Ginkgo biloba extract EGb761 protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of SAMP8 mice

Platelets

Volumn 21, Issue 5, 2010, Pages 373-379

  Shi, Chun ^a,b   Xiao, Songhua ^c   Liu, Jun ^c   Guo, Kaihua ^a   Wu, Fengming ^a   Yew, David T ^b   Xu, Jie ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

EGb761; mitochondrial dysfunction; senescence accelerated mice

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; GINKGO BILOBA EXTRACT; GLUTATHIONE; CYCLOOXYGENASE 2; GINKGO BILOBA EXTRACT 761; PLANT EXTRACT;

AGE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CHONDROPROTECTION; CONTROLLED STUDY; DEGENERATION; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; ENZYME ACTIVITY; HERB; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MEMBRANE PERMEABILITY; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE; TREATMENT DURATION; ANIMAL; BLOOD; DRUG EFFECTS; ENZYMOLOGY; METABOLISM;

GINKGO BILOBA; MUS;

ADENOSINE TRIPHOSPHATE; AGE FACTORS; ANIMALS; BLOOD PLATELETS; CYCLOOXYGENASE 2; GLUTATHIONE; HIPPOCAMPUS; MICE; MITOCHONDRIA; PLANT EXTRACTS;

EID: 77954806158     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537100903511448     Document Type: Article

References (44)

1. Gruber J, Schaffer S, Halliwell B. The mitochondrial free radical theory of ageing - Where do we stand? Front Biosci 2008;13:6554-6579.
2. Bossy-Wetzel E, Barsoum MJ, Godzik A, Schwarzenbacher R, Lipton SA. Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol 2003;15:706-716.
3. Miquel J, Economos AC, Fleming J, Johnson Jr JE. Mitochondrial role in cell aging. Exp Gerontol 1980;15: 575-591.
4. Alemany J, de la Cruz MJ, Roncero I, Miquel J. Effects of aging on respiration, ATP levels and calcium transport in rat liver mitochondria. Response to theophylline. Exp Gerontol 1988;23:25-34.
5. Pallotti F, Chen X, Bonilla E, Schon EA. Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging. Am J Hum Genet 1996;59:591-602.
6. Cortopassi GA, Wong A. Mitochondria in organismal aging and degeneration. Biochim Biophys Acta 1999;1410: 183-193.
7. Krause KH. Aging: A revisited theory based on free radicals generated by NOX family NADPH oxidases. Exp Gerontol 2007;42:256-262.
8. Hiona A, Leeuwenburgh C. The role of mitochondrial DNA mutations in aging and sarcopenia: Implications for the mitochondrial vicious cycle theory of aging. Exp Gerontol 2008;43:24-33.
9. Kuro-o M. Disease model: Human aging. Trends Mol Med 2001;7:179-181.
10. Johnson TE. Caenorhabditis elegans 2007: The premier model for the study of aging. Exp Gerontol 2008;43:1-4.
11. Cedar SH, Minger SL. Human embryonic stem cells: A model for human ageing in vitro. Exp Gerontol 2008;43: 1005-1008.
12. Fernández-Gómez FJ, Munoz-Delgado E, Montenegro MF, Campoy FJ, Vidal CJ, Jordán J. The level of butyrylcholinesterase activity increases and the content of the mRNA remains unaffected in brain of senescence-accelerated mouse SAMP8. Chem Biol Interact 2008;175:332-335.
13. Luo C, Tong M, Maxwell DM, Saxena A. Comparison of oxime reactivation and aging of nerve agent-inhibited monkey and human acetylcholinesterases. Chem Biol Interact 2008; 175:261-266.
14. Takeda T, Hosokawa M, Higuchi K. Senescence-accelerated mouse (SAM): A novel murine model of senescence. Exp Gerontol 1997;32:105-109.
15. Chiba Y, Shimada A, Kumagai N, Yoshikawa K, Ishii S, Furukawa A, Takei S, Sakura M, Kawamura N, Hosokawa M. The senescence-accelerated mouse (SAM): A higher oxidative stress and age-dependent degenerative diseases model. Neurochem Res 2009;34:679-687.
16. Xu J, Shi C, Li Q, Wu J, Forster EL, Yew DT. Mitochondrial dysfunction in platelets and hippocampi of senescenceaccelerated mice. J Bioenerg Biomembr 2007;39:195-202.
17. D'Aurelio M, Merlo Pich M, Catani L, Sgarbi GL, Bovina C, Formiggini G, Parenti Castelli G, Baum H, Tura S, Lenaz G. Decreased Pasteur effect in platelets of aged individuals. Mech Ageing Dev 2001;122:823-833.
18. Shi C, Guo K, Yew DT, Yao Z, Forster EL, Wang H, Xu J. Effects of ageing and Alzheimer's disease on mitochondrial function of human platelets. Exp Gerontol 2008;43:589-594.
19. Smith JV, Luo Y. Studies on molecular mechanisms of Ginkgo biloba extract. Appl Microbiol Biotechnol 2004;64: 465-472.
20. Shi C, Zhao L, Zhu B, Li Q, Yew DT, Yao Z, Xu J. Dosage effects of EGb761 on hydrogen peroxide-induced cell death in SH-SY5Y cells. Chem Biol Interact 2009;180:389-397.
21. Shi C, Yao Z, Xu J, Yew DT. Effects of Gingko Extract (EGb761) on oxidative damage under different conditions of serum supply. J Bioenerg Biomembr 2009;41:61-69.
22. Sastre J, Pallardó FV, Garća de la Asunción J, Vina J. Mitochondria, oxidative stress and aging. Free Radic Res 2000;32:189-198.
23. Wu Z, Smith JV, Paramasivam V, Butko P, Khan I, Cypser JR, Luo Y. Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans. Cell Mol Biol (Noisy-le-grand) 2002;48:725-731.
24. Christen Y. Ginkgo biloba and neurodegenerative disorders. Front Biosci 2004;9:3091-3104.
25. Abdel-Kader R, Hauptmann S, Keil U, Scherping I, Leuner K, Eckert A, Müller WE. Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761). Pharmacol Res 2007;56:493-502.
26. Ahlemeyer B, Krieglstein J. Neuroprotective effects of Ginkgo biloba extract. Cell Mol Life Sci 2003;60:1779-1792.
27. Tendi EA, Bosetti F, Dasgupta SF, Stella AM, Drieu K, Rapoport SI. Ginkgo biloba extracts (EGb 761) and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells. Neurochem Res 2002;27:319-323.
28. Lorke DE, Wong LY, Lai HW, Poon PW, Zhang A, Chan WY, Yew DT. Early postnatal sound exposure induces lasting neuronal changes in the inferior colliculus of senescence accelerated mice (SAMP8): A morphometric study on GABAergic neurons and NMDA expression. Cell Mol Neurobiol 2003;2:143-164.
29. Mancuso M, Filosto M, Bosetti F, Ceravolo R, Rocchi A, Tognoni G, Manca ML, Solaini G, Siciliano G, Murri L. Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease. Exp Neurol 2003;182:421-426.
30. Shi C, Xu XW, Forster EL, Tang LF, Ge Z, Yew DT, Xu J. Possible role of mitochondrial dysfunction in central neurodegeneration of ovariectomized rats. Cell Biochem Funct 2008;26:172-178.
31. Takeda T. Senescence-accelerated mouse (SAM) with special references to neurodegeneration models, SAMP8 and SAMP10 mice. Neurochem Res 2009;34:639-659.
32. Sato E, Oda N, Ozaki N, Hashimoto S, Kurokawa T, Ishibashi S. Early and transient increase in oxidative stress in the cerebral cortex of senescence-accelerated mouse. Mech Ageing Dev 1996;86:105-114. (Pubitemid 26069348)
33. Sato E, Kurokawa T, Oda N, Ishibashi S. Early appearance of abnormality of microperoxisomal enzymes in the cerebral cortex of senescence-accelerated mouse. Mech Ageing Dev 1996;92:175-184. (Pubitemid 27129288)
34. Fujibayashi Y, Yamamoto S, Waki A, Konishi J, Yonekura y. Increased mitochondrial DNA deletion in the brain of SAMP8, a mouse model for spontaneous oxidative stress brain. Neurosci Lett 1998;254:109-112.
35. Rossignol R, Faustin B, Rocher C, Malgat M, Mazat JP, Letellier T. Mitochondrial threshold effects. Biochem J 2003; 370:751-762.
36. Letellier T, Heinrich R, Malgat M, Mazat JP. The kinetic basis of the threshold effects observed in mitochondrial diseases: A systemic approach. Biochem J 1994;302:171-174.
37. Ueno M, Akiguchi I, Yagi H, Naiki H, Fujibayashi Y, Kimura J, Takeda T. Age-related changes in barrier function in mouse brain I. Accelerated age-related increase of brain transfer of serum albumin in accelerated senescence prone SAM-P/8 mice with deficits in learning and memory. Arch Gerontol Geriatr 1993;16:233-248.
38. Ueno M, Dobrogowska DH, Vorbrodt AW. Immunocytochemical evaluation of the blood-brain barrier to endogenous albumin in the olfactory bulb and pons of senescence-accelerated mice (SAM). Histochem Cell Biol 1996;105:203-212.
39. Ueno M, Akiguchi I, Hosokawa M, Shionnou M, Sakamoto H, Takemura M, Hiquchi K. Age-related changes in the brain transfer of blood-borne horseradish peroxidase in the hippocampus of senescence-accelerated mouse. Acta Neuropathol 1997;93:233-240.
40. Pelegr? C, Canudas AM, Valle JD, Casadesus G, Smith MA, Camins A, Pallàs M, Vilaplana J. Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence. Mech. Ageing Dev 2007;128:522-528.
41. Farrall AJ, Wardlaw JM. Blood-brain barrier: Ageing and microvascular disease -systematic review and meta-analysis. Neurobiol Aging 2009;30:337-352.
42. Popescu BO, Toescu EC, Popescu LM, Bajenaru O, Muresanu DF, Schultzberg M, Bogdanovic N. Blood-brain barrier alterations in ageing and dementia. J Neurol Sci 2009;283:99-106.
43. Kanowski S, Herrmann WM, Stephan K, Wierich W, Hörr R. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 1996;29:47-56.
44. Garcia-Alloza M, Dodwell SA, Meyer-Luehmann M, Hyman BT, Bacskai BJ. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol 2006;65:1082-1089.