Cardioprotection in ischemia/reperfusion injury: Spotlight on sphingosine-1-phosphate and bradykinin signalling

Progress in Biophysics and Molecular Biology

Volumn 103, Issue 1, 2010, Pages 142-147

  Egom, Emmanuel Eroume A ^a,b   Ke, Yunbo ^c   Solaro, R John ^c   Lei, Ming ^b  

^a VICTORIA HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Cardiac ischemia; Pak1; S1P

Indexed keywords

EID: 77954341984     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbiomolbio.2010.01.001     Document Type: Review

References (45)

1. Baxter G.F., Ebrahim Z. Role of bradykinin in preconditioning and protection of the ischaemic myocardium. Br. J. Pharmacol. 2002, 135:843-854.
2. Bokoch G.M., Reilly A.M., Daniels R.H., King C.C., Olivera A., Spiegel S., Knaus U.G. A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids. J. Biol. Chem. 1998, 273:8137-8144.
3. Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol. Ther. 2007, 115:84-105.
4. Cohen M.V., Yang X.M., Liu G.S., Heusch G., Downey J.M. Acetylcholine, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial K(ATP) channels. Circ. Res. 2001, 89:273-278.
5. Downey J.M., Davis A.M., Cohen M.V. Signaling pathways in ischemic preconditioning. Heart Fail. Rev. 2007, 12:181-188.
6. Ebrahim Z., Yellon D.M., Baxter G.F. Bradykinin elicits "second window" myocardial protection in rat heart through an NO-dependent mechanism. Am. J. Physiol. Heart Circ. Physiol. 2001, 281:H1458-H1464.
7. Egom E.A., Ke Y., Musa H., Mohamed T., Wang T., Cartwright E., Solaro R.J., Lei M. FTY720 prevents ischemia/reperfusion injury associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signalling. JMCC 2009, 10.1016/j.yjmcc.2009.10.009.
8. Graler M.H., Bernhardt G., Lipp M. EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. Genomics 1998, 53:164-169.
9. Higuchi M., Onishi K., Kikuchi C., Gotoh Y. Scaffolding function of PAK in the PDK1-Akt pathway. Nat. Cell Biol. 2008, 10:1356-1364.
10. Hla T., Maciag T. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J. Biol. Chem. 1990, 265:9308-9313.
11. Hofmann U., Burkard N., Vogt C., Thoma A., Frantz S., Ertl G., Ritter O., Bonz A. Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion. Cardiovasc. Res. 2009, 83:285-293.
12. Im D.S., Heise C.E., Ancellin N., O'Dowd B.F., Shei G.J., Heavens R.P., Rigby M.R., Hla T., Mandala S., McAllister G., George S.R., Lynch K.R. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. J. Biol. Chem. 2000, 275:14281-14286.
13. Ishii I., Friedman B., Ye X., Kawamura S., McGiffert C., Contos J.J., Kingsbury M.A., Zhang G., Brown J.H., Chun J. Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J. Biol. Chem. 2001, 276:33697-33704.
14. Jin Z.Q., Goetzl E.J., Karliner J.S. Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Circulation 2004, 110:1980-1989.
15. Jin Z.Q., Zhang J., Huang Y., Hoover H.E., Vessey D.A., Karliner J.S. A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. Cardiovasc. Res. 2007, 76:41-50.
16. Jin Z.Q., Zhou H.Z., Zhu P., Honbo N., Mochly-Rosen D., Messing R.O., Goetzl E.J., Karliner J.S., Gray M.O. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Am. J. Physiol. Heart Circ. Physiol. 2002, 282:H1970-H1977.
17. Karliner J.S. Sphingosine kinase regulation and cardioprotection. Cardiovasc. Res 2008, 10.1093/cvr/cvn309.
18. Karliner J.S. Sphingosine kinase regulation and cardioprotection. Cardiovasc. Res. 2009, 82:184-192.
19. Karliner J.S., Honbo N., Summers K., Gray M.O., Goetzl E.J. The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. J. Mol. Cell. Cardiol. 2001, 33:1713-1717.
20. Ke Y., Lei M., Collins T.P., Rakovic S., Mattick P.A., Yamasaki M., Brodie M.S., Terrar D.A., Solaro R.J. Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells. Circ. Res. 2007, 100:1317-1327.
21. Ke, Y., Sheehan, C., Egom, Emmanuel Eroume A., Lei, M., Solaro, R.J. Novel bradykinin signaling in adult rat cardiac myocytes through activation of p21 activated kinase. Am. J. Physiol. Heart Circ. Physiol. (in revision).
22. Ke Y., Solaro R.J. Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide related activation. Biologics Target Ther. 2008, 2:903-909.
23. Ke Y., Wang L., Pyle W.G., de Tombe P.P., Solaro R.J. Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes. Circ. Res. 2004, 94:194-200.
24. Kon J., Sato K., Watanabe T., Tomura H., Kuwabara A., Kimura T., Tamama K., Ishizuka T., Murata N., Kanda T., Kobayashi I., Ohta H., Ui M., Okajima F. Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells. J. Biol. Chem. 1999, 274:23940-23947.
25. Kozma R., Ahmed S., Best A., Lim L. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 1995, 15:1942-1952.
26. Lecour S., Smith R.M., Woodward B., Opie L.H., Rochette L., Sack M.N. Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotection. J. Mol. Cell. Cardiol. 2002, 34:509-518.
27. Lee M.J., Van B., Thangada S., Liu C.H., Hand A.R., Menzeleev R., Spiegel S., Hla T. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 1998, 279:1552-1555.
28. Liebmann C., Offermanns S., Spicher K., Hinsch K.D., Schnittler M., Morgat J.L., Reissmann S., Schultz G., Rosenthal W. A high-affinity bradykinin receptor in membranes from rat myometrium is coupled to pertussis toxin-sensitive G-proteins of the Gi family. Biochem. Biophys. Res. Commun. 1990, 167:910-917.
29. Liu Q., Zhao X., Frissora F., Ma Y., Santhanam R., Jarjoura D., et al. FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood 2008, 111:275-284.
30. Mathers, Loncar Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006, 3(11):e442.
31. Murry C.E., Jennings R.B., Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986, 74:1124-1136.
32. Okajima F. Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?. Biochim. Biophys. Acta 2002, 1582:132-137.
33. Payne S.G., Milstien S., Spiegel S. Sphingosine-1-phosphate: dual messenger functions. FEBS Lett. 2002, 531:54-57.
34. Peters S.L., Alewijnse A.E. Sphingosine-1-phosphate signaling in the cardiovascular system. Curr. Opin. Pharmacol. 2007, 7:186-192.
35. Pyne S., Pyne N.J. Sphingosine 1-phosphate signalling in mammalian cells. Biochem. J. 2000, 349:385-402.
36. Sato K., Ui M., Okajima F. Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells. Brain Res. Mol. Brain Res. 2000, 85:151-160.
37. Spiegel S., Milstien S. Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. Biochem. Soc. Trans. 2003, 31:1216-1219.
38. Su J.B. Kinins and cardiovascular diseases. Curr. Pharm. Des. 2006, 12:3423-3435.
39. Vessey D.A., Li L., Honbo N., Karliner J.S. Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and post-conditioning. Am. J. Physiol. Heart Circ. Physiol 2009, 10.1152/ajpheart.00358.2009.
40. Vessey D.A., Li L., Kelley M., Karliner J.S. Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia. Biochem. Biophys. Res. Commun. 2008, 375:425-429.
41. Wolfrum S., Schneider K., Heidbreder M., Nienstedt J., Dominiak P., Dendorfer A. Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform. Cardiovasc. Res. 2002, 55:583-589.
42. Yatomi Y., Igarashi Y., Yang L., Hisano N., Qi R., Asazuma N., Satoh K., Ozaki Y., Kume S. Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. J. Biochem. 1997, 121:969-973.
43. Zhang J., Honbo N., Goetzl E.J., Chatterjee K., Karliner J.S., Gray M.O. Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia. Am. J. Physiol. Heart Circ. Physiol. 2007, 293:H3150-H3158.
44. Zhang G., Contos J.J., Weiner J.A., Fukushima N., Chun J. Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene 1999, 227:89-99.
45. Zhao Y., Man K., Lo C.M., Ng K.T., Li X.L., Sun C.K., Lee T.K., Dai X.W., Fan S.T. Attenuation of small-for-size liver graft injury by FTY720: significance of cell-survival Akt signaling pathway. Am. J. Transplant. 2004, 4:1399-1407.