Reduction in choline acetyltransferase immunoreactivity but not muscarinic-m2 receptor immunoreactivity in the brainstem of SIDS infants

Journal of Neuropathology and Experimental Neurology

Volumn 58, Issue 3, 1999, Pages 255-264

  Mallard, Carina ^a   Tolcos, Mary ^a   Leditschke, Jodie ^a   Campbell, Peter ^a   Rees, Sandra ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Airway patency; Arcuate nucleus; Cardiorespiratory control; DMV; Hypoglossal nucleus

Indexed keywords

CHOLINE ACETYLTRANSFERASE; MUSCARINIC M2 RECEPTOR; NEUROTRANSMITTER;

ARTICLE; BRAIN STEM; CHOLINERGIC NERVE CELL; CHOLINERGIC SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HYPOGLOSSAL NUCLEUS; IMMUNOREACTIVITY; INFANT; MEDULLA OBLONGATA; MOTONEURON NUCLEUS; OPTICAL DENSITY; PRIORITY JOURNAL; SUDDEN INFANT DEATH SYNDROME; VAGUS NERVE NUCLEUS;

EID: 0033042102     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199903000-00005     Document Type: Article

References (55)

1. Kinney HC, Filiano JJ, Harper RM. The neuropathology of the sudden infant death syndrome. A review. J Neuropathol Exp Neurol 1992;51:115-26
2. Naeye RL. Brain-stem and adrenal abnormalities in the sudden-infant-death syndrome. Am J Clin Pathol 1976;66:526-30
3. Takashima S, Armstrong DL, Becker LE, Bryan C. Cerebral hypoperfusion in sudden infant death syndrome? Brainstem gliosis and vasculature. Ann Neurol 1978;4:257-62
4. Kinney HC, Burger PC, Harell FE, Hudson RP. "Reactive gliosis" in the medulla oblongata of victims of sudden infant death syndrome. Pediatrics 1983;72:181-87
5. Takashima S, Becker LE. Developmental abnormalities of medullary "respiratory centers" in sudden infant death syndrome. Exp Neurol 1985;90:580-87
6. Bruce K, Becker LE. Quantitation of medullary astrogliosis in sudden infant death syndrome. Pediatr Neurosurg 1991;17:74-79
7. Pamphlett R, Treloar L. Astrocytes in the hypoglossal nuclei of sudden infant death syndrome (SIDS) infants: A quantitative study. Neuropathol Appl Neurobiol 1996;22:136-43
8. Quattrochi JJ, McBride T, Yates AJ. Brainstem immaturity in sudden infant death syndrome: A quantiative rapid Golgi study of dendritic spines in 95 infants. Brain Res 1985;325:39-48
9. Becker LE, Zhang W, Pereyra PM. Delayed maturation of the vagus nerve in sudden infant death syndrome. Acta Neuropathol Berlin 1993;86:617-22
10. O'Kusky JR, Norman MG. Sudden infant death syndrome: Post-natal changes in the numerical density and total number of neurons in the hypoglossal nucleus. J Neuropathol Exp Neurol 1992;51: 577-84
11. Konrat G, Halliday G, Sullivan C, Harper C. Preliminary evidence suggesting delayed development in the hypoglossal and vagal nuclei of SIDS infants: A necropsy study. J Child Neurol 1992;7: 44-49
12. Lamont P, Murray N, Halliday G, Hilton J, Pamphlett R. Brain stem nuclei in sudden infant death syndrome (SIDS): Volumes, neuronal numbers and positions. Neuropathol Appl Neurobiol 1995;21: 262-68
13. Denoroy L, Gay N, Gilly R, Tayot J, Pasquier B, Kopp N. Catecholamine synthesizing enzyme activity in brainstem areas from victims of sudden infant death syndrome. Neuropediatrics 1987;18: 187-90
14. Obonai T, Yasuhara M, Nakamura T, Takashima S. Catecholamine neurons alteration in the brainstem of sudden infant death syndrome victims. Pediatrics 1998;101:285-88
15. Bergstrom L, Lagercrantz H, Terenius L. Post-mortem analyses of neuropeptides in brains from sudden infant death victims. Brain Res 1984;323:279-85
16. Obonai T, Takashima S, Becker LE, et al. Relationship of substance P and gliosis in medulla oblongata in neonatal sudden infant death syndrome. Pediatr Neurol 1996;15:189-92
17. Panigrahy A, Filiano JJ, Sleeper LA, et al. Decreased kainate receptor binding in the arcuate nucleus of the sudden infant death syndrome. J Neuropathol Exp Neurol 1997;56:1253-61
18. Burton MD, Nouri K, Baichoo S, Samuels TN, Kazemi H. Ventilatory output and acetylcholine: Perturbations in release and muscarinic receptor activation. J Appl Physiol 1994;77:2275-84
19. Criscione L, Reis DJ, Talman WT. Cholinergic mechanisms in the nucleus tractus solitarii and cardiovascular regulation in the rat. Eur J Pharmacol 1983;88:47-55
20. Kinney HC, Filiano JJ, Sleeper LA, Mandell F, Valdes-Dapena M, Frost White W. Decreased muscarinic receptor binding in the arcuate nucleus in sudden infant death syndrome. Science 1995;269: 1446-50
21. Quattrochi JJ, Mamelak AN, Madison RD, Macklis JD, Hobson JA. Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres. Science 1989;245:984-86
22. Levey AI, Kitt CA, Simonds WF, Price DL, Brann MR. Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 1991;11: 3218-26
23. Willinger M, James LS, Catz C. Defining the sudden infant death syndrome (SIDS): Deliberations of an expert panel convened by the National Institute of Child Health and Human Development. Pediatr Pathol 1991;11:677-84
24. Mallard EC, Rees S, Stringer M, Cock ML, Harding R. Effects of chronic placental insufficiency on brain development in fetal sheep. Pediatr Res 1998;43:262-70
25. Kalia M. Brain stem localization of vagal preganglionic neurons. J Auton Nerv Syst 1981;3:451-81
26. Burton MD, Nouri M, Kazemi H. Acetylcholine and central respiratory control: Perturbations of acetylcholine synthesis in the isolated brainstem of the neonatal rat. Brain Res 1995;670:39-47
27. Brouillette RT, Thach BT. A neuromuscular mechanism maintaining extrathoracic airway patency. J Appl Physiol 1979;46:772-79
28. Mallard C, Rehn A, Rees S, Tolcos M, Copolov D. Ventriculomegaly and reduced volume of the hippocampus following growth-restriction: Implications for schizophrenia. Schizophr Res, (in press, 1999)
29. Paxinos G, Huang X-F. Atlas of the human brainstem. San Diego: Academic Press Inc., 1995
30. Mizukawa K, McGeer PL, Tago H, Peng JH, McGeer EG, Kimura H. The cholinergic system of the human hindbrain studied by choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Brain Res 1986;379:39-55
31. Tago H, McGeer PL, McGeer EG, Akiyama H, Hersh LB. Distribution of choline acetyltransferase immunopositive structures in the rat brainstem. Brain Res 1989;495:271-97
32. Kimura H, McGeer PL, Peng JH, McGeer EG. The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat. J Comp Neurol 1981;200:151-201
33. Cortes R, Probst A, Tobler HJ, Palacios JM. Muscarinic cholinergic receptor subtypes in the human brain. II. Quantitative autoradiographic studies. Brain Res 1986;362:239-53
34. Kinney HC, Panigrahy A, Rava LA, White WF. Three-dimensional distribution of [3H]quinuclidinyl benzilate binding to muscarinic cholinergic receptors in the developing human brainstem. J Comp Neurol 1995;362:350-67
35. Hyde TM, Gibbs M, Peroutka SJ. Distribution of muscarinic cholinergic receptors in the dorsal vagal complex and other selected nuclei in the human medulla. Brain Res 1988;447:287-92
36. Schlumpf M, Lichtensteiger W. Benzodiazepine and muscarinic cholinergic binding sites in striatum and brainstem of the human fetus. Int J Dev Neurosci 1987;5:283-87
37. Wamsley JK, Lewis MS, Young WS, Kuhar MJ. Autoradiographic localization of muscarinic cholinergic receptors in rat brainstem. J Neurosci 1981;1:176-91
38. Schlumpf M, Palacios JM, Cortes R, Lichtensteiger W. Regional development of muscarinic cholinergic binding sites in the prenatal rat brain. Neuroscience 1991;45:347-57
39. Mufson EJ, Jaffar S, Levey AI. m2 muscarinic acetylcholine receptor-immunoreactive neurons are not reduced within the nucleus basalis in Alzheimer's disease: Relationship with cholinergic and galaninergic perikarya. J Comp Neurol 1998;392:313-29
40. Levey AI, Edmunds SM, Hersch SM, Wiley RG, Heilman CJ. Light and electron microscopic study of m2 muscarinic acetylcholine receptor in the basal forebrain of the rat. J Comp Neurol 1995;351: 339-56
41. Quirion R, Wilson A, Rowe W, et al. Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired. J Neurosci 1995;15:1455-62
42. Rouse ST, Thomas TM, Levey AI. Muscarinic acetylcholine receptor subtype, m2: diverse functional implications of differential synaptic localization. Life Sciences 1997;60:1031-38
43. Mrzljak L, Levey AI, Goldman RP. Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: Morphological evidence for cholinergic modulation of excitatory neurotransmission. Proc Natl Acad Sci USA 1993;90:5194-98
44. Sparks DL, Hunsaker JC. Sudden infant death syndrome: Altered aminergic-cholinergic synaptic markers in hypothalamus. J Child Neurol 1991;6:335-39
45. Kalaria RN, Fiedler C, Hunsaker JC, Sparks DL. Synaptic neurochemistry of human striatum during development: changes in sudden infant death syndrome. J Neurochem 1993;60:2098-105
46. Krammer EB, Rath T, Lischka MF. Somatotopic organization of the hypoglossal nucleus: A HRP study in the rat. Brain Res 1979;170: 533-37
47. Jeffery HE, Page M, Post EJ, Wood AK. Physiological studies of gastro-oesophageal reflux and airway protective responses in the young animal and human infant. Clin Exp Pharmacol Physiol 1995;22:544-49
48. Filiano JJ, Kinney HC. Arcuate nucleus hypoplasia in the sudden infant death syndrome. J Neuropathol Exp Neurol 1992;51:394-403
49. Lams BE, Isacson O, Sofroniew MV. Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons. Brain Res 1988;475:401-6
50. Matsuura J, Ajiki K, Ichikawa T, Misawa H. Changes of expression levels of choline acetyltransferase and vesicular acetylcholine transporter mRNAs after transection of the hypoglossal nerve in adult rats. Neuorsci Lett 1997;236:95-98
51. Wang W, Salvaterra PM, Loera S, Chiu AY. Brain-derived neurotrophic factor spares choline acetyltransferase mRNA following axotomy of motor neurons in vivo. J Neurosci Res 1997;47:134-43
52. Gibson GE, Duffy TE. Impaired synthesis of acetylcholine by mild hypoxic hypoxia or nitrous oxide. J Neurochem 1981;36:28-33
53. Chleide E, Ishikawa K. Hypoxia-induced decrease of brain acetylcholine release detected by microdialysis. Neuroreport 1990;1: 197-99
54. Tanaka H, Takahashi S, Miyamoto A, Oki J, Cho K, Okuno A. Effects of neonatal hypoxia on brainstem cholinergic neurons-pedunculopontine nucleus and laterodorsal tegmental nucleus. Brain Dev 1995;17:264-70
55. Opdal SH, Rognum TO, Vege A, Saugstad OD. Hypoxanthine levels in vitreous humor: A study on influencing factors in Sudden Infant Death Syndrome. Pediatr Res 1998;44:192-96