Tumor-associated macrophages in the prospect of development of targeted anticancer therapy

Cytology and Genetics

Volumn 43, Issue 4, 2009, Pages 283-292

  Skivka, L M ^a   Gorbik, G V ^b   Fedorchuk, O G ^b   Pozur, V V ^a  

^a TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

^b R E KAVETSKY INSTITUTE OF EXPERIMENTAL PATHOLOGY   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77954507912     PISSN: 00954527     EISSN: 19349440     Source Type: Journal    
DOI: 10.3103/S0095452709040094     Document Type: Article

References (92)

1. Jeneway, C.A., Travers, P., Walport, M., and Shlomchik, M., Immunology: the Immune System in Health and Disease, New York and London: Garland Publ., 2002.
2. Stout, R.D. and Suttles, J., Functional Plasticity of Macrophages: Reversible Adaptation to Changing Microenvironments, J. Leuk. Biol., 2004, vol.76, no.3, pp. 509-513.
3. Laskin, D.L., Weinberger, B., and Laskin, J.D., Functional Heterogeneity in Liver and Lung Macrophages, J. Leuk. Biol., 2001, vol.70, pp. 163-170.
4. Mor, G. and Abrahams, V.M., Potential Role of Macrophages as Immunoregulators of Pregnancy, Reprod. Biol. Endocrinol., 2003, vol.1, p. 119.
5. Mosser, D.M., The Many Faces of Macrophage Activation, J. Leuk. Biol., 2003, vol.73, pp. 209-212.
6. Mills, C.D., Kinaid, K., Alt, J.M., Heilman, M.J., and Hill, A.M., M-1/M-2 Macrophages and the Th1/Th2 Paradigm, J. Immunol., 2000, vol.164, pp. 6166-6173.
7. Martinez, F.O., Sica, A., Mantovani, A., and Locati, M., Macrophage Activation and Polarization, Front. Biosci., 2008, vol.13, pp. 453-461.
8. Van Ginderachter, J.A. and Movahedi, K., Hassanzadeh Ghassabeh G., Meerschaut S., Beschin A., Raes G., De Baetselier P. Classical and Alternative Activation of Mononuclear Phagocytes: Picking the Best of Both Worlds for Tumor Promotion, Immunobiology, 2006, vol.211, nos. 6-8, pp. 487-501.
9. Kidd, P., Th1/Th2 Balance: the Hypothesis, Its Limitations, and Implications for Health and Disease, Altern. Med. Rev., 2003, vol.8, no.3, pp. 223-246.
10. Navratilova, Z., Polymorphisms in CCL2 and CCL5 Chemokines/Chemokine Receptors Genes and Their Association with Diseases, Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech. Repub., 2006, vol.150, no.2, pp. 191-204.
11. Ben-Baruch, A., The Multifaceted Roles of Chemokines in Malignancy, Cancer Metas. Rev., 2006, vol.25, no.3, pp. 357-371.
12. Nesbit, M., Schaider, H., Miller, T.H., and Herlyn, M., Lowlevel Monocyte Chemoattractant Protein-1 Stimulation of Monocytes Leads to Tumor Formation in Nontu-morigenic Melanoma Cells, J. Immunol., 2001, vol.166, pp. 6483-6490.
13. Raman, D., Baugher, P.J., Thu, Y.M., and Richmond, A., Role of Chemokines in Tumor Growth, Cancer Lett., 2007, vol.256, no.2, pp. 137-165.
14. Ali, S. and Lazennec, G., Chemokines: Novel Targets for Breast Cancer Metastasis, Cancer Metast. Rev., 2007, vol.26, nos. 3/4, pp. 401-1120
15. Koizumi, K., Hojo, S., Akashi, T., Yasumoto, K., and Saiki, I., Chemokine Receptors in Cancer Metastasis and Cancer Cell-Derived Chemokines in Host Immune Response, Cancer Sci., 2007, vol.98, no.11, pp. 1652-1658.
16. Mroczko, B. and Szmitkowski, M., Hematopoietic Cytokines as Tumor Markers, Clin. Chem. Lab. Med., 2004, vol.42, no.12, pp. 1347-1354.
17. Jiang, Y.P., Wu, X.H., Xing, H.Y., and Du, X.Y., Role of CXCL12 in Metastasis of Human Ovarian Cancer, Chin. Med. J. (Engl.), 2007, vol.120, no.14, pp. 1251-1255.
18. Lamagna, C., Arrand-Kions, M., and Imhof, B.A., Dual Role of Macrophages in Tumor Growth and Angiogenesis, J. Leukocyte Biol., 2006, vol.80, pp. 705-713.
19. Espey, M.G., Tumor Macrophage Redox and Effector Mechanisms Associated with Hypoxia, Free. Radic. Biol. Med., 2006, vol.41, no.11, pp. 621-628.
20. Knowles, H.J. and Harris, A.L., Macrophages and the Hypoxic Tumour Microenvironment, Front. Biosci., 2007, vol.12, pp. 4298-4314.
21. Porta, C., Subhra, KumarB., Larghi, P., Rubino, L., Mancino, A., and Sica, A., Tumor Promotion by Tumor Associated Macrophages, Adv. Exp. Med. Biol., 2007, vol.604, pp. 67-86.
22. Djavaheri-Mergny, M., Amelotti, M., Mathieu, J., Besancon, F., Bauvy, C., and Codogno, P., Regulation of Autophagy by NFkappaB Transcription Factor and Reactive Oxygen Species, Autophagy, 2007, vol.3, no.4, pp. 390-392.
23. Chen, Y., McMillan-Ward, E., Kong, J., Israels, S.J., and Gibson, S.B., Oxidative Stress Induces Autophagic Cell Death Independent of Apoptosis in Transformed and Cancer Cells, Cell Death Diff., 2008, vol.15, no.1, pp. 171-182.
24. Kiffin, R., Bandyopadhyay, U., and Cuervo, A.M., Oxidative Stress and Autophagy, Antioxid Redox Signal, 2006, vol.8, nos. 1/2, pp. 152-162.
25. Hayakawa, Y. and Smyth, M.J., Innate Immune Recognition and Suppression of Tumors, Adv. Cancer Res., 2006, vol.95, pp. 293-322.
26. Airley, R.E. and Mobasheri, A., Hypoxic Regulation of Glucose Transport, Anaerobic Metabolism and Angio-genesis in Cancer: Novel Pathways and Targets for Anticancer Therapeutics, Chemotherapy, 2007, vol.53, no.4, pp. 233-256.
27. Brahimi-Horn, M.C., Chicle, J., and Pouyssegur, J., Hypoxia and Cancer, J. Mol. Med., 2007, vol.85, no.12, pp. 1301-1307.
28. Mizukami, Y., Kohgo, Y., and Chung, D.C., Hypoxia Inducible Factor-1 Independent Pathways in Tumor Angiogenesis, Clin. Cancer Res., 2007, vol.13, no.19, pp. 5670-5674.
29. Jin, S., DiPaola, R.S., Mathew, R., and White, E., Metabolic Catastrophe as a Means to Cancer Cell Death, J. Cell Sci., 2006, vol.120, no.3, pp. 379-383.
30. Van der Bij, G.L., Oosterling, S.J., Meijer, S., Beelen, R.H., and Van Gmond, M., The Role of Macrophages in Tumor Development, Cell Oncol., 2005, vol.27, pp. 203-213.
31. Shin, J.-Y., Yuan, A., Chen, J.J.-W., and Yang, P.-C., Tumor-Associated Macrophages: Its Role in Cancer Invasion and Metastasis, J. Cancer Mol., 2006, vol.2, no.3, pp. 101-106.
32. Lewis, C.E. and Pollard, J.W., Distinct Role of Macrophages in Different Tumor Microenvironment, Cancer Res., 2006, vol.66, no.2, pp. 605-612.
33. Haremann, T., Wilson, J., Burke, F., Kulbe, H., Li, N.F., Pluddemann, A., Charles, K., Gordon, S., and Balkwill, F.R., Ovarian Cancer Polarize Macrophages toward a Tumor- Associated Phenotype, J. Immunol., 2006, vol.176, pp. 5023-5032.
34. Iessi, E., Marino, M.L., Lozupone, F., Fais, S., and De Milito, A., Tumor Acidity and Malignancy: Novel Aspects in the Design of Anti-Tumor Therapy, Cancer Therapy, 2008, vol.6, pp. 55-66.
35. Pistoia, V., Morandi, F., Wang, X., and Ferrone, S., Soluble HLA-G: Are They Clinically Relevant?, Semin Cancer Biol., 2007, vol.17, no.6, pp. 469-479.
36. Mellor, A.L. and Munn, D.H., Creating Immune Privilege: Active Local Suppression That Benefits Friends, but Protects Foes, Nat. Rev. Immunol., 2008, vol.8, no.1, pp. 74-80.
37. Debatin, K.M., Apoptosis Pathways in Cancer and Cancer Therapy, Cancer Immunol. Immunother., 2004, vol.53, no.3, pp. 153-159.
38. Zhang, L. and Fang, B., Mechanisms of Resistance To TRAIL-Induced Apoptosis in Cancer, Cancer Gene Ther., 2005, vol.12, no.3, pp. 228-237.
39. Folkman, J., Angiogenez, Annu, Rev. Med., 2006, vol.57, pp. 1-18.
40. Folkman, J., Tumor Angiogenesis: Therapeutic Implications, N. Engl. J. Med., 1971, vol.285, pp. 1182-1186.
41. Naumov, G.N., Akslen, L.A., and Folkman, J., Role of Angiogenesis in Human Tumor Dormancy: Animal Models of the Angiogenic Switch, Cell Cycle, 2006, vol.5, no.16, pp. 1779-1787.
42. Narazaki, M. and Tosato, G., Tumor Cell Populations Differ in Angiogenic Activity: A Model System for Spontaneous Angiogenic Switch Can Tell Us Why, J. Natl. Cancer Ins., 2006, vol.98, no.5, pp. 294-295.
43. Ailles, L.E. and Weissman, I.L., Cancer Stem Cells in Solid Tumors, Curr. Opin. Biotechnol., 2007, vol.18, no.5, pp. 460-466.
44. Spillane, J.B. and Henderson, M.A., Cancer Stem Cells: a Review, ANZ J. Surg., 2007, vol.77, no.6, pp. 464-468.
45. Rapp, U.R., Ceteci, F., and Schreck, R., Oncogene- Induced Plasticity and Cancer Stem Cells, Cell Cycle, 2008, vol.77, no.1, pp. 45-51.
46. Lin, E.Y., Li, J.F., Gnatovskiy, L., Deng, Y., Zhu, L., Grzesic, D.A., Qian, H., Xue, X., and Pollard, J.W., Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer, Cancer Res., 2006, vol.66, no.23, pp. 11238-11246.
47. Crowther, M., Brown, N.J., Bishop, E.T., and Lewis, C.E., Microenvironmental Influence on Macrophage Regulation of Angiogenesis in Wounds and Malignant Tumors, J. Leukocyte Biol., 2001, vol.70, pp. 478-1190
48. Papetti, M. and Herman, I.M., Mechanisms of Normal and Tumor-Derived Angiogenesis, AJP Cell Physiol., 2002, vol.282, pp. 947-963.
49. Indraccolo, S., Stievano, L., Minuzzo, S., Tosello, V., Esposito, G., Piovan, E., Zamarchi, R., Chieco-Bianchi, L., and Amadori, A., Interruption of Tumor Microenvironment, Proc. Nat. Acad. Sci. USA, 2006, vol.103, no.11, pp. 4216-4221.
50. Naumov, G.N., Bender, E., Zurakovski, D., Kang, S.-Y., Sampson, D., Flynn, E., Watnick, R.S., Straume, O., Akslen, L.A., Folkman, J., and Almog, N., A Model of Human Tumor Dormancy: An Angiogenic Switch from the Nonangiogenic Phenotype, J. Natl. Cancer Inst., 2006, vol.98, no.5, pp. 316-325. (Pubitemid 43338211)
51. Noonan, D.M., De Lerma Barbaro A., Vannini, N., Mortara, L., and Albini, A., Inflammation, Inflammatory Cells and Angiogenesis: Decisions and Indecisions, Cancer Metast. Rev., 2008, vol.27, no.1, pp. 31-40.
52. Porta, C., Subhra Kumar, B., Larghi, P., Rubino, L., Mancino, A., and Sica, A., Tumor Promotion by Tumor-Associated Macrophages, Adv. Exp. Med. Biol., 2007, vol.604, pp. 67-86.
53. Magdolen, V., Krüger, A., Sato, S., Nagel, J., Sperl, S., Reuning, U., Rettenberger, P., Magdolen, U., and Schmitt, M., Inhibition of the Tumor-Associated Uroki-nase-Type Plasminogen Activation System: Effects of High-Level Synthesis of Soluble Urokinase Receptor in Ovarian and Breast Cancer Cells in Vitro and in Vivo, Recent Results Cancer Res., 2003, vol.162, pp. 43-63.
54. Ge, Y. and Elghtany, M.T., Urokinase Plasminogen Activator Receptor (CD87): Something Old, Something New, Lab. Hematol., 2003, vol.9, no.2, pp. 67-71.
55. Tang, D.G. and Conti, C.J., Endothelial Cell Development, Vasculogenesis, Angiogenesis, and Tumor Neovascularization: An Update, Semin. Thromb. Hemost., 2004, vol.30, no.1, pp. 109-117.
56. Patan, S., Vasculogenesis and Angiogenesis, Cancer Treat. Res., 2004, vol.117, pp. 3-32.
57. Bouis, D., Kusumanto, Y., Meijer, C., Mulder, N.H., and Hospers, G.A., A Review on Pro- and Anti-Angiogenic Factors as Targets of Clinical Intervention, Pharmacol. Res., 2006, vol.53, no.2, pp. 89-103.
58. Distler, J.H., Hirth, A., Kurowska-Stolarska, M., Gay, R.E., Gay, S., and Distler, O., Angiogenic and Angiostatic Factors in the Molecular Control of Angiogenesis, J. Nucl. Med., 2003, vol.47, no.3, pp. 149-161.
59. Charalambous, C., Ren, L.B., Su, Y.S., Milan, J., Chen, T.C., and Hofman, F.M., Interleukin-8 Differentially Regulates Migration of Tumor-Associated and Normal Human Brain Endothelial Cells, Cancer Res., 2005, vol.65, pp. 10347-10354.
60. Brat, D.J., Bellail, A.C., and Van Meir, E.G., The Role of Interleukin-8 and Its Receptors in Gliomagenesis and Tumoral Angiogenesis, Neuro Oncol., 2005, vol.7, no.2, pp. 122-133.
61. Li, A., Dubey, S., Varney, M.L., Dave, B.J., and Singh, R.K., IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis, J. Immunol., 2003, vol.170, pp. 3369-3376.
62. Abramsson, A., Berlin, Ö., Papayan, H., Paulin, D., Shani, M., and Betsholtz, C., Analysis of Mural Cell Recruitment to Tumor Vessels, Circulation, 2002, vol.105, pp. 112-117.
63. Aias, J.I., Aller, M.A., and Arias, J., Cancer Cell: Using Inflammation to Invade the Host, Mol. Cancer, 2007, vol.6, p. 29.
64. Lugini, L., Matarrese, P., Tinari, A., Lozupone, F., Federici, C., Iessi, E., Gentile, M., Luciani, F., Parmiani, G., Rivoltini, L., Malorni, W., and Fais, S., Cannibalism of Live Lymphocytes by Human Metastatic But Not Primary Melanoma Cells, Cancer Res., 2006, vol.66, pp. 3629-3638.
65. Helming, L. and Gordon, S., The Molecular Basis of Macrophage Fusion, Immunobiology, 2007, vol.212, nos. 9/10, pp. 785-793.
66. Condeelis, J. and Pollard, J.W., Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis, Cell, 2006, vol.124, no.2, pp. 263-266.
67. Vingery, A., Macrophage Fusion: Are Somatic and Cancer Cells Possible Partners?, Trends Cell Biol., 2005, vol.15, no.4, pp. 188-193.
68. Mochizuki, S. and Okada, Y., ADAMs in Cancer Cell Proliferation and Progression, Cancer Sci., 2007, vol.98, no.5, pp. 621-628.
69. Lin, C.Y., Lin, C.J., Chen, K.H., Wu, J.C., Huang, S.H., and Wang, S.M., Macrophage Activation Increases the Invasive Properties of Hepatoma Cells by Destabilization of the Adherens Junction, FEBS Lett., 2006, vol.580, no.13, pp. 3043-3050.
70. Zavadil, J. and Bettinger, E.P., TGF-Beta and Epithelial-to-Mesenchymal Transitions, Oncogene, 2005, vol.24, no.37, pp. 5764-5774.
71. Luo, Y., Zhou, H., Krueger, J., Kaplan, C., Lee, S.H., Dolman, C., Markowitz, D., Wu, W., Liu, C., Reisfeld, R.A., and Xiang, R., Targeting Tumor-Associated Macrophages As a Novel Strategy Against Breast Cancer, J. Clin. Invest., 2006, vol.116, no.8, pp. 2132-2141.
72. Demidova, T.N. and Hamblin, M.R., Macrophage-Tar- geted Photodynamic Therapy, Int. J. Immunopathol. Pharmacol., 2004, vol.17, no.2, pp. 117-126.
73. Pan, P.Y., Wang, G.X., Yin, B., Ozao, J., Ku, T., Divino, C.M., and Chen, S.H., Reversion of Immune Tolerance in Advanced Malignancy: Modulation of Myeloid-Derived Suppressor Cell Development by Blockade of Stem-Cell Factor Function, Blood, 2008, vol.111, no.1, pp. 219-228.
74. John, A.R., Bramhall, S.R., and Eggo, M.C., Antiangiogenic Therapy and Surgical Practice, Brit. J. Surg., 2008, vol.95, no.3, pp. 281-293.
75. Mahtani, R.L. and Macdonald, J.S., Synergy between Cetuximab and Chemotherapy in Tumors of the Gastrointestinal Tract, Oncologist, 2008, vol.13, no.1, pp. 39-50.
76. Nénan, S., Boichot, E., Lagente, V., and Bertrand, C.P., Macrophage Elastase (MMP-12): A Pro-Inflammatory Mediator?, Mem. Inst. Oswaldo. Cruz., 2005, vol.100, Suppl. 1, pp. 167-172.
77. Ramnath, N. and Creaven, P.J., Matrix Metalloproteinase Inhibitors, Curr. Oncol. Rep., 2004, vol.6, no.2, pp. 96-102.
78. Gutierrez, M. and Giaccone, G., Antiangiogenic Therapy in Nonsmall Cell Lung Cancer, Curr. Opin. Oncol., 2008, vol.20, no.2, pp. 176-182.
79. Folkman, J., Angiogenesis: An Organizing Principle for Drug Discovery?, Nat. Rev. Drug. Discov., 2007, vol.6, no.4, pp. 273-286. (Pubitemid 46505878)
80. Weiss, J.M., Subleski, J.J., Wigginton, J.M., and Wiltrout, R.H., Immunotherapy of Cancer by IL-12-Based Cytokine Combinations, Exp. Opin. Biol. Ther., 2007, vol.7, no.11, pp. 1705-1721.
81. Dirkx, A.E.M., de Egbrink, M.G.A., Wagstaff, J., and Griffioen, A.W., Monocyte/Macrophage Infiltration in Tumors: Modulators of Angiogenesis, J. Leukocyte Biol., 2006, vol.80, pp. 1183-1186.
82. Tozer, G.M., Kanthou, C., and Baguley, B.C., Disrupting Tumour Blood Vessels, Nat. Rev. Cancer, 2005, vol.5, no.6, pp. 423-435.
83. Yun-San, YipA., Yuen-Yuen, Ong E., and Chow, L.W., Vinflunine: Clinical Perspectives of An Emerging Anticancer Agent, Exp. Opin Investig Drugs, 2008, vol.17, no.4, pp. 583-591.
84. Moretti, L., Yang, E.S., Kim, K.W., and Lu, B., Autophagy Signaling in Cancer and Its Potential as Novel Target to Improve Anticancer Therapy, Drug Resist. Updat., 2007, vol.10, nos. 4/5, pp. 135-143.
85. Kondo, Y. and Kondo, S., Autophagy and Cancer Therapy, Autophagy, 2006, vol.2, no.2, pp. 85-90.
86. Amaravadi, R.K. and Thompson, C.B., The Roles of Therapy-Induced Autophage and Necrosis in Cancer Treatment, Clin. Cancer Res., 2007, vol.13, no.24, pp. 7271-7279.
87. Pedersen, P.L., The Cancer Cells "Power Plants" As Promising Therapeutic Targets: An Overview, J. Bioenegr. Biomembr, 2007, vol. 39, no. 1, pp. 1-12.
88. Nelson, D.A. and White, E., Exploiting Different Ways to Die, Genes Dev., 2004, vol.18, pp. 1223-1226.
89. Hengge, U.R. and Ruzicka, T., Topical Immunomodulation in Dermatology: Potential of Toll-Like Receptor Agonists, Dermatol. Surg., 2004, vol.30, no.8, pp. 1101-1112.
90. Azuma, I. and Seya, T., Development of Immunoadju-vants for Immunotherapy of Cancer, Int. Immunophar-macol., 2002, vol.1, no.7, pp. 1249-1259.
91. Jahrsdörfer, B., Wooldridge, J.E., Blackwell, S.E., Taylor, C.M., Griffith, T.S., Link, B.K., and Weiner, G.J., Immunostimulatory Oligodeoxynucleotides Induce Apo- ptosis of B Cellchronic Lymphocytic Leukemia Cells, J. Leukocyte Biol., 2005, vol.77, no.3, pp. 378-387.
92. Garland, S.M., Imiquimod, Curr. Opin. Infect. Dis., 2003, vol.16, no.2, pp. 85-89.