Overexpression of the EGFR/FKBP12/HIF-2α pathway identified in childhood astrocytomas by angiogenesis gene profiling

Cancer Research

Volumn 63, Issue 8, 2003, Pages 1865-1870

  Khatua, Soumen ^a   Peterson, Katia M ^a   Brown, Kevin M ^b,e   Lawlor, Christopher ^a   Santi, Maria R ^c   LaFleur, Bonnie ^d   Dressman, Devin ^b   Stephan, Dietrich A ^b   MacDonald, Tobey J ^a,c  

^a CHILDREN S RESEARCH INSTITUTE   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; FK 506 BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; SOMATOMEDIN BINDING PROTEIN 2; TRANSCRIPTION FACTOR; TUMOR MARKER; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; ASTROCYTOMA; CANCER GRADING; CHILDHOOD CANCER; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSDUCTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; NEUROPATHOLOGY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION;

ASTROCYTOMA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN NEOPLASMS; CHILD; GENE EXPRESSION PROFILING; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TACROLIMUS BINDING PROTEIN 1A; TRANS-ACTIVATORS;

EID: 0037447352     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Gurney, J. G. Topical topics: brain cancer incidence in children: time to look beyond the trends. Med. Pediatr. Oncol., 33: 110-112, 1999.
2. Cohen, K. J., Broniscer, A., and Glod, J. Pediatric glial tumors. Curr. Treat. Options Oncol., 2: 529-536, 2001.
3. Hockel, M., and Vaupel, P. Tumor hypoxia: definitions and current clinical, biologic and molecular aspects. J. Natl. Cancer Inst. (Bethesda), 93: 266-276, 2001.
4. Semenza, G. L. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol. Med., 7: 345-350, 2001.
5. Ding, H., Roncari, L., Wu, X., Lau, N., Shannon, P., Nagy, A., and Guha, A. Expression and hypoxic regulation of angiopoietins in human astrocytomas. Neurooncol., 3: 1-10, 2001.
6. Pollack, I. F., Finkelstein, S. D., Burnham, J., Holmes, E. J., Hamilton, R. L., Yates, A. J., Finlay, J. L., and Sposto, R. Age and TP53 mutation frequency in childhood malignant gliomas: results in a multi-institutional cohort. Children's Cancer Group. Cancer Res., 61: 7404-7407, 2001.
7. Raffel, C., Frederick, L., O'Fallon, J. R., Atherton-Skaff, P., Perry, A., Jenkins, R. B., and James, C. D. Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations. Clin. Cancer Res., 5: 4085-4090, 1999.
8. Van Meir, E. G., Polverini, P. J., Chazin, V. R., Su Huang, H. J., de Tribolet, N., and Cavenee, W. K. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nat. Genet., 8: 171-176, 1994.
9. Wen, S., Stolarov, J., Myers, M. P., Su, J. D., Wigler, M. H., Tonks, N. K., and Durden, D. L. PTEN controls tumor-induced angiogenesis. Proc. Natl. Acad. Sci. USA, 98: 4622-4627. 2001.
10. MacDonald, T. J., Brown, K. M., LaFleur, B., Peterson, K. M., Lawlor, C., Chen, Y., Packer, R. J., Cogen, P., and Stephan, D. A. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat. Genet., 29: 143-152, 2001.
11. Misra, J., Schmitt, W., Hwang, D., Hsiao, L. L., Gulans, S., and Stephanpoulas, G. Interactive exploration of microarray gene expression patterns in a reduced dimensional space. Genome Res., 12: 1112-1120, 2002.
12. Weisener, S. M., Turley, H., Allen, E. W., Williams, C., Eckardt, K. U., Talks, L. K., Wood, M. S., Gatter, C. K., Harris, L. A., Pugh, W. C., Ratcliffe, J. P., and Maxwell, H. P. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1. Blood, 92: 2260-2268, 1998.
13. Zagzag, D., Zhong, H., Scalzitti, J. M., Laughner, E., Simons, J. W., and Semenza, G. L. Expression of hypoxia-inducible factor 1α in brain tumors: association with angiogenesis, invasion and progression. Cancer (Phila.), 88: 2606-2618, 2000.
14. Leek, R. D., Talks, K. L., Pezzella, F., Turley, H., Campo, L., Brown, N. S., Bicknell, R., Taylor, M., Gatter, K. C., and Harris, A. L. Relation of hypoxia-inducible factor-2α (HIF-2α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer. Cancer Res., 62: 1326-1329, 2002.
15. Muthuswamy, S. K., Gilman, M., and Brugge, J. S. Controlled dimerization of ErbB receptors provides evidence for differential signalling by homo-and heterodimers. Mol. Cell. Biol., 19: 6845-6857, 1999.
16. Liu, W., James, C. D., Frederick, L., Alderete, B. E., and Jenkins, R. B. PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. Cancer Res., 57: 5254-5257, 2002.
17. Seagroves, T., and Johnson, R. S. Two HIFs may be better than one. Cancer Cell, 1: 211-213, 2002.
18. Lay, A. J., Jiang, X. M., Daley, E., Sun, L., and Hogg, P. J. Plasmin reduction by phosphoglycerate kinase is a thiol-independent process. J. Biol. Chem., 277: 9026-9028, 2002.
19. Chan, A. S., Leung, S. Y., Wong, M. P., Yuen, S. T., Cheung, N., Fan, Y. W., and Chung, L. P. Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma. Am. J. Surg. Pathol., 22: 816-826, 1998.
20. Hidalgo, M., and Rowinsky, E. K. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene, 19: 6680-6686, 2000.