Immunohistological evaluation of Ki-67, p63, CK19 and p53 expression in oral epithelial dysplasias

Journal of Oral Pathology and Medicine

Volumn 35, Issue 6, 2006, Pages 369-375

  Takeda, T ^a   Sugihara, K ^a   Hirayama, Y ^a   Hirano, M ^a   Tanuma, J I ^a   Semba, I ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

CK19; Ki 67; Oral epithelial dysplasia; p53; p63

Indexed keywords

CYTOKERATIN 19; KI 67 ANTIGEN; PROTEIN P53; PROTEIN P63;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DYSPLASIA; FEMALE; HISTOLOGY; HUMAN; IMMUNOHISTOLOGY; LABELING INDEX; MALE; MOUTH CARCINOMA; MOUTH MUCOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CELL PROLIFERATION; EPITHELIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; KI-67 ANTIGEN; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM PROTEINS; PRECANCEROUS CONDITIONS; TUMOR STEM CELLS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33745061991     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2006.00444.x     Document Type: Article

References (40)

1. Hsieh LL Huang TH Chen IH, et al. p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan. Br J Cancer 2005 92 : 30 5.
2. Carinci F Muzio LL Piattelli A, et al. Genetic portrait of mild and severe lingual dysplasia. Oral Oncol 2005 41 : 365 74.
3. Hunter KD Parkinson K Harrison PR. Profiling early head and neck cancer. Nat Rev Cancer 2005 5 : 127 35.
4. Gale N Pilch BZ Sidramsky D, et al. Epithelial precursor lesions. In : Barnes L Eveson J Reichart P Sidransky D, eds. World Health Organization classification of tumors. Pathology and genetics of head and neck tumours. Lyon : Iarc Press, 2005 177 9.
5. Crussman JD Sakr WA. Squamous intraepithelial neoplasia of the upper aerodigestive tract. In : Gnepp DR, ed. Diagnostic Surgical Pathology of the Head and Neck. Philadelphia : WB Saunders, 2001 1 17.
6. Krutchkoff DJ Eisenberg E Anderson C. Dysplasia of oral mucosa: a unified approach to proper evaluation. Mod Pathol 1991 4 : 113 9.
7. Crissman JD Zarbo RJ. Dysplasia, in situ carcinoma, and progression to invasive squamous cell carcinoma of the upper aerodigestive tract. Am J Surg Pathol 1989 13 Suppl. 1 5 16.
8. Schepman KP Van Der Meij EH Smeele LE Van Der Waal I. Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands. Oral Oncol 1998 34 : 270 5.
9. Janes SM Lowell S Hutter C. Epidermal stem cells. J Pathol 2002 197 : 479 91.
10. Yang A Schweitzer R Sun D, et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999 398 : 714 8.
11. Mills AA Zheng B Wang XJ Vogel H Roop DR Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999 398 : 708 13.
12. Koster MI Kim S Mills AA De Mayo FJ Roop DR. p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev 2004 18 : 126 31.
13. Pellegrini G Dellambra E Golisano O, et al. p63 identifies keratinocyte stem cells. Proc Natl Acad Sci USA 2001 98 : 3156 61.
14. Hu H Xia SH Li AD, et al. Elevated expression of p63 protein in human esophageal squamous cell carcinoma. Int J Cancer 2002 102 : 580 3.
15. Nylander K Coates PJ Hall PA. Characterization of the expression pattern of p63α and ΔNp63α in benign and malignant oral epithelial lesions. Int J Cancer 2000 87 : 368 72.
16. Crook T Nicholls JM Brooks L O'Nions J Allday MJ. High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC). Oncogene 2000 19 : 3439 44.
17. Larouche D Hayward C Cuffley K Germain L. Keratin 19 as a stem cell marker in vivo and in vitro. Methods Mol Biol 2005 289 : 103 10.
18. Mittal KR Demopoulos RI Goswami S. Patterns of keratin 19 expression in normal, metaplastic, condylomatous, atrophic, dysplastic, and malignant cervical squamous epithelium. Am J Clin Pathol 1992 98 : 419 23.
19. Kushner J Bradley G Jordan RCK. Patterns of p53 and Ki-67 protein expression in epithelial dysplasia from the floor of the mouth. J Pathol 1997 183 : 418 23.
20. Saito T Nakajima T Mogi K. Immunohistochemical analysis of cell cycle-associated proteins p16, pRb, p53, 27 and Ki-67 in oral cancer and precancer with special reference to verrucous carcinomas. J Oral Pathol Med 1999 28 : 226 32.
21. Syafriadi M Cheng J Jen KY Ida-Yonemochi H Suzuki M Saku T. Two-phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells. J Oral Pathol Med 2005 34 : 140 9.
22. Kotelnikov VM Coon JS Taylor S, et al. Proliferation of epithelia of noninvolved mucosa in patients with head and neck cancer. Head Neck 1996 18 : 522 8.
23. Chen YK Hsue SS Lin LM. Expression of p63 protein and mRNA in oral epithelial dysplasia. J Oral Pathol Med 2005 34 : 232 9.
24. Gkickman JN Yang A Shahsafaei A McKeon F Odze RD. Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Hum Pathol 2001 32 : 1157 65.
25. Bilder D. Epithelial polarity and proliferation control: links from the Dorsophila neoplastic tumor suppressors. Genes Dev 2004 18 : 1909 25.
26. Caussinus E Gonzalex C. Induction of tumor growth by altered stem-cell asymmetrical division in Dorsophila melanogaster. Nat Genet 2005 37 : 1125 9.
27. Gonzalez-Moles MA Ruiz-Avila I Rodriguez-Archilla A Martinez-Lara I. Suprabasal expression of Ki-67 antigen as a marker for the presence and severity of oral epithelial dysplasia. Head Neck 2000 22 : 658 61.
28. Liu SC Klein-Szanto AJP. Markers of proliferation in normal and leukoplakic oral epithelia. Oral Oncol 2000 36 : 145 51.
29. Liu SC Sauter ER Clapper ML, et al. Markers of cell proliferation in normal epithelia and dysplastic leukoplakias of the oral cavity. Cancer Epidemiol Biomarkers Prev 1998 7 : 597 603.
30. Westfall MD Pietenpol JA. p63: molecular complexity in development and cancer. Carcinogenesis 2004 25 : 857 64.
31. Bortoluzzi MC Yurgel LS Dekker NP Jordan RCK Regezi JA. Assessment of p63 expression in oral squamous cell carcinomas and dysplasias. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004 98 : 698 704.
32. Nylander K Vojtesek B Nenutil R, et al. Differential expression of p63 isoforms in normal tissues and neoplastic cells. J Pathol 2002 198 : 417 27.
33. Geddert H Kiel S Heep HJ Gabbert HE Sarbia M. The role of p63 and ΔNp63 (p40) protein expression and gene amplification in esophageal carcinogenesis. Hum Pathol 2003 34 : 850 6.
34. Bérnard J Douc-Rasy S Ahomadegbe C. TP53 family members and human cancers. Hum Mutat 2003 21 : 182 91.
35. Little NA Jochemsen AG. p63. Int J Biochem Cell Biol 2002 34 : 6 9.
36. Chen YK Hsue SS Lin LM. Immunohistochemical demonstration of p63 in DMBA-induced hamster buccal pouch squamous cell carcinogenesis. Oral Dis 2003 9 : 235 40.
37. Foschini MP Gaiba A Cocchi R, et al. Pattern of p63 expression in squamous cell carcinoma of the oral cavity. Virchows Arch 2004 444 : 332 9.
38. Cruz IB Mwijer CJLM Snijders PJF Snow GB Walboomers JMM Van Der Waal I. p53 immunoexpression in non-malignant oral mucosa adjacent to oral squamous cell carcinoma: potential consequences for clinical management. J Pathol 2000 191 : 132 7.
39. Kövesi G Szende B. Change in apoptosis and mitotic index, p53 and Ki-67 expression in various types of oral leukoplakia. Oncology 2003 65 : 331 6.
40. Sudbø J Lippman SM Lee JJ, et al. The influence of resection and aneuploidy on mortality in oral leukoplakia. N Engl J Med 2004 350 : 1405 13.