Stereoselective transport of amethopterin enantiomers by the proton-coupled folate transporter

Drug Metabolism and Pharmacokinetics

Volumn 25, Issue 3, 2010, Pages 283-289

  Narawa, Tomoya ^a   Itoh, Tomoo ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Amethopterin; Enantiomer; Methotrexate; Pcft; Stereoselective transport

Indexed keywords

DEXTRO METHOTREXATE; METHOTREXATE; PROTON COUPLED FOLATE TRANSPORTER; REDUCED FOLATE CARRIER; UNCLASSIFIED DRUG; CARRIER PROTEIN; FOLIC ACID; FOLIC ACID ANTAGONIST; SLC46A1 PROTEIN, HUMAN;

ARTICLE; CELL PH; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG CLEARANCE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG TRANSPORT; DRUG UPTAKE; ENANTIOMER; GENE EXPRESSION; HUMAN; HUMAN CELL; MICHAELIS MENTEN KINETICS; STEREOCHEMISTRY; ALGORITHM; ANALOGS AND DERIVATIVES; CELL LINE; CHEMISTRY; CYTOLOGY; EMBRYOLOGY; GENETIC TRANSFECTION; INTESTINE ABSORPTION; KIDNEY; KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PH; STEREOISOMERISM; TRANSPORT AT THE CELLULAR LEVEL;

ALGORITHMS; BIOLOGICAL TRANSPORT; CELL LINE; CHROMATOGRAPHY, LIQUID; FOLIC ACID; FOLIC ACID ANTAGONISTS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; KIDNEY; KINETICS; MASS SPECTROMETRY; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; PROTON-COUPLED FOLATE TRANSPORTER; STEREOISOMERISM; TRANSFECTION;

EID: 77954251916     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.25.283     Document Type: Article

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