메뉴 건너뛰기




Volumn 9, Issue , 2010, Pages

A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; AURORA A KINASE; CELL PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GGTI 298; MANUMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PEPTIDOMIMETIC AGENT; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN MAD2; RAS PROTEIN; S6 KINASE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTOME; AURORA KINASE; DRUG DERIVATIVE; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; MESSENGER RNA; METHIONINE; PROTEIN SERINE THREONINE KINASE;

EID: 77954801753     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-197     Document Type: Article
Times cited : (9)

References (53)
  • 1
    • 0029966304 scopus 로고    scopus 로고
    • Protein prenyltransferases
    • 10.1074/jbc.271.10.5289, 8621375
    • Casey PJ, Seabra MC. Protein prenyltransferases. J Biol Chem 1996, 271:5289-5292. 10.1074/jbc.271.10.5289, 8621375.
    • (1996) J Biol Chem , vol.271 , pp. 5289-5292
    • Casey, P.J.1    Seabra, M.C.2
  • 2
    • 0029166661 scopus 로고
    • Use of yeast for identification of farnesyltransferase inhibitors and for generation of mutant farnesyltransferases
    • full_text, 8524140
    • Tamanoi F, Mitsuzawa H. Use of yeast for identification of farnesyltransferase inhibitors and for generation of mutant farnesyltransferases. Methods Enzymol 1995, 255:82-91. full_text, 8524140.
    • (1995) Methods Enzymol , vol.255 , pp. 82-91
    • Tamanoi, F.1    Mitsuzawa, H.2
  • 4
    • 26444574802 scopus 로고    scopus 로고
    • Development of farnesyl transferase inhibitors: a review
    • 10.1634/theoncologist.10-8-565, 16177281
    • Appels NM, Beijnen JH, Schellens JH. Development of farnesyl transferase inhibitors: a review. Oncologist 2005, 10:565-578. 10.1634/theoncologist.10-8-565, 16177281.
    • (2005) Oncologist , vol.10 , pp. 565-578
    • Appels, N.M.1    Beijnen, J.H.2    Schellens, J.H.3
  • 5
    • 30844467746 scopus 로고    scopus 로고
    • Lipid posttranslational modifications. Farnesyl transferase inhibitors
    • 10.1194/jlr.R500012-JLR200, 16278491
    • Basso AD, Kirschmeier P, Bishop WR. Lipid posttranslational modifications. Farnesyl transferase inhibitors. J Lipid Res 2006, 47:15-31. 10.1194/jlr.R500012-JLR200, 16278491.
    • (2006) J Lipid Res , vol.47 , pp. 15-31
    • Basso, A.D.1    Kirschmeier, P.2    Bishop, W.R.3
  • 7
    • 34748922324 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in vivo
    • 10.1158/1535-7163.MCT-06-0452, 17876043
    • Martin LA, Head JE, Pancholi S, Salter J, Quinn E, Detre S, Kaye S, Howes A, Dowsett M, Johnston SR. The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in vivo. Mol Cancer Ther 2007, 6:2458-2467. 10.1158/1535-7163.MCT-06-0452, 17876043.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2458-2467
    • Martin, L.A.1    Head, J.E.2    Pancholi, S.3    Salter, J.4    Quinn, E.5    Detre, S.6    Kaye, S.7    Howes, A.8    Dowsett, M.9    Johnston, S.R.10
  • 8
    • 77952291716 scopus 로고    scopus 로고
    • Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia
    • 2721391, 19707379
    • Karp JE, Lancet JE. Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia. Biologics 2008, 2:491-500. 2721391, 19707379.
    • (2008) Biologics , vol.2 , pp. 491-500
    • Karp, J.E.1    Lancet, J.E.2
  • 11
    • 0034730625 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules
    • 10.1074/jbc.M003469200, 10852915
    • Ashar HR, James L, Gray K, Carr D, Black S, Armstrong L, Bishop WR, Kirschmeier P. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. J Biol Chem 2000, 275:30451-30457. 10.1074/jbc.M003469200, 10852915.
    • (2000) J Biol Chem , vol.275 , pp. 30451-30457
    • Ashar, H.R.1    James, L.2    Gray, K.3    Carr, D.4    Black, S.5    Armstrong, L.6    Bishop, W.R.7    Kirschmeier, P.8
  • 12
    • 0035844247 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor, FTI-2153 blocks bipolar spindle formation and chromosome alignement and causes prometaphase accumulation during mitosis of human lung cancer cells
    • 10.1074/jbc.M006213200, 11154688
    • Crespo NC, Ohkanda J, Yen TJ, Hamilton AD, Sebti SM. The farnesyltransferase inhibitor, FTI-2153 blocks bipolar spindle formation and chromosome alignement and causes prometaphase accumulation during mitosis of human lung cancer cells. J Biol Chem 2001, 276:16161-16167. 10.1074/jbc.M006213200, 11154688.
    • (2001) J Biol Chem , vol.276 , pp. 16161-16167
    • Crespo, N.C.1    Ohkanda, J.2    Yen, T.J.3    Hamilton, A.D.4    Sebti, S.M.5
  • 13
    • 34248170746 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function
    • 10.1158/1535-7163.MCT-06-0703, 17431110
    • Schafer-Hales K, Iaconelli J, Snyder JP, Prussia A, Nettles JH, El-Naggar A, Khuri FR, Giannakakou P, Marcus AI. Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function. Mol Cancer Ther 2007, 6:1317-1328. 10.1158/1535-7163.MCT-06-0703, 17431110.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1317-1328
    • Schafer-Hales, K.1    Iaconelli, J.2    Snyder, J.P.3    Prussia, A.4    Nettles, J.H.5    El-Naggar, A.6    Khuri, F.R.7    Giannakakou, P.8    Marcus, A.I.9
  • 15
    • 34247527215 scopus 로고    scopus 로고
    • Identification of molecular predictors of response in a study of tipifarnib treatment in relapsed and refractory acute myelogenous leukemia
    • 10.1158/1078-0432.CCR-06-2609, 17404110
    • Raponi M, Harousseau JL, Lancet JE, Löwenberg B, Stone R, Zhang Y, Rackoff W, Wang Y, Atkins D. Identification of molecular predictors of response in a study of tipifarnib treatment in relapsed and refractory acute myelogenous leukemia. Clin Cancer Res 2007, 13:2254-2260. 10.1158/1078-0432.CCR-06-2609, 17404110.
    • (2007) Clin Cancer Res , vol.13 , pp. 2254-2260
    • Raponi, M.1    Harousseau, J.L.2    Lancet, J.E.3    Löwenberg, B.4    Stone, R.5    Zhang, Y.6    Rackoff, W.7    Wang, Y.8    Atkins, D.9
  • 18
    • 34047179422 scopus 로고    scopus 로고
    • Genetic basis of individual differences in the response to small-molecule drugs in yeast
    • 10.1038/ng1991, 17334364
    • Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L. Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat Genet 2007, 39:496-502. 10.1038/ng1991, 17334364.
    • (2007) Nat Genet , vol.39 , pp. 496-502
    • Perlstein, E.O.1    Ruderfer, D.M.2    Roberts, D.C.3    Schreiber, S.L.4    Kruglyak, L.5
  • 19
    • 57849146808 scopus 로고    scopus 로고
    • Identification of human intracellular targets of the medicinal Herb St. John's Wort by chemical-genetic profiling in yeast
    • 10.1021/jf801593a, 2645918, 18975972
    • McCue PP, Phang JM. Identification of human intracellular targets of the medicinal Herb St. John's Wort by chemical-genetic profiling in yeast. J Agric Food Chem 2008, 56:11011-11017. 10.1021/jf801593a, 2645918, 18975972.
    • (2008) J Agric Food Chem , vol.56 , pp. 11011-11017
    • McCue, P.P.1    Phang, J.M.2
  • 20
    • 0141842714 scopus 로고    scopus 로고
    • Farnesyltransferase Inhibitors: An Overview of the results of preclinical and Clinical Investigation
    • Brunner TB, Hahan SM, Gupta AK, Muschel RJ, McKenna G, Bernhard EJ. Farnesyltransferase Inhibitors: An Overview of the results of preclinical and Clinical Investigation. Cancer Res 2003, 63:5656-5668.
    • (2003) Cancer Res , vol.63 , pp. 5656-5668
    • Brunner, T.B.1    Hahan, S.M.2    Gupta, A.K.3    Muschel, R.J.4    McKenna, G.5    Bernhard, E.J.6
  • 21
    • 0027998986 scopus 로고
    • The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation
    • Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD, Brenner DA, Der CJ. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J Biol Chem 1994, 269:19203-19206.
    • (1994) J Biol Chem , vol.269 , pp. 19203-19206
    • Cox, A.D.1    Garcia, A.M.2    Westwick, J.K.3    Kowalczyk, J.J.4    Lewis, M.D.5    Brenner, D.A.6    Der, C.J.7
  • 22
    • 0037549328 scopus 로고    scopus 로고
    • Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI-277 on inhibition of MCF-7 breast cancer cell-cycle progression
    • 10.1002/ijc.11263, 12866041
    • Doisneau-Sixou SF, Cestac P, Faye JC, Favre G, Sutherland RL. Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI-277 on inhibition of MCF-7 breast cancer cell-cycle progression. Int J Cancer 2003, 106:789-798. 10.1002/ijc.11263, 12866041.
    • (2003) Int J Cancer , vol.106 , pp. 789-798
    • Doisneau-Sixou, S.F.1    Cestac, P.2    Faye, J.C.3    Favre, G.4    Sutherland, R.L.5
  • 23
    • 3042597804 scopus 로고    scopus 로고
    • Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model
    • 10.1161/01.STR.0000129898.68350.9f, 15143294
    • Yamaguchi M, Zhou C, Nanda A, Zhang JH. Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model. Stroke 2004, 35:1750-1755. 10.1161/01.STR.0000129898.68350.9f, 15143294.
    • (2004) Stroke , vol.35 , pp. 1750-1755
    • Yamaguchi, M.1    Zhou, C.2    Nanda, A.3    Zhang, J.H.4
  • 24
    • 23744461504 scopus 로고    scopus 로고
    • Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a
    • 10.1182/blood-2004-09-3655, 1895195, 15860663
    • Zhang B, Groffen J, Heisterkamp N. Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a. Blood 2005, 106:1355-1361. 10.1182/blood-2004-09-3655, 1895195, 15860663.
    • (2005) Blood , vol.106 , pp. 1355-1361
    • Zhang, B.1    Groffen, J.2    Heisterkamp, N.3
  • 25
    • 0037459072 scopus 로고    scopus 로고
    • Un ménage à quatre: the molecular biology of chromosome segregation in meiosis
    • 10.1016/S0092-8674(03)00083-7, 12600308
    • Petronczki M, Siomos MF, Nasmyth K. Un ménage à quatre: the molecular biology of chromosome segregation in meiosis. Cell 2003, 112:423-440. 10.1016/S0092-8674(03)00083-7, 12600308.
    • (2003) Cell , vol.112 , pp. 423-440
    • Petronczki, M.1    Siomos, M.F.2    Nasmyth, K.3
  • 26
    • 0442323489 scopus 로고    scopus 로고
    • Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase
    • 10.1016/S0014-5793(04)00046-8, 14960317
    • Mamnun YM, Schüller C, Kuchler K. Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Letters 2004, 559:111-117. 10.1016/S0014-5793(04)00046-8, 14960317.
    • (2004) FEBS Letters , vol.559 , pp. 111-117
    • Mamnun, Y.M.1    Schüller, C.2    Kuchler, K.3
  • 27
    • 0035887454 scopus 로고    scopus 로고
    • The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein
    • Wang E, Casciano CN, Clement RP, Johnson WW. The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein. Cancer Res 2001, 61:7525-7529.
    • (2001) Cancer Res , vol.61 , pp. 7525-7529
    • Wang, E.1    Casciano, C.N.2    Clement, R.P.3    Johnson, W.W.4
  • 28
    • 34447321311 scopus 로고    scopus 로고
    • Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein
    • 10.1158/1535-7163.MCT-07-0148, 17620438
    • Katayama K, Yoshioka S, Tsukahara S, Mitsuhashi J, Sugimoto Y. Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein. Mol Cancer Ther 2007, 6:2092-2102. 10.1158/1535-7163.MCT-07-0148, 17620438.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2092-2102
    • Katayama, K.1    Yoshioka, S.2    Tsukahara, S.3    Mitsuhashi, J.4    Sugimoto, Y.5
  • 30
    • 33646918976 scopus 로고    scopus 로고
    • Expression of the HXT13, HXT15 and HXT17 genes in Saccharomyces cerevisiae and stabilization of the HXT1 gene transcript by sugar-induced osmotic stress
    • 10.1007/s00294-005-0046-x, 16397765
    • Greatrix BW, Van Vuuren HJ. Expression of the HXT13, HXT15 and HXT17 genes in Saccharomyces cerevisiae and stabilization of the HXT1 gene transcript by sugar-induced osmotic stress. Curr Genet 2006, 49:205-217. 10.1007/s00294-005-0046-x, 16397765.
    • (2006) Curr Genet , vol.49 , pp. 205-217
    • Greatrix, B.W.1    Van Vuuren, H.J.2
  • 31
    • 0030837532 scopus 로고    scopus 로고
    • Multi-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: involvement of two hexose transporters
    • 232394, 9271421
    • Nourani A, Wesolowski-Louvel M, Delaveau T, Jacq C, Delahodde A. Multi-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: involvement of two hexose transporters. Mol Cell Biol 1997, 17:5453-5460. 232394, 9271421.
    • (1997) Mol Cell Biol , vol.17 , pp. 5453-5460
    • Nourani, A.1    Wesolowski-Louvel, M.2    Delaveau, T.3    Jacq, C.4    Delahodde, A.5
  • 32
    • 0032484024 scopus 로고    scopus 로고
    • Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome
    • 10.1074/jbc.273.49.32848, 9830032
    • Plemper RK, Egner R, Kuchler K, Wolf DH. Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome. J Biol Chem 1998, 273:32848-32856. 10.1074/jbc.273.49.32848, 9830032.
    • (1998) J Biol Chem , vol.273 , pp. 32848-32856
    • Plemper, R.K.1    Egner, R.2    Kuchler, K.3    Wolf, D.H.4
  • 33
    • 0028783747 scopus 로고
    • Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae
    • 230839, 7565740
    • Egner R, Mahé Y, Pandjaitan R, Kuchler K. Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 1995, 15:5879-5887. 230839, 7565740.
    • (1995) Mol Cell Biol , vol.15 , pp. 5879-5887
    • Egner, R.1    Mahé, Y.2    Pandjaitan, R.3    Kuchler, K.4
  • 34
    • 4644255309 scopus 로고    scopus 로고
    • The novel yeast PAS kinase Rim 15 orchestrates G0-associated antioxidant defense mechanisms
    • Cameroni E, Hulo N, Roosen J, Winderickx J, De Virgilio C. The novel yeast PAS kinase Rim 15 orchestrates G0-associated antioxidant defense mechanisms. Cell cycle 2004, 3:462-468.
    • (2004) Cell cycle , vol.3 , pp. 462-468
    • Cameroni, E.1    Hulo, N.2    Roosen, J.3    Winderickx, J.4    De Virgilio, C.5
  • 35
    • 38949137849 scopus 로고    scopus 로고
    • Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9
    • 10.1371/journal.pgen.0040013, 2213705, 18225956
    • Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet 2008, 4:e13. 10.1371/journal.pgen.0040013, 2213705, 18225956.
    • (2008) PLoS Genet , vol.4
    • Wei, M.1    Fabrizio, P.2    Hu, J.3    Ge, H.4    Cheng, C.5    Li, L.6    Longo, V.D.7
  • 36
    • 34347256711 scopus 로고    scopus 로고
    • TOR Signaling and S6 Kinase 1: Yeast Catches Up
    • 10.1016/j.cmet.2007.06.009, 17618850
    • Powers T. TOR Signaling and S6 Kinase 1: Yeast Catches Up. Cell Metabolism 2007, 6:1-2. 10.1016/j.cmet.2007.06.009, 17618850.
    • (2007) Cell Metabolism , vol.6 , pp. 1-2
    • Powers, T.1
  • 38
    • 40649126759 scopus 로고    scopus 로고
    • MTOR is activated in the majority of malignant melanomas
    • 10.1038/sj.jid.5701074, 17914450
    • Karbowniczek M, Spittle CS, Morrison T, Wu H, Henske EP. mTOR is activated in the majority of malignant melanomas. J Invest Dermatol 2008, 128:980-987. 10.1038/sj.jid.5701074, 17914450.
    • (2008) J Invest Dermatol , vol.128 , pp. 980-987
    • Karbowniczek, M.1    Spittle, C.S.2    Morrison, T.3    Wu, H.4    Henske, E.P.5
  • 39
    • 24744465206 scopus 로고    scopus 로고
    • The Farnesyl Transferase Inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity
    • 10.1074/jbc.M503763200, 16006564
    • Basso AD, Mirza A, Liu G, Long BJ, Bishop WR, Kirschmeier P. The Farnesyl Transferase Inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity. J Biol Chem 2005, 280:31101-31108. 10.1074/jbc.M503763200, 16006564.
    • (2005) J Biol Chem , vol.280 , pp. 31101-31108
    • Basso, A.D.1    Mirza, A.2    Liu, G.3    Long, B.J.4    Bishop, W.R.5    Kirschmeier, P.6
  • 41
    • 34547216984 scopus 로고    scopus 로고
    • Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae
    • 10.1016/j.bbamcr.2007.05.003, 2031910, 17604854
    • Chen RE, Thorner J. Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 2007, 1773:1311-1340. 10.1016/j.bbamcr.2007.05.003, 2031910, 17604854.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1311-1340
    • Chen, R.E.1    Thorner, J.2
  • 42
    • 0037077207 scopus 로고    scopus 로고
    • Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase
    • 10.1074/jbc.M202557200, 11923319
    • Hahn JS, Thiele DJ. Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase. J Biol Chem 2002, 277:21278-21284. 10.1074/jbc.M202557200, 11923319.
    • (2002) J Biol Chem , vol.277 , pp. 21278-21284
    • Hahn, J.S.1    Thiele, D.J.2
  • 44
    • 0036049408 scopus 로고    scopus 로고
    • The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae
    • 10.1046/j.1365-2958.2002.03110.x, 12207708
    • Schmidt A, Schmelzle T, Hall MN. The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae. Mol Microbiol 2002, 45:1433-1441. 10.1046/j.1365-2958.2002.03110.x, 12207708.
    • (2002) Mol Microbiol , vol.45 , pp. 1433-1441
    • Schmidt, A.1    Schmelzle, T.2    Hall, M.N.3
  • 46
    • 0028037478 scopus 로고
    • Regulation of yeast chromosome segregation by Ipl1 protein kinase and type 1 protein phosphatase
    • Francisco L, Chan CS. Regulation of yeast chromosome segregation by Ipl1 protein kinase and type 1 protein phosphatase. Cell Mol Biol Res 1994, 40:207-213.
    • (1994) Cell Mol Biol Res , vol.40 , pp. 207-213
    • Francisco, L.1    Chan, C.S.2
  • 47
    • 0037155870 scopus 로고    scopus 로고
    • Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1
    • 10.1074/jbc.M108252200, 11790771
    • Tanaka M, Ueda A, Kanamori H, Ideguchi H, Yang J, Kitajima S, Ishigatsubo Y. Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1. J Biol Chem 2002, 277:10719-10726. 10.1074/jbc.M108252200, 11790771.
    • (2002) J Biol Chem , vol.277 , pp. 10719-10726
    • Tanaka, M.1    Ueda, A.2    Kanamori, H.3    Ideguchi, H.4    Yang, J.5    Kitajima, S.6    Ishigatsubo, Y.7
  • 48
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of Farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
    • Sepp-Lorenzino L, Ma Z, Rands E, Kohl NE, Gibbs JB, Oliff A, Rosen N. A peptidomimetic inhibitor of Farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res 1995, 55:5302-5309.
    • (1995) Cancer Res , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3    Kohl, N.E.4    Gibbs, J.B.5    Oliff, A.6    Rosen, N.7
  • 49
    • 33947361191 scopus 로고    scopus 로고
    • The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines
    • Medeiros BC, Landau HJ, Morrow M, Lockerbie RO, Pitts T, Eckardt SG. The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines. Leukemia 2007, 21:739-746.
    • (2007) Leukemia , vol.21 , pp. 739-746
    • Medeiros, B.C.1    Landau, H.J.2    Morrow, M.3    Lockerbie, R.O.4    Pitts, T.5    Eckardt, S.G.6
  • 50
    • 0037011063 scopus 로고    scopus 로고
    • Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p
    • 10.1093/emboj/cdf650, 136954, 12456647
    • Wagner W, Bielli P, Wacha S, Ragnini-Wilson A. Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p. EMBO J 2002, 21:6397-6408. 10.1093/emboj/cdf650, 136954, 12456647.
    • (2002) EMBO J , vol.21 , pp. 6397-6408
    • Wagner, W.1    Bielli, P.2    Wacha, S.3    Ragnini-Wilson, A.4
  • 51
    • 33645084002 scopus 로고    scopus 로고
    • GTP drives myosin light chain 1 interaction with the class V myosin Myo2 IQ motifs via a Sec2 RabGEF-mediated pathway
    • 10.1111/j.1365-2958.2006.05041.x, 16468996
    • Bielli P, Casavola EC, Biroccio A, Urbani A, Ragnini-Wilson A. GTP drives myosin light chain 1 interaction with the class V myosin Myo2 IQ motifs via a Sec2 RabGEF-mediated pathway. Mol Microbiol 2006, 59:1576-1590. 10.1111/j.1365-2958.2006.05041.x, 16468996.
    • (2006) Mol Microbiol , vol.59 , pp. 1576-1590
    • Bielli, P.1    Casavola, E.C.2    Biroccio, A.3    Urbani, A.4    Ragnini-Wilson, A.5
  • 53
    • 0034062298 scopus 로고    scopus 로고
    • Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance
    • 10.1046/j.1365-2958.2000.01782.x, 10760132
    • Bialek-Wyrzykowska U, Bauer BE, Wagner W, Kohlwein SD, Schweyen RJ, Ragnini A. Low levels of Ypt protein prenylation cause vesicle polarization defects and thermosensitive growth that can be suppressed by genes involved in cell wall maintenance. Mol Microbiol 2000, 35:1295-1311. 10.1046/j.1365-2958.2000.01782.x, 10760132.
    • (2000) Mol Microbiol , vol.35 , pp. 1295-1311
    • Bialek-Wyrzykowska, U.1    Bauer, B.E.2    Wagner, W.3    Kohlwein, S.D.4    Schweyen, R.J.5    Ragnini, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.