Mutations are involved in emergence of aminoglycoside-induced small colony variants of Staphylococcus aureus

International Journal of Medical Microbiology

Volumn 293, Issue 6, 2003, Pages 427-435

  Schaaff, Franziska ^a,b,c   Bierbaum, Gabriele ^a,d   Baumert, Nicole ^a   Bartmann, Peter ^b   Sahl, Hans Georg ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^d Inst fur Med Mikrobiol/Immunol   (Germany)

Author keywords

Aminoglycosides; Hem operon; Mutator strain; Small colony variants; Staphylococcus aureus

Indexed keywords

AMINOGLYCOSIDE; COTRIMOXAZOLE; GENTAMICIN; MENAQUINONE; RIFAMPICIN;

ARTICLE; AUXOTROPHY; BACTERIAL MUTATION; BACTERIUM COLONY; GENE CLUSTER; GENE DELETION; NONHUMAN; OPERON; RECURRENT INFECTION; STAPHYLOCOCCUS AUREUS;

STAPHYLOCOCCUS AUREUS;

EID: 0347753318     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4221-00282     Document Type: Article

References (34)

1. Aubry-Damon, H., Soussy, C. J., Courvalin, P.: Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 42, 2590-2594 (1998).
2. Balwit, J. M., van Langevelde, P., Vann, J. M., Proctor, R. A.: Gentamicin-resistant menadione and hemin auxotrophic Staphylococcus aureus persist within cultured endothelial cells. J. Infect. Dis. 170, 1033-1037 (1994).
3. Berger-Bächi, B., Kohler, M. L.: A novel site on the chromosome of Staphylococcus aureus influencing the level of methicillin resistance: genetic mapping. FEMS Microbiol. Lett. 20, 305-309 (1983).
4. Bischoff, M., Entenza, J. M., Giachino, P.: Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus. J Bacteriol. 183, 5171-5179 (2001).
5. Boe, L.: Translational errors as the cause of mutations in Escherichia coli. Mol. Gen. Genet. 231, 469-471 (1992).
6. Goering, R. V., Duensing, T. D.: Rapid field inversion gel electrophoresis in combination with an rRNA gene probe in the epidemiological evaluation of staphylococci. J. Clin. Microbiol. 28, 426-429 (1990).
7. Häußler, S., Tümmler, B., Weissbrodt, H., Rohde, M., Steinmetz, I.: Small-colony variants of Pseudomonas aeruginosa in cystic fibrosis. Clin. Infect. Dis. 29, 621-625 (1999).
8. B modulates virulence determinant expression and stress resistance: Characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4. J. Bacteriol. 184, 5457-5467 (2002).
9. Horst, J. P., Wu, T. H., Marinus, M. G.: Escherichia coli mutator genes. Trends. Microbiol. 7, 29-36 (1999).
10. Humayun, M. Z.: SOS and Mayday: multiple inducible mutagenic pathways in Escherichia coli. Mol. Microbiol. 30, 905-910 (1998).
11. Kahl, B., Herrmann, M., Everding, A. S., Koch, H. G., Becker, K., Harms, E., Proctor, R. A., Peters, G.: Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosis. J. Infect. Dis. 177, 1023-1029 (1998).
12. Kolle, W., Hetsch, H.: Die Experimentelle Bacteriologie und die Infektionskrankheiten mit besonderer Berücksichtigung der Immunitätslehre. Urban und Schwarzenberg, Berlin, 1911.
13. Massey, R. C., Buckling, A., Peacock, S. J.: Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus. Curr. Biol. 11, 1810-1814 (2001).
14. McNamara, P. J., Proctor, R. A.: Staphylococcus aureus small colony variants, electron transport and persistent infections. Int. J. Antimicrob. Agents 14, 117-122 (2000).
15. Modrich, P., Lahue, R.: Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65, 101-133 (1996).
16. Murphy, H. S., Humayun, M. Z.: Escherichia coli cells expressing a mutant glyV (glycine tRNA) gene have a UVM-constitutive phenotype: implications for mechanisms underlying the mutA or mutC mutator effect. J. Bacteriol. 179, 7507-7514 (1997).
17. Musher, D. M., Baughn, R. E., Templeton, G. B., Minuth, J. N.: Emergence of variant forms of Staphylococcus aureus after exposure to gentamicin and infectivity of the variants in experimental animals. J. Infect. Dis. 136, 360-369 (1977).
18. Novick, R. P.: Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology 33, 155-166 (1967).
19. O'Neill, A. J., Chopra, I.: Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low. J. Antimicrob. Chemother. 50, 161-169 (2002).
20. Pelletier, L. L., Richardson, M., Feist, M.: Virulent gentamicin-induced small colony variants of Staphylococcus aureus. J. Lab. Clin. Med. 94, 324-334 (1979).
21. Proctor, R. A.: Microbial Pathogenic Factors: Small Colony Variants. In: Infections associated with in-dwelling medical devices (A. L. Bisno., F. A. Waldvogel, eds.), pp. 79-90. American Society for Microbiology, Washington, D. C. 1994.
22. Proctor, R. A., Balwit, J. M., Vesga, O.: Variant sub-populations of Staphylococcus aureus as cause of persistent and recurrent infections. Infect. Agents Dis. 3, 302-312 (1994).
23. Proctor, R. A., Kahl, B., von Eiff, C., Vaudaux, P. E., Lew, D. P., Peters, G.: Staphylococcal small colony variants have novel mechanisms for antibiotic resistance. Clin. Infect. Dis. 27, Suppl. 1, S68-74 (1998).
24. Proctor, R. A., Peters, G.: Small colony variants in staphylococcal infections: diagnostic and therapeutic implications. Clin. Infect. Dis. 27, 419-422 (1998).
25. Proctor, R. A., van Langevelde, P., Kristjansson, M., Maslow, J. N., Arbeit, R. D.: Persistent and relapsing infections associated with small-colony variants of Staphylococcus aureus. Clin. Infect. Dis. 20, 95-102 (1995).
26. Ren, L., Rahman, M. S., Humayun, M. Z.: Escherichia coli cells exposed to streptoraycin display a mutator phenotype. J. Bacteriol. 181, 1043-1044 (1999).
27. Richardson, A. R., Stojiljkovic, I.: Mismatch repair and the regulation of phase variation in Neisseria meningitidis. Mol. Microbiol. 40, 645-655 (2001).
28. Sanger, F., Nicklen, S., Coulson, A. R.: DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467 (1977).
29. Schaaff, F., Reipert, A., Bierbaum, G.: An elevated mutation frequency favors development of vancomycin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 46, 3540-3548 (2002).
30. Schroeder, R., Waldsich, C., Wank, H.: Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19, 1-9 (2000).
31. Vesga, O., Groeschel, M. C., Otten, M. F., Brar, D. W., Vann, J. M., Proctor, R. A.: Staphylococcus aureus small colony variants are induced by the endothelial cell intracellular milieu. J. Infect. Dis. 173, 739-742 (1996).
32. von Eiff, C., Bettin, D., Proctor, R. A., Rolauffs, B., Lindner, N., Winkelmann, W., Peters, G.: Recovery of small colony variants of Staphylococcus aureus following gentamicin bead placement for osteomyelitis. Clin. Infect. Dis. 25, 1250-1251 (1997a).
33. von Eiff, C., Heilmann, C., Prcctor, R. A., Woltz, C., Peters, G., Götz, F.: A site-directed Staphylococcus aureus hemB mutant is a small-colony variant which persists intracellularly. J. Bacteriol. 179, 4706-4712 (1997b).
34. von Eiff, C., Lindner, N., Proctor, R. A., Winkelmann, W., Peters, G.: Development of gentamicin-resistant small colony variants of S. aureus after implantation of gentamicin chains in osteomyelitis as a possible cause of recurrence. Z. Orthop. Ihre Grenzgeb. 136, 268-271 (1998).