A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 25, Issue 4, 2010, Pages 480-484

  Kassa, Jiri ^a   Karasova, Jana Zdarova ^a   Caisberger, Filip ^c   Musilek, Kamil ^a   Kuca, Kamil ^b   Jung, Young Sik ^d  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

^d Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

HI 6; K oximes; Obidoxime; Tabun; Trimedoxime

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ANTIDOTE; ATROPINE; KR 22836; OBIDOXIME; OXIME K203; TABUN; TRIMEDOXIME; UNCLASSIFIED DRUG; 1-(4-CARBAMOYLPYRIDINIUM)-4-(4-HYDROXYIMINOMETHYLPYRIDINIUM)BUT-2-ENE; ASOXIME CHLORIDE; CHOLINESTERASE INHIBITOR; CHOLINESTERASE REACTIVATOR; ORGANOPHOSPHATE; OXIME; PYRIDINIUM DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG INTOXICATION; DRUG POTENCY; DRUG TISSUE LEVEL; ENZYME INHIBITION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; THERAPY EFFECT; ANIMAL; COMPARATIVE STUDY; TOXICITY;

MUS; RATTUS;

ANIMALS; ANTIDOTES; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; MICE; OBIDOXIME CHLORIDE; ORGANOPHOSPHATES; OXIMES; PYRIDINIUM COMPOUNDS; RATS; TRIMEDOXIME;

EID: 77954402239     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756360903257918     Document Type: Article

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