NF449 is a novel inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells

Journal of Biological Chemistry

Volumn 285, Issue 27, 2010, Pages 20644-20653

  Krejci, Pavel ^a,b,c   Murakami, Shunichi ^d   Prochazkova, Jirina ^b   Trantirek, Lukas ^e   Chlebova, Katarina ^b   Ouyang, Zhufeng ^d   Aklian, Anie ^a   Smutny, Jiri ^b   Bryja, Vitezslav ^b,c   Kozubik, Alois ^b,c   Wilcox, William R ^a,f  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b MASARYK UNIVERSITY   (Czech Republic)

^c INSTITUTE OF BIOPHYSICS   (Czech Republic)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UTRECHT UNIVERSITY   (Netherlands)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-BINDING SITE; CELLULAR PHENOTYPES; CHEMOKINES; CHONDROCYTES; EXTRACELLULAR MATRICES; FIBROBLAST GROWTH FACTOR RECEPTORS; GROWTH INHIBITION; HUMAN DISORDERS; IN-CELL; INHIBITORY ACTIVITY; KINASE ACTIVITY; KINASE ASSAYS; MOLECULAR LIBRARIES; MULTIPLE MYELOMA; ORGAN CULTURE; RECEPTOR TYROSINE KINASE; WILD TYPES;

AMINO ACIDS; BINDING ENERGY; BODY FLUIDS; PEPTIDES; PHOSPHATASES; SIGNALING; TISSUE;

CELL CULTURE;

3 [4 METHYL 2 (2 OXO 3 INDOLINYLMETHYLIDENYL) 3 PYRROLYL]PROPIONIC ACID; ADENOSINE TRIPHOSPHATE; FIBROBLAST GROWTH FACTOR RECEPTOR 3; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; NF 007; NF 023; NF 110; NF 157; NF 279; NF 449; PROTEIN TYROSINE KINASE INHIBITOR; SURAMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARTILAGE; CARTILAGE CELL; CELL CULTURE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ASSAY; EXTRACELLULAR MATRIX; GROWTH INHIBITION; MOUSE; MULTIPLE MYELOMA; MYELOMA CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; BENZENESULFONATES; BONE AND BONES; CELL LINE, TUMOR; CHO CELLS; CHONDROCYTES; CRICETINAE; CRICETULUS; FEMALE; HUMANS; MICE; MULTIPLE MYELOMA; PROTEIN KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, NEOPLASM; SIGNAL TRANSDUCTION; SULFATES; URINARY BLADDER NEOPLASMS; UTERINE CERVICAL NEOPLASMS;

MURINAE;

EID: 77954220940     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.083626     Document Type: Article

References (43)

1. Passos-Bueno, M. R., Wilcox, W. R., Jabs, E. W., Sertié, A. L., Alonso, L. G., and Kitoh, H. (1999) Hum. Mutat. 14, 115-125
2. Chesi, M., Nardini, E., Brents, L. A., Schröck, E., Ried, T., Kuehl, W. M., and Bergsagel, P. L. (1997) Nat. Genet. 16, 260-264
3. Intini, D., Baldini, L., Fabris, S., Lombardi, L., Ciceri, G., Maiolo, A. T., and Neri, A. (2001) Br. J. Haematol. 114, 362-364
4. Cappellen, D., De Oliveira, C., Ricol, D., de Medina, S., Bourdin, J., Sastre-Garau, X., Chopin, D., Thiery, J. P., and Radvanyi, F. (1999) Nat. Genet. 23, 18-20
5. L'Hôte, C. G., and Knowles, M. A. (2005) Exp. Cell Res. 304, 417-431
6. Plowright, E. E., Li, Z., Bergsagel, P. L., Chesi, M., Barber, D. L., Branch, D. R., Hawley, R. G., and Stewart, A. K. (2000) Blood 95, 992-998
7. Krejci, P., Pejchalova, K., and Wilcox, W. R. (2007) Invest. New Drugs 25, 391-395
8. Krejci, P., Masri, B., Salazar, L., Farrington-Rock, C., Prats, H., Thompson, L. M., and Wilcox, W. R. (2007) J. Biol. Chem. 282, 2929-2936
9. Krejci, P., Bryja, V., Pachernik, J., Hampl, A., Pogue, R., Mekikian, P., and Wilcox, W. R. (2004) Exp. Cell Res. 297, 152-164
10. Dailey, L., Laplantine, E., Priore, R., and Basilico, C. (2003) J. Cell Biol. 161, 1053-1066
11. Aikawa, T., Segre, G. V., and Lee, K. (2001) J. Biol. Chem. 276, 29347-29352
12. Krejci, P., Masri, B., Fontaine, V., Mekikian, P. B., Weis, M., Prats, H., and Wilcox, W. R. (2005) J. Cell Sci. 118, 5089-5100
13. Yasoda, A., Komatsu, Y., Chusho, H., Miyazawa, T., Ozasa, A., Miura, M., Kurihara, T., Rogi, T., Tanaka, S., Suda, M., Tamura, N., Ogawa, Y., and Nakao, K. (2004) Nat. Med. 10, 80-86
14. Sahni, M., Ambrosetti, D. C., Mansukhani, A., Gertner, R., Levy, D., and Basilico, C. (1999) Genes Dev. 13, 1361-1366
15. Ronchetti, D., Greco, A., Compasso, S., Colombo, G., Dell'Era, P., Otsuki, T., Lombardi, L., and Neri, A. (2001) Oncogene 20, 3553-3562
16. Krejci, P., Mekikian, P. B., and Wilcox, W. R. (2006) Leukemia 20, 1165-1168
17. Masih-Khan, E., Trudel, S., Heise, C., Li, Z., Paterson, J., Nadeem, V., Wei, E., Roodman, D., Claudio, J. O., Bergsagel, P. L., and Stewart, A. K. (2006) Blood 108, 3465-3471
18. Krejci, P., Salazar, L., Goodridge, H. S., Kashiwada, T. A., Schibler, M. J., Jelinkova, P., Thompson, L. M., and Wilcox, W. R. (2008) J. Cell Sci. 121, 272-281
19. Mohammadi, M., McMahon, G., Sun, L., Tang, C., Hirth, P., Yeh, B. K., Hubbard, S. R., and Schlessinger, J. (1997) Science 276, 955-960
20. Hernández, S., de Muga, S., Agell, L., Juanpere, N., Esgueva, R., Lorente, J. A., Mojal, S., Serrano, S., and Lloreta, J. (2009) Mod. Pathol. 22, 848-856
21. Muenke, M., Gripp, K. W., McDonald-McGinn, D. M., Gaudenz, K., Whitaker, L. A., Bartlett, S. P., Markowitz, R. I., Robin, N. H., Nwokoro, N., Mulvihill, J. J., Losken, H. W., Mulliken, J. B., Guttmacher, A. E., Wilroy, R. S., Clarke, L. A., Hollway, G., Adès, L. C., Haan, E. A., Mulley, J. C., Cohen, M. M., Jr., Bellus, G. A., Francomano, C. A., Moloney, D. M., Wall, S. A., and Wilkie, A. O. (1997) Am. J. Hum. Genet. 60, 555-564
22. Hafner, C., van Oers, J. M., Vogt, T., Landthaler, M., Stoehr, R., Blaszyk, H., Hofstaedter, F., Zwarthoff, E. C., and Hartmann, A. (2006) J. Clin. Invest. 116, 2201-2207
23. Hafner, C., Landthaler, M., Mentzel, T., and Vogt, T. (2010) Br. J. Dermatol. 162, 508-512
24. Goriely, A., Hansen, R. M., Taylor, I. B., Olesen, I. A., Jacobsen, G. K., McGowan, S. J., Pfeifer, S. P., McVean, G. A., Meyts, E. R., and Wilkie, A. O. (2009) Nat. Genet. 41, 1247-1252
25. Aviezer, D., Golembo, M., and Yayon, A. (2003) Curr. Drug Targets 4, 353-365
26. Meyer, A. N., McAndrew, C. W., and Donoghue, D. J. (2008) Cancer Res. 68, 7362-7370
27. Qing, J., Du, X., Chen, Y., Chan, P., Li, H., Wu, P., Marsters, S., Stawicki, S., Tien, J., Totpal, K., Ross, S., Stinson, S., Dornan, D., French, D., Wang, Q. R., Stephan, J. P., Wu, Y., Wiesmann, C., and Ashkenazi, A. (2009) J. Clin. Invest. 119, 1216-1229
28. Braun, K., Rettinger, J., Ganso, M., Kassack, M., Hildebrandt, C., Ullmann, H., Nickel, P., Schmalzing, G., and Lambrecht, G. (2001) Naunyn Schmiedebergs Arch. Pharmacol. 364, 285-290
29. Hohenegger, M., Waldhoer, M., Beindl, W., Böing, B., Kreimeyer, A., Nickel, P., Nanoff, C., and Freissmuth, M. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 346-351
30. Soto, F., Lambrecht, G., Nickel, P., Stühmer, W., and Busch, A. E. (1999) Neuropharmacology 38, 141-149
31. Guzmán-Aránguez, A., Crooke, A., Yayon, A., and Pintor, J. (2008) Eur. J. Pharmacol. 584, 72-77
32. Kathir, K. M., Kumar, T. K., and Yu, C. (2006) Biochemistry 45, 899-906
33. Botta, M., Manetti, F., and Corelli, F. (2000) Curr. Pharm. Des. 6, 1897-1924
34. Sola, F., Capolongo, L., Moneta, D., Ubezio, P., and Grandi, M. (1999) Cancer Chemother. Pharmacol. 43, 241-246
35. Zamai, M., Hariharan, C., Pines, D., Safran, M., Yayon, A., Caiolfa, V. R., Cohen-Luria, R., Pines, E., and Parola, A. H. (2002) Biophys. J. 82, 2652-2664
36. Lozano, R. M., Jiménez, M., Santoro, J., Rico, M., and Giménez-Gallego, G. (1998) J. Mol. Biol. 281, 899-915
37. Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., and Ornitz, D. M. (1991) Cell 64, 841-848
38. Schlessinger, J., Plotnikov, A. N., Ibrahimi, O. A., Eliseenkova, A. V., Yeh, B. K., Yayon, A., Linhardt, R. J., and Mohammadi, M. (2000) Mol. Cell 6, 743-750
39. Yeh, B. K., Eliseenkova, A. V., Plotnikov, A. N., Green, D., Pinnell, J., Polat, T., Gritli-Linde, A., Linhardt, R. J., and Mohammadi, M. (2002) Mol. Cell Biol. 22, 7184-7192
40. Mohammadi, M., Olsen, S. K., and Goetz, R. (2005) Curr. Opin. Struct. Biol. 15, 506-516
41. Firsching, A., Nickel, P., Mora, P., and Allolio, B. (1995) Cancer Res. 55, 4957-4961
42. Kassack, M. U., Braun, K., Ganso, M., Ullmann, H., Nickel, P., Böing, B., Müller, G., and Lambrecht, G. (2004) Eur. J. Med. Chem. 39, 345-357
43. Hausmann, R., Rettinger, J., Gerevich, Z., Meis, S., Kassack, M. U., Illes, P., Lambrecht, G., and Schmalzing, G. (2006) Mol. Pharmacol. 69, 2058-2067