RhBMP-2/alphaBSM induces significant vertical alveolar ridge augmentation and dental implant osseointegration

Clinical implant dentistry and related research

Volumn 4, Issue 4, 2002, Pages 174-182

  Wikesjoö, Ulf M E ^a   Sorensen, Rachel G ^b   Kinoshita, Atsuhiro ^c   Wozney, John M ^b  

^a TEMPLE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BMP2 PROTEIN, HUMAN; BONE CEMENT; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; DRUG CARRIER; HYDROXYAPATITE; HYDROXYAPATITE CEMENT; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; BONE REGENERATION; DOG; DRUG EFFECT; EVALUATION; HUMAN; IMPLANT; MALE; MANDIBLE; METHODOLOGY; ORAL SURGERY; TOOTH IMPLANTATION;

ALVEOLAR RIDGE AUGMENTATION; ANIMALS; BONE CEMENTS; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; DENTAL IMPLANTATION, ENDOSSEOUS; DENTAL IMPLANTS; DOGS; DRUG CARRIERS; DURAPATITE; HUMANS; HYDROXYAPATITES; IMPLANTS, EXPERIMENTAL; MALE; MANDIBLE; OSSEOINTEGRATION; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0038519784     PISSN: 15230899     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1708-8208.2002.tb00169.x     Document Type: Article

References (27)

1. 1 Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, Wang EA. The healing of segmentai bone defects, induced by recombinant bone morphogenetic protein (rhBMP‐2). A radiographie, histological, and biochemical study in rats. J Bone Joint Surg Am 1992 ; 74A: 659–670.
2. 2 Gerhart TN, Kirker‐Head CA, Kriz MJ, et al. Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop 1993 ; 293: 317–326.
3. 3 Tornimi DM, Kotler HS, Luxenberg DP, Holtrop ME, Wang EA. Mandibular reconstruction with a recombinant bone‐inducing factor. Functional, histologie, and biomechanical evaluation. Arch Otolaryngol Head Neck Surg 1991 ; 117: 1101–1112.
4. 4 Toriumi DM, O'Grady K, Horlbeck DM, Desai D, Turek TJ, Wozney J. Mandibular reconstruction using bone morphogenetic protein 2: long‐term follow‐up in a canine model. Laryngoscope 1999 ; 109: 1481–1489.
5. 5 Boyne PJ. Animal studies of the application of rhBMP‐2 in maxillofacial reconstruction. Bone 1996 ; 19: 83S–92S.
6. 6 Boyne PJ, Nakamura A, Shabahang S. Evaluation of the long‐term effect of function on rhBMP‐2 regenerated hemimandibulectomy defects. Br J Oral Maxillofac Surg 1999 ; 37: 344–352.
7. 7 Boyne PJ, Nath R, Nakamura A. Human recombinant BMP‐2 in osseous reconstruction of simulated cleft palate defects. Br J Oral Maxillofac Surg 1998 ; 36: 84–90.
8. 8 Yudell RM, Block MS. Bone gap healing in the dog using recombinant human bone morphogenetic protein‐2. J Oral Maxillofac Surg 2000 ; 58: 761–766.
9. 9 Cochran DL, Wozney JM. Biological mediators for periodontal regeneration. Periodontol 2000 1999 ; 19: 40–58.
10. 10 Wikesjö UME, Sorensen RG, Wozney JM. Augmentation of alveolar bone and dental implant osseointegration. Clinical implications of studies with rhBMP‐2. A comprehensive review. J Bone Joint Surg Am 2001 ; 83A (Suppl 1 Pt 2): S136–S145.
11. 11 Barboza EP, Leite Duarte ME, Geolas L, Sorensen RG, Riedel GE, Wikesjö UME. Ridge augmentation following implantation of recombinant human bone morphogenetic protein‐2 in the dog. J Periodontol 2000 ; 71: 488–496.
12. 12 Ishikawa K, Miyamoto Y, Takechi M, et al. Non‐decay type fast‐setting calcium phosphate cement: hydroxyapatite putty containing an increased amount of sodium alginate. J Biomed Mater Res 1997 ; 36: 393–399.
13. 13 Schmitz JP, Hollinger JO, Milam SB. Reconstruction of bone using calcium phosphate bone cements: a critical review. J Oral Maxillofac Surg 1999 ; 57: 1122–1126.
14. 14 Lee DD, Tofighi A, Aiolova M, et al. Alpha‐BSM: a biomimetic bone substitute and drug delivery vehicle. Clin Orthop 1999 ; 367: S396–S405.
15. 15 Knaack D, Goad ME, Aiolova M, et al. Resorbable calcium phosphate bone substitute. J Biomed Mater Res 1998 ; 43: 399–409.
16. 16 Seeherman H, Aiolova M, Bouxsein M, Wozney J. Single injection of rhBMP‐3/calcium phosphate paste accelerates healing in a non‐human primate osteotomy model. ORS Trans 2001. (abstract 0251)
17. 17 Li R, Seeherman H, Bouxsein M, Li J, Wozney J. Evaluation of α‐BSM (ETEX) as an injectable carrier for rhBMP‐2 in the rabbit ulnar osteotomy model. GI Tech Rep P99138‐11.
18. 18 Donath K, Breuner G. A method for the study of undecalcified bones and teeth with attached soft tissues. The SägeSchliff (sawing and grinding) technique. J Oral Pathol 1982 ; 11: 318–326.
19. 19 Caplanis N, Sigurdsson TJ, Rohrer MD, Wikesjö UME. Effect of allogeneic, freeze‐dried, demineralized bone matrix on guided bone regeneration in supra‐alveolar periimplant defects in dogs. Int J Oral Maxillofac Implants 1997 ; 12: 634–642.
20. 20 Sigurdsson TJ, Fu E, Tatakis DN, Rohrer MD, Wikesjö UME. Bone morphogenetic protein‐2 enhances peri‐implant bone regeneration and osseointegration. Clin Oral Implants Res 1997 ; 8: 367–374.
21. 21 Tatakis DN, Koh A, Jin L, Wozney JM, Rohrer MD, Wikesjö UME. Peri‐implant bone regeneration using rhBMP‐2/ACS in a canine model: a dose‐response study. J Periodont Res 2002 ; 37: 93–100.
22. 22 Wikesjö UME, Guglielmoni PG, Promsudthi A, et al. Periodontal repair in dogs: effect of rhBMP‐2 concentration on regeneration of alveolar bone and periodontal attachment, J Clin Periodontol 1999 ; 26: 392–400.
23. 23 Wikesjö UME, Lim WH, Thomson RC, Hardwick WR. Gingival tissue exclusion, a critical requirement for GTR. J Dent Res 2001 ; 80. (AADR abstract 165)
24. 24 Kim C‐K, Cho K‐S, Choi S‐c, Prewett A, Wikesjö UME. Periodontal repair in dogs: effect of allogeneic freeze‐dried demineralized bone matrix implants on alveolar bone and cementum regeneration. J Periodontol 1998 ; 69: 26–33.
25. 25 Wikesjö UME, Qahash M, Thomson RC, et al. rhBMP‐2 significantly enhances GBR at machined and surface‐etched dental implants. J Dent Res 2001 ; 80. (AADR abstract 380)
26. 26 Wikesjö UME, Qahash M, Thomson RC, et al. Space providing ePTFE devices define rhBMP‐2 induced alveolar augmentation at dental implants. J Dent Res 2001 ; 80. (IADR abstract 40)
27. 27 Jovanovic SA, Hunt DR, Bernard GW, Spiekermann H, Wozney JM, Wikesjö UME. Long‐term functional loading of dental implants in rhBMP‐2 induced bone. A histologie study in the canine ridge augmentation model. Clin Oral Implants Res 2002. (accepted for publication)