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Volumn 1, Issue 2, 2010, Pages 109-113

The many roads traveled by Helicobacter pylori to NFκB activation

Author keywords

CagA; Helicobacter pylori; NF B; TAK1; TRAF6; Ubiquitination

Indexed keywords

CAGA PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1;

EID: 77954840044     PISSN: 19490976     EISSN: 19490984     Source Type: Journal    
DOI: 10.4161/gmic.1.2.11587     Document Type: Article
Times cited : (40)

References (43)
  • 1
    • 0033843035 scopus 로고    scopus 로고
    • The immune response against Helicobacter pylori-a direct linkage to the development of gastroduodenal disease
    • Ibraghimov A, Pappo J. The immune response against Helicobacter pylori-a direct linkage to the development of gastroduodenal disease. Microbes Infect 2000; 2:23-5.
    • (2000) Microbes Infect , vol.2 , pp. 23-25
    • Ibraghimov, A.1    Pappo, J.2
  • 2
    • 43649109029 scopus 로고    scopus 로고
    • Inflammation and cancer: Role of nuclear factor-kappaB activation
    • Maeda S, Omata M. Inflammation and cancer: role of nuclear factor-kappaB activation. Cancer Sci 2008; 99:836-42.
    • (2008) Cancer Sci , vol.99 , pp. 836-842
    • Maeda, S.1    Omata, M.2
  • 3
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NFkappaB signaling
    • Hayden MS, Ghosh S. Shared principles in NFkappaB signaling. Cell 2008; 132:344-62.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 5
    • 18044373212 scopus 로고    scopus 로고
    • Identification of two new Helicobacter pylori surface proteins involved in attachment to epithelial cell lines
    • Rubinsztein-Dunlop S, Guy B, Lissolo L, Fischer H. Identification of two new Helicobacter pylori surface proteins involved in attachment to epithelial cell lines. J Med Microbiol 2005; 54:427-34.
    • (2005) J Med Microbiol , vol.54 , pp. 427-434
    • Rubinsztein-Dunlop, S.1    Guy, B.2    Lissolo, L.3    Fischer, H.4
  • 6
    • 0029043658 scopus 로고
    • Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
    • Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995; 55:2111-5.
    • (1995) Cancer Res , vol.55 , pp. 2111-2115
    • Blaser, M.J.1    Perez-Perez, G.I.2    Kleanthous, H.3    Cover, T.L.4    Peek, R.M.5    Chyou, P.H.6
  • 8
    • 0029963677 scopus 로고    scopus 로고
    • cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
    • Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 1996; 93:14648-53.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14648-14653
    • Censini, S.1    Lange, C.2    Xiang, Z.3    Crabtree, J.E.4    Ghiara, P.5    Borodovsky, M.6
  • 9
    • 4544334936 scopus 로고    scopus 로고
    • Oncogenic mechanisms of the Helicobacter pylori CagA protein
    • Hatakeyama M. Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat Rev Cancer 2004; 4:688-94.
    • (2004) Nat Rev Cancer , vol.4 , pp. 688-694
    • Hatakeyama, M.1
  • 10
    • 0032030668 scopus 로고    scopus 로고
    • Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappaB in gastric epithelial cells
    • Sharma SA, Tummuru MK, Blaser MJ, Kerr LD. Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappaB in gastric epithelial cells. J Immunol 1998; 160:2401-7.
    • (1998) J Immunol , vol.160 , pp. 2401-2407
    • Sharma, S.A.1    Tummuru, M.K.2    Blaser, M.J.3    Kerr, L.D.4
  • 11
    • 21544441173 scopus 로고    scopus 로고
    • NFkappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein
    • Brandt S, Kwok T, Hartig R, Konig W, Backert S. NFkappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci USA 2005; 102:9300-5.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9300-9305
    • Brandt, S.1    Kwok, T.2    Hartig, R.3    Konig, W.4    Backert, S.5
  • 12
    • 33644817536 scopus 로고    scopus 로고
    • Helicobacter pylori CagA transfection of gastric epithelial cells induces interleukin-8
    • Kim SY, Lee YC, Kim HK, Blaser MJ. Helicobacter pylori CagA transfection of gastric epithelial cells induces interleukin-8. Cell Microbiol 2006; 8:97-106.
    • (2006) Cell Microbiol , vol.8 , pp. 97-106
    • Kim, S.Y.1    Lee, Y.C.2    Kim, H.K.3    Blaser, M.J.4
  • 13
    • 33750503428 scopus 로고    scopus 로고
    • CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model
    • Shibata W, Hirata Y, Maeda S, Ogura K, Ohmae T, Yanai A, et al. CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model. J Pathol 2006; 210:306-14.
    • (2006) J Pathol , vol.210 , pp. 306-314
    • Shibata, W.1    Hirata, Y.2    Maeda, S.3    Ogura, K.4    Ohmae, T.5    Yanai, A.6
  • 14
    • 70449093718 scopus 로고    scopus 로고
    • Helicobacter pylori CagA activates NFkappaB by targeting TAK1 for TRAF6- mediated Lys 63 ubiquitination
    • Lamb A, Yang XD, Tsang YH, Li JD, Higashi H, Hatakeyama M, et al. Helicobacter pylori CagA activates NFkappaB by targeting TAK1 for TRAF6- mediated Lys 63 ubiquitination. EMBO Rep 2009; 10:1242-9.
    • (2009) EMBO Rep , vol.10 , pp. 1242-1249
    • Lamb, A.1    Yang, X.D.2    Tsang, Y.H.3    Li, J.D.4    Higashi, H.5    Hatakeyama, M.6
  • 15
    • 26944433842 scopus 로고    scopus 로고
    • Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells
    • Naumann M. Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells. Int J Med Microbiol 2005; 295:335-41.
    • (2005) Int J Med Microbiol , vol.295 , pp. 335-341
    • Naumann, M.1
  • 16
    • 0035725211 scopus 로고    scopus 로고
    • Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: Essential genes for CagA translocation in host cells and induction of interleukin-8
    • Fischer W, Puls J, Buhrdorf R, Gebert B, Odenbreit S, Haas R. Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol Microbiol 2001; 42:1337-48.
    • (2001) Mol Microbiol , vol.42 , pp. 1337-1348
    • Fischer, W.1    Puls, J.2    Buhrdorf, R.3    Gebert, B.4    Odenbreit, S.5    Haas, R.6
  • 17
    • 0037195107 scopus 로고    scopus 로고
    • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
    • Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T, et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci USA 2002; 99:14428-33.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14428-14433
    • Higashi, H.1    Tsutsumi, R.2    Fujita, A.3    Yamazaki, S.4    Asaka, M.5    Azuma, T.6
  • 18
    • 54949087520 scopus 로고    scopus 로고
    • Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA
    • Lu HS, Saito Y, Umeda M, Murata-Kamiya N, Zhang HM, Higashi H, et al. Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA. Cancer Sci 2008; 99:2004-11.
    • (2008) Cancer Sci , vol.99 , pp. 2004-2011
    • Lu, H.S.1    Saito, Y.2    Umeda, M.3    Murata-Kamiya, N.4    Zhang, H.M.5    Higashi, H.6
  • 19
    • 0035977010 scopus 로고    scopus 로고
    • Distinct mechanism of Helicobacter pylori-mediated NFkappaB activation between gastric cancer cells and monocytic cells
    • Maeda S, Akanuma M, Mitsuno Y, Hirata Y, Ogura K, Yoshida H, et al. Distinct mechanism of Helicobacter pylori-mediated NFkappaB activation between gastric cancer cells and monocytic cells. J Biol Chem 2001; 276:44856-64.
    • (2001) J Biol Chem , vol.276 , pp. 44856-44864
    • Maeda, S.1    Akanuma, M.2    Mitsuno, Y.3    Hirata, Y.4    Ogura, K.5    Yoshida, H.6
  • 20
    • 34248331321 scopus 로고    scopus 로고
    • Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori
    • Obonyo M, Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira S, et al. Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori. Infect Immun 2007; 75:2408-14.
    • (2007) Infect Immun , vol.75 , pp. 2408-2414
    • Obonyo, M.1    Sabet, M.2    Cole, S.P.3    Ebmeyer, J.4    Uematsu, S.5    Akira, S.6
  • 21
    • 28244441376 scopus 로고    scopus 로고
    • Helicobacter pylori activates NFkappaB via the alternative pathway in B lymphocytes
    • Ohmae T, Hirata Y, Maeda S, Shibata W, Yanai A, Ogura K, et al. Helicobacter pylori activates NFkappaB via the alternative pathway in B lymphocytes. J Immunol 2005; 175:7162-9.
    • (2005) J Immunol , vol.175 , pp. 7162-7169
    • Ohmae, T.1    Hirata, Y.2    Maeda, S.3    Shibata, W.4    Yanai, A.5    Ogura, K.6
  • 22
    • 33645740999 scopus 로고    scopus 로고
    • The pathogenesis of Helicobacter pyloriinduced gastro-duodenal diseases
    • Atherton JC. The pathogenesis of Helicobacter pyloriinduced gastro-duodenal diseases. Annu Rev Pathol 2006; 1:63-96.
    • (2006) Annu Rev Pathol , vol.1 , pp. 63-96
    • Atherton, J.C.1
  • 23
    • 9244245293 scopus 로고    scopus 로고
    • Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
    • Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 2004; 5:1166-74.
    • (2004) Nat Immunol , vol.5 , pp. 1166-1174
    • Viala, J.1    Chaput, C.2    Boneca, I.G.3    Cardona, A.4    Girardin, S.E.5    Moran, A.P.6
  • 25
    • 77954332543 scopus 로고    scopus 로고
    • The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides
    • Grubman A, Kaparakis M, Viala J, Allison C, Badea L, Karrar A, et al. The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides. Cell Microbiol 2010.
    • (2010) Cell Microbiol
    • Grubman, A.1    Kaparakis, M.2    Viala, J.3    Allison, C.4    Badea, L.5    Karrar, A.6
  • 26
    • 76249086428 scopus 로고    scopus 로고
    • Helicobacter pylori Induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism
    • Allison CC, Kufer TA, Kremmer E, Kaparakis M, Ferrero RL. Helicobacter pylori Induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism. J Immunol 2009; 183:8099-109.
    • (2009) J Immunol , vol.183 , pp. 8099-8109
    • Allison, C.C.1    Kufer, T.A.2    Kremmer, E.3    Kaparakis, M.4    Ferrero, R.L.5
  • 27
    • 30644468837 scopus 로고    scopus 로고
    • The PAK1 autoregulatory domain is required for interaction with NIK in Helicobacter pylori-induced NFkappaB activation
    • Neumann M, Foryst-Ludwig A, Klar S, Schweitzer K, Naumann M. The PAK1 autoregulatory domain is required for interaction with NIK in Helicobacter pylori-induced NFkappaB activation. Biol Chem 2006; 387:79-86.
    • (2006) Biol Chem , vol.387 , pp. 79-86
    • Neumann, M.1    Foryst-Ludwig, A.2    Klar, S.3    Schweitzer, K.4    Naumann, M.5
  • 28
    • 33644838832 scopus 로고    scopus 로고
    • MyD88 and TNF receptorassociated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells
    • Hirata Y, Ohmae T, Shibata W, Maeda S, Ogura K, Yoshida H, et al. MyD88 and TNF receptorassociated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells. J Immunol 2006; 176:3796-803.
    • (2006) J Immunol , vol.176 , pp. 3796-3803
    • Hirata, Y.1    Ohmae, T.2    Shibata, W.3    Maeda, S.4    Ogura, K.5    Yoshida, H.6
  • 29
    • 34248570795 scopus 로고    scopus 로고
    • Ubiquitin-mediated activation of TAK1 and IKK
    • Adhikari A, Xu M, Chen ZJ. Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 2007; 26:3214-26.
    • (2007) Oncogene , vol.26 , pp. 3214-3226
    • Adhikari, A.1    Xu, M.2    Chen, Z.J.3
  • 30
    • 2342629277 scopus 로고    scopus 로고
    • The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
    • Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 2004; 14:289-301.
    • (2004) Mol Cell , vol.14 , pp. 289-301
    • Sun, L.1    Deng, L.2    Ea, C.K.3    Xia, Z.P.4    Chen, Z.J.5
  • 31
    • 77950367657 scopus 로고    scopus 로고
    • Two mechanistically and temporally distinct NFkappaB activation pathways in IL-1 signaling
    • Yamazaki K, Gohda J, Kanayama A, Miyamoto Y, Sakurai H, Yamamoto M, et al. Two mechanistically and temporally distinct NFkappaB activation pathways in IL-1 signaling. Sci Signal 2009; 2:66.
    • (2009) Sci Signal , vol.2 , pp. 66
    • Yamazaki, K.1    Gohda, J.2    Kanayama, A.3    Miyamoto, Y.4    Sakurai, H.5    Yamamoto, M.6
  • 32
    • 77954837720 scopus 로고    scopus 로고
    • Lysine 63-linked polyubiquitination of transforming growth factor-[beta]-activated kinase 1 at lysine 158 is required for tumor necrosis factor [alpha] and interleukin-1[beta]-induced I[kappa]B kinase/nuclear factor-[kappa]B and c-JUN N-terminal kinase/ activator protein 1 activation
    • Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, et al. Lysine 63-linked polyubiquitination of transforming growth factor-[beta]-activated kinase 1 at lysine 158 is required for tumor necrosis factor [alpha] and interleukin-1[beta]-induced I[kappa]B kinase/nuclear factor-[kappa]B and c-JUN N-terminal kinase/ activator protein 1 activation. J Biol Chem 2009.
    • (2009) J Biol Chem
    • Fan, Y.1    Yu, Y.2    Shi, Y.3    Sun, W.4    Xie, M.5    Ge, N.6
  • 33
    • 53349164136 scopus 로고    scopus 로고
    • The type I TGFbeta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
    • Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, et al. The type I TGFbeta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat Cell Biol 2008; 10:1199-207.
    • (2008) Nat Cell Biol , vol.10 , pp. 1199-1207
    • Sorrentino, A.1    Thakur, N.2    Grimsby, S.3    Marcusson, A.4    von Bulow, V.5    Schuster, N.6
  • 34
    • 20744458702 scopus 로고    scopus 로고
    • EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells
    • Higashi H, Yokoyama K, Fujii Y, Ren S, Yuasa H, Saadat I, et al. EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells. J Biol Chem 2005; 280:23130-7.
    • (2005) J Biol Chem , vol.280 , pp. 23130-23137
    • Higashi, H.1    Yokoyama, K.2    Fujii, Y.3    Ren, S.4    Yuasa, H.5    Saadat, I.6
  • 35
    • 33845943988 scopus 로고    scopus 로고
    • Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells
    • Ren S, Higashi H, Lu H, Azuma T, Hatakeyama M. Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells. J Biol Chem 2006; 281:32344-52.
    • (2006) J Biol Chem , vol.281 , pp. 32344-32352
    • Ren, S.1    Higashi, H.2    Lu, H.3    Azuma, T.4    Hatakeyama, M.5
  • 37
    • 5444223519 scopus 로고    scopus 로고
    • The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    • Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 2004; 5:1052-60.
    • (2004) Nat Immunol , vol.5 , pp. 1052-1060
    • Boone, D.L.1    Turer, E.E.2    Lee, E.G.3    Ahmad, R.C.4    Wheeler, M.T.5    Tsui, C.6
  • 38
    • 34250368115 scopus 로고    scopus 로고
    • Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses
    • Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF, et al. Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med 2007; 204:1475-85.
    • (2007) J Exp Med , vol.204 , pp. 1475-1485
    • Reiley, W.W.1    Jin, W.2    Lee, A.J.3    Wright, A.4    Wu, X.5    Tewalt, E.F.6
  • 39
    • 58249083314 scopus 로고    scopus 로고
    • Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation
    • Suzuki M, Mimuro H, Kiga K, Fukumatsu M, Ishijima N, Morikawa H, et al. Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation. Cell Host Microbe 2009; 5:23-34.
    • (2009) Cell Host Microbe , vol.5 , pp. 23-34
    • Suzuki, M.1    Mimuro, H.2    Kiga, K.3    Fukumatsu, M.4    Ishijima, N.5    Morikawa, H.6
  • 40
    • 69549116880 scopus 로고    scopus 로고
    • The E3 ligase TRAF6 regulates Akt ubiquitination and activation
    • Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, et al. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 2009; 325:1134-8.
    • (2009) Science , vol.325 , pp. 1134-1138
    • Yang, W.L.1    Wang, J.2    Chan, C.H.3    Lee, S.W.4    Campos, A.D.5    Lamothe, B.6
  • 42
    • 69949093459 scopus 로고    scopus 로고
    • Direct activation of protein kinases by unanchored polyubiquitin chains
    • Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, et al. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 2009; 461:114-9.
    • (2009) Nature , vol.461 , pp. 114-119
    • Xia, Z.P.1    Sun, L.2    Chen, X.3    Pineda, G.4    Jiang, X.5    Adhikari, A.6
  • 43
    • 0033571334 scopus 로고    scopus 로고
    • Differential activation of mitogenactivated protein kinases in AGS gastric epithelial cells by cag+ and cag-Helicobacter pylori
    • Keates S, Keates AC, Warny M, Peek RM Jr, Murray PG, Kelly CP. Differential activation of mitogenactivated protein kinases in AGS gastric epithelial cells by cag+ and cag-Helicobacter pylori. J Immunol 1999; 163:5552-9.
    • (1999) J Immunol , vol.163 , pp. 5552-5559
    • Keates, S.1    Keates, A.C.2    Warny, M.3    Peek Jr., R.M.4    Murray, P.G.5    Kelly, C.P.6


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