Mechanical ventilation modulates Toll-like receptor signaling pathway in a sepsis-induced lung injury model

Intensive Care Medicine

Volumn 36, Issue 6, 2010, Pages 1049-1057

  Villar, Jesús ^a,b,c   Cabrera, Nuria ^a,b   Casula, Milena ^a,b   Flores, Carlos ^a,d   Valladares, Francisco ^a   Muros, Mercedes ^a   Blanch, Lluis ^a,e   Slutsky, Arthur S ^f,g   Kacmarek, Robert M ^h,i  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^e Critical Care Center   (Spain)

^f UNIVERSITY OF TORONTO   (Canada)

^g KING SAUD UNIVERSITY   (Saudi Arabia)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Acute lung injury; Cytokine; Positive pressure ventilation; Sepsis; Toll like receptor

Indexed keywords

I KAPPA B ALPHA; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 3; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; LUNG INJURY; MALE; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PROSPECTIVE STUDY; PROTEIN LOCALIZATION; RAT; RNA EXTRACTION; SEPSIS; SIGNAL TRANSDUCTION; TIDAL VOLUME; WESTERN BLOTTING;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LUNG INJURY; MALE; PROSPECTIVE STUDIES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATION, ARTIFICIAL; SEPSIS; TOLL-LIKE RECEPTOR 4;

EID: 77954455713     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-010-1799-3     Document Type: Article

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