Enhancement of endoprosthesis anchoring using BMP-2

Technology and Health Care

Volumn 18, Issue 3, 2010, Pages 217-229

  Thorey, Fritz ^a   Menzel, Henning ^b   Lorenz, Corinna ^b   Gross, Gerhard ^c   Hoffmann, Andrea ^c   Windhagen, Henning ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

BMP 2; endoprosthesis; implant; osseointegration; titanium

Indexed keywords

BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; TITANIUM;

ANIMAL; BONE REGENERATION; CLINICAL TRIAL; DRUG DELIVERY SYSTEM; DRUG SCREENING; HUMAN; METABOLISM; PROSTHESES AND ORTHOSES; PROTEIN BINDING; REVIEW;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CLINICAL TRIALS AS TOPIC; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; HUMANS; OSSEOINTEGRATION; PROSTHESES AND IMPLANTS; PROTEIN BINDING; TITANIUM;

EID: 77954786231     PISSN: 09287329     EISSN: None     Source Type: Journal    
DOI: 10.3233/THC-2010-0584     Document Type: Article

References (89)

1. N. Adden, L.J. Gamble, D.G. Castner, A. Hoffmann, G. Gross and H. Menzel, Phosphonic acid monolayers for binding of bioactive molecules to titanium surfaces, Langmuir 22 (2006), 8197-8204.
2. N. Adden, A. Hoffmann, G. Gross, H. Windhagen, F. Thorey and H. Menzel, Screening of photochemically grafted polymer films for compatibility with osteogenic precursor cells, JBiomate Sci Polymer Edn 18 (2007), 303-316.
3. N. Aebli, H. Stich, P. Schawalder, J.C. Theis and J. Krebs, Effects of bone morphogenetic protein-2 and hyaluronic acid on the osseointegration of hydroxyapatite-coated implants: an experimental study in sheep, J Biomed Mater Res A 73 (2005), 295-302.
4. T. Albrektsson, P.I. Branemark, H.A. Hannson and J. Lindstrom, Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man., Acta Orthop Scand 52 (1981), 155-170.
5. A. Bagno and C. Di Bello, Surface treatment and roughness properties of Ti-based biomaterials, J Mater Sci Mater Med 15 (2004), 935-949.
6. B. Barnes, S.D. Boden, J. Louis-Ugbo, P.R. Tomak, J.S. Park, M.S. Park and A. Minamide, Lower dose of rhBMP-2 achieves spine fusion when combined with an osteoconductive bulking agent in non-human primates, Spine 30 (2005), 1127-1133.
7. J.E. Bechtold, V. Kubic and K. Soballe, A controlled experimental model of revision implants: Part I. Development, Acta Orthop Scand 72 (2001), 642-649.
8. J.E. Bechtold, O. Mouzin, L. Kidder and K. Soballe, A controlled experimental model of revision implants: Part II. Implementation with loaded titanium implants and bone graft, Acta Orthop Scand 72 (2001), 650-656.
9. J. Becker, A. Kirsch, F. Schwarz, M. Chatzinikolaidou, D. Rothamel, V. Lekovic, M. Laub and H.P. Jennissen, Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs, Clin Oral Investig 10 (2006), 217-224.
10. K. Bessho, D.L. Carnes, R. Cavin and J.L. Ong, Experimental studies on bone induction using low-molecular-weight poly (DL-lactide-co-glycolide) as a carrier for recombinant human bone morphogenetic protein-2, J BiomedMater Res 61 (2002), 61-65.
11. S.D. Boden, J. Kang, H. Sandhu and J.G. Heller, Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies, Spine 27 (2002), 2662-2673.
12. B.D. Boyan, C.H. Lohmann, A. Somers, G.G. Niederauer, J.M. Wozney, D.D. Dean, D.L. Carnes, Jr. and Z. Schwartz, Potential of porous poly-D,L-lactide-co- glycolide particles as a carrier for recombinant human bone morphogenetic protein-2 during osteoinduction in vivo, J Biomed Mater Res 46 (1999), 51-59.
13. C.R. Bragdon, A.M. Doherty, H.E. Rubash, M. Jasty, X.J. Li, H. Seeherman and W.H. Harris, The efficacy of BMP-2 to induce bone ingrowth in a total hip replacement model, Clin Orthop RelatRes (2003), 50-61.
14. D. Brovelli, G. Hahner, L. Ruiz, R. Hofer, G. Kraus, A. Waldner, P. Schlosse, P. Oroszlan, M. Ehrat and N.D. Spencer, Monolayers on Tantalum(V) Oxide Surfaces, Langmuir 15 (1999), 4324-4327.
15. T.M. Chu, P. Sargent, S.J. Warden, C.H. Turner and R.L. Stewart, Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration, Biomed Sci Instrum 42 (2006), 42-47.
16. D.L. Cochran, A.A. Jones, L.C. Lilly, J.P. Fiorellini andH. Howell, Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-year results of a pilot study in humans, J Periodontol 71 (2000), 1241-1257.
17. D.L. Cochran, R. Schenk, D. Buser, J.M. Wozney and A.A. Jones, Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants, J Periodontol 70 (1999), 139-150.
18. C.M. Cowan, T. Aghaloo, Y.F. Chou, B. Walder, X. Zhang, C. Soo, K. Ting and B. Wu, MicroCT evaluation of three- dimensional mineralization in response to BMP-2 doses in vitro and in critical sized rat calvarial defects, Tissue Eng 13 (2007), 501-512.
19. E. De Smet, S.V. Jaecques, M. Wevers, J.A. Jansen, R. Jacobs, J.V Sloten and I.E. Naert, Effect of controlled early implant loading on bone healing and bone mass in guinea pigs, as assessed by micro-CT and histology, Eur J Oral Sci 114 (2006), 232-242.
20. R. Derynck and Y.Q. Zhang, Smad-dependent and Smad-independent pathways in TGF-beta family signalling, Nature 425 (2003), 577-584.
21. C. Eriksson, J. Lausmaa and H. Nygren, Interactions between human whole blood and modified TiO2-surfaces: influence of surface topography and oxide thickness on leukocyte adhesion and activation, Biomaterials 22 (2001), 1987-1996.
22. C. Eriksson and H. Nygren, Polymorphonuclear leukocytes in coagulating whole blood recognize hydrophilic and hydrophobic titanium surfaces by different adhesion receptors and show different patterns of receptor expression, J Lab Clin Med 137 (2001), 296-302.
23. T. Gao and H. Uludag, Effect of molecular weight of thermoreversible polymer on in vivo retention of rhBMP-2, J Biomed Mater Res 57 (2001), 92-100.
24. E.H. Groeneveld and E.H. Burger, Bone morphogenetic proteins in human bone regeneration, Eur J Endocrinol 142 (2000), 9-21.
25. A. Hoffmann, H. A. Weich, G. Gross, and G. Hillmann, Perspectives in the biological function, the technical and therapeutic application of bone morphogenetic proteins, Appl Microbiol Biotechnol 57 (2001), 294-308.
26. J.O. Hollinger, J.M. Schmitt, D.C. Buck, R. Shannon, S.P. Joh, H.D. Zegzula and J. Wozney, Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration, J Biomed Mater Res 43 (1998), 356-364.
27. P.A. Hoodless, T. Haerry, S. Abdollah, M. Stapleton, M.B. O'Connor, L. Attisano and J.L. Wrana, MADR1, a MAD- related protein that functions in BMP2 signaling pathways, Cell 85 (1996), 489-500.
28. M. Hoshino, T. Namikawa, M. Kato, H. Terai, S. Taguchi and K. Takaoka, Repair of bone defects in revision hip arthroplasty by implantation of a new bone-inducing material comprised of recombinant human BMP-2, Beta-TCP powder, and a biodegradable polymer: An experimental study in dogs, J Orthop Res (2007).
29. H.P. Jennissen, T. Zumbrink, M. Chatzinikolaidou and Steppuhn.J., Biocoating of implants with mediator molecules: surface enhancement of metals by treatment with chromosulfuric acid, Mat -wiss u Werkstofftech 30 (1999), 838-845.
30. T.B. Jensen, S. Overgaard, M. Lind, O. Rahbek, C. Bunger and K. Soballe, Osteogenic protein 1 device increases bone formation and bone graft resorption around cementless implants, Acta Orthop Scand 73 (2002), 31-39.
31. Q.M. Jin, H. Takita, T. Kohgo, K. Atsumi, H. Itoh and Y. Kuboki, Effects of geometry of hydroxyapatite as a cell substratum in BMP-induced ectopic bone formation, JBiomedMater Res 51 (2000), 491-499.
32. A.A. Jones, D. Buser, R. Schenk, J. Wozney and D.L. Cochran, The effect of rhBMP-2 around endosseous implants with and without membranes in the canine model, JPeriodontol 77 (2006), 1184-1193.
33. F. Kandziora, H. Bail, G. Schmidmaier, G. Schollmeier, M. Scholz, C. Knispel, T. Hiller, R. Pflugmacher, T. Mittlmeier, M. Raschke and N.P. Haas, Bone morphogenetic protein-2 application by a poly(D,L-lactide)-coated interbody cage: in vivo results of a new carrier for growth factors, J Neurosurg 97 (2002), 40-48.
34. F. Kandziora, R. Pflugmacher, M. Scholz, C. Knispel, T. Hiller, G. Schollmeier, H. Bail, G. Schmidmaier, G. Duda, M. Raschke and N.P. Haas, Comparison ofBMP-2 and combined IGF-I/TGF-ss1 application in a sheep cervical spine fusion model, Eur Spine J 11 (2002), 482-493.
35. V. Karageorgiou, L. Meinel, S. Hofmann, A. Malhotra, V. Volloch and D. Kaplan, Bone morphogenetic protein-2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells, J Biomed Mater Res A 71 (2004), 528-537.
36. M. Kawabata, A. Chytil and H.L. Moses, Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor, J Biol Chem 270 (1995), 5625-5630.
37. B.B. Koenig, D.H. Cook, D.H. Wolsing, J. TIng, J.P. Tiesman, P.E. Correa, C.A. Olson, A.L. Pecquet, F. Ventura and R.A. Grant, Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells, Mol Cell Biol 14 (1994), 5961-5974.
38. T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi and T. Yamamuro, Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W, J BiomedMater Res 24 (1990), 721-734.
39. J. Lan, Z. Wang, Y. Wang, J. Wang and X. Cheng, The effect of combination of recombinant human bone morphogenetic protein-2 and basic fibroblast growth factor or insulin-like growth factor-I on dental implant osseointegration by confocal laser scanning microscopy, J Periodontol 77 (2006), 357-363.
40. J. Lan, Z.F. Wang, B. Shi, H.B. Xia and X.R. Cheng, The influence of recombinant human BMP-2 on bone-implant osseointegration: biomechanical testing and histomorphometric analysis, Int J OralMaxillofac Surg 36 (2007), 345-349.
41. M. Lind, S. Overgaard, T.B. Jensen, Y. Song, S.B. Goodman, C. Bunger and K. Soballe, Effect of osteogenic protein 1/collagen composite combined with impacted allograft around hydroxyapatite-coated titanium alloy implants is moderate, J BiomedMater Res 55 (2001), 89-95.
42. M. Lind, S. Overgaard, Y. Song, S. B. Goodman, C. Bunger and K. Soballe, Osteogenic protein 1 device stimulates bone healing to hydroxyapaptite-coated and titanium implants, J Arthroplasty 15 (2000), 339-346.
43. Y. Liu, K. de Groot and E.B. Hunziker, BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model, Bone 36 (2005), 745-757.
44. Y. Liu, L. Enggist, A.F. Kuffer, D. Buser and E.B. Hunziker, The influence ofBMP-2 and its mode of delivery on the osteoconductivity of implant surfaces during the early phase of osseointegration, Biomaterials 28 (2007), 2677-2686.
45. Y. Liu, E.B. Hunziker, P. Layrolle, J.D. De Bruijn and K. de Groot, Bone morphogenetic protein 2 incorporated into biomimetic coatings retains its biological activity, Tissue Eng 10 (2004), 101-108.
46. Y. Liu, R.O. Huse, K. de Groot, D. Buser and E.B. Hunziker, Delivery mode and efficacy ofBMP-2 in association with implants, J Dent Res 86 (2007), 84-89.
47. M. Macias-Silva, P.A. Hoodless, S.J. Tang, M. Buchwald and J.L. Wrang, Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2, J Biol Chem 173 (1998), 25628-25636.
48. I. Maege, E. Jaehne, A. Henke, A.J. Adler, C. Bram, C. Jung and M. Stratmann, Ultrathin. Organic Layers for Corrosion Protection, Macromol Symp 126 (1997), 7-24.
49. A. Moustakas and C.H. Heldin, From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction, Genes Dev 16 (2002), 1867-1871.
50. N. Murakami, N. Saito, H. Horiuchi, T. Okada, K. Nozaki and K. Takaoka, Repair of segmental defects in rabbit humeri with titanium fiber mesh cylinders containing recombinant human bone morphogenetic protein-2 (rhBMP-2) and a synthetic polymer, J BiomedMater Res 62 (2002), 169-174.
51. N. Murakami, N. Saito, J. Takahashi, H. Ota, H. Horiuchi, M. Nawata, T. Okada, K. Nozaki and K. Takaoka, Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier, Biomaterials 24 (2003), 2153-2159.
52. R. Nishimura, Y. Kato, D. Chen, S.E. Harris, G.R. Mundy and T. Yoneda, Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12, J Biol Chem 273 (1998), 1872-1879.
53. T. Noshi, T. Yoshikawa, Y. Dohi, M. Ikeuchi, K. Horiuchi, K. Ichijima, M. Sugimura, K. Yonemasu and H. Ohgushi, Recombinant human bone morphogenetic protein-2 potentiates the in vivo osteogenic ability of marrow/hydroxyapatite composites, Artif Organs 25 (2001), 201-208.
54. Y. Okubo, K. Bessho, K. Fujimura, K. Kusumoto, Y. Ogawa and T. Iizuka, Osteogenesis by recombinant human bone morphogenetic protein-2 at skeletal sites, Clin Orthop RelatRes (2000), 295-301. (Pubitemid 30366602)
55. M.P. Patel, P. Pavlovic, F.J. Hughes, G.N. King, A. Cruchley and M. Braden, Release of recombinant human bone morphogenetic protein-2 from heterocyclic methacrylate polymer systems, Biomaterials 22 (2001), 2081-2086.
56. D.A. Puleo, R.A. Kissling and M.S. Sheu, A technique to immobilize bioactive proteins, including bone morphogenetic protein-4 (BMP-4), on titanium alloy, Biomaterials 23 (2002), 2079-2087.
57. U. Ripamonti, S.S. Ma, H.B. van den and A.H. Reddi, Osteogenin, a bone morphogenetic protein, adsorbed on porous hydroxyapatite substrata, induces rapid bone differentiation in calvarial defects of adult primates, PlastReconstr Surg 90 (1992), 382-393.
58. B.L. Rosenzweig, T. Imamura, T. Okadome, G.N. Cox, H. Yamashita, P. ten Dijke, C.H. Heldin, and K. Miyazono, Cloning and characterization of a human type II receptor for bone morphogenetic proteins, Proc Natl Acad Sci USA 92, 7632-7636
59. A. Sachse, A. Wagner, M. Keller, O. Wagner, W.D. Wetzel, F. Layher, R.A. Venbrocks, P. Hortschansky, M. Pietraszczyk, B. Wiederanders, H.J. Hempel, J. Bossert, J. Horn, K. Schmuck and J. Mollenhauer, Osteointegration of hydroxyapatite- titanium implants coated with nonglycosylated recombinant human bone morphogenetic protein-2 (BMP-2) in aged sheep, Bone 37 (2005), 699-710.
60. A.H. Schmaier, L. Silver, A.L. Adams, G.C. Fischer, P.C. Munoz, L. Vroman and R.W. Colman, The effect of high molecular weight kininogen on surface-adsorbed fibrinogen, Thromb Res 33 (1984), 51-67.
61. H. Seeherman and J.M. Wozney, Delivery of bone morphogenetic proteins for orthopedic tissue regeneration, Cytokine Growth Factor Rev 16 (2005), 329-345.
62. K. Soballe, T.B. Jensen, O. Mouzin, L. Kidder and J.E. Bechtold, Differential effect of a bone morphogenetic protein-7 (OP-1) on primary and revision loaded, stable implants with allograft, J BiomedMater Res A 71 (2004), 569-576.
63. V.F. Stenport, C. Johansson, S.J. Heo, P. Aspenberg and T. Albrektsson, Titanium implants and BMP-7 in bone: an experimental model in the rabbit, J Mater Sci Mater Med 14 (2003), 247-254.
64. D.R. Sumner, T.M. Turner, R.M. Urban, T. Turek, H. Seeherman and J.M. Wozney, Locally delivered rhBMP-2 enhances bone ingrowth and gap healing in a canine model, J Orthop Res 22 (2004), 58-65.
65. D.R. Sumner, T.M. Turner, R.M. Urban, A.S. Virdi and N. Inoue, Additive enhancement of implant fixation following combined treatment with rhTGF-beta2 and rhBMP-2 in a canine model, J Bone Joint Surg Am 88 (2006), 806-817.
66. N. Sykaras, R.G. Triplett, M.E. Nunn, A.M. Iacopino and L.A. Opperman, Effect of recombinant human bone morphogenetic protein-2 on bone regeneration and osseointegration of dental implants, Clin Oral Implants Res 12 (2001), 339-349.
67. N. Sykaras, R.D. Woody, A.M. Lacopino, R.G. Triplett and M.E. Nunn, Osseointegration of dental implants complexed with rhBMP-2: a comparative histomorphometric and radiographic evaluation, Int J Oral Maxillofac Implants 19 (2004), 667-678.
68. Y. Takahashi, M. Yamamoto, K. Yamada, O. Kawakami and Y. Tabata, Skull bone regeneration in nonhuman primates by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel, Tissue Eng 13 (2007), 293-300.
69. J.O. Teixeira and M.R. Urist, Bone morphogenetic protein induced repair of compartmentalized segmental diaphyseal defects, Arch Orthop Trauma Surg 117 (1998), 27-34.
70. P. ten Dijke, H. Yamashita, T.K. Sampath, A.H. Reddi, M. Estevez, D.L. Riddle, H. Ichijo, C.H. Helding and K. Miyazono, Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4, J Biol Chem 269 (1994), 16985-16988.
71. F. Thorey, F. Witte, J. Nellesen, N. Griep-Raming, H. Menzel, G. Gross, A. Hoffmann, J. Seufert and H. Windhagen, [Improved osseointegration of titanium implants after surface coating with polymers in a rabbit model], Orthopade 34 (2005), 1112, 1114-1112, 1117.
72. M.R. Urist, Bone formation by autoinduction, Science 150 (1965), 893-899.
73. M.R. Urist, R.J. DeLange and G.A. Finerman, Bone cell differentiation and growth factors, Science 220 (1983), 680-686.
74. J.G. van Alsten, Self-assembled monolayers on engineering metals: Structure, derivatization, and utility, Langmuir 15, 7605-7614.
75. A.T. Villavicencio, S. Burneikiene, E.L. Nelson, K.R. Bulsara, M. Favors and J. Thramann, Safety of transforaminal lumbar interbody fusion and intervertebral recombinant human bone morphogenetic protein-2, J Neurosurg Spine 3 (2005), 436-443.
76. G. Voggenreiter, K. Hartl, S. Assenmacher, M. Chatzinikolaidou, H.M. Rumpf and H.P. Jennissen, Assesment of the biological activity of chemically immobilized rhBMP-2 on titanium surfaces in vivo, Mat -wiss u Werkstofftech 32 (2001), 942-948.
77. B. Walivaara, A. Askendal, H. Elwig, I. Lundstrom and P. Tengvall, Antisera binding onto metals immersed in human plasma in vitro, J BiomedMater Res 26 (1992), 1205-1216.
78. U.M. Wikesjo, M. Qahash, R.C. Thomson, A.D. Cook, M.D. Rohrer, J.M. Wozney and W.R. Hardwick, rhBMP-2 significantly enhances guided bone regeneration, Clin Oral Implants Res 15 (2004), 194-204.
79. U.M.Wikesjo, R.G. Sorensen, A. Kinoshita and J.M.Wozney, RhBMP-2/alphaBSM induces significant vertical alveolar ridge augmentation and dental implant osseointegration, Clin Implant Dent Relat Res 4 (2002), 174-182.
80. J.T. Woodward, A. Ulman and D.K. Schwartz, Self-assembled monolayer growth of octadecylphosphonic acid on mica, Langmuir 12 (1996), 3626-3629.
81. J. Wozney, Novel regulators of bone formation: molecular clones and activities, Science 242 (1988), 1528-1534.
82. J. Wozney, The bone morphogenetic protein family and osteogenesis, Mol Reprod Dev 32 (1992), 160-167.
83. J.Wozney, V. Rosen, M. Byrne, A.J. Celeste, I. Moutsatsos and E.A.Wang, Growth factors influencing bone development, J Cell Sci Suppl 13 (1990), 149-156.
84. M. Yamamoto, Y. Takahashi and Y. Tabata, Enhanced bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel, Tissue Eng 12 (2006), 1305-1311.
85. H. Yamashita, P. ten Dijke, D. Huylebroeck, T.K. Sampath, M. Andries, J.C. Smith, C.H. Heldin and K. Miyazono, Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects, J Cell Biol 130 (1995), 217-226.
86. Y. Yamazaki, S. Oida, K. Ishihara and N. Nakabayashi, Ectopic induction of cartilage and bone by bovine bone morphogenetic protein using a biodegradable polymeric reservoir, J Biomed Mater Res 30 (1996), 1-4.
87. K. Yoshida, K. Bessho, K. Fujimura, Y. Konishi, K. Kusumoto, Y. Ogawa and T. Iizuka, Enhancement by recombinant human bone morphogenetic protein-2 of bone formation by means of porous hydroxyapatite in mandibular bone defects, J Dent Res 78 (1999), 1505-1510.
88. K. Yoshida, K. Bessho, K. Fujimura, K. Kusumoto, Y. Ogawa, Y. Tani and T. Iizuka, Osteoinduction capability of recombinant human bone morphogenetic protein-2 in intramuscular and subcutaneous sites: an experimental study, J Craniomaxillofac Surg 26 (1998), 112-115.
89. G. Zellin and A. Linde, Treatment of segmental defects in long bones using osteopromotive membranes and recombinant human bone morphogenetic protein-2. An experimental study in rabbits, Scand J Plast Reconstr Surg Hand Surg 31 (1997), 97-104.