Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 3228-3233

  Ettari, Roberta ^a   Zappalà, Maria ^a   Micale, Nicola ^a   Schirmeister, Tanja ^b   Gelhaus, Christoph ^c   Leippe, Matthias ^c   Evers, Astrid ^c   Grasso, Silvana ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Cysteine proteases; Falcipain 2 inhibitors; Peptidomimetics; Rhodesain inhibitors

Indexed keywords

( 4 CHLORO 2 TRIFLUOROMETHYLPHENYL)CARBAMIC ACID 1 [[ 2 BENZYLOXY 5 OXO TETRAHYDROFURAN 3 YLCARBAMOYL]METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][ 1,4 ]DIAZEPIN 3 YLMETHYL ESTER; ( 4 CHLORO 2 TRIFLUOROMETHYLPHENYL)CARBAMIC ACID 1 [[ 2 BENZYLOXY 5 OXO TETRAHYDROFURAN 3 YLCARBAMOYL]METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][ 1,4 ]DIAZEPIN 3YLMETHYL ESTER; ( 4 CHLORO 2 TRIFLUOROMETHYLPHENYL)CARBAMIC ACID 1 [[ 2 TERT BUTYLTHIO 5 OXO TETRAHYDROFURAN 3 YLCARBAMOUL]METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][ 1,4 ]DIAZEPIN 3YLMETHYL ESTER; ( 4 CHLORO 2 TRIFLUOROMETHYLPHENYL)CARBAMIC ACID 1 [[ 2 TERT BUTYLTHIO 5 OXO TETRAHYDROFURAN 3 YLCARBAMOYL]METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][ 1,4 ]DIAZEPIN 3YLMETHYL ESTER; ACYLAL; ALDEHYDE DERIVATIVE; ASPARTYLALDEHYDE; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; EFLORNITHINE; FALCIPAIN 2; FALCIPAIN 2 INHIBITOR; PEPTIDOMIMETIC AGENT; RHODESAIN; RHODESAIN INHIBITOR; TETRAHYDROFURAN DERIVATIVE; THIOACYLAL; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULE; PLASMODIUM FALCIPARUM; PROTEIN TARGETING; PROTOZOON; TRYPANOSOMA BRUCEI;

EID: 77954349475     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.04.003     Document Type: Article

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