Structure of a class I tagatose-1,6-bisphosphate aldolase: Investigation into an apparent loss of stereospecificity

Journal of Biological Chemistry

Volumn 285, Issue 27, 2010, Pages 21143-21152

  LowKam, Clotilde ^a   Liotard, Brigitte ^a   Sygusch, Jurgen ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALDOLASES; BISPHOSPHATES; CATALYTIC EFFICIENCIES; CHIRAL DISCRIMINATION; CIS-TRANS ISOMERISM; CLASS I; CONFORMATIONAL RESPONSE; CRYSTALLINE STATE; DETRITIATION; DIASTEREOISOMERS; DIHYDROXYACETONE; DIHYDROXYACETONE PHOSPHATE; ELECTRON DENSITIES; ENAMINES; ENZYMATIC MECHANISMS; EPIMERIZATION; EXCHANGE REACTION; HIGH RESOLUTION CRYSTAL STRUCTURE; HYDROXYL GROUPS; KINETIC STUDY; NATIVE ENZYMES; PSICOSE; STEREOCHEMICAL CONTROL; STEREOSPECIFIC; STEREOSPECIFICITY; STREPTOCOCCUS PYOGENES; TAGATOSE; TRITIATED WATER; WATER MOLECULE;

CRYSTALLINE MATERIALS; STEREOCHEMISTRY; STRUCTURAL ANALYSIS; TRITIUM;

ENZYMES;

CARBON; DIHYDROXYACETONE PHOSPHATE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYDROGEN; LYSINE; TAGATOSE 1,6 BIPHOSPHATE ALDOLASE; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME STRUCTURE; EPIMERIZATION; ISOMERISM; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTON TRANSPORT; STEREOSPECIFICITY; STREPTOCOCCUS PYOGENES; STRUCTURE ANALYSIS;

ALDEHYDE-LYASES; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; KINETICS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; REPRODUCIBILITY OF RESULTS; SOLVENTS; STREPTOCOCCUS PYOGENES;

STREPTOCOCCUS PYOGENES;

EID: 77954232498     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.080358     Document Type: Article

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