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Volumn 18, Issue 13, 2010, Pages 4844-4854

Optimization of isochromanone based urotensin II receptor agonists

(7) Lehmann, Fredrik a Currier, Erika A c Olsson, Roger b Ma, Jian Nong c Burstein, Ethan S c Hacksell, Uli c Luthman, Kristina a

a UNIVERSITY OF GOTHENBURG (Sweden)

b ACADIA Pharmaceuticals AB (Sweden)

c ACADIA PHARMACEUTICALS INC (United States)

Author keywords

Agonist; GRP14; Isochromane; Isochromanone; SAR; Tetrahydroisoquinolinone; Urotensin II; UT receptor

Indexed keywords

2 (4 CHLOROPHENYL) 2 (2 DIMETHYLAMINOETHYL) 1,2 DIHYDRO 3 OXA PHENANTHREN 4 ONE OXALATE; 3 (2 DIMETHYLAMINOETHYL) 3 (3 BIPHENYL)ISOCHROMAN 1 ONE; 3 (2 DIMETHYLAMINOETHYL) 3 (4 BIPHENYL)ISOCHROMAN 1 ONE; 3 (2 DIMETHYLAMINOETHYL) 3 [4 (2 PHENYLETHYNYL)PHENYL]ISOCHROMAN 1 ONE; 3 (2 DIMETHYLAMINOETHYL) 6,7 DIMETHYL 3 (2 NAPHTHYL)ISOCHROMAN 1 ONE; 3 (3 BIS ALLYLAMINOPHENYL) 3 (2 DIMETHYLAMINOETHYL)ISOCHROMAN 1 ONE; 3 (3 BROMOPHENYL) 3 (2 DIMETHYLAMINOETHYL)ISOCHROMAN 1 ONE; 3 (3,4 DICHLOROPHENYL) 3 (2 DIMETHYLAMINOETHYL)ISOCHROMAN 1 ONE; 3 (3,4 DICHLOROPHENYL) 6,7 DIMETHYL 3 (2 DIMETHYLAMINOETHYL)ISOCHROMAN 1 ONE; 3 (4 BIS ALLYLAMINOPHENYL) 3 (2 DIMETHYLAMINOETHYL)ISOCHROMAN 1 ONE; 3 (4 BROMOPHENYL) 3 (2 DIMETHYLAMINOETHYL)ISOCHROMAN 1 ONE; 3 (4 CHLOROPHENYL) 3 (2 DIMETHYLAMINOETHYL) 6 METHOXY 5 METHYL ISOCHROMAN 1 ONE OXALATE; 3 (4 CHLOROPHENYL) 3 (2 DIMETHYLAMINOETHYL) 6 METHOXY ISOCHROMAN 1 ONE OXALATE; 3 (4 CHLOROPHENYL) 3 (2 DIMETHYLAMINOETHYL) 6 PHENYLISOCHROMAN 1 ONE; 3 [2 (ALLYLMETHYLAMINO)ETHYL] 3 (4 CHLOROPHENYL)ISOCHROMAN 1 ONE OXALATE; 6 (BIS ALLYLAMINO) 3 (4 CHLOROPHENYL) 3 (2 DIMETHYLAMINOETHYL)ISOCHROMAN 1 ONE; CHROMAN DERIVATIVE; UNCLASSIFIED DRUG; UROTENSIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS;

BENZAMIDES; CHROMANS; HUMANS; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954218912 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.04.041 Document Type: Article

Times cited : (9)

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