Physical capacity influences the response of insulin-like growth factor and its binding proteins to training

Journal of Applied Physiology

Volumn 93, Issue 5, 2002, Pages 1669-1675

  Rosendal, Lars ^a,b   Langberg, Henning ^a   Flyvbjerg, Allan ^c   Frystyk, Jan ^c   Ørskov, Hans ^c   Kjæer, Michael ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

^b NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Exercise; Fitness level; Human; Insulin like growth factor binding protein; Proteolysis

Indexed keywords

SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN C;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIET RESTRICTION; EXERCISE; FITNESS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHYSICAL CAPACITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; TRAINING;

EID: 0036873368     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00145.2002     Document Type: Article

References (44)

1. Abrahamsson SO. Similar effects of recombinant human insulin-like growth factor-I and II on cellular activities in flexor tendons of young rabbits: experimental studies in vitro. J Orthop Res 15: 256-262, 1997.
2. Banes AJ, Tsuzaki M, Hu P, Brigman B, Brown T, Almekinders L, Lawrence WT, and Fischer T. PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro. J Biomech 28: 1505-1513, 1995.
3. Chicharro JL, Lopez-Calderon A, Hoyos J, Martin-Velasco AI, Villa G, Villanua MA, and Lucia A. Effects of an endurance cycling competition on resting serum insulin-like growth factor I (IGF-I) and its binding proteins IGFBP-1 and IGFBP-3. Br J Sports Med 35: 303-307, 2001.
4. Clemmons DR. Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev 8: 45-62, 1997.
5. Conover CA. Regulation and physiological role of insulin-like growth factor binding proteins. Endocr J 43, Suppl: S43-S48, 1996.
6. Cooper DM. Evidence for and mechanisms of exercise modulation of growth - an overview. Med Sci Sports Exerc 26: 733-740, 1994.
7. Dall R, Lange KH, Kjaer M, Jorgensen JO, Christiansen JS, Orskov H, and Flyvbjerg A. No evidence of insulin-like growth factor-binding protein 3 proteolysis during a maximal exercise test in elite athletes. J Clin Endocrinol Metab 86: 669-674, 2001.
8. Deuschle M, Blum WF, Frystyk J, Orskov H, Schweiger U, Weber B, Korner A, Gotthardt U, Schmider J, Standhardt H, and Heuser I. Endurance training and its effect upon the activity of the GH-IGFs system in the elderly. Int J Sports Med 19: 250-254, 1998.
9. Eliakim A, Brasel JA, Mohan S, Barstow TJ, Berman N, and Cooper DM. Physical fitness, endurance training, and the growth hormone-insulin-like growth factor I system in adolescent females. J Clin Endocrinol Metab 81: 3986-3992, 1996.
10. Eliakim A, Brasel JA, Mohan S, Wong WL, and Cooper DM. Increased physical activity and the growth hormone-IGF-I axis in adolescent males. Am J Physiol Regul Integr Comp Physiol 275: R308-R314, 1998.
11. Florini JR, Ewton DZ, Falen SL, and Van Wyk JJ. Biphasic concentration dependency of stimulation of myoblast differentiation by somatomedins. Am J Physiol Cell Physiol 250: C771-C778, 1986.
12. Flyvbjerg A, Kessler U, Dorka B, Funk B, Ørskov H, and Kiess W. Transient increase in renal insulin-like growth factor binding proteins during initial kidney hypertrophy in experimental diabetes in rats. Diabetologia 35: 589-593, 1992.
13. Fowlkes JL. Insulinlike growth factor-binding protein proteolysis. An emerging paradigm in insulinlike growth factor physiology. Trends Endocrinol Metab 8: 299-306, 1997.
14. Fowlkes JL, Serra DM, Rosenberg CK, and Thrailkill KM. Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) functions as an IGF-reversible inhibitor of IGFBP-4 proteolysis. J Biol Chem 270: 27481-27488, 1995.
15. Friedl KE, Moore RJ, Hoyt RW, Marchitelli LJ, Martinez-Lopez LE, and Askew EW. Endocrine markers of semistarvation in healthy lean men in a multistressor environment. J Appl Physiol 88: 1820-1830, 2000.
16. Frystyk J, Dinesen B, and Ørskov H. Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II. Growth Regul 5: 169-176, 1995.
17. Frystyk J, Ivarsen P, Skjaerbaek C, Flyvbjerg A, Pedersen EB, and Ørskov H. Serum-free insulin-like growth factor I correlates with clearance in patients with chronic renal failure. Kidney Int 56: 2076-2084, 1999.
18. Frystyk J, Ivarsen P, Stoving RK, Dall R, Bek T, Hagen C, and Orskov H. Determination of free insulin-like growth factor-I in human serum: comparison of ultrafiltration and direct immunoradiometric assay. Growth Horm IGF Res 11: 117-127, 2001.
19. Frystyk J, Skjaerbaek C, Dinesen B, and Ørskov H. Free insulin-like growth factors (IGF-I and IGF-II) in human serum. FEBS Lett 348: 185-191, 1994.
20. Gulmans V, van der Laag J, Wattimena D, van Doom J, Oostveen D, Berger R, and de Meer K. Insulin-like growth factors and leucine kinetics during exercise training in children with cystic fibrosis. J Pediatr Gastroenterol Nutr 32: 76-81, 2001.
21. Hasegawa T, Hasegawa Y, Takada M, and Tsuchiya Y. The free form of insulin-like growth factor I increases in circulation during normal human pregnancy. J Clin Endocrinol Metab 80: 3284-3286, 1995.
22. Haydar ZR, Blackman MR, Tobin JD, Wright JG, and Fleg JL. The relationship between aerobic exercise capacity and circulating IGF-1 levels in healthy men and women. J Am Geriatr Soc 48: 139-145, 2000.
23. Hossenlopp P, Seurin D, Segovia-Quinson B, Hardouin S, and Binoux M. Analysis of serum insulin-like growth factor binding proteins using western blotting: use of the method for titration of the binding proteins and competitive binding studies. Anal Biochem 154: 138-143, 1986.
24. Jahreis G, Kauf E, Frohner G, and Schmidt HE. Influence of intensive exercise on insulin-like growth factor I, thyroid and steroid hormones in female gymnasts. Growth Regul 1: 95-99, 1991.
25. Jia D and Heersche JN. Insulin-like growth factor-1 and -2 stimulate osteoprogenitor proliferation and differentiation and adipocyte formation in cell populations derived from adult rat bone. Bone 27: 785-794, 2000.
26. Koziris LP, Hickson RC, Chatterton RT Jr, Groseth RT, Christie JM, Goldflies DG, and Unterman TG. Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training. J Appl Physiol 86: 1436-1442, 1999.
27. Kraemer WJ, Hakkinen K, Newton RU, Nindl BC, Volek JS, McCormick M, Gotshalk LA, Gordon SE, Fleck SJ, Campbell WW, Putukian M, and Evans WJ. Effects of heavy-resistance training on hormonal response patterns in younger vs. older men. J Appl Physiol 87: 982-992, 1999.
28. Lamson G, Giudice LC, and Rosenfeld RG. A simple assay for proteolysis of IGFBP-3. J Clin Endocrinol Metab 72: 1391-1393, 1991.
29. Langberg H, Rosendal L, and Kjaer M. Training-induced changes in peritendinous type I collagen turnover determined by microdialysis in humans. J Physiol 534: 297-302, 2001.
30. Leveritt M, Abernethy PJ, Barry BK, and Logan PA. Concurrent strength and endurance training. A review. Sports Med 28: 413-427, 1999.
31. Maddalozzo GF and Snow CM. High intensity resistance training: effects on bone in older men and women. Calcif Tissue Int 66: 399-404, 2000.
32. McCusker RH. Controlling insulin-like growth factor activity and the modulation of insulin-like growth factor binding protein and receptor binding, J Dairy Sci 81: 1790-1800, 1998.
33. National Institutes of Health. Healthy people 2000: national health promotion and disease prevention objectives. US Public Health Service. J Allied Health 19: 297-311, 1990.
34. Nindl BC, Montain JW, Castellani MD, Smith WTJ, and Stulz DA. Military operational stress alters serum concentrations of insulin-like growth factor-I binding proteins (Abstract). FASEB J 1: A757, 2001.
35. Poehlman ET and Copeland KC. Influence of physical activity on insulin-like growth factor-I in healthy younger and older men. J Clin Endocrinol Metab 71: 1468-1473, 1990.
36. Rajaram S, Baylink DJ, and Mohan S. Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocr Rev 18: 801-831, 1997.
37. Schwarz AJ, Brasel JA, Hintz RL, Mohan S, and Cooper DM. Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men. J Clin Endocrinol Metab 81: 3492-3497, 1996.
38. Smith AT, Clemmons DR, Underwood LE, Ben Ezra V, and McMurray R. The effect of exercise on plasma somatomedin-C/insulinlike growth factor I concentrations. Metabolism 36: 533-537, 1987.
39. Smith WJ, Underwood LE, and Clemmons DR. Effects of caloric or protein restriction on insulin-like growth factor-I (IGF-I) and IGF-binding proteins in children and adults. J Clin Endocrinol Metab 80: 443-449, 1995.
40. Van Doorn J, Cornelissen AJ, and Buul-Offers SC. Plasma levels of insulin-like growth factor binding protein-4 (IGFBP-4) under normal and pathological conditions. Clin Endocrinol (Oxf) 54: 655-664, 2001.
41. Vandenburgh HH, Karlisch P, Shansky J, and Feldstein R. Insulin and IGF-I induce pronounced hypertrophy of skeletal myofibers in tissue culture. Am J Physiol Cell Physiol 260: C475-C484, 1991.
42. Washburn RA, Adams LL, and Haile GT. Physical activity assessment for epidemiologic research: the utility of two simplified approaches. Prev Med 16: 636-646, 1987.
43. Yeh JK, Aloia JF, Chen M, Ling N, Koo HC, and Millard WJ. Effect of growth hormone administration and treadmill exercise on serum and skeletal IGF-I in rats. Am J Physiol Endocrinol Metab 266: E129-E135, 1994.
44. Zanconato S, Moromisato DY, Moromisato MY, Woods J, Brasel JA, Leroith D, Roberts CT Jr, and Cooper DM. Effect of training and growth hormone suppression on insulin-like growth factor I mRNA in young rats, J Appl Physiol 76: 2204-2209, 1994.