CD11c+CD8+ T cells: Two-faced adaptive immune regulators

Cellular Immunology

Volumn 264, Issue 1, 2010, Pages 18-22

  Vinay, Dass S ^a   Kwon, Byoung S ^a,b  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b National Cancer Center   (South Korea)

Author keywords

4 1BB; CD11c+CD8+ T cells; GCN2; IDO; IFN

Indexed keywords

CD103 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR BETA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GCN2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ADOPTIVE TRANSFER; ANTIGEN EXPRESSION; AUTOIMMUNE DISEASE; CD11C+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CONTACT; COLITIS; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE MODEL; HUMAN; IMMUNE DEFICIENCY; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVIEW; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION;

ADAPTIVE IMMUNITY; ANIMALS; ANTIGENS, CD11C; ANTIGENS, CD8; ARTHRITIS, RHEUMATOID; CELL COMMUNICATION; COLITIS; CYTOKINES; HUMANS; IMMUNE TOLERANCE; IMMUNOTHERAPY, ADOPTIVE; MICE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

MUS;

EID: 77954141827     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.05.010     Document Type: Review

References (47)

1. Miller J.F.A.P., Mitchell G.F. Cell to cell interaction in the immune response: I. Hemolysin forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes. J. Exp. Med. 1968, 128:801-820.
2. Nishizuka Y., Sakakura T. Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science 1969, 166:753-755.
3. Gershon R.K., Kondo K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology 1970, 18:723-735.
4. Germain R.N. Special regulatory T-cell review: a rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm. Immunology 2008, 123:20-27.
5. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155:1151-1164.
6. Roy S., Barnes P.F., Garg A., Wum S., Cosmanm D., Vankayalapatim R. NK cells lyse regulatory cells that expand in response to an intracellular pathogen. J. Immunol. 2008, 180:1729-1736.
7. Chan C.W., Crafton E., Fan H.N., Flook J., Yoshimura K., Skarcia M., Brockstedt D., Dubensky T.W., Stins M.F., Lanier L.L., Pardoll D.M., Housseau F. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat. Med. 2006, 12:207-213.
8. Taieb J., Chaput N., Menard C., Apetoh L., Ulrich E., Bonmort M., Pequignot M., et al. A novel dendritic cell subset involved in tumor immunosurveillance. Nat. Med. 2006, 12:214-219.
9. + T cells. Recent Development in Immunology 2008, 57-71. Transworld Research Network, India. J. Jim Xiang (Ed.).
10. Mizoguchi A., Bhan A.K. A case for regulatory B cells. J. Immunol. 2006, 176:705-710.
11. Gershon R.K., Kondo K. Infectious tolerance. Immunology 1971, 21:903-914.
12. + Treg-mediated suppression. Trends Immunol. 2008, 29:337-342.
13. Wang Y.M., Alexander S.I. CD8 regulatory T cells: what's old is now new. Immunol. Cell Biol. 2009, 87:192-193.
14. + T cells. Eur. J. Immunol. 2009, 39:1552-1563.
15. Choi B.K., Asai T., Vinay D.S., Kim Y.H., Kwon B.S. 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms. Cytokine 2006, 34:233-242.
16. Seo S.K., Choi J.H., Kim Y.H., Kang W.J., Park Y.H., Suh J.H., Choi B.K., Vinay D.S., Kwon B.S. 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat. Med. 2004, 10:1088-1094.
17. Choi B.K., Kim Y.H., Kang W.J., Lee S.K., Kim S.H., Shin S.M., Yokoyama W.M., Kim T.Y., Kwon B.S. Mechanisms involved in synergistic anti-cancer immunity of anti-4-1BB and anti-CD4 therapy. Cancer Res. 2007, 67:8891-8899.
18. Keizer G.D., Borst J., Visser W., Schwarting R., de Vries J.E., Figdor C.G. Membrane glycoprotein p150, 95 of human cytotoxic T cell clone is involved in conjugate formation with target cells. J. Immunol. 1987, 138:3130-3136.
19. + T cells in vivo. J. Immunol. 1995, 154:5684-5693.
20. Kim S.W., Schluns K.S., Lefrancois L. Induction and visualization of mucosal CD8 T cells following systemic virus infection. J. Immunol. 1999, 163:4125-4132.
21. Ward C., Whitford H., Snell G., Bao H., Zheng L., Reid D., Williams T.J., Walters E.H. Bronchoalveolar lavage macrophage and lymphocyte phenotypes in lung transplant recipients. J. Heart Lung Transplant. 2001, 20:1064-1074.
22. + T cells following an acute virus infection. Eur. J. Immunol. 2003, 33:2736-2743.
23. Beyer M., Bartz H., Hörner K., Doths S., Koerner-Rettberg C., Schwarze J. Sustained increases in numbers of pulmonary dendritic cells following respiratory syncytial virus infection. J. Allergy Clin. Immunol. 2004, 113:127-133.
24. Beyer M., Wang H., Peters N., Doths S., Koerner-Rettberg C., Openshaw P.J.M., Schwarze J. The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo. Respir. Res. 2005, 6:70-81.
25. Kao J.K., Hsue Y.T., Lin C.Y. Role of new population of peripheral CD11c(+)CD8(+) T cells and CD4(+)CD25(+) regulatory T cells during acute and remission stages in rheumatoid arthritis patients. J. Microbiol. Immunol. Infect. 2007, 40:419-427.
26. Vinay D.S., Cha K., Kwon B.S. Dual immunoregulatory pathways of 4-1BB signaling. J. Mol. Med. 2006, 84:726-736.
27. Kim Y.H., Choi B.K., Kang W.J., Kim K.H., Kang S.W., Mellor A.L., Munn D.H., Kwon B.S. IFN-gamma-indoleamine-2,3-dioxygenase acts as a major suppressive factor in 4-1BB-mediated immune suppression in vivo. J. Leukobiol. 2009, 85:817-825.
28. Sharma M.D., Baban B., Chandler P., Hou D.Y., Singh N., Yagita H., Azuma M., Blazar B.R., Mellor A.L., Munn D.H. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J. Clin. Invest. 2007, 117:570-2582.
29. Munn D.H., Sharma M.D., Baban B., Harding H.P., Zhang Y., Ron D., Mellor A.L. GCN2 kinase in T cell mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 2005, 22:633-642.
30. + T cells. Cell. Immunol. 2005, 238:76-86.
31. Vinay D.S., Kim J.D., Kwon B.S. Amelioration of mercury-induced autoimmunity by 4-1BB. J. Immunol. 2006, 177:5708-5717.
32. - T cells in an autoimmune disease model. J. Clin. Invest. 2003, 112:1037-1048.
33. + T-cell maturation following lung transplantation: the differential impact of CMV and acute rejection. Transpl. Immunol. 2007, 18:186-192.
34. Jiang S., Lechler R.I., He X.S., Huang J.F. Regulatory T cells and transplantation tolerance. Hum. Immunol. 2006, 67:765-776.
35. S cells: the critical role of inhibitory receptors ILT3 and ILT4. Nat. Immunol. 2002, 3:237-243.
36. + T cells. J. Immunol. 2006, 177:2775-2783.
37. Rihs S., Walker C., Virchow J.C., Boer C., Kroegel C., Giri S.N., Braun R.K. Differential expression of alpha E beta 7 integrins on bronchoalveolar lavage T lymphocyte subsets: regulatory by alpha 4 beta 1-integrin crosslinking and TGF-beta. Am. J. Respir. Cell Mol. Biol. 1996, 15:600-610.
38. Sarnacki S., Bègue B., Buc H., Le Deist F., Cerf-Bensussan N. Enhancement of CD3-induced activation of human intestinal intraepithelial lymphocytes by stimulation of the beta 7-containing integrin defined by HML-1 monoclonal antibody. Eur. J. Immunol. 1992, 22:2887-2892.
39. + T lymphocytes. J. Invest. Dermatol. 2001, 117:569-575.
40. Kilshaw P.J., Baker K.C. A unique surface antigen on intraepithelial lymphocytes in the mouse. Immunol. Lett. 1988, 18:149-154.
41. Cerf-Bensussan N., Jarry A., Brousse N., Lisowska-Grospierre B., Guy-Grand D., Griscelli C. A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes. Eur. J. Immunol. 1987, 17:1279-1285.
42. Hamann A., Andrew D.P., Jablonski-Westrich D., Holzmann B., Butcher E.C. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J. Immunol. 1994, 152:3282-3293.
43. Ahmadzadeh M., Antony P.A., Rosenberg S.A. IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells. J. Immunother. 2007, 30:294-302.
44. Peng Y., Shao H., Ke Y., Zhang P., Han G., Kaplan H.J., Sun D. Minimally activated CD8 autoreactive T cells specific for IRBP express a high level of Foxp3 and are functionally suppressive. Invest. Opthalmol. Vis. Sci. 2007, 48:2178-2184.
45. + T cells with a regulatory phenotype and function. Eur. J. Immunol. 2005, 35:2896-2908.
46. + T cells upon antigen recognition in vitro. J. Immunol. 2007, 179:1039-1048.
47. + T cells. J. Immunol. 2005, 175:7093-7097.