Nature of interaction between basic fibroblast growth factor and the antiangiogenic drug 7,7-(carbonyl-bis[imino-N-methyl-4,2-pyrrolecarbonylimino [N-methyl-4,2-pyrrole]-carbonylimino])-bis-(1,3-naphtalene disulfonate). II. Removal of polar interactions affects protein folding

Biophysical Journal

Volumn 82, Issue 5, 2002, Pages 2652-2664

  Zamai, Moreno ^a,b   Hariharan, Chithra ^a   Pines, Dina ^a   Safran, Michal ^c   Yayon, Avner ^c   Caiolfa, Valeria R ^d   Cohen Luria, Rivka ^a   Pines, Ehud ^a   Parola, Abraham H ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b Pharmacia Corporation   (Italy)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

7,7 [CARBONYLBIS[IMINO N METHYL 4,2 PYRROLECARBONYLIMINO (N METHYL 4,2 PYRROLE)CARBONYLIMINO]]BIS(1,3 NAPHTHALENEDISULFONATE); ANGIOGENESIS INHIBITOR; DISTAMYCIN A DERIVATIVE; FIBROBLAST GROWTH FACTOR; HEPARIN; PNU 145156E; SURADISTA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANISOTROPY; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; COMPLEX FORMATION; DRUG PROTEIN BINDING; ENERGY TRANSFER; FLUORESCENCE; LIGHT ABSORPTION; MEASUREMENT; MOLECULAR INTERACTION; POINT MUTATION; PROTEIN FOLDING; THERMODYNAMICS; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY;

EID: 0036229960     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(02)75607-5     Document Type: Article

References (55)

1. Angiogenesis inhibitors: A review
2. Receptor- and heparin-binding domains of basic fibroblast growth factor
3. New heterocyclic analogs of suramin with bFGF inhibiting activity: Synthesis, sar and possible mode of action
4. Tumor interaction with the vasculature: Angiogenesis and tumor metastasis
5. Energy transfer in tRNAPhe (yeast): Solution structure of transfer RNA
6. A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor suramin and related polyanions
7. The heparin-binding (fibroblast) growth factor family of proteins
8. New sulfonated distamycin A derivatives with bFGF complexing activity
9. Photoisomerization of stilbene in low viscosity solvents: Comparison of isolated and solvated molecules
10. The orientational freedom of molecular probes: The orientation factor in intramolecular energy transfer
11. Structure of a heparin-linked biologically active dimer of fibroblast growth factor
12. Refinement of the structure of human basic fibroblast growth factor at 1.6 Å resolution and analysis of presumed heparin binding sites by selenates substitution
13. Three-dimensional structure of human basic fibroblast growth factor
14. Thermodynamics of ligand binding to acyl-coenzyme A binding protein studied by titration calorimetry
15. Heparin structure and interactions with basic fibroblast growth factor
16. Fibroblast growth factors and their receptors: An information network controlling tissue growth, morphogenesis and repair
17. Tumor angiogenesis: Therapeutic implications
18. Tumor angiogenesis
19. Angiogeneic factors
20. Delocalized excitation and excitation transfer
21. Nonlocal interactions stabilize compact folding intermediates in reduced unfolded bovine pancreatic trypsin inhibitor
22. Angiogenesis and oncogenesis
23. The problem of protein folding and dynamics: Time resolved dynamic non-radiative excitation energy transfer measurements
24. Subpicosecond fluorescence depolarization studies of tryptophan and tryptophanyl residues of proteins
25. Recent advances in angiogenesis inhibitors
26. Heparin-induced self-association of fibroblast growth factor-2: Evidence for two oligomerization processes
27. Strategy and tactics in receptor-binding studies
28. Regulators of angiogenesis
29. Suramin: A novel growth factor antagonist with activity in hormone-refractory metastatic cancer
30. Suramin: Prototype of a new generation of antitumor compounds
31. Diminished heparin binding of a basic fibroblast growth factor mutant is associated with reduced receptor binding, mitogenesis, plasminogen activator induction, and in vitro angiogenesis
32. More to heparin than anticoagulation
33. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
34. Solution structure of acidic fibroblast growth factor bound to 1,3,6-naphthalenetrissulfonate: A minimal model for the antitumoral action of suramins and suradistas
35. Synthesis and binding mode of heterocyclic analogs of suramin inhibiting the human basic fibroblast growth factor
36. Fibroblast growth factors and their inhibitors
37. Nature of the interaction of growth factors with suramin
38. Solution structure of human acidic fibroblast growth factor and interaction with heparin-derived hexasaccharide
39. FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides
40. Three-dimensional structure of acidic fibroblast growth factor in solution: Effects of binding to a heparin functional analog
41. Structural basis for FGF receptor dimerization and activation
42. Human basic fibroblast growth factor: Structure-function relationship of an angiogeneic molecule
43. The antitumor efficacy of cytotoxic drugs is potentiated by treatment with PNU 145156E, a growth factor complexing molecule
44. Antitumoral activity of FCE26644 a new growth-factor complexing molecule
45. Coupling of local folding to site-specific binding of proteins to DNA
46. Identification and concerted function of two receptor-binding surfaces on basic fibroblast growth factor required for mitogenesis
47. Energetic characterization of the basic fibroblast growth factor-heparin interaction: Identification of the heparin binding domain
48. Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation
49. New insights into heparin-induced FGF oligomerization
50. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
51. Nature of interaction between basic fibroblast growth factor and the antiangiogenic drug 7,7-(carbonyl-bis-[imino-N-methyl-4,2-pyrrolecarbonylimino [N-methyl-4,2-pyrrole]-carbonylimino])-bis-(1,3-napthalene disulfonate)
52. Antiangiogenic naphthalene sulfonic distamycin-A derivatives tightly interact with human basic fibroblast growth factor
53. Glu-96 of basic fibroblast growth factor is essential for high affinity receptor binding
54. Three-dimensional structure of acidic and basic fibroblast growth factors