Keratins 2 and 4/13 in reconstituted human skin are reciprocally regulated by retinoids binding to nuclear receptor RARα

Experimental Dermatology

Volumn 19, Issue 7, 2010, Pages 674-681

  Virtanen, Marie ^a   Sirsjö, Allan ^b   Vahlquist, Anders ^a   Törmä, Hans ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ÖREBRO UNIVERSITY   (Sweden)

Author keywords

Cellular retinoic acid binding proteins; Immunohistochemistry; Keratinocytes; RT qPCR; Transcription factors; Vitamin A

Indexed keywords

4 [(5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL)CARBOXAMIDO]BENZOIC ACID; 4 [2 [5,6 DIHYDRO 5,5 DIMETHYL 8 (4 METHYLPHENYL) 2 NAPHTHYL]ETHYNYL]BENZOIC ACID; ADAPALENE; CYTOKERATIN 1; CYTOKERATIN 10; CYTOKERATIN 13; CYTOKERATIN 2; CYTOKERATIN 4; ETRETIN; MESSENGER RNA; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; RETINOID; RETINOID BINDING PROTEIN; RETINOID X RECEPTOR; TAZAROTENE;

ARTICLE; BINDING AFFINITY; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENCY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; NORMAL HUMAN; PROTEIN EXPRESSION; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; UPREGULATION;

BENZOATES; GENE EXPRESSION REGULATION; HUMANS; KERATIN-13; KERATIN-2; KERATIN-4; KERATINOCYTES; KERATINS; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; RETINOIDS; RNA, MESSENGER; SKIN; TETRAHYDRONAPHTHALENES; TRETINOIN;

EID: 77954639608     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2010.01079.x     Document Type: Article

References (47)

1. Peck G L, DiGiovanna J J. Synthetic retinoids in dermatology. The Retinoids: Biology, Chemistry, and Medicine 1994, 631-658. Sporn M B, Roberts A BGoodman D S. In, eds, New York, Raven Press
2. Ruiz-Maldonado R, Tamayo-Sanchez L, Orozco-Covarrubias M L. The use of retinoids in the pediatric patient. Dermatol Clin 1998, 16:553-569.
3. Happle R, van de Kerkhof P C, Traupe H. Retinoids in disorders of keratinization: their use in adults. Dermatologica 1987, 175(Suppl. 1):107-124.
4. Bastien J, Rochette-Egly C. Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene 2004, 328:1-16.
5. Fisher G, Talwar H, Xiao J-H. Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. J Biol Chem 1994, 269:20629-20635.
6. Lee D D, Stojadinovic O, Krzyzanowska A, Vouthounis C, Blumenberg M, Tomic-Canic M. Retinoid-responsive transcriptional changes in epidermal keratinocytes. J Cell Physiol 2009, 220:427-439.
7. Lane E B, McLean W H. Keratins and skin disorders. J Pathol 2004, 204:355-366.
8. Rosenthal D S, Griffiths C E, Yuspa S H, Roop D R, Voorhees J J. Acute or chronic topical retinoic acid treatment of human skin in vivo alters the expression of epidermal transglutaminase, loricrin, involucrin, filaggrin, and keratins 6 and 13 but not keratins 1, 10, and 14. J Invest Dermatol 1992, 98:343-350.
9. Schön M, Rheinwald J G. A limited role for retinoic acid and retinoic acid receptors RAR alpha and RAR beta in regulating keratin 19 expression and keratinization in oral and epidermal keratinocytes. J Invest Dermatol 1996, 107:428-438.
10. Virtanen M, Törmä H, Vahlquist A. Keratin 4 upregulation by retinoic acid in vivo: a sensitive marker for retinoid bioactivity in human epidermis. J Invest Dermatol 2000, 114:487-493.
11. Bloor B K, Su L, Shirlaw P J, Morgan P R. Gene expression of differentiation-specific keratins (4/13 and 1/10) in normal human buccal mucosa. Lab Invest 1998, 78:787-795.
12. Eckert R L, Welter J F. Transcription factor regulation of epidermal keratinocyte gene expression. Mol Biol Rep 1996, 23:59-70.
13. Lu B, Rothnagel J A, Longley M A, Tsai S Y, Roop D R. Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1 steroid hormone element. J Biol Chem 1994, 269:7443-7449.
14. Tomic-Canic M, Sunjevaric I, Freedberg I M, Blumenberg M. Identification of the retinoic acid and thyroid hormone receptor responsive element in the human k14 keratin gene. J Invest Dermatol 1992, 99:842-847.
15. Tomic-Canic M, Day D, Samuels H, Freedberg I, Blumenberg M. Novel regulation of keratin gene expression by thyroid hormone and retinoic acid receptors. J Biol Chem 1996, 271:1416-1423.
16. Rikimaru K, Moles J P, Watt F M. Correlation between hyperproliferation and suprabasal integrin expression in human epidermis reconstituted in culture. Exp Dermatol 1997, 6:214-221.
17. Lu H, Rollman O. Fluorescence imaging of reepithelialization from skin explant cultures on acellular dermis. Wound Repair Regen 2004, 12:575-586.
18. Pruniéras M, Régnier M, Woodley D. Methods for cultivation of keratinocytes with an air-liquid interface. J Invest Dermatol 1983, 81:28s-33s.
19. Agarwal C, Chandraratna R A, Johnson A T, Rorke E A, Eckert R L. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem 1996, 271:12209-12212.
20. Toth R, Szegezdi E, Reichert U. Activation-induced apoptosis and cell surface expression of Fas (CD95) ligand are reciprocally regulated by retinoic acid receptor alpha and gamma and involve nur77 in T cells. Eur J Immunol 2001, 31:1382-1391.
21. Shroot B, Michel S. Pharmacology and chemistry of adapalene. J Am Acad Dermatol 1997, 36:S96-S103.
22. Hembree J R, Agarwal C, Beard R L, Chandraratna R A, Eckert R. Retinoid X receptor-specific retinoids inhibit the ability of retinoic acid receptor-specific retinoids to increase the level of insulin-like growth factor binding protein-3 in human ectocervical epithelial cells. Cancer Res 1996, 56:1794-1799.
23. Saurat J H. Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. J Am Acad Dermatol 1999, 41:S2-S6.
24. Törmä H, Karlsson T, Michaëlsson G, Rollman O, Vahlquist A. Decreased mRNA levels of retinoic acid receptor α, retinoid X receptor α and thyroid hormone receptor α in lesional psoriatic skin. Acta Derm Venereol 2000, 80:4-9.
25. Karlsson T, Rollman O, Vahlquist A, Törmä H. Immunofluorescence localization of nuclear retinoid receptors in psoriasis versus normal human skin. Acta Derm Venereol 2004, 84:363-369.
26. Collin C, Ouhayoun J P, Grund C, Franke W W. Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different. Differentiation 1992, 51:137-148.
27. Balmer J E, Blomhoff R. Gene expression regulation by retinoic acid. J Lipid Res 2002, 43:1773-1808.
28. Radoja N, Diaz D V, Minars T J, Freedberg I M, Blumenberg M, Tomic-Canic M. Specific organization of the negative response elements for retinoic acid and thyroid hormone receptors in keratin gene family. J Invest Dermatol 1997, 109:566-572.
29. Stellmach V, Leask A, Fuchs E. Retinoid-mediated transcriptional regulation of keratin genes in human epidermal and squamous cell carcinoma cells. Proc Natl Acad Sci U S A 1991, 88:4582-4586.
30. Diaz B V, Lenoir M C, Ladoux A, Frelin C, Demarchez M, Michel S. Regulation of vascular endothelial growth factor expression in human keratinocytes by retinoids. J Biol Chem 2000, 275:642-650.
31. Sirsjö A, Gidlöf A C, Olsson A. Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-α. Biochem Biophys Res Commun 2000, 270:846-851.
32. Yoshimura K, Uchida G, Okazaki M, Kitano Y, Harii K. Differential expression of heparin-binding EGF-like growth factor (HB-EGF) mRNA in normal human keratinocytes induced by a variety of natural and synthetic retinoids. Exp Dermatol 2003, 12(Suppl. 2):28-34.
33. Chen S, Ostrowski J, Whiting G. Retinoic acid receptor gamma mediates topical retinoid efficacy and irritation in animal models. J Invest Dermatol 1995, 104:779-783.
34. Standeven A M, Teng M, Chandraratna R A. Lack of involvement of retinoic acid receptor alpha in retinoid-induced skin irritation in hairless mice. Toxicol Lett 1997, 92:231-240.
35. Törmä H, Rollman O, Vahlquist A. Detection of mRNA transcripts for retinoic acid, vitamin D3, and thyroid hormone (c-erb-A) nuclear receptors in human skin using reverse transcription and polymerase chain reaction. Acta Derm Venereol 1993, 73:102-107.
36. Pavez Loriè E, Cools M, Borgers M. Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis. Br J Dermatol 2009, 160:26-36.
37. Pavez Loriè E, Gånemo A, Borgers M. Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole. Acta Derm Venereol 2009, 89:12-20.
38. Lucker G P, Heremans A M, Boegheim P J, van de Kerkhof P C, Steijlen P M. Oral treatment of ichthyosis by the cytochrome P-450 inhibitor liarozole. Br J Dermatol 1997, 136:71-75.
39. Pavez Loriè E, Chamcheu J C, Vahlquist A, Törmä H. Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis. Arch Dermatol Res 2009, 301:475-485.
40. Boisvieux-Ulrich E, Le Pechon-Vallee C, Million K. Differential effects of several retinoid receptor-selective ligands on squamous differentiation and apoptosis in airway epithelial cells. Cell Tissue Res 2000, 300:67-81.
41. Briata P, D'Anna F, Franzi A T, Gherzi R. AP-1 activity during normal human keratinocyte differentiation: evidence for a cytosolic modulator of AP-1/DNA binding. Exp Cell Res 1993, 204:136-146.
42. Rossi A, Jang S I, Ceci R, Steinert P M, Markova N G. Effect of AP1 transcription factors on the regulation of transcription in normal human epidermal keratinocytes. J Invest Dermatol 1998, 110:34-40.
43. Wanner R, Henseleit-Walter U, Wittig B, Kolde G. Proliferation-dependent induction of apoptosis by the retinoid CD437 in p53-mutated keratinocytes. J Mol Med 2002, 80:61-67.
44. Wanner R, Zhang J, Dorbic T. The promoter of the HaCaT keratinocyte differentiation-related gene keratin 4 contains a functional AP-2 binding site. Arch Dermatol Res 1997, 289:705-708.
45. Crowe D L. Retinoic acid mediates post-transcriptional regulation of keratin-19 messenger RNA levels. J Cell Sci 1993, 106:183-188.
46. Garzon R, Pichiorri F, Palumbo T. MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene 2007, 26:4148-4157.
47. Di W, Li X Y, Datta S. Keratinocyte-specific retinoid regulation of human cellular retinoic acid binding protein-II (hCRABPII) gene promoter requires an evolutionarily conserved DR1 retinoic acid-responsive element. J Invest Dermatol 1998, 111:1109-1115.