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Volumn 13, Issue 8, 2005, Pages 3057-3068

Isochromanone-based urotensin-II receptor agonists

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 CHLOROPHENYL) 3 (2 DIMETHYLAMINOETHYL) 6,7 DIMETHYLISOCHROMAN 1 ONE; 3 (4 CHLOROPHENYL) 3 (2 DIMETHYLAMINOETHYL)ISOCHROMAN 1 ONE; ISOCHROMAN DERIVATIVE; UNCLASSIFIED DRUG; UROTENSIN II RECEPTOR AGONIST;

EID: 15244344609     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.01.056     Document Type: Article
Times cited : (24)

References (40)
  • 20
    • 85030813043 scopus 로고    scopus 로고
    • note
    • Exchanging the ketone for benzaldehyde increased the yield to 44% indicating that these reactions could be sensitive to steric hindrance
  • 24
    • 85030809107 scopus 로고    scopus 로고
    • note
    • It should be noted that the hydrochloride salts were hygroscopic and turned into oils when allowed to stand in contact with air for several hours
  • 26
    • 85030816056 scopus 로고    scopus 로고
    • note
    • Attempts were also performed using the corresponding iodide synthesized from the chloride via a Finkelstein reaction. This strategy was however equally unsuccessful as that using the chloride
  • 31
    • 0030898145 scopus 로고    scopus 로고
    • Initially, UII was considered to be a 'somatostatin-like' peptide, due to the presence of the tripeptide sequence Phe-Tyr-Lys. However, the two peptides are not evolutionary related. See e.g. J.M. Conlon, H. Tostivint, and H. Vaudry Regulatory Peptides 69 1997 95 103
    • (1997) Regulatory Peptides , vol.69 , pp. 95-103
    • Conlon, J.M.1    Tostivint, H.2    Vaudry, H.3
  • 36
    • 85030812999 scopus 로고    scopus 로고
    • note
    • It is of vital importance that the concentration is kept at this level. If a more concentrated solution is used local 'hot-spots' could occur resulting in the formation of a dark brown solid


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.