Bioavailability of seocalcitol. II: Development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides

European Journal of Pharmaceutical Sciences

Volumn 28, Issue 3, 2006, Pages 233-242

  Grove, Mette ^a,b   Müllertz, Anette ^b   Nielsen, Jeanet Løgsted ^a   Pedersen, Gitte Pommergaard ^a  

^a LEO PHARMA A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Lipid based formulations; Oral absorption; Oral bioavailability; Poorly soluble drug substances; Seocalcitol; SMEDDS; Stability

Indexed keywords

COSURFACTANT; CREMOPHOR; FLUPENTIXOL DECANOATE; GLYCEROL OLEATE; LIPID; LONG CHAIN TRIACYLGLYCEROL; MEDIUM CHAIN TRIACYLGLYCEROL; SEOCALCITOL; SESAME SEED OIL; SURFACTANT; VITAMIN D DERIVATIVE; WATER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DILUTION; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; IN VIVO STUDY; ISOTOPE LABELING; LIPID COMPOSITION; MALE; MICROEMULSION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; CALCITRIOL; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; INTESTINAL ABSORPTION; MOLECULAR STRUCTURE; OLEIC ACIDS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SESAME OIL; SOLUBILITY; SURFACE-ACTIVE AGENTS; TRIGLYCERIDES;

EID: 33646813333     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2006.02.005     Document Type: Article

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