Characterisation of density distributions in roller-compacted ribbons using micro-indentation and X-ray micro-computed tomography

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 72, Issue 1, 2009, Pages 173-182

  Miguélez Morán, Andres M ^a,b   Wu, Chuan Yu ^a   Dong, Hanshan ^a   Seville, Jonathan P K ^c  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Agglomeration; Density distribution; Granulation; Micro indentation; Ribbon; Roller compaction; X ray tomography

Indexed keywords

MICROCRYSTALLINE CELLULOSE;

ARTICLE; CALIBRATION; COMPUTER ASSISTED TOMOGRAPHY; DRUG GRANULATION; INTERMETHOD COMPARISON; RELATIVE DENSITY; X RAY MICROANALYSIS;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; COMPRESSIVE STRENGTH; DRUG COMPOUNDING; EQUIPMENT DESIGN; PARTICLE SIZE; POROSITY; POWDERS; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TENSILE STRENGTH; X-RAY MICROTOMOGRAPHY;

EID: 62949188230     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.12.005     Document Type: Article

References (44)

1. Shlieout G., Lammens R.F., and Kleinebudde P. Dry granulation with a roller compactor. Part I: The functional units and operation modes. Pharm. Technol. Eur. (2000) 25-35
2. Vervaet C., and Remon J.P. Continuous granulation in the pharmaceutical industry. Chem. Eng. Sci. 60 (2005) 3949-3957
3. Parrott E.L. Densification of powders by concavo-convex roller compactor. J. Pharm. Sci. 70 3 (1981) 288-291
4. Miller R.W. Handbook of Pharmaceutical Granulation Technology (1997), Marcel Dekker, Inc., New York, Basel pp. 100-148 (Chapter 6)
5. Guigon P., Simon O., Saleh K., Bindhumadhavan G., Adams M.J., and Seville J.P.K. Handbook of Powder Technology vol. 11 (2007), Granulation Elsevier, Amsterdam pp. 256-286
6. Kleinebudde P. Roll compaction/dry granulation: pharmaceutical applications. Eur. J. Pharm. Biopharm. 58 (2004) 317-326
7. Weyenberg W., Vermeire A., Vandervoort J., Remon J.P., and Ludwig A. Effects of roller compaction settings on the preparation of bioadhesive granules on ocular minitablets. Eur. J. Pharm. Biopharm. 59 (2005) 527-536
8. Guigon P., and Simon O. Interaction between feeding and compaction during lactose compaction in a laboratory roll press. KONA 18 (2000) 131-138
9. Guigon P., and Simon O. Correlation between powder-packing properties and roll press compact heterogeneity. Powder Technol. 130 1-3 (2003) 41-48
10. Simon O., and Guigon P. Roll press design - influence of force feed systems on compaction. Powder Technol. 130 1-3 (2003) 257-264
11. Bindhumadhavan G., Seville J.P.K., Adams M.J., Greenwood R.W., and Fitzpatrick S. Roll compaction of a pharmaceutical excipient: experimental validation of rolling theory for granular solids. Chem. Eng. Sci. 60 (2005) 3891-3897
12. Mansa R.F., Bridson R.H., Greenwood R.W., Barker H., and Seville J.P.K. Using intelligent software to predict the effects of formulation and processing parameters on roller compaction. Powder Technol. 181 2 (2008) 217-225
13. Herting M., and Kleinebudde P. Roll compaction/dry granulation: effect of raw material particle size on granule and tablet properties. Int. J. Pharm. 338 1-2 (2007) 110-118
14. Zinchuk A.V., Mullarney M.P., and Hancock B.C. Simulation of roller compaction using a laboratory scale compaction simulator. Int. J. Pharm. 269 (2004) 403-415
15. Nystrom C., and Alderborn G. Bonding surface area and bonding mechanism: two important factors for understanding of powder compactability. The compaction behaviour of pharmaceutical materials. Drug Dev. Ind. Pharm. 19 17-18 (1993) 2143-2196
16. Sheskey P.J., and Hendren J. The effects of roll compaction equipment variables granulation technique and HPMC polymer level on a controlled-release matrix model drug formulation. Pharm. Technol. 23 (1999) 90-106
17. Inghelbrecht S., and Remon J.P. Reducing dust and improving granule and tablet quality in the roller compaction process. Int. J. Pharm. 171 (1998) 195-206
18. von Eggelkraut-Gottanka S.G., Abed S.A., Mueller W., and Schmidt P.C. Roller compaction and tabletting of St. John's wort plant dry extract suing a gap width and force controlled roller compactor. I: Granulation and tabletting of eight different extract batches. Pharm. Dev. Technol. 7 4 (2002) 433-445
19. Tye C.K., Sun Ch.C., and Amidon G.E. Evaluation of the effects of tabletting speed on the relationships between compaction pressure tablet tensile strength and tablet solid fraction. J. Pharm. Sci. 94 3 (2005) 465-472
20. Wu C.-Y., Best S.M., Bentham A.C., Hancock B.C., and Bonfield W. A simple predictive model for the tensile strength of binary tablets. Eur. J. Pharm. Sci. 25 (2005) 331-336
21. Wu C.-Y., Best S.M., Bentham A.C., Hancock B.C., and Bonfield W. Predicting the tensile strength of multi-component pharmaceutical tablets. Pharm. Res. 23 8 (2006) 1898-1905
22. Funakoshi Y., Asogawa T., and Satake E. Use of a novel roller compactor with a concavo-convex roller pair to obtain uniform compacting pressure. Drug Dev. Ind. Pharm. 6 3 (1977) 555-573
23. Freitag F., Reincke K., Runge J., Grellmann W., and Kleinebudde P. How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets. Eur. J. Pharm. Sci. 22 4 (2004) 325-333
24. Sinka I.C., Burch S.F., Tweed J.H., and Cunningham J.C. Measurement of density variations in tablets using X-ray computed tomography. Int. J. Pharm. 271 1-2 (2004) 215-224
25. Busignies V., Leclerc B., Porion P., Evesque P., Couarraze G., and Tchoreloff P. Quantitative measurements of localized density variations in cylindrical tablets using X-ray microtomography. Eur. J. Pharm. Biopharm. 64 1 (2006) 38-50
26. Djemai A., and Sinka I.C. NMR imaging of density distributions in tablets. Int. J. Pharm. 319 1-2 (2006) 55-62
27. Busignies V., Porion P., Leclerc B., Evesque P., and Tchoreloff P. Application of PGSTE-NMR technique to characterize the porous structure of pharmaceutical tablets. Eur. J. Pharm. Biopharm. 69 3 (2008) 1160-1170
28. Busignies V., Tchoreloff P., Leclerc B., Hersen C., and Keller G. Compaction of crystallographic forms of pharmaceutical granular lactoses. II: Compacts mechanical properties. Eur. J. Pharm. Biopharm. 58 (2004) 577-586
29. Sinka C., Cunningham J.C., and Zavaliangos A. Analysis of tablet compaction. II: Finite element analysis of density distributions in convex tablets. J. Pharm. Sci. 93 8 (2004) 2040-2053
30. Lee J. Structural heterogeneity of pharmaceutical compacts probed by micro-indentation. J. Mater. Sci.: Mater. Med. 19 (2008) 1981-1990
31. Rohera B.D., and Parikh N.H. Influence of plasticizer type and coat level on Surelease film properties. Pharm. Dev. Technol. 7 4 (2002) 407-420
32. McCullough E.C. Photon attenuation in computed tomography. Med. Phys. 2 6 (1975) 307-320
33. Phillips D.H., and Lannutti J.J. Measuring physical density with X-ray computed tomography. NDT&E Int. 30 6 (1997) 339-350
34. Burch S. Measurement of density variations in compacted parts using X-ray computerised tomography. MPR (2002) 24-28
35. Farbera L., Tardosb G., and Michaelsa J.N. Use of X-ray tomography to study the porosity and morphology of granules. Powder Technol. 132 (2003) 57-63
36. Wu C.Y., Ruddy O.M., Bentham A.C., Hancock B.C., Best S.M., and Elliott J.A. Modelling the mechanical behaviour of pharmaceutical powders during compaction. Powder Technol. 152 1-3 (2005) 107-117
37. Wu C.-Y., Hancock B.C., Mills A., Bentham A.C., Best S.M., and Elliott J.A. Numerical and experimental investigation of capping mechanisms during pharmaceutical tablet compaction. Powder Technol. 181 2 (2008) 121-129
38. Hancock B.C., and Mullarney P. X-ray micro-tomography of solid dosage forms. Pharm. Technol. (2005) 92-100
39. F. Woell, Ph.D. Dissertation, Entwicklung von Methoden zur Charakterisierung von Schuelpen, University of Halle, Germany, 2003.
40. Miguélez-Morán A.M., Wu C.-Y., and Seville J.P.K. The effect of lubrication on density distributions of roller compacted ribbons. Int. J. Pharm. 362 (2008) 52-59
41. B. Michel, Ph.D. Dissertation, Contribution a l'etude de l'agglomeration des pourdres en presse a rouleaux lises, Universite de Compiegne, France, 1994.
42. Kumar V., and Kothary S.H. Effect of compressional force on the crystallinity of directly compressible cellulose excipients. Int. J. Pharm. 177 2 (1999) 173-182
43. Lubjuhn U., Sander U., and Schoenert K. Pressure profile in the compression zone of the high-pressure roller mill. ZKG 47 (1994) 157-163 (English translation)
44. Katashinskii V.P., Vinogradov G.A., and Kalutskii G.Ya. Nonuniformity of stress and strain distribution over the width of rolled powder strip. Poroshkovaya Metallurgiya 12 156 (1975) 28-32 (Translated)