Circulating bioactive and immunoreactive IGF-I remain stable in women, despite physical fitness improvements after 8 weeks of resistance, aerobic, and combined exercise training

Journal of Applied Physiology

Volumn 109, Issue 1, 2010, Pages 112-120

  Nindl, Bradley C ^a   Alemany, Joseph A ^a   Tuckow, Alexander P ^a   Rarick, Kevin R ^a   Staab, Jeffery S ^a   Kraemer, William J ^b   Maresh, Carl M ^b   Spiering, Barry A ^b   Hatfield, Disa L ^b   Flyvbjerg, Allan ^c   Frystyk, Jan ^c  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Hormones; Insulin like growth factor binding proteins; Kinase receptor activation assay; Physical training

Indexed keywords

SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; BLOOD; BODY COMPOSITION; EXERCISE; FEMALE; FITNESS; HUMAN; METABOLISM; MUSCLE STRENGTH; YOUNG ADULT;

ADOLESCENT; ADULT; BODY COMPOSITION; EXERCISE; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MUSCLE STRENGTH; PHYSICAL FITNESS; RECEPTOR, IGF TYPE 1; YOUNG ADULT;

EID: 77954319591     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00025.2010     Document Type: Article

References (43)

1. Adams GR. Invited Review: Autocrine/paracrine IGF-I and skeletal muscle adaptation. J Appl Physiol 93: 1159-1167, 2002.
2. Berg U, Bang P. Exercise and circulating insulin-like growth factor-I. Horm Res 62: 50-58, 2004.
3. Berg U, Gustafsson T, Sundberg CJ, Kaijser L, Carlsson-Skwirut C, Bang P. Interstitial fluid in exercising skeletal muscle in women. Eur J Endocrinol 157: 427-435, 2007.
4. Brugts MP, van Beld W, Hofland LJ, van der Wansem K, van Koetsveld PM, Frystyk J, Lambert SWJ, Janssen JAMJL. Low circulating insulin-like growth factor-I bioactivity in elderly men is associated with increases mortality. J Clin Endocrinol Metab 93: 2515-2522, 2008.
5. Brugts MP, Ranke MB, Hofland LJ, van der Wansem K, Weber K, Frystyk J, Lamberts SWJ, Janssen JAMJL. Normal values of circulating insulin-like growth factor-I bioactivity in the healthy population: comparson with, five widely used IGF-I immunoassays. J Clin Endocrinol Metab 93: 2539-2545, 2008.
6. Chen J, Hojlund K, Beck-Nielsen H, Christiansen JS, Orskov H, Frystyk J. Free rather than total circulating insulin-like growth factor-I determines the feedback on growth hormone release in normal subjects. J Clin Endocrinol Metab 90: 366-371, 2005.
7. Chen J, Ledet T, Orskov H, Jessen N, Lund S, Whittaker J, De Meyts P, Larsen MB, Christiansen JS, Frystyk J. A highly sensitive and specific assay for determiniation of IGF-I bioactivity in human serum. Am J Physiol Endocrinol Metab 284: E1149-E1155, 2003.
8. Eliakim A, Brasel JA, Mohan S, Wong WLT, Cooper DM. Increased physical activity and the growth hormone-IGF-I axis in adolescent males. Am J Physiol 44: R308-R314, 1998.
9. Eliakim A, Nemet D, Cooper DM. Exercise, training, and the GH-IGF-I axis. In: The Endocrine System in Sports and Exercise, edited by WJ Kraemer and AD Rogol. Maiden, MA: Blackwell, 2005, p. 165-179.
10. Eliakim A, Scheett TP, Newcomb R, Mohan S, Cooper DM. Fitness, training, and the growth hormone/insulin-like growth factor-I axis in prepubertal girls. J Clin Endocrinol Metab 86: 2797-2802, 2001.
11. Frystyk J. Exercise and the growth hormone-insulin-like growth factor-I axis. Med Sci Sports Exerc 42: 58-66, 2010.
12. Frystyk J. Utility of free IGF-I measurements. Pituitary 10: 181-187, 2007.
13. Frystyk J, Dinesen B, Orskov H. Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II. Growth Regul 5: 169-176, 1995.
14. Frystyk J, Hojlund K, Rasmussen KN, Jorgensen SP, Wildner-Christensen M, Orskov H. Development and clinical evaluation of a novel immune-assay for the binary complex of insulin-like growth factor-I and IGF-binding protein-1 in human, serum. J Clin Endocrinol Metab 87: 260-266, 2002.
15. Frystyk J, Ivarsen P, Stoving RK, Dall R, Bek T, Hagen C, Orskov H. Determination of free insulin-like growth factor-I in human serum: comparison of ultrafiltration and direct immunoradiometric assay. Growth Horm IGF Res 11: 117-127, 2001.
16. Frystyk Skjaerbaek JC, Dinesen B, Orskov H. Free insulin-like growth factors (IGF-I and IGF-II) in human serum. FEBS Lett 348: 185-191, 1994.
17. Hansen M, Koskinen SO, Petersen SG, Doessing S, Frystyk J, Flyvbjerg A, Westh E, Magnusson SP, Kjaer M, Langberg H. Ethinyl oestradiol administration in women suppress synthesis of collagen in response to exercise. J Physiol 586: 3005-30016, 2008.
18. Kanaley JA, Frystyk J, Moller N, Dall R, Chen JW, Nielsen SC, Christiansen JS, Jorgensen JOL, Flyvberg A. The effect of submaximal exerciseon immune- and bioassayable IGF-I activity in patients with GH-deficiency and healthy patients. Growth Horm IGF Res 15: 283-290, 2005.
19. Karl JP, Alemany JA, Koenig C, Kraemer WJ, Frystyk J, Young AJ, Nindl BC. Diet, body composition, and physical fitness influences on IGF-I bioactivity in women. Growth Horm IGF Res 19: 491-496, 2009.
20. Krassas GE, Pontikides N, Kaltsas T, Dumas A, Frystyk J, Chen JW, Flyvbjerg A. Free and total insulin-like growth factor (IGF)-I, II, and IGF binding protein-1, -2, and -3 serum levels in patients with active thyroid disease. J Clin Endocrinol Metab 88: 132-135, 2003.
21. Lavoie JM. The contribution of afferent signals from the liver to metabolic regulation during exercise. Can J Phydol Pharmacol 80: 1035-1044, 2002.
22. Lavoie JM, Fillion Y, Couturier K, Corriveau P. Selected contribution: evidence that the decrease in liver glycogen is associated with the exercise-induced increase in IGFBP-I. J Appl Physiol 93: 798-804, 2002.
23. Lester MW, Urso MU, Evans RK, Pierce JR, Spiering BA, Maresh CM, Hatfield DL, Kraemer WJ, Nindl BC. Influence of exercise mode and osteogenic index on bone biomarker responses during short-term, training. Bone 45: 768-776, 2009.
24. Matheny RW, Merritt E, Zannikos SV, Farrar RP, Adamo ML. Serum IGF-I deficiency does not prevent compensatory muscle hypertrophy in resistance exercise. Exp Biol, Med (Maywood) 234: 164-170, 2009.
25. Nemet D, Connolly PH, Pontello-Pescatello AM, Rose-Gottron C, Larson JK, Galassetti P, Cooper DM. Negative energy balance plays a major role in the IGF-I response to exercise training. J Appl Physiol 96: 276-282, 2004.
26. Nindl BC, JA , Alemany Kellogg MD, Rood J, Allison SA, Young AJ, Montain SJ. Utility of circulating IGF-I as a biomarker for assessing body composition changes in men during periods of high physical activity superimposed upon energy and sleep restriction. J Appl Physiol 103: 340-346, 2007.
27. Nindl BC, Alemany JA, Tuckow AP, Kellogg MD, Sharp MA, Patton JF. Effects of exercise mode and duration on 24-h IGF-I system recovery responses. Med Sci Sports Exerc 41: 1261-1270, 2009.
28. Nindl BC, Castellani JW, Young AJ, Patton JF, Khosravi MJ, Diamandi A, Montain SJ. Differential responses of IGF-I molecular complexes to military operational field training. J Appl Physiol 95: 1083-1089, 2003.
29. Nindl BC, Headley SA, Tuckow AP, Pandorf CE, Diamandi A, Khosravi MJ, Welles R, Jones M. IGF-I system responses during 12 weeks of resistance training in end-stage renal disease. Growth Horm IGF Res 14: 245-250, 2004.
30. Nindl BC, Kraemer WJ, Marx JO, Arciero PJ, Dohi K, Kellogg MD, Loomis GA. Overnight responses of the circulating IGF-I system, after acute, heavy-resistance exercise. J Appl Physiol 90: 1319-1326, 2001.
31. Nindl BC, Pierce JR. Insulin-like growth factor-I as a biomarker of health, fitness and training status. Med Sci Sports Exer 42: 39-49, 2010.
32. Nindl BC, Pierce JR, Durkot MJ, Tuckow AP, Kennett MJ, Nieves JW, Cosman F, Alemany JA, Hymer WC. Relationship between growth hormone in vivo bioactivity, the insulin-like growth factor-I system, and bone mineral density in young, physically fit men and women. Growth Horm IGF Res 18: 439-445, 2008.
33. Nindl BC, Rarick KR, Castellani JW, Tuckow AP, Patton JF, Young AJ, Montain SJ. Altered secretion of growth hormone and luteinizing hormone after 84 h of sustained physical exertion superimposed on caloric and sleep restriction. J Appl Physiol 100: 120-128, 2006.
34. Nindl BC, Scoville CR, Sheehan KM, Leone CD, Mello RP. Gender differences in regional body composition and somatotrophic influences of IGF-I and leptin. J Appl Physiol 92: 1611-1618, 2002.
35. Nindl BC, Tuckow AP, Alemany JA, Harman EA, Rarick KR, Staab JS, Faupel ML, Khosravi MJ. Minimally invasive sampling of transdermal body fluid for the purpose of measuring insulin-like growth factor-I during exercise training. Diabetes Technol Ther 8: 244-252, 2006.
36. Ohlsson C, Mohan S, Sjogren K, Tivesten A, Isgaard J, Isaksson O, Jansson J, Svensson J. The role of liver-derived insulin-like growth factor-I. Endocr Rev 30: 494-535, 2009.
37. Ormsbee MJ, Clapper JA, Clapper J, Vukovich MD. Moderate changes in energy balance combined with exercise do not alter insulin-like growth factor I or insulin-like growth factor binding protein 3. Nutr Res 26: 467-473, 2006.
38. Rarick KR, Pikosky MA, Grediagin A, Smith TJ, Glickman EL, Alemany JA, Staab JS, Young AJ, Nindl BC. Energy flux, more so than energy balance, protein intake, or fitness level, influenced insulin-like growth factor-I system responses during 7 days of increases physical activity. J Appl Physiol 103: 1613-1621, 2007.
39. Rosendahl L, Langberg H, Flyvberg A, Frystyk J, Orskov H, Kjaer M. Physical capacity influences the response of insulin-like growth factor and its binding proteins to training. J Appl Physiol 93: 1669-1675, 2002.
40. Schmitz KH, Ahmed RL, Yee D. Effects of a 9-month strength training interventions on insulin, insulin-like growth factor (IGF-I), IGF-binding protein. (IGFBP-I) and IGFBP-3 in 30-50-year old women. Cancer Epidemiol Biomarkers Prev 11: 1597-1604, 2002.
41. Spangenburg EE, Le Roith D, Ward CW, Bodine SC. A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy. J Physiol 581: 283-291, 2008.
42. Stoving RK, Chen JW, Glintborg D, Brixen K, Flyvberg A, Horder K, Frystyk J. Bioactive insulin-like growth factor-I and IGF-binding protein- 1 in anorexia nervosa. J Clin Endocrinol Metab 92: 2323-2329, 2007.
43. Yakar S, Rosen CJ, Bouzsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffer MB, Majeska RJ, Gavrilova O, Gutierrez M, Hang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. Serum, complexes of insulin-like growth factor-I modulate skeletal integrity and carbohydrate metabolism. FASEB J 23: 709-719, 2009.