Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications

Metabolic Brain Disease

Volumn 25, Issue 1, 2010, Pages 39-48

  Montoliu, Carmina ^a   Rodrigo, Regina ^b   Monfort, Pilar ^b   Llansola, Marta ^b   Cauli, Omar ^b   Boix, Jordi ^b   Elmlili, Nisrin ^b   Agusti, Ana ^b   Felipo, Vicente ^b  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

cGMP; Guanylate cyclase; Hepatic encephalopathy; Hyperammonemia; Phosphodiesterase; Protein kinase G

Indexed keywords

AMMONIA; BICUCULLINE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; IBUPROFEN; NITRIC OXIDE; SILDENAFIL; ZAPRINAST;

BRAIN CORTEX; CELL SWELLING; CEREBELLUM; COGNITION; CONFERENCE PAPER; HEPATIC ENCEPHALOPATHY; HIPPOCAMPUS; HYPERAMMONEMIA; IN VIVO STUDY; LEARNING; LIVER CIRRHOSIS; LONG TERM POTENTIATION; LYMPHOCYTE; NONHUMAN; PREFRONTAL CORTEX; PSYCHOMETRY; SIGNAL TRANSDUCTION; TASK PERFORMANCE;

ANIMALS; BRAIN; CYCLIC GMP; GLUTAMIC ACID; HEPATIC ENCEPHALOPATHY; HUMANS; HYPERAMMONEMIA; LEARNING DISORDERS; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITORS; RATS; SIGNAL TRANSDUCTION;

RATTUS;

EID: 77954144763     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-010-9184-z     Document Type: Conference Paper

References (92)

1. MA Aguilar J Miñarro V Felipo 2000 Chronic moderate hyperammonemia impairs active, passive avoidance behavior, conditional discrimination learning in rats Exp Neurol 161 704 713 10.1006/exnr.1999.7299 1:CAS:528: DC%2BD3cXht1Ontbo%3D 10686089 (Pubitemid 30137027)
2. P Amodio F Del Piccolo P Marchetti P Angeli R Iemmolo L Caregaro C Merkel G Gerunda A Gatta 1999 Clinical features and survival of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests Hepatology 29 1662 1667 10.1002/hep. 510290619 1:STN:280:DyaK1M3nvVaktQ%3D%3D 10347105 (Pubitemid 29247036)
3. P Amodio S Montagnese A Gatta MY Morgan 2004 Characteristics of minimal hepatic encephalopathy Metab Brain Dis 19 253 267 10.1023/B:MEBR.0000043975. 01841.de 15554421 (Pubitemid 39361187)
4. CR Andrew EL Green DM Lawson RR Eady 2001 Resonance raman studies of cytochrome c' support the binding of NO and CO to opposite sides of the heme: implications for ligand discrimination in heme-based sensors Biochemistry 40 4115 4122 10.1021/bi0023652 1:CAS:528:DC%2BD3MXhsFKgs7g%3D 11300792 (Pubitemid 32280449)
5. CJ Barnstable JY Wei MH Han 2004 Modulation of synaptic function by cGMP and cGMP-gated cation channels Neurochem Int 45 875 884 10.1016/j.neuint.2004. 03.018 1:CAS:528:DC%2BD2cXmslOiu7w%3D 15312982 (Pubitemid 39108060)
6. R Bernabeu P Scmitz MP Faillace I Izquierdo JM Medina 1996 Hippocampal cGMP, cAMP are differentially involved in memory processing of inhibitory avoidance learning NeuroReport 7 585 588 10.1097/00001756-199601310-00050 1:CAS:528:DyaK28XisVCmsL0%3D 8730835
7. R Bernabeu N Schroder J Quevedo M Cammarota I Izquierdo JM Medina 1997 Further evidence for the involvement of a hippocampal cGMP/cGMP-dependent protein kinase cascade in memory consolidation NeuroReport 8 2221 2224 10.1097/00001756-199707070-00026 1:CAS:528:DyaK2sXlt1Wgsbo%3D 9243615
8. TVP Bliss GL Collingridge 1993 A synaptic model of memory: long-term potentiation in the hippocampus Nature 361 31 39 10.1038/361031a0 1:CAS:528:DyaK3sXntlOntw%3D%3D 8421494 (Pubitemid 23020772)
9. CL Boulton E Southam J Garthwaite 1995 Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase Neuroscience 69 699 703 10.1016/0306-4522(95)00349-N 1:CAS:528: DyaK2MXpsVGrsr8%3D 8596640
10. B Brune KU Schmidt V Ullrich 1990 Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion Eur J Biochem 192 683 688 10.1111/j.1432-1033.1990.tb19276.x 1:STN:280:DyaK3M%2Fgs1Wlsw%3D%3D 1976516
11. O Cauli R Rodrigo B Piedrafita J Boix V Felipo 2007 Inflammation, hepatic encephalopathy: ibuprofen restores learning ability in rats with porto-caval shunts Hepatology 46 514 519 10.1002/hep.21734 1:CAS:528:DC%2BD2sXhtVSisbzP 17659565 (Pubitemid 47344787)
12. O Cauli R Rodrigo J Boix B Piedrafita A Agusti V Felipo 2008 Acute liver failure-induced death of rats is delayed or prevented by blocking NMDA receptors in brain Am J Physiol Gastr Liv Physiol 295 G503 G511 1:CAS:528: DC%2BD1cXhtFCgt73E
13. O Cauli MT Mansouri A Agusti V Felipo 2009 Hyperammonemia increases GABAergic tone in cerebellum but decreases it in cortex of rats. Role in cognitive impairment Gastroenterology 136 1359 1367 10.1053/j.gastro.2008.12.057 1:CAS:528:DC%2BD1MXkslWgtrk%3D 19245864
14. R Corbalán MD Miñana JA Del Olmo MA Serra JM Rodrigo V Felipo 2002 Altered modulation of soluble guanylate cyclase in lymphocytes from patients with liver disease J Mol Med 80 117 123 10.1007/s00109-001-0286-2 11907648 (Pubitemid 34169819)
15. R Corbalán N Chatauret S Behrends RF Butterworth V Felipo 2002 Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients Hepatology 36 1155 1162 10.1053/jhep.2002.36365 12395325 (Pubitemid 35253431)
16. S Davis SP Butcher RG Morris 1992 The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro J Neurosci 12 21 34 1:CAS:528:DyaK38Xit1yks7g%3D 1345945
17. VL Dawson TM Dawson ED London DS Bredt SH Snyder 1991 Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures Proc Natl Acad Sci USA 88 6368 6371 10.1073/pnas.88.14.6368 1:CAS:528:DyaK3MXltVyis7s%3D 1648740
18. VL Dawson T Dawson DA Bartley GR Uhl SH Snyder 1993 Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures J Neurosci 13 2651 2661 1:CAS:528:DyaK3sXltFSktLg%3D 7684776
19. E Degerman P Belfrage VC Manganiello 1996 cGMP-inhibited phosphodiesterases (PDE3 gene family) Biochem Soc Trans 24 1010 1014 1:CAS:528:DyaK28XnsVOkt7c%3D 8968502
20. A Elithorn M Lunzer J Weinman 1975 Cognitive deficit associated with chronic hepatic encephalopathy and their response to levodopa J Neurol Neurosurg Psych 38 794 798 10.1136/jnnp.38.8.794 1:STN:280:DyaE28%2FkslCnug%3D%3D
21. N El-Mlili R Rodrigo B Naghizadeh O Cauli V Felipo 2008 Chronic hyperammonemia reduces the activity of neuronal nitric oxide synthase in cerebellum by altering its localization and increasing its phosphorylation by calcium-calmodulin kinase II J Neurochem 106 440 1449 10.1111/j.1471-4159.2008. 05495.x
22. S Erceg P Monfort M Hernández-Viadel M Llansola C Montoliu V Felipo 2005 Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain Brain Res 1036 115 121 10.1016/j.brainres.2004.12. 045 1:CAS:528:DC%2BD2MXhslWksbw%3D 15725408 (Pubitemid 40255850)
23. S Erceg P Monfort M Hernández-Viadel R Rodrigo C Montoliu V Felipo 2005 Oral administration of sildenafil restores learning ability in rats with hyperammonemia, with portacaval shunt Hepatology 45 2 10
24. E Fedele Y Jin G Varnier M Raiteri 1996 In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway Br J Pharmacol 119 590 594 1:CAS:528:DyaK28XmtF2htb0%3D 8894183
25. Felipo V (2008) Hyperammonemia. In Handbook of neurochemistry and molecular neurobiology, vol 24, 3rd edn. Kluwer Academic/Plenum, USA, pp 1-27
26. V Felipo RF Butterworth 2002 Neurobiology of ammonia Prog Neurobiol 67 259 279 10.1016/S0301-0082(02)00019-9 1:CAS:528:DC%2BD38Xms1Kisbk%3D 12207972 (Pubitemid 35229984)
27. V Felipo C Hermenegildo C Montoliu M Llansola MD Miñana 1998 Neurotoxicity of ammonia and glutamate: molecular mechanisms and prevention NeuroToxicology 19 675 682 1:CAS:528:DyaK1cXlvVCnu7Y%3D 9745928
28. P Ferenci A Lockwood K Mullen R Tarter K Weissenborn AT Blei 2002 Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998 Hepatology 35 716 721 10.1053/jhep.2002.31250 11870389 (Pubitemid 34183979)
29. LM García-Moreno NM Conejo H González-Pardo MA Aller MP Nava J Arias JL Arias 2005 Evaluation of two experimental models of hepatic encephalopathy in rats Braz J Med Biol Res 38 127 132 10.1590/S0100- 879X2005000100019 15665999
30. SJ Gilberstadt H Gilberstadt L Zieve B Buegel RO Collier Jr CJ McClain 1980 Psychomotor performance defects in cirrhotic patients without overt encephalopathy Arch Intern Med 140 519 521 10.1001/archinte.140.4.519 1:STN:280:DyaL3c7lt1Ghug%3D%3D 7362383 (Pubitemid 10156655)
31. N Gordon 2007 The cerebellum and cognition Eur J Paediatr Neurol 11 232 234 10.1016/j.ejpn.2007.02.003 17400009 (Pubitemid 46832170)
32. RD Hawkins 1996 NO honey, I don't remember Neuron 16 465 467 10.1016/S0896-6273(00)80064-1 1:CAS:528:DyaK28XhvFylsL0%3D 8785042 (Pubitemid 26101097)
33. C Hermenegildo G Marcaida C Montoliu S Grisolia MD Minana V Felipo 1996 NMDA receptor antagonists prevent acute ammonia toxicity in mice Neurochem Res 21 1237 1244 10.1007/BF02532401 1:CAS:528:DyaK28XmtlKntbw%3D 8923486 (Pubitemid 26357276)
34. C Hermenegildo C Montoliu M Llansola MD Muñoz JM Gaztelu MD Miñana V Felipo 1998 Chronic hyperammonemia impairs glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo Eur J NeuroSci 10 3201 3209 10.1046/j.1460-9568.1998.00329.x 1:STN:280:DyaK1M%2FgtVWmsA%3D%3D 9786213 (Pubitemid 29070616)
35. C Hermenegildo P Monfort V Felipo 2000 Activation of NMDA receptors in rat brain in vivo following acute ammonia intoxication. Characterization by in vivo brain microdialysis Hepatology 31 709 715 10.1002/hep.510310322 1:CAS:528:DC%2BD3cXhvFGjsrc%3D 10706562
36. W Hilgier SS Oja P Saransaari J Albrecht 2004 A novel glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/cGMP pathway by ammonia Brain Res 1015 186 188 10.1016/j.brainres. 2004.05.014 1:CAS:528:DC%2BD2cXlt1WgtL8%3D 15223384 (Pubitemid 38829754)
37. F Hofmann D Bernhard R Lukowski P Weinmeister 2009 cGMP regulated protein kinases (cGK) Handb Exp Pharmacol 191 137 162 10.1007/978-3-540-68964-5-8 1:CAS:528:DC%2BD1MXitlaisL4%3D 19089329
38. P Humbert F Niroomand G Fischer B Mayer D Koesling KD Hinsch H Gausepohl R Frank G Schultz E Bohme 1990 Purification of soluble guanylate cyclase from bovine lung by a new immunoaffinity chromatographic method Eur J Biochem 190 273 278 10.1111/j.1432-1033.1990.tb15572.x 1:CAS:528:DyaK3cXktVagtbc%3D 1973095 (Pubitemid 20201512)
39. XH Jin HM Siragy RM Carey 2001 Renal interstitial cGMP mediates natriuresis by direct tubule mechanism Hypertension 38 309 316 1:CAS:528:DC%2BD3MXoslWrtrY%3D 11566896
40. T Kleppisch 2009 Phosphodiesterases in the central nervous system Handb Exp Pharmacol 191 71 92 10.1007/978-3-540-68964-5-5 1:CAS:528: DC%2BD1MXitlais7o%3D 19089326
41. A Konopacka M Zielińska J Albrecht 2008 Ammonia inhibits the C-type natriuretic peptide-dependent cyclic GMP synthesis and calcium accumulation in a rat brain endothelial cell line Neurochem Int 52 1160 1166 10.1016/j.neuint.2007.12.005 1:CAS:528:DC%2BD1cXktVKlsLs%3D 18222015
42. A Konopacka FA Konopacki J Albrecht 2009 Protein kinase G is involved in ammonia-induced swelling of astrocytes J Neurochem 109 Suppl 1 246 251 10.1111/j.1471-4159.2009.05802.x 1:CAS:528:DC%2BD1MXlsFyktrc%3D 19393034
43. E Kosenko YG Kaminsky V Felipo MD Miñana S Grisolía 1993 Chronic hyperammonemia prevents changes in brain energy and ammonia metabolites induced by acute ammonium intoxication Biochim Biophys Acta 1180 321 326 1:CAS:528:DyaK3sXhtFynt78%3D 8422438
44. M Kuhn 2009 Function and dysfunction of mammalian membrane guanylyl cyclase receptors: lessons from genetic mouse models and implications for human diseases Handb Exp Pharmacol 191 47 69 10.1007/978-3-540-68964-5-4 1:CAS:528:DC%2BD1MXitlais7w%3D 19089325
45. CS Lin G Lin ZC Xin TF Lue 2006 Expression, distribution and regulation of phosphodiesterase 5 Curr Pharm Des 12 3439 3457 10.2174/138161206778343064 1:CAS:528:DC%2BD28XhtVGlt7%2FJ 17017938 (Pubitemid 44400482)
46. M Llansola M Hernandez-Viadel S Erceg C Montoliu V Felipo 2009 Increasing the function of the glutamate-nitric oxide-cGMP pathway increases the ability to learn a Y maze task J Neurosci Res 87 2351 2355 10.1002/jnr.22064 1:CAS:528:DC%2BD1MXnt1Sit7Y%3D 19326454
47. KA Lucas GM Pitari S Kazerounian I Ruiz-Stewart J Park S Schulz KP Chepenik SA Waldman 2000 Guanylyl cyclases and signaling by cyclic GMP Pharmacol Rev 52 375 414 1:CAS:528:DC%2BD3cXntFCmsbg%3D 10977868
48. G Marcaida V Felipo C Hermenegildo MD Miñana S Grisolía 1992 Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors FEBS Lett 296 67 68 10.1016/0014-5793(92)80404-5 1:CAS:528:DyaK38XnvVWisw%3D%3D 1346118
49. G Marcaida MD Miñana S Grisolía V Felipo 1995 Lack of correlation between glutamate-induced depletion of ATP and neuronal death in primary cultures of cerebellum Brain Res 695 146 150 10.1016/0006-8993(95)00703- S 1:CAS:528:DyaK2MXos1Ggs7c%3D 8556324
50. M McCrea J Cordoba G Vessey AT Blei C Randolph 1996 Neuropsychological characterization and detection of subclinical hepatic encephalopathy Arch Neurol 53 758 763 1:STN:280:DyaK28zis1Wkug%3D%3D 8759982
51. M Méndez M Méndez-López L López MA Aller J Arias JM Cimadevilla JL Arias 2008 Spatial memory alterations in three models of hepatic encephalopathy Behav Brain Res 188 32 40 10.1016/j.bbr.2007.10.019 18063138
52. M Méndez M Méndez-López L López MA Aller J Arias JL Arias 2008 Working memory impairment and reduced hippocampal and prefrontal cortex c-Fos expression in a rat model of cirrhosis Physiol Behav 95 302 307 10.1016/j.physbeh.2008.06.013 18634813
53. M Méndez M Méndez-López L López MA Aller J Arias JL Arias 2009 Associative learning deficit in two experimental models of hepatic encephalopathy Behav Brain Res 98 346 351 10.1016/j.bbr.2008.11.015
54. MD Miñana V Felipo S Grisolía 1988 Protective effect of long term ammonium ingestion against acute ammonium intoxication Biochem Biophys Res Commun 153 979 983
55. MD Miñana C Hermenegildo M Llansola C Montoliu S Grisolía V Felipo 1996 Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons J Pharmacol Exp Ther 279 194 199 8858993
56. P Monfort C Montoliu C Hermenegildo MD Muñoz V Felipo 2000 Differential effects of acute and chronic hyperammonemia on signal transduction pathways associated to NMDA receptors Neurochem Int 37 249 253 10.1016/S0197-0186(00)00027-9 1:CAS:528:DC%2BD3cXksF2gtrY%3D 10812210 (Pubitemid 30254157)
57. P Monfort R Corbalán L Martinez JC López-Talavera J Córdoba V Felipo 2001 Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis Neuroscience 104 1119 1125 10.1016/S0306-4522(01)00128-2 1:CAS:528:DC%2BD3MXlt1SitL4%3D 11457595 (Pubitemid 32701971)
58. P Monfort MD Muñoz E Kosenko V Felipo 2002 Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase and cGMP-degrading phosphodiesterase J Neurosci 22 10116 10122 1:CAS:528:DC%2BD38XpsVams74%3D 12451112
59. P Monfort MD Muñoz A ElAyadi E Kosenko V Felipo 2002 Effects of hyperammonemia and liver disease on glutamatergic neurotransmission Metab Brain Dis 17 237 250 10.1023/A:1021993431443 1:CAS:528:DC%2BD3sXislGktw%3D%3D 12602501 (Pubitemid 36204754)
60. P Monfort MD Muñoz V Felipo 2004 Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G Neurobiol Dis 15 1 10 10.1016/j.nbd.2003. 09.008 1:CAS:528:DC%2BD2cXntVOitw%3D%3D 14751765 (Pubitemid 38134375)
61. P Monfort MD Muñoz E Kosenko M Llansola A Sánchez- Pérez O Cauli V Felipo 2004 Sequential activation of soluble guanylate cyclase, protein kinase G and cGMP-degrading phosphodiesterase is necessary for proper induction of long-term potentiatio in CA1 of hippocampus. Alterations in hyperammonemia Neurochem Int 45 895 902 10.1016/j.neuint.2004.03.020 1:CAS:528:DC%2BD2cXmslOiu7o%3D 15312984 (Pubitemid 39108062)
62. P Monfort MD Muñoz V Felipo 2005 Chronic hyperammonemia in vivo impairs long-term potentiation in hippocampus by altering activation of cGMP dependent-protein kinase and of phosphodiesterase 5 J Neurochem 94 934 942 10.1111/j.1471-4159.2005.03236.x 1:CAS:528:DC%2BD2MXpsFCltrw%3D 16092938 (Pubitemid 41170582)
63. P Monfort S Erceg B Piedrafita M Llansola V Felipo 2007 Chronic liver failure in rats impairs glutamatergic synaptic transmission and long-term potentiation in hippocampus and learning ability Eur J NeuroSci 25 2103 2111 10.1111/j.1460-9568.2007.05444.x 17439494 (Pubitemid 46581728)
64. P Monfort O Cauli C Montoliu R Rodrigo M Llansola B Piedrafita N El Mlili J Boix A Agustí V Felipo 2009 Mechanisms of cognitive alterations in hyperammonemia and hepatic encephalopathy. Therapeutical implications Neurochem Int 55 106 112 10.1016/j.neuint.2009.01.021 1:CAS:528:DC%2BD1MXltVKrsrc%3D 19428813
65. C Montoliu M Llansola E Kosenko R Corbalán V Felipo 1999 Role of cyclic GMP in glutamate neurotoxicity in primary cultures of cerebellar neurons Neuropharmacology 38 1883 1891 10.1016/S0028-3908(99)00071-4 1:CAS:528:DyaK1MXotVOqs7Y%3D 10608283 (Pubitemid 29509726)
66. C Montoliu E Kosenko JJ Calvete A Nies JA Del Olmo MA Serra JM Rodrigo V Felipo 2004 Increased protein kinase A regulatory subunit and cGMP binding in erythrocyte membranes in liver cirrhosis J Hepatol 40 766 773 10.1016/j.jhep.2004.01.023 1:CAS:528:DC%2BD2cXjtFOiur4%3D 15094223 (Pubitemid 38507356)
67. C Montoliu E Kosenko JA Del Olmo MA Serra JM Rodrigo V Felipo 2005 Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis Liver Int 25 787 795 10.1111/j.1478-3231. 2005.01066.x 1:CAS:528:DC%2BD2MXpsVantrk%3D 15998430 (Pubitemid 41038660)
68. C Montoliu B Piedrafita MA Serra JA del Olmo A Ferrandez JM Rodrigo V Felipo 2007 Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients J Mol Med 85 233 241 10.1007/s00109-006-0149-y (Pubitemid 46295247)
69. MD Muñoz P Monfort JM Gaztelu V Felipo 2000 Hyperammonemia impairs NMDA receptor-dependent long-term potentiation in the CA1 of rat hippocampus in vitro Neurochem Res 25 437 441 10.1023/A:1007547622844 10823575 (Pubitemid 30317675)
70. M Oliveri S Torriero G Koch S Salerno L Petrosini C Caltagirone 2007 The role of transcranial magnetic stimulation in the study of cerebellar cognitive function Cerebellum 6 95 101 10.1080/14734220701213421 17366271 (Pubitemid 46410665)
71. B Piedrafita O Cauli C Montoliu V Felipo 2007 The function of the glutamate-nitric oxide-cGMP pathway in brain in vivo, learning ability decrease in parallel in mature compared to young rats Learn Mem 14 254 258 10.1101/lm.541307 1:CAS:528:DC%2BD1cXms1Oruro%3D 17412964 (Pubitemid 46625627)
72. B Piedrafita S Erceg O Cauli V Felipo 2008 Developmental exposure to polychlorinated biphenyls or methylmercury, but not to its combination, impairs the glutamate-nitric oxide-cyclic GMP pathway, learning in 3 months-old rats Neuroscience 1544 1408 1416 10.1016/j.neuroscience.2008.05.013
73. J Prickaerts A Sik WC van Staveren G Koopmans HW Steinbusch FJ van der Staay J de Vente A Blokland 2004 Phosphodiesterase type 5 inhibition improves early memory consolidation of object information Neurochem Int 45 915 928 10.1016/j.neuint.2004.03.022 1:CAS:528:DC%2BD2cXmslOiu7g%3D 15312986 (Pubitemid 39108064)
74. S Rehnström G Simert JA Hansson G Johnson J Vang 1977 Chronic hepatic encephalopathy. A psychometrical study Scand J Gastroenterol 12 305 311 10.3109/00365527709180932 866992
75. L Rikkers P Jenko D Rudman D Freides 1978 Subclinical hepatic encephalopathy: detection, prevalence, and relationship to nitrogen metabolism Gastroenterology 75 462 469 1:STN:280:DyaE1c3jvF2jug%3D%3D 680502
76. R Rodrigo C Montoliu N Chatauret R Butterworth S Behrends JA Del Olmo MA Serra JM Rodrigo S Erceg V Felipo 2004 Alterations in soluble guanylate cyclase content and modulation by nitric oxide in liver disease Neurochem Int 45 947 954 10.1016/j.neuint.2004.03.025 1:CAS:528:DC%2BD2cXmslOiu7c%3D 15312989 (Pubitemid 39108067)
77. R Rodrigo R Jover A Candela A Compañ J Sáez-Valero S Erceg V Felipo 2005 Bile duct ligation plus hyperammonemia in rats reproduces the alterations in the modulation of soluble guanylate cyclase by nitric oxide in brain of cirrhotic patients Neuroscience 130 435 443 10.1016/j.neuroscience. 2004.09.027 1:CAS:528:DC%2BD2MXhvFCluw%3D%3D 15664700 (Pubitemid 40125482)
78. R Rodrigo S Erceg V Felipo 2005 Neurons exposed to ammonia reproduce the differential alteration in nitric oxide modulation of guanylate cyclase in cerebellum and cortex of patients with liver cirrhosis Neurobiol Dis 19 150 161 10.1016/j.nbd.2004.12.001 1:CAS:528:DC%2BD2MXjtlajs7Y%3D 15837570 (Pubitemid 40544732)
79. R Rodrigo S Erceg J Rodriguez-Diaz J Saez-Valero B Piedrafita I Suarez V Felipo 2007 Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failure J Neurochem 102 51 64 10.1111/j.1471-4159.2006.04446.x 1:CAS:528:DC%2BD2sXnvVWjtLg%3D 17286583 (Pubitemid 46906252)
80. K Rutten JD Vente A Sik MM Ittersum J Prickaerts A Blokland 2005 The selective PDE5 inhibitor, sildenafil, improves object memory in Swiss mice and increases cGMP levels in hippocampal slices Behav Brain Res 164 11 16 10.1016/j.bbr.2005.04.021 1:CAS:528:DC%2BD2MXpvFalsrY%3D 16076505 (Pubitemid 41253727)
81. G Sager 2004 Cyclic GMP transporters Neurochem Int 45 865 873 10.1016/j.neuint.2004.03.017 1:CAS:528:DC%2BD2cXmslOiu78%3D 15312981 (Pubitemid 39108059)
82. H Schomerus W Hamster 1998 Neuropsychological aspects of portal-systemic encephalopathy Metab Brain Dis 13 361 377 10.1023/A:1020645110880 1:STN:280:DyaK1M7jvF2qsA%3D%3D 10206827 (Pubitemid 29063735)
83. S Smith HC Dringenberg BM Bennett GRJ Thatcher JN Reynolds 2000 A novel nitrate ester reverses the cognitive impairment caused by scopolamine in the Morris water maze NeuroReport 11 3883 3886 1:CAS:528:DC%2BD3cXovVams7Y%3D 11117508
84. JR Stone MA Marletta 1996 Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide Biochem 35 1093 1099 10.1021/bi9519718 1:CAS:528:DyaK28XivVeisw%3D%3D (Pubitemid 26050770)
85. RE Tarter AM Hegedus DH Van Thiel RR Schade JS Gavaler TE Starzl 1984 Nonalcoholic cirrhosis associated with neuropsychological dysfunction in the absence of overt evidence of hepatic encephalopathy Gastroenterology 86 1421 1427 1:STN:280:DyaL2c7otlChuw%3D%3D 6714571
86. RE Tarter AM Arria J Carra DH Van Thiel 1987 Memory impairments concomitant with nonalcoholic cirrhosis Int J Neurosci 32 853 859 10.3109/00207458709043340 1:STN:280:DyaL2s3kvFClug%3D%3D 3596928
87. HC Thiesson BL Jensen B Jespersen OBS de Muckadell C Bistrup S Walter PD Ottosen A Veje O Skott 2005 Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites Am J Physiol 288 F1044 F1052 10.1152/ajprenal.00142.2004 1:CAS:528:DC%2BD2MXktlSgtL8%3D (Pubitemid 40569770)
88. C Tzathas A Christidou SD Ladas 2002 Sildenafil (viagra) is a risk factor for acute variceal bleeding Am J Gastroenterol 97 1856 10.1111/j.1572-0241. 2002.05876.x 12135063
89. K Weissenborn S Heidenreich K Giewekemeyer N Rückert H Hecker 2003 Memory function in early hepatic encephalopathy J Hepatol 39 320 325 10.1016/S0168-8278(03)00295-2 12927916 (Pubitemid 37070247)
90. K Yamada M Hiramatsu Y Noda T Mamiya M Murai T Kameyama Y Komori T Nikai H Sugihara T Nabeshima 1996 Role of nitric oxide, cyclic GMP in the dizocilpine-induced impairment of spontaneous alternation behaviour in mice Neuroscience 74 365 374 10.1016/0306-4522(96)00161-3 1:CAS:528: DyaK28Xlt1Wqs7o%3D 8865189 (Pubitemid 26274208)
91. M Zaccolo MA Movsesian 2007 cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology Circ Res 100 1569 78 10.1161/CIRCRESAHA.106.144501 1:CAS:528:DC%2BD2sXmtVGjtLY%3D 17556670 (Pubitemid 46897260)
92. M Zielińska I Fresko A Konopacka V Felipo J Albrecht 2007 Hyperammonemia inhibits the natriuretic peptide receptor 2 (NPR-2)-mediated cyclic GMP synthesis in the astrocytic compartment of rat cerebral cortex slices Neurotoxicology 28 1260 1263 10.1016/j.neuro.2007.05.012 17629948 (Pubitemid 350026590)