Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: Generation of antiinflammatory and antiproliferative metabolites

American Journal of Clinical Nutrition

Volumn 71, Issue 1 SUPPL., 2000, Pages

  Ziboh, Vincent A ^a   Miller, Craig C ^a   Cho, Yunhi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

13 HODE; 13 HODE substituted diacylglycerol; 13 hydroxyoctadecadienoic acid; Arachidonic acid; DGLA; DHA; Dihomo linolenic acid; Docosahexaenoic acid; Eicosapentaenoic acid; EPA; Essential fatty acid; GLA; Leukotriene B4; LTB4; PGE2; Polymorphonuclear cell; Polyunsaturated fatty acid; Prostaglandin E2; Protein kinase C; PUFA; linolenic acid

Indexed keywords

ARACHIDONIC ACID; DIHOMO GAMMA LINOLENIC ACID; DOCOSAHEXAENOIC ACID; ENZYME; ESSENTIAL FATTY ACID; FATTY ACID; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; LEUKOTRIENE B4; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN E2; PROTEIN KINASE C;

ANTIINFLAMMATORY ACTIVITY; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; EPIDERMIS; FATTY ACID METABOLISM; HUMAN; METABOLITE; PATHOGENESIS; POLYMORPHONUCLEAR CELL; SKIN INFLAMMATION;

EID: 0033977323     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/71.1.361s     Document Type: Conference Paper

References (28)

1. Aron H. Uber den nahrwert (On the nutritional value). Biochem Z 1918;92:211-33 (in German).
2. Burr GO, Burr MM. A new deficiency disease produced by the rigid exclusion of fat from the diet. J Biol Chem 1929;82:345-6.
3. Burr GO, Burr MM. On the nature of the fatty acids essential in nutrition. J Biol Chem 1930;86:587-621.
4. Chapkin RS, Ziboh VA, Marcelo CL, Voorhees JJ. Metabolism of essential fatty acids by human epidermal preparations: evidence of chain elongation. J Lipid Res 1986;27:945-54.
5. Hansen HS, Jensen B. Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and α-linolate. Biochim Biophys Acta 1985;834:357-63.
6. Elias PM, Brown BE, Fritsch P, Goerke J, Gray GM, White RJ. Localization and composition of lipids in neonatal mouse stratum granulosum and stratum corneum. J Invest Dermatol 1979;73:339-48.
7. Wertz PW, Cho ES, Downing DT. Effect of essential fatty acid deficiency on the epidermal sphingolipids of the rat. Biochim Biophys Acta 1983;753:350-5.
8. Wertz PW, Downing DT. Ceramides of pig epidermis: structure determination. J Lipid Res 1983;24:759-65.
9. Bowser PA, Nugteren DH, White RJ, Houtsmuller UMT, Prottey C. Identification, isolation and characterization of epidermal lipids containing linoleic acid. Biochim Biophys Acta 1985;834:419-28.
10. Nugteren DH, Christ-Hazelhof E, van der Beek A, Houtsmuller UMT. Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. Biochim Biophys Acta 1985;834: 429-36.
11. Cho Y, Ziboh VA. Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol. J Lipid Res 1994;35:255-62.
12. Cho Y, Ziboh VA. Expression of protein kinase C isozymes in guinea pig epidermis: selective inhibition of PKC-β activity by 13-hydroxyoctadecadienoic acid-containing diacylglycerol. J Lipid Res 1994;35:913-21.
13. Cho Y, Ziboh VA. Nutritional modulation of skin hyperproliferation in essential fatty acid-deficiency is associated with selective down-regulation of protein kinase C-β. J Nutr 1995;125: 2744-50.
14. Vroman HE, Nemeck RA, Hsia SL. Synthesis of lipids from acetate by human preputial and abnormal skin in vitro. J Lipid Res 1969; 10:507-14.
15. 4 hydrolase. J Invest Dermatol 1993; 100:293-8.
16. Miller CC, McCreedy CA, Jones AD, Ziboh VA. Oxidative metabolism of dihomo-γ-linolenic acid by guinea pig epidermis: evidence of generation of anti-inflammatory products. Prostaglandins 1988; 35:917-38.
17. 4. Am J Clin Nutr 1992;55:39-45.
18. Miller CC, Ziboh VA. Gammalinolenic acid-enriched diet alters cutaneous eicosanoids. Biochem Biophys Res Commun 1988; 154:967-74.
19. Lovell CR, Burton JL, Horrobin DF. Treatment of atopic eczema with evening primrose oil. Lancet 1981;1:278 (letter).
20. Wright S, Burton JL. Oral evening primrose-seed oil improves atopic eczema. Lancet 1982;99:1120-1.
21. Miller CC, Ziboh VA, Wong T, Fletcher MP. Dietary supplementation with n-3 and n-6 enriched oils influences in vivo levels of epidermal lipoxygenase products. J Nutr 1990;120:36-44.
22. Miller CC, Tang W, Ziboh VA, Fletcher MP. Dietary supplementation with ethyl ester concentrates of fish oil (n-3) and borage oil (n-6) polyunsaturated fatty acids induces epidermal generation of local putative antiinflammatory metabolites. J Invest Dermatol 1991;96:98-103.
23. Ziboh VA, Cohen KA, Ellis CN, et al. Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids. Arch Dermatol 1986;122:1277-82.
24. Bittinger SB, Cartwright I, Tucker WFG, et al. A double-blind, randomized placebo-controlled trial of fish oil in psoriasis. Lancet 1988;1:378-80.
25. Maurice PDL, Allen BR, Barkeley ASJ, et al. The effects of dietary supplementation with fish oil in patients with psoriasis. Br J Dermatol 1987;117:599-606.
26. Fjornboe A, Smith AK, Bjornbeo G-EA, et al. Effect of dietary supplementation with n-3 fatty acids on clinical manifestations of psoriasis. Br J Dermatol 1988;118:77-83.
27. Lassus A, Dahlgren AL, Halpern MJ, et al. Effects of dietary supplementation with ethyl ester lipids (angiosan) in patients with psoriasis and psoriatic arthritis. J Int Med Res 1990;18:68-73.
28. 4-induced chemotaxis of human neutrophils. Skin Pharmacol 1988;1:93-9.