compaction optimization-NIR in-process mapping. J Pharm Technol Year-book Suppl.:30-39.
12. Kirsch JD, Drennen JK. 1999. Nondestructive tablet hardness testing by near-infrared spectroscopy: A new and robust spectral best-fit algorithm. J Pharm Biomed Anal 19:351-362.