Intra-individual variability in genetic and environmental models of attention-deficit/ hyperactivity disorder

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 153, Issue 5, 2010, Pages 1094-1101

  Perry, G M L ^a   Sagvolden, T ^b   Faraone, S V ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Hyperactivity; IIV; Impulsiveness; Inattention; Spontaneous hypertensive rat

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENTION DEFICIT DISORDER; ATTENTION DISTURBANCE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; GENETIC MODEL; HYPERACTIVITY; IMPULSIVENESS; INSTRUMENTAL CONDITIONING; LEWIS RAT; MALE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT; ANIMAL; BIOLOGICAL MODEL; ENVIRONMENT; GENETIC DATABASE; GENETICS; HUMAN; PHENOTYPE; SEXUAL DEVELOPMENT; SPRAGUE DAWLEY RAT;

RATTUS; RODENTIA;

ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CONDITIONING, OPERANT; DATABASES, GENETIC; ENVIRONMENT; FEMALE; HUMANS; IMPULSIVE BEHAVIOR; MALE; MODELS, GENETIC; PHENOTYPE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS;

EID: 77954362532     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31070     Document Type: Article

References (70)

1. Aase H, Sagvolden T. 2005. Moment-to-moment dynamics of ADHD behaviour. Behav Brain Funct 1:12.
2. Aase H, Meyer A, Sagvolden T. 2006. Moment-to-moment dynamics of ADHD behaviour in South African children. Behav Brain Funct 2:11.
3. Andreou P, Neale BM, Chen W, Christiansen H, Gabriels I, Heise A, Meidad S, Muller UC, Uebel H, Banaschewski T, Manor I, Oades R, Roeyers H, Rothenberger A, Sham P, Steinhausen H-C, Asherson P, Kuntsi J. 2007. Reaction time performance in ADHD: Improvement under fast-incentive condition and familial effects. Psychol Med 37: 1703-1716.
4. Anstey K, Mack H, Christensen H, Li S-C, Reglade-Meslin C, Maller J, Kumar R, Dear K, Easteal S, Sachdev P. 2007. Corpus callosum size, reaction time speed and variability in mild cognitive disorders and in a normative sample. Neuropsychologia 45:1911-1920.
5. Arnsten A, Steere J, Hunt R. 1996. The contribution of a-2 noradrenergic mechanisms to prefrontal cortical cognitive function: Potenial significance to attention deficity hyperactivity disorder. Arch Gen Psychiatry 8:448-455. (Pubitemid 26149234)
6. Bellgrove M, Hawi Z, Kirley A, Gill M, Robertson I. 2005. Dissecting the attention deficit hyperactivity disorder (ADHD) phenotype: Sustained attention, response variability and spatial asymmetries in relation to dopamine transporter (DAT1) genotype. Neuropsychologia 43: 1847-1857.
7. Bendel P, Eilam R. 1992. Quantitation of ventricular size in normal and spontaneously hypertensive rats by magnetic resonance imaging. Brain Res 574:224-228.
8. Berger DF, Sagvolden T. 1998. Sex differences in operant discrimination behaviour in an animal model of attention-deficit hyperactivity disorder. Behav Brain Res 94(1):73-82.
9. Berger DF, Lombardo JP, Jeffers PM, Hunt AE, Bush B, Casey A, Quimby F. 2001. Hyperactivity and impulsiveness in rats fed diets supplemented with either Aroclor 1248 or PCB-contaminated St. Lawrence river fish. Behav Brain Res 126(1-2):1-11.
10. Boix F, Qiao S-W, Kolpus T, Sagvolden T. 1998. Chronic L-deprenyl treatment alters brain monoamine levels and reduces impulsiveness in an animal model of attention-deficit: Hyperactivity disorder. Behav Brain Res 94:153-162.
11. Boucher O, Muckle G, Bastien C. 2009. Prenatal exposure to polychlorinated biphenyls: A neuropsychologic analysis. Environ Health Perspect 117:7-16.
12. Bucci DJ, Hopkins ME, Keene CS, Sharma M, Orr LE. 2008. Sex differences in learning and inhibition in spontaneously hypertensive rats. Behav Brain Res 187:27-32. (Pubitemid 350216186)
13. Castellanos FX, Lee PP, Sharp W, Jeffries NO, Greenstein DK, Clasen LS, Blumenthal JD, James RS, Ebens CL, Walter JM, et al. 2002. Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. Jama 288(14):1740-1748.
14. Castellanos FX, Sonuga-Barke E, Scheres A, DiMartino A, Hyde C, Walters JR. 2005. Varieties of attention-deficit/hyperactivity disorder-related intra-individual variability. Biol Psychiatry 57:1416-1423.
15. Cho S-C, Kim J-W, Kim B-J, Hwang J-W, Park M, Ae Kim S, Cho D-Y, Yoo H-J,Chung U-S, Son J-W, et al. 2008. Possible association of the alpha-2A -adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiat Genet 147B:957-963.
16. Daly HB, Hertzler DR, Sargent DM. 1989. Ingestion of environmentally contaminated Lake Ontario salmon by laboratory rats increases avoidance of unpredictable aversive nonreward and mild electric shock. Behav Neurosci 103(6):1356-1365.
17. Das-Banerjee T, Middleton F, Berger D, Lombardo J, Sagvolden T, Faraone S. 2008. A comparison of molecular alterations in environmental and genetic rat models of ADHD: A pilot study. Am J Med Genet Part B 147B(8):1554-1563.
18. Di Martino A, Ghaffari M, Curchack J, Reiss P, Hyde C, Vannucci M, Petkova E, Klein D, Castellanos F. 2008. Decomposing intrasubject variability in children with attention-deficit/hyperactivity disorder. Biol Psychiatry 64:607-614.
19. Faraone SV. 2004. Genetics of adult attention-deficit/hyperactivity disorder. Psychiatr Clin North Am 27(2):303-321.
20. Faraone SV. 2006. Advances in the genetics and neurobiology of attention deficit hyperactivity disorder. Biol Psychiatry 60(10):1025-1027.
21. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick J, Holmgren MA, Sklar P. 2005. Molecular genetics of attention deficit hyperactivity disorder. Biol Psychiatry 57(11):1313-1323.
22. Fisher R. 1918. The correlation between relatives on the supposition of Mendelian inheritance. Trans R Soc Edinb 52:399-433.
23. Geurts H, Grasman R, Vertéd S, Oosterlaan J, Roeyers H, van Kammen S, Sergeant J. 2008. Intra-individual variability in ADHD, autism spectrum disorders and Tourette's syndrome. Neuropsychologia 46:3030-3041.
24. Grimaldi M, Florio T, Schettini G. 1997. Somatostatin inhibits interleukin 6 release from rat cortical type I astrocytes via the inhibition of adenylyl cyclase. Biochem Biophys Res Commun 235:242-248.
25. Holene E, Nafstad I, Skaare JU, Benrnhoft A, Engen P, Sagvolden T. 1995. Behavioral effects of pre and postnatal exposure to individual polychlorinated biphenyl congeners in rats. Environ Toxicol Chem 14:967-976.
26. Holene E, Nafstad I, Skaare JU, Sagvolden T. 1998. Behavioural hyperactivity in rats following postnatal exposure to sub-toxic doses of polychlorinated biphenyl congeners 153 and 126. Behav Brain Res 94(1): 213-224.
27. Johansen E, Killeen P, Sagvolden T. 2007. Behavioral variability, elimination of responses, and delay-of-reinforcement gradients in SHR and WKY rats. Behav Brain Funct 3:60.
28. Johansen E, Killeen P, Russell V, Tripp G, Wickens J, Tannock R, Williams J, Sagvolden T. 2009. Origins of altered reinforcement effects in ADHD. BehavBrain Funct 5:7.
29. Johnson K, Kelly S, Bellgrove M, Barry E, Cox M, Gill M, Robertson I. 2007. Response variability in attention deficit hyperactivity disorder: Evidence for neuropsychological heterogeneity. Neuropsychologia 45:630-638.
30. Johnson KA, Wiersema JR, Kuntsi J. 2009. What would Karl Popper say? Are current theories of ADHD falsifiable? Behav Brain Funct 5:15.
31. Kantak KM, Singh T, Kerstetter K, Dembro K, Mutebi M, Harvey R, Deschepper C, LP D. 2008. Advancing the spontaneous hypertensive rat model of attention deficit/hyperactivity disorder. Behavl Neurosci 122:340-357.
32. Kasischke K, Vishwasrao H, Fisher P, Zipfel W, Webb W. 2004. Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science 305:99-103.
33. Klein C, Wendling K, Huettner P, Ruder H, Peper M. 2006. Intra-subject variability in attention-deficit hyperactivity disorder. Biol Psychiatry 60:1088-1097.
34. Lilienthal H, Winneke G. 1991. Sensitive periods for behavioral toxicity of polychlorinated biphenyls: Determination by cross-fostering in rats. Fundam Appl Toxicol 17(2):368-375.
35. Loo SK, Specter E, Smolen A, Hopfer C, Teale PD, Reite ML. 2003. Functional effects of the DAT1 polymorphism on EEG measures in ADHD. J Am Acad Child Adolesc Psychiatry 42(8):986-993.
36. Mackay T, Lyman R. 2005. Drosophila bristles and the nature of quantitative genetic variation. Philos Trans R Soc B Biol Sci 360:1513-1527.
37. McFarland V, Clarke J. 1989. Environmental occurrence, abundance, and potential toxicity of polychlorinated biphenyl congeners: Considerations for a congener-specific analysis. Environ Health Perspect 81:225-239. (Pubitemid 19156889)
38. Mick E, Faraone SV. 2008. Genetics of attention deficit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 17(2):261-284. vii-viii.
39. Mill J, Sagvolden T, Asherson P. 2005. Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains. Behav Brain Funct 1(1):24.
40. Miyazaki I, Asanuma M, az-Corrales F, Miyoshi K, Ogawa N. 2004. Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia. Brain Res 1029:120-123.
41. Moisan MP,Llamas B, CookMN,Mormede P. 2003. Further dissection of a genomic locus associated with behavioral activity in the Wistar-Kyoto hyperactive rat, an animal model of hyperkinesis. Mol Psychiatry 8(3): 348-352.
42. Moldrich R, Aprico K, Diwakarla S, O'Shea R, Beart P. 2002. Astrocyte mGlu(2/3)-mediated cAMP potentiation is calcium sensitive: Studies in murine neuronal and astrocyte cultures. Neuropharmacology 43: 189-203.
43. Morse D, Brouwer A. 1995. Fetal, neonatal, and long-term alterations in hepatic retinoid levels following maternal polychlorinated biphenyl exposure in rats. Toxicol Appl Pharmacol 131:175-182.
44. Murtha S. 2002. Increased variability accompanies frontal lobe damage in dementia. J Int Neuropsychol Soc 8:360-372.
45. Nigg JT, Willcutt EG, Doyle AE, Sonuga-Barke E. 2005. Causal heterogeneity in ADHD: Do we need neuropsychological subtypes? Biol Psychiatry 57:1224-1230.
46. Pantaleoni GC, Fanini D, Sponta AM, Palumbo G, Giorgi R, Adams PM. 1988. Effects of maternal exposure to polychlorobiphenyls (PCBs) on F1 generation behavior in the rat. Fundam Appl Toxicol 11(3):440-449.
47. Paule M, Rowland A, Ferguson S, Chelonis J, Tannock R, Swanson J, Castellanos F. 2000. Attention deficit/hyperactivity disorder: Characteristics, interventions and models. Neurotoxicol Teratol 22:631-651.
48. Perry G, Ferguson M, Danzmann R. 2003. Effects of genetic sex and genomic background on epistasis in rainbow trout (Oncorhynchus mykiss). Genetica 119:35-50.
49. Peterson BS, Leckman JF. 1998. The temporal dynamics of tics in Gilles de la Tourette Syndrome. Soc Biol Psychiatry 44:1337-1348.
50. Russell VA, Sagvolden T, Johansen EB. 2005. Animal models of attention-deficit hyperactivity disorder. Behav Brain Funct 1:9.
51. Russell V, Oades R, Tannock R, Killeen P, Auerbach J, Johansen E, Sagvolden T. 2006. Attention-Deficit/hyperactivity disorder: A neuronal and glial energetics hypothesis. Behav Brain Funct 2:30.
52. Sagvolden T. 2006. The alpha-2A adrenoceptor agonist guanfacine improves sustained attention and reduces overactivity and impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder (ADHD). Behav Brain Funct 2:41.
53. Sagvolden T, Berger DF. 1996. An animal model of attention deficit disorder: The female shows more behavioural problems and is more impulsive than the male. Eur Psychologist 1:113-122.
54. Sagvolden T, Xu T. 2008. l-Amphetamine improves poor sustained attention while d-amphetamine reduces overactivity and impulsiveness as well as improves sustained attention in an animal model of Attention-Deficit/ Hyperactivity Disorder (ADHD). Behav Brain Funct 4:3.
55. Sagvolden T, Hendley ED, Knardahl S. 1992. Behavior of hypertensive and hyperactive rat strains: Hyperactivity is not unitarily determined. Physiol Behav 52(1):49-57.
56. Sagvolden T, Pettersen MB, Larsen MC. 1993. Spontaneously hypertensive rats (SHR) as a putative animal model of childhood hyperkinesis: SHR behavior compared to four other rat strains. Physiol Behav 54(6): 1047-1055.
57. Sagvolden T, Johansen E, Aase H, Russell V. 2005a. A dynamic developmental theory of Attention-Deficit/Hyperactivity Disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes. Behav Brain Sci 28:397-468.
58. Sagvolden T, Russell VA, Aase H, Johansen EB, Farshbaf M. 2005b. Rodent models of attention-deficit/hyperactivity disorder. Biol Psychiatry 57(11):1239-1247.
59. Sagvolden T, Das-Banerjee T, Zhang-James Y, Middleton F, Faraone S. 2008. Behavioral and genetic evidence for a novel animal model of Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype. Behav Brain Funct 4:56.
60. Sanchez L, Tabernero A, Medina J. 2001. Oligodendrocytes use lactate as a source of energy and as a precursor of lipids. Glia 36:321-329.
61. SanCristobal-Gaudy M, Elsen J-M, Bodin L, Chevalet C. 1998. Prediction of the breeding response to selection for canalisation of a continuous trait in animal breeding. Genetics, Selection, Evolution 30:423-451.
62. SAS. 2000. Version 8.1. Cary, NC: SAS Institute.
63. Schantz SL, Moshtaghian J, Ness DK. 1995. Spatial learning deficits in adult rats exposed to ortho-substituted PCB congeners during gestation and lactation. Fundam Appl Toxicol 26(1):117-126.
64. Schwartz F, Carr A, Munich R, Glauber S, Lesser B, Murray J. 1989. Reaction time impairment in schizophrenia and affective illness: The role of attention. Biol Psychiatry 25:540-548.
65. Sorensen D, Waagepetersen R. 2003. Normal linear models with genetically structured residual variance heterogeneity: A case study. Genet Res Cambridge 82:207-222.
66. Staller JA, Faraone SV. 2007. Targeting the dopamine system in the treatment of attention-deficit/hyperactivity disorder. Expert Rev Neurother 7(4):351-362.
67. Stuss D, Stethem L, Hugenholtz H, Picton T, Pivik J, Richard M. 1989. Reaction time after head injury: Fatigue, divided and focused attention, and consistency of performance. J Neurol Neurosurg Psychiatry 52:742-748. (Pubitemid 19165640)
68. Walker AJ, Shores EA, Trollor JN, Lee T, Sachdev PS. 2000. Neuropsychological functioning of adults with attention deficit hyperactivity disorder. J Clin Exp Neuropsychol 22(1):115-124. (Pubitemid 30114648)
69. Walters J, Ruskin D, Baek D, Allers K, Bergstrom D. 2001. Cognitive function paradigms: Implications of neurophysiological studies of dopamine stimulants for Tourette syndrome and comorbid attention-deficit hyperactivity disorder. Adv Neurol 85:133-149.
70. Wood AC, Asherson P, van der Meere JJ, Kuntsi J. 2009. Separation of genetic influences on attention deficit hyperactivity disorder symptoms and reaction time performance from those on IQ. Psychol Medicine Sep 15:1-11. (Epub ahead of print).