Analysis of tablet compaction. I. Characterization of mechanical behavior of powder and powder/tooling friction

Journal of Pharmaceutical Sciences

Volumn 93, Issue 8, 2004, Pages 2022-2039

  Cunningham, J C ^a   Sinka, I C ^b   Zavaliangos, A ^c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Merck Sharp & Dohme Limited   (United Kingdom)

^c Drexel University   (United States)

Author keywords

Compaction; Mechanical properties; Tableting

Indexed keywords

MICROCRYSTALLINE CELLULOSE;

ARTICLE; CRYSTAL STRUCTURE; DENSITY; DRUG MANUFACTURE; ELASTICITY; MODEL; PLASTICITY; POWDER; TABLET; TABLET COMPRESSION;

EID: 3843107053     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20110     Document Type: Article

References (38)

1. Paronen P, Ilkka J. 1996. Porosity-pressure functions. In: Alderborn G, Nystrom C, editors. Pharmaceutical powder compaction technology. New York: Marcel Dekker, pp 55-75.
2. Trasorras JRL, Parameswaran R, Cocks ACF. 1998. Mechanical behavior of metal powders and compaction modeling. ASM handbook, Vol. 7. Powder metal technologies and applications. Materials Park, OH: ASM International, pp 326-342.
3. Zavaliangos A. 2002. Constitutive models for the simulation of P/M processes. Int J Powder Metall 38(2):27-39.
4. Zavaliangos A. 2003. A numerical study of the development of tensile principle stresses during die compaction. Part Science Tech 21:105-115.
5. Martin CL, Bouvard D. 2003. Study of the cold compaction of composite powders by the discrete element method. Acta Mater 51:373-386.
6. Federzoni L, Riedel H, Coube O, Oldenburg M, Gethin DT, Mosbah P, Virta J, Martikainen H, Frachon A, Doremus P, Imbault D (PM Modnet Computer Modeling Group). 1999. State of the art review: Comparison of computer models representing powder compaction process. Powder Metall 42(4):301-311.
7. Cocks ACF. 2001. Constitutive modeling of powder compaction and sintering. Prog Mater Sci 46(3-4):201-229.
8. Ewsuk KG, editor. 1997. Compaction science and technology. MRS Bull 22(12):14-51.
9. Drucker DC, Gibson RE, Henkel DJ. 1955. Soil mechanics and work-hardening theories of plasticity. Proc ASCE 81:1-14.
10. Drucker DC, Gibson RE, Henkel DJ. 1957 Soil mechanics and work hardening theories of plasticity. ASCE Trans 122:338-346.
11. Timoshenko SP, Goodier JN. 1970. Theory of elasticity. New York: McGraw-Hill.
12. Lubliner J. 1998. Plasticity theory. Pearson Education POD. Upper Saddle River, NJ.
13. Sinka IC, Cunningham JC, Zavaliangos A. 2001. Experimental characterization and numerical simulation of die wall friction in pharmaceutical powder compaction. Proceedings of the PM2TEC 2001 International Conference on Powder Metallurgy and Particulate Materials, May 13-17, 2001, New Orleans, LA, Part 1, pp 46-60. Metal Power Industries Federation, 105 College Road East, Princeton, NJ.
14. Sinka IC, Cunningham JC, Zavaliangos A. 2002. Density distributions in pharmaceutical tablets: Experiments and modeling. Proceedings of the 2002 International Conference on Process Modeling in Powder Metallurgy and Particulate Materials, October 28-29, 2002: Newport Beach, CA. Princeton, NJ: Metal Powder Industries Federation, pp 123-132.
15. Michrafy A, Ringenbacher D, Tchoreloff P. 2002. Modeling the compaction behavior of powders: Application to pharmaceutical powders. Powder Technol 127:257-266.
16. Sinka IC, Cunningham JC, Zavaliangos A. 2003. The effect of wall friction in the compaction of pharmaceutical tablets with curved faces: A validation study of the Drucker-Prager Cap model. Powder Technol 133(1-3):33-43.
17. Lia G, Jinna JT, Wu WT, Ohb SI. 2001. Recent development and applications of three-dimensional finite element modeling in bulk forming processes. J Mater Process Technol 113(1-3):40-45.
18. Tenek LT, Argyris JJ. 1998. Finite element analysis for composite structures. Dordrecht: Kluwer Academic Publishers.
19. Rashidi AA, Arulanandan K. 1995. Elasto-plastic finite element analyses of a soil-structure system under earthquake excitations. Comput Geotech 17(3):301-325.
20. Zavaliangos A, Anand L. 1993. Thermo-elastoviscoplasticity for isotropic porous metals. J Mech Phys Solids 41(6):1087-1118.
21. Spencer AJM. 1971. Theory of invariants. In: Eringen AC, editor. Continuum physics, Vol. 1. New York: Academic Press, pp 240-352.
22. Mosbah P, Kojima J, Shima S, Kotera H. 1997. Influence of the third stress invariant on iron powder behavior during compaction. International Workshop on Modeling of Metal Powder Forming Process, pp 19-27. GPM2 Laboratory, Grenoble, France.
23. Gurson AL. 1977. Continuum theory of ductile rupture by void nucleation and growth. Part I. Yield criteria and flow rules for porous ductile media. Transactions of the ASME. J Eng Mat Technol Jan: 2-15.
24. Schofield AN, Wroth CP. 1968. Critical state solid mechanics. New York: McGraw Hill.
25. DiMaggio FL, Sandler IS. 1971, Material models for granular soils. J Eng Mech Div ASCE 97(EM3): 935-950.
26. Kuhn HA, Downey CL. 1971. Deformation and plasticity theory of sintered powder materials. Int J Powder Metall 7:15-25.
27. Hibbitt, Karlsson and Sorensen, Inc. 1988. ABAQUS theory manual.
28. Hill R. 1950. The mathematical theory of plasticity. Oxford, UK: Oxford University Press.
29. Procopio A, Zavaliangos A, Cunningham JC. 2003. Analysis of the diametrical compression test and its applicability to plastically deforming materials. J Mater Sci 38:3629-3639.
30. Li F, Puri VM. 1996. Measurement of anisotropic behavior of dry cohesive and cohesionless powders using a cubical triaxial tester. Powder Technol 89: 197-207.
31. Coube O, Riedel H. 2000. Numerical simulation of metal powder die compaction with special consideration to cracking. Powder Metall 43(2): 123-131.
32. Glass SJ, Ewsuk KG. 1997. Ceramic powder compaction. MRS Bull 22(14):24-28.
33. Doremus P, Toussaint F, Alvain O. 2001. Simple tests and standard procedure for the characterization of green compacted powder. In: Zavaliangos A, Laptev A, editors. Recent developments in computer modeling of powder metallurgy operations. The Netherlands: IOS Press, pp 262-270.
34. Sinka IC, Cunningham JC, Zavaliangos A. Analysis of tablet compaction. 2. Finite element analysis of density distributions in convex tablets. J Pharm Sci 93:2040-2053.
35. Wikman B, Haggblad H-A, Oldenburg M. 1997. Modelling of powder-wall friction for simulation of iron powder pressing. Proceedings of the International Workshop on Modelling of Metal Powder Forming Processes, Grenoble, France, pp 149-156.
36. Pavier E, Doremus P. Friction behavior of an iron powder investigated with two different apparatus. Proceedings of the International Workshop on Modelling of Metal Powder Forming Processes, Grenoble, France, pp 335-344.
37. Wikman B, Solimannezhad N, Larsson R, Oldenburg M, Haggblad H-A. 2000. Wall friction coefficient estimation through modelling of powder die pressing experiment. Powder Metall 43(2): 132-138.
38. Turenne S, Godere C, Thomas Y. 2000. Effect of temperature on the behavior of lubricants during powder compaction. Powder Metall 43(2): 139-142.