Modelling the compaction behaviour of powders: Application to pharmaceutical powders

Powder Technology

Volumn 127, Issue 3, 2002, Pages 257-266

  Michrafy, A ^a   Ringenbacher, D ^b   Tchoreloff, P ^c  

^a UMR CNRS 2392   (France)

^b Z I Les Gailletrous   (France)

^c UNIV PARIS SUD   (France)

Author keywords

Compaction; Elasto plasticity; Finite element modelling; Mechanical behaviour; Powders

Indexed keywords

COMPACTION; DATA ACQUISITION; DRUG PRODUCTS; FINITE ELEMENT METHOD; FRICTION; PLASTICITY; PRESSURE EFFECTS; STRAIN; STRAIN HARDENING; STRESSES;

PHARMACEUTICAL POWDERS;

POWDERS;

LACTOSE;

COMPACTION; MECHANICAL PROPERTY; MODELING; POWDER;

ADHESION; ARTICLE; CALIBRATION; DENSITY; ELASTICITY; FRICTION; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PLASTICITY; POWDER; STRESS STRAIN RELATIONSHIP; TABLET COMPRESSION; TABLET HARDNESS; TABLET PROPERTY;

EID: 0037027457     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0032-5910(02)00119-5     Document Type: Article

References (33)

1. Heckel R.W. Trans. Metall. Soc. AIME. 221:1961;671.
2. Rue P.J., Rees J.E. Limitations of the Heckel relation for predicting powder compaction mechanisms. J. Pharmacol. 30:1978;642-643.
3. York P. A consideration of experimental variables in the analysis of powder compaction behaviour. J. Pharmacol. 31:1979;244-246.
4. Zetzer W., Leuenberger H., Sucher H. Compressibility and compactibility of powder mixtures. Pharm. Technol. 7(11):1983;33-48.
5. Leuenberger H., Rohera B.D. Fundamentals of powder compression: 1. The compactibility and compressibility of pharmaceutical powders. Pharm. Res. 3(1):1986;12-22.
6. Leuenberger H., Rohera B.D. Fundamentals of powder compression: 2. The compression of binary mixtures. Pharm. Res. 3(2):1986;65-74.
7. Guyot J.C., Delacourte A., Marie B. Computer determination and comparison of the compression behaviour of powder mixtures. Drug Devel. Ind. Pharm. 12(11):1986;1869-1884.
8. Krycer I., Pope D.G., Hersey J.A. Pharm. Pharmacol. 34:1982;802.
9. Armstrong N.A., Haines-Nutt R.F. J. Pharm. Pharmacol. 24:1972;135.
10. Summers M.P., Enever R.P., Carless J.E. J. Pharm. Pharmacol. 28:1976;89.
11. Çelik M., Travers D.N. Drug Devel. Ind. Pharm. 11:1985;299.
12. Kuhn H.A., Downey C.L. Deformation characteristics and plasticity theory of sintered powder materials. Int. J. Powder Metall. 7:1971;15-25.
13. DiMaggio F.L., ASCE M., Sandler I. Material model for granular soils. J. Eng. Mech. Div., Proc. Am. Soc. Civ. Eng. 1971;935-950.
14. Fleck N.A. On the cold compaction of powders. J. Mech. Phys. Solids. 43(9):1995;1409-1431.
15. Oyane M., Shima S., Tabata T. Consideration of basic equations, and their application, in the forming of metal powders and porous metals. J. Mech. Work. Technol. 1:1978;325-341.
16. Deraivelu S.M., Gegel H.L., Gunasekera J.S., Malas J.C., Morgan J.T. A new yield function for compressible P/M materials. Int. J. Mech. Sci. 26(9/10):1984;527-535.
17. ABAQUS Theory Manual Version 5.7, p. 4.4.4-1, Hibbit, Karlsson and Sorensson.
18. Drucker D.C., Prager W. Soil mechanics and plastic analysis or limit design. Q. Appl. Math. 10:1952;157.
19. Haggblad H.A. Constitutive model for powder materials. Powder Technol. 67:1991;127-136.
20. Pavier E., Dorémus P. Comparison between constitutive equations modelling the compaction of iron powder and experimental data obtained with triaxial tests. International Wokshop on Modelling of Metal Powder Forming Processes, Univ. Joseph Fourier, Grenoble, France, 21-23 July:1997;1-8.
21. Es-Saheb M.H. Uniaxial strain rate effects in pharmaceutical powders during cold compaction. J. Mater. Sci. 27:1992;4151-4159.
22. Jenike A.W., Carson J. Measurement principles of the flowability of powders. Adv. Ceram. 21:1985;759-766.
23. Guerin E., Tchoreloff P., Leclerc B., Tanguy D., Deleuil M., Couarraze G. Rheological characterization of pharmaceutical powders using tap testing, shear cell and mercury porosimeter. Int. J. Pharm. 189:1999;91-103.
24. Kuhn H.A. Deformation processing of sintered powder materials. Powder Metallurgy Processing: New Techniques and Analyses. 1978;99 Academic Press, New York.
25. Aydin I., Briscoe B.J., Sanliturk K.Y. The internal form of compacted ceramic components: a comparison of a finite element modelling with experiment. Powder Technol. 89:1996;239-254.
26. A. Zaoui, Comportement des matériaux, cours E.N.S.T.A., 1983.
27. DiMilia R.A., Reed J.S. J. Am. Ceram. Soc. 66:1983;667.
28. Al-Khattat I.M., Al-Hassani S.T.S. Towards a computer-aided analysis and design of tablet compaction. Chem. Eng. Sci. 42(4):1987;707-712.
29. Train D. An investigation into the compaction of powders. J. Pharm. Pharmacol. 8:1956;745-761.
30. Train D. Trans. Inst. Chem. Eng. 35:1957;258.
31. Shaxby J.H., Evans J.C. Trans. Faraday Soc. 19:1923;60.
32. Unckel H. Arch. Eisenhuttenwes. 18:1945;161.
33. Toor H.L., Eagleton S.D. Ind. Eng. Chem. 48:1965;825.