Fast capillary GC using a low thermal mass column oven for the determination of residual solvents in pharmaceuticals

Journal of Separation Science

Volumn 29, Issue 5, 2006, Pages 695-698

  David, Frank ^a,b   Szücs, Roman ^c   Makwana, Jay ^c   Sandra, Pat ^a,b  

^a GHENT UNIVERSITY   (Belgium)

^b Research Institute for Chromatography   (Belgium)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Capillary gas chromatography; High throughput; Low thermal mass column oven; Pharmaceutical analysis; Residual solvents

Indexed keywords

CAPILLARY TUBES; CHEMICAL ANALYSIS; DRUG PRODUCTS; ORGANIC SOLVENTS; SENSITIVITY ANALYSIS; SEPARATION;

CAPILLARY GAS CHROMATOGRAPHY; LOW THERMAL MASS COLUMN OVEN; PHARMACEUTICAL ANALYSIS; RESIDUAL SOLVENTS;

GAS CHROMATOGRAPHY;

2 PROPANOL; 4 METHYL 2 PENTANONE; ACETIC ACID DERIVATIVE; ACETIC ACID ETHYL ESTER; ACETONE; ACETONITRILE; ALCOHOL; BENZENE; BUTANOL; CHLOROFORM; CYCLOHEXANE; DICHLOROMETHANE; DIOXANE; DRUG; ETHER; HEXANE; METHANOL; PENTANE; PROPANOL; SOLVENT; TOLUENE;

ARTICLE; CAPILLARY GAS CHROMATOGRAPHY; CHEMICAL PROCEDURES; CONTROLLED STUDY; DRUG DETERMINATION; DRUG FORMULATION; HIGH THROUGHPUT SCREENING; INTERMETHOD COMPARISON; LABORATORY; LINEAR SYSTEM; LOW TEMPERATURE; METHODOLOGY; PRIORITY JOURNAL; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; TIME;

CHROMATOGRAPHY, GAS; HEAT; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLVENTS;

EID: 33645751308     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200500430     Document Type: Article

References (10)

1. United States Pharmacopoeia, Organic Volatile Impurities <467>, Methods I, IV, and V, 2002.
2. European Pharmacopoeia, Section V.3.3.9.-2, Residual Solvents, System A, 2002.
3. Sandra, P., David, F., Szucs, R., TrAC-Trend. Anal. Chem. 2002, 21, 662-671.
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6. Mustacich, R., US patents 6 217 829 (2001), 6 209 386 (2001), and 6 530 260 (2003).
7. Luong, J. C., Gras, R. L., Cortes, H. J., Mustacich, R. M., in: Sandra, P. (Ed.), Paper presented at the 27th International Symposium on Capillary Chromatography, May 31-June 4 2004, Riva del Garda, Italy, CD-ROM PL-11, Publ. IOPMS, Kortrijk, Belgium.
8. Mustacich, R. M., Everson, J. F., Richards, J. P., Gras, R. L., Luong, J. C., in: Sandra, P. (Ed.), Paper presented at the 27th International Symposium on Capillary Chromatography, May 31-June 4 2004, Riva del Garda, Italy, CD-ROM, P-I-19, Publ. IOPMS, Kortrijk, Belgium.
9. Magni, P., Facchetti, R., Cavagnino, D., Trestianu, S., Paper presented at the 25th International Symposium on Capillary Chromatography, Sandra P. (Ed.), May 13-17, 2002, Riva del Garda, Italy, CD-ROM, KLN05, IOPMS, Kortrijk, Belgium.
10. Bicchi, C., Brunelli, C., Cordero, C., Rubiolo, P. et al., J. Chromatogr. A 2004, 1024, 195-207.