Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693

BMC Genomics

Volumn 11, Issue 1, 2010, Pages

  Kumar, Rakesh ^a   Blakemore, Stephen J ^a   Ellis, Catherine E ^a   Petricoin III, Emanuel F ^b   Pratt, Dexter ^c   Macoritto, Michael ^c   Matthews, Andrea L ^c   Loureiro, Joseph J ^c   Elliston, Keith ^c  

^a GLAXOSMITHKLINE   (United States)

^b GEORGE MASON UNIVERSITY   (United States)

^c Genstruct Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 (4 AMINO 1,2,5 OXADIAZOL 3 YL) 1 ETHYL 7 (3 PIPERIDINYLMETHOXY) 1H IMIDAZO[4,5 C]PYRIDIN 4 YL] 2 METHYL 3 BUTYN 2 OL; CELL CYCLE PROTEIN; MYC PROTEIN; ONCOPROTEIN; PROTEIN KINASE B; PROTEIN RB1; PROTEIN TFRC; RNA; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CD71 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; FOXO3 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MYC PROTEIN, HUMAN; OXADIAZOLE DERIVATIVE; PHOSPHOPROTEIN; PROTEIN KINASE INHIBITOR; PROTEOME; RETINOBLASTOMA PROTEIN; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEOMICS; TRANSCRIPTOMICS; TUMOR XENOGRAFT; ANIMAL; BIOLOGICAL MODEL; CELL CYCLE; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; FEMALE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; HUMANS; MICE; MODELS, BIOLOGICAL; OXADIAZOLES; PHOSPHOPROTEINS; PROTEIN KINASE INHIBITORS; PROTEOME; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, TRANSFERRIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION, GENETIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77954181353     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-11-419     Document Type: Article

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