Relationship between growth hormone in vivo bioactivity, the insulin-like growth factor-I system and bone mineral density in young, physically fit men and women

Growth Hormone and IGF Research

Volumn 18, Issue 5, 2008, Pages 439-445

  Nindl, B C ^a   Pierce, J R ^a   Durkot, M J ^a   Tuckow, A P ^a   Kennett, M J ^b   Nieves, J W ^c   Cosman, F ^c   Alemany, J A ^a   Hymer, W C ^b  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c HELEN HAYES HOSPITAL   (United States)

Author keywords

Bioassay; Hormones; Insulin like growth factor I binding proteins; pQCT

Indexed keywords

ACID LABILE SUBUNIT; BIOLOGICAL MARKER; GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICAL BONE; DUAL ENERGY X RAY ABSORPTIOMETRY; EPIPHYSIS; FEMALE; FEMUR NECK; GROWTH PLATE; HIP; HORMONE ACTION; HORMONE DETERMINATION; HUMAN; HUMAN EXPERIMENT; HYPOPHYSECTOMY; IMMUNOREACTIVITY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SPINE; SPRAGUE DAWLEY RAT; STATISTICAL SIGNIFICANCE; TIBIA; VOLUNTEER;

ADOLESCENT; ADULT; ANIMALS; BONE DENSITY; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 46749085095     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2008.03.004     Document Type: Article

References (20)

1. Barrett-Connor E., and Goodman-Gruen D. Gender differences in insulin-like growth factor and bone mineral density association in old age: the Rancho Bernardo Study. J. Bone Miner. Res. 8 (1998) 1343-1349
2. Greenspan F.S., Li C.H., Simpson M.E., and Evans H.M. Bioassay of hypophyseal growth hormone; the tibia test. Endocrinology 5 (1949) 455-463 Illust
3. Langlois J.A., Rosen C.J., Visser M., et al. Association between insulin-like growth factor I and bone mineral density in older women and men: the Framingham Heart Study. J. Clin. Endocr. Metab. 12 (1998) 4257-4262
4. Yakar S., Bouxsein M.L., Canalis E., et al. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J. Endocrinol. 2 (2006) 289-299
5. McCall G.E., Goulet C., Grindeland R.E., Hodgson J.A., Bigbee A.J., and Edgerton V.R. Bed rest suppresses bioassayable growth hormone release in response to muscle activity. J. Appl. Physiol. 6 (1997) 2086-2090
6. Ziros P.G., Georgakopoulos T., Habeos I., Basdra E.K., and Papavassiliou A.G. Growth hormone attenuates the transcriptional activity of Runx2 by facilitating its physical association with Stat3beta. J. Bone. Miner. Res. 11 (2004) 1892-1904
7. Ohlsson C., Bengtsson B.A., Isaksson O.G., Andreassen T.T., and Slootweg M.C. Growth hormone and bone. Endocr. Rev. 1 (1998) 55-79
8. Hymer W.C., Kraemer W.J., Nindl B.C., et al. Characteristics of circulating growth hormone in women after acute heavy resistance exercise. Am. J. Physiol. Endocr. Metab. 4 (2001) E878-E887
9. Kraemer W.J., Nindl B.C., Marx J.O., et al. Chronic resistance training in women potentiates growth hormone in vivo bioactivity: characterization of molecular mass variants. Am. J. Physiol. Endocr. Metab. 6 (2006) E1177-E1187
10. Nindl B.C., Kraemer W.J., Marx J.O., Tuckow A.P., and Hymer W.C. Growth hormone molecular heterogeneity and exercise. Exercise Sport. Sci. Rev. 4 (2003) 161-166
11. Nindl B.C., Scoville C.R., Sheehan K.M., Leone C.D., and Mello R.P. Gender differences in regional body composition and somatotrophic influences of IGF-I and leptin. J. Appl. Physiol. 4 (2002) 1611-1618
12. Ruffing J., Cosman F., Zion M., et al. Determinants of bone mass and bone size in a large cohort of physically active young adult men. Nutr. Metab. (2006) 14
13. Ruffing J.A., Nieves J.W., Zion M., et al. The influence of life style, menstrual function and oral contraceptive use on bone mass and size in female military cadets. Nutr. Metab. (2007) 17
14. McCall G.E., Goulet C., Roy R.R., et al. Spaceflight suppresses exercise-induced release of bioassayable growth hormone. J. Appl. Physiol. 3 (1999) 1207-1212
15. Gosselink K.L., Grindeland R.E., Roy R.R., et al. Skeletal muscle afferent regulation of bioassayable growth hormone in the rat pituitary. J. Appl. Physiol. 4 (1998) 1425-1430
16. Gosselink K.L., Roy R.R., Zhong H., Grindeland R.E., Bigbee A.J., and Edgerton V.R. Vibration-induced activation of muscle afferents modulates bioassayable growth hormone release. J. Appl. Physiol. 6 (2004) 2097-2102
17. Baumann G. Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocr. Rev. 4 (1991) 424-449
18. Ueland T. Bone metabolism in relation to alterations in systemic growth hormone. Growth Horm. IGF Res. 6 (2004) 404-417
19. Mohan S., and Baylink D.J. IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J. Endocrinol. 1 (2002) 19-31
20. Yakar S., Rosen C.J., Beamer W.G., et al. Circulating levels of IGF-1 directly regulate bone growth and density. J. Clin. Invest. 6 (2002) 771-781