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Volumn 1217, Issue 32, 2010, Pages 5158-5164
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Multiple headspace single-drop microextraction coupled with gas chromatography for direct determination of residual solvents in solid drug product
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Author keywords
Drug product; Gas chromatography; Multiple headspace single drop microextraction; Residual solvents
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Indexed keywords
ANALYTES;
DIRECT DETERMINATION;
EXHAUSTIVE EXTRACTION;
EXTRACTION PROCESS;
EXTRACTION SOLVENTS;
EXTRACTION TIME;
FLAME IONIZATION DETECTION;
HEADSPACE SINGLE DROP MICROEXTRACTION;
INCUBATION TIME;
LOW COSTS;
MATRIX EFFECTS;
MICRODROPS;
MODEL DRUGS;
PEAK AREA;
QUANTITATIVE ANALYSIS;
QUANTITATIVE DETERMINATIONS;
RESIDUAL SOLVENTS;
SOLID SAMPLES;
STANDARD SOLUTIONS;
CHEMICAL ANALYSIS;
DIMETHYL SULFOXIDE;
DISSOLUTION;
DROPS;
DRUG PRODUCTS;
DRUG PRODUCTS PLANTS;
ETHANOL;
GAS CHROMATOGRAPHY;
IONIZATION OF GASES;
METHANOL;
ORGANIC SOLVENTS;
SOLVENT EXTRACTION;
ALCOHOL;
DIMETHYL SULFOXIDE;
DRUG;
METHANOL;
SOLVENT;
ARTICLE;
CHEMICAL ANALYSIS;
CONCENTRATION (PARAMETERS);
CONTROLLED STUDY;
DRUG FORMULATION;
DRUG QUALITY;
DRUG SOLUBILITY;
ENVIRONMENTAL PROTECTION;
EXTRACTION AND EXTRACTS;
GAS CHROMATOGRAPHY;
INCUBATION TIME;
MULTIPLE HEADSPACE SINGLE DROP MICROEXTRACTION;
PRIORITY JOURNAL;
QUALITY CONTROL;
QUANTITATIVE ANALYSIS;
SENSITIVITY AND SPECIFICITY;
SOLVENT EXTRACTION;
TEMPERATURE;
CALIBRATION;
CHEMISTRY;
DEVICES;
DRUG CONTAMINATION;
FRACTIONATION;
PROCEDURES;
REPRODUCIBILITY;
STATISTICAL MODEL;
TIME;
CALIBRATION;
CHEMICAL FRACTIONATION;
CHROMATOGRAPHY, GAS;
DRUG CONTAMINATION;
LINEAR MODELS;
PHARMACEUTICAL PREPARATIONS;
REPRODUCIBILITY OF RESULTS;
SOLVENTS;
TEMPERATURE;
TIME FACTORS;
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EID: 77954759424
PISSN: 00219673
EISSN: None
Source Type: Journal
DOI: 10.1016/j.chroma.2010.06.009 Document Type: Article |
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Times cited : (33)
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References (40)
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