-
1
-
-
34250020201
-
Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
-
El-Serag HB, Rudolph KL: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132, 2557-2576 (2007).
-
(2007)
Gastroenterology
, vol.132
, pp. 2557-2576
-
-
El-Serag, H.B.1
Rudolph, K.L.2
-
3
-
-
58949095678
-
Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of US veterans
-
El-Serag HB, Engels EA, Landgren O et al.: Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: a population-based study of US veterans. Hepatology 49, 116-123 (2009).
-
(2009)
Hepatology
, vol.49
, pp. 116-123
-
-
El-Serag, H.B.1
Engels, E.A.2
Landgren, O.3
-
4
-
-
40849139208
-
Epigenetics in cancer
-
Esteller M: Epigenetics in cancer. N. Engl. J. Med. 358, 1148-1159 (2008).
-
(2008)
N. Engl. J. Med
, vol.358
, pp. 1148-1159
-
-
Esteller, M.1
-
5
-
-
33846463379
-
Transcriptome classifcation of HCC is related to gene alterations and to new therapeutic targets
-
Boyault S, Rickman DS, de Reynies A et al.: Transcriptome classifcation of HCC is related to gene alterations and to new therapeutic targets. Hepatology 45, 42-52 (2007).
-
(2007)
Hepatology
, vol.45
, pp. 42-52
-
-
Boyault, S.1
Rickman, D.S.2
De Reynies, A.3
-
7
-
-
68349160654
-
Epigenetic events in gastrointestinal cancer
-
Selaru FM, David S, Meltzer SJ, Hamilton JP: Epigenetic events in gastrointestinal cancer. Am. J. Gastroenterol. 104, 1910-1912 (2009).
-
(2009)
Am. J. Gastroenterol
, vol.104
, pp. 1910-1912
-
-
Selaru, F.M.1
David, S.2
Meltzer, S.J.3
Hamilton, J.P.4
-
8
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
Herman JG, Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349, 2042-2054 (2003).
-
(2003)
N. Engl. J. Med
, vol.349
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
9
-
-
23744461983
-
Transposons reanimated in mice
-
Bestor TH: Transposons reanimated in mice. Cell 122, 322-325 (2005).
-
(2005)
Cell
, vol.122
, pp. 322-325
-
-
Bestor, T.H.1
-
10
-
-
0036392059
-
DNA methylation and genomic imprinting: Insights from cancer into epigenetic mechanisms
-
Feinberg AP, Cui H, Ohlsson R: DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms. Semin. Cancer Biol. 12, 389-398 (2002).
-
(2002)
Semin. Cancer Biol
, vol.12
, pp. 389-398
-
-
Feinberg, A.P.1
Cui, H.2
Ohlsson, R.3
-
11
-
-
17744391429
-
Co-evolution of X-chromosome inactivation and imprinting in mammals
-
Reik W, Lewis A: Co-evolution of X-chromosome inactivation and imprinting in mammals. Nat. Rev. Genet. 6, 403-410 (2005).
-
(2005)
Nat. Rev. Genet
, vol.6
, pp. 403-410
-
-
Reik, W.1
Lewis, A.2
Reik, W.3
Lewis, A.4
-
12
-
-
0020699979
-
Hypomethylation distinguishes genes of some human cancers from their normal counterparts
-
Feinberg AP, Vogelstein B: Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301, 89-92 (1983).
-
(1983)
Nature
, vol.301
, pp. 89-92
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
15
-
-
0037068353
-
DNA methylation in cancer: Too much, but also too little
-
Ehrlich M: DNA methylation in cancer: too much, but also too little. Oncogene 21, 5400-5413 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 5400-5413
-
-
Ehrlich, M.1
-
16
-
-
4143140030
-
A mouse skin multistage carcinogenesis model refects the aberrant DNA methylation patterns of human tumors
-
Fraga MF, Herranz M, Espada J et al.: A mouse skin multistage carcinogenesis model refects the aberrant DNA methylation patterns of human tumors. Cancer Res. 64, 5527-5534 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 5527-5534
-
-
Fraga, M.F.1
Herranz, M.2
Espada, J.3
-
17
-
-
34447625911
-
Epigenetics and aging: The targets and the marks
-
Fraga MF, Esteller M: Epigenetics and aging: the targets and the marks. Trends Genet. 23, 413-418 (2007).
-
(2007)
Trends Genet
, vol.23
, pp. 413-418
-
-
Fraga, M.F.1
Esteller, M.2
-
18
-
-
0029843950
-
Methylation-specifc PCR: A novel PCR assay for methylation status of CpG islands
-
Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB: Methylation-specifc PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl Acad. Sci. USA 93, 9821-9826 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 9821-9826
-
-
Herman, J.G.1
Graff, J.R.2
Myohanen, S.3
Nelkin, B.D.4
Baylin, S.B.5
-
19
-
-
4444346815
-
De novo quantitative bisulfte sequencing using the pyrosequencing technology
-
Dupont JM, Tost J, Jammes H, Gut IG: De novo quantitative bisulfte sequencing using the pyrosequencing technology. Anal. Biochem. 333, 119-127 (2004).
-
(2004)
Anal. Biochem
, vol.333
, pp. 119-127
-
-
Dupont, J.M.1
Tost, J.2
Jammes, H.3
Gut, I.G.4
-
20
-
-
23044514626
-
Chromosome-wide and promoter-specifc analyses identify sites of differential DNA methylation in normal and transformed human cells
-
Weber M, Davies JJ, Wittig D et al.: Chromosome-wide and promoter-specifc analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat. Genet. 37, 853-862 (2005).
-
(2005)
Nat. Genet
, vol.37
, pp. 853-862
-
-
Weber, M.1
Davies, J.J.2
Wittig, D.3
-
21
-
-
0033563165
-
Identifcation of differentially methylated sequences in colorectal cancer by methylated CpG island amplifcation
-
Toyota M, Ho C, Ahuja N et al.: Identifcation of differentially methylated sequences in colorectal cancer by methylated CpG island amplifcation. Cancer Res. 59, 2307-2312 (1999).
-
(1999)
Cancer Res
, vol.59
, pp. 2307-2312
-
-
Toyota, M.1
Ho, C.2
Ahuja, N.3
-
23
-
-
0348134871
-
Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer
-
Ballestar E, Paz MF, Valle L et al.: Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. EMBO J. 22, 6335-6345 (2003).
-
(2003)
EMBO J
, vol.22
, pp. 6335-6345
-
-
Ballestar, E.1
Paz, M.F.2
Valle, L.3
-
24
-
-
33847065486
-
The epigenomics of cancer
-
Jones PA, Baylin SB: The epigenomics of cancer. Cell 128, 683-692 (2007).
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
25
-
-
70349100446
-
Histone deacetylase inhibitors: Current status and overview of recent clinical trials
-
Ma X, Ezzeldin HH, Diasio RB: Histone deacetylase inhibitors: current status and overview of recent clinical trials. Drugs 69, 1911-1934 (2009).
-
(2009)
Drugs
, vol.69
, pp. 1911-1934
-
-
Ma, X.1
Ezzeldin, H.H.2
Diasio, R.B.3
-
26
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histone-modifcation maps
-
Esteller M: Cancer epigenomics: DNA methylomes and histone-modifcation maps. Nat. Rev. Genet. 8, 286-298 (2007).
-
(2007)
Nat. Rev. Genet
, vol.8
, pp. 286-298
-
-
Esteller, M.1
-
27
-
-
84984555343
-
Hepatitis B e antigen and the risk of hepatocellular carcinoma
-
Yang HI, Lu SN, Liaw YF et al.: Hepatitis B e antigen and the risk of hepatocellular carcinoma. N. Engl. J. Med. 347, 168-174 (2002).
-
(2002)
N. Engl. J. Med
, vol.347
, pp. 168-174
-
-
Yang, H.I.1
Lu, S.N.2
Liaw, Y.F.3
-
28
-
-
28844480321
-
Management of hepatocellular carcinoma
-
Bruix J, Sherman M: Management of hepatocellular carcinoma. Hepatology 42, 1208-1236 (2005).
-
(2005)
Hepatology
, vol.42
, pp. 1208-1236
-
-
Bruix, J.1
Sherman, M.2
-
29
-
-
0036614299
-
Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B
-
Hsu YS, Chien RN, Yeh CT et al.: Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. Hepatology 35, 1522-1527 (2002).
-
(2002)
Hepatology
, vol.35
, pp. 1522-1527
-
-
Hsu, Y.S.1
Chien, R.N.2
Yeh, C.T.3
-
30
-
-
15844415447
-
An afatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico
-
Soini Y, Chia SC, Bennett WP et al.: An afatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico. Carcinogenesis 17, 1007-1012 (1996).
-
(1996)
Carcinogenesis
, vol.17
, pp. 1007-1012
-
-
Soini, Y.1
Chia, S.C.2
Bennett, W.P.3
-
31
-
-
77954119208
-
Molecular and functional genetics of hepatocellular carcinoma
-
Yam JW, Wong CM, Ng IO: Molecular and functional genetics of hepatocellular carcinoma. Front. Biosci. (Schol. Ed.) 2, 117-134 (2010).
-
(2010)
Front. Biosci. (Schol. Ed.)
, vol.2
, pp. 117-134
-
-
Yam, J.W.1
Wong, C.M.2
Ng, I.O.3
-
32
-
-
0036386996
-
Mechanisms underlying epigenetically mediated gene silencing in cancer
-
Baylin SB: Mechanisms underlying epigenetically mediated gene silencing in cancer. Semin. Cancer Biol. 12, 331-337 (2002).
-
(2002)
Semin. Cancer Biol
, vol.12
, pp. 331-337
-
-
Baylin, S.B.1
-
33
-
-
34848881905
-
Mechanistic and prognostic signifcance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma
-
Calvisi DF, Ladu S, Gorden A et al.: Mechanistic and prognostic signifcance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. J. Clin. Invest. 117, 2713-2722 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 2713-2722
-
-
Calvisi, D.F.1
Ladu, S.2
Gorden, A.3
-
34
-
-
20344366296
-
Hepatocellular carcinoma: Molecular pathways and new therapeutic targets
-
Roberts LR, Gores GJ: Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin. Liver Dis. 25, 212-225 (2005).
-
(2005)
Semin. Liver Dis
, vol.25
, pp. 212-225
-
-
Roberts, L.R.1
Gores, G.J.2
-
35
-
-
61349143203
-
Prognostic implications of and relationship between CpG island hypermethylation and repetitive DNA hypomethylation in hepatocellular carcinoma
-
Lee HS, Kim BH, Cho NY et al.: Prognostic implications of and relationship between CpG island hypermethylation and repetitive DNA hypomethylation in hepatocellular carcinoma. Clin. Cancer Res. 15, 812-820 (2009).
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 812-820
-
-
Lee, H.S.1
Kim, B.H.2
Cho, N.Y.3
-
36
-
-
4544273428
-
Classifcation and prediction of survival in hepatocellular carcinoma by gene expression profling
-
Lee JS, Chu IS, Heo J et al.: Classifcation and prediction of survival in hepatocellular carcinoma by gene expression profling. Hepatology 40, 667-676 (2004).
-
(2004)
Hepatology
, vol.40
, pp. 667-676
-
-
Lee, J.S.1
Chu, I.S.2
Heo, J.3
-
37
-
-
58149376548
-
Molecular mechanisms of hepatocellular carcinoma
-
Aravalli RN, Steer CJ, Cressman EN: Molecular mechanisms of hepatocellular carcinoma. Hepatology 48, 2047-2063 (2008).
-
(2008)
Hepatology
, vol.48
, pp. 2047-2063
-
-
Aravalli, R.N.1
Steer, C.J.2
Cressman, E.N.3
-
38
-
-
77954112841
-
Epigenetic disruption of the WNT/p-catenin signaling pathway in human cancers
-
Ying Y, Tao Q: Epigenetic disruption of the WNT/p-catenin signaling pathway in human cancers. Epigenetics 4, 307-312 (2009).
-
(2009)
Epigenetics
, vol.4
, pp. 307-312
-
-
Ying, Y.1
Tao, Q.2
-
39
-
-
41049096579
-
APC promoter methylation and protein expression in hepatocellular carcinoma
-
Csepregi A, Rocken C, Hoffmann J et al.: APC promoter methylation and protein expression in hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 134, 579-589 (2008).
-
(2008)
J. Cancer Res. Clin. Oncol
, vol.134
, pp. 579-589
-
-
Csepregi, A.1
Rocken, C.2
Hoffmann, J.3
-
40
-
-
0035754080
-
To cycle or not to cycle: A critical decision in cancer
-
Malumbres M, Barbacid M: To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 1, 222-231 (2001).
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
41
-
-
0033590404
-
INK4A gene alterations in hepatocellular carcinoma
-
INK4A gene alterations in hepatocellular carcinoma. Oncogene 18, 789-795 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 789-795
-
-
Liew, C.T.1
Li, H.M.2
Lo, K.W.3
-
42
-
-
0032924622
-
INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
-
INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma. Gastroenterology 116, 394-400 (1999).
-
(1999)
Gastroenterology
, vol.116
, pp. 394-400
-
-
Matsuda, Y.1
Ichida, T.2
Matsuzawa, J.3
-
43
-
-
0034235843
-
P16 is a major inactivation target in hepatocellular carcinoma
-
Jin M, Piao Z, Kim NG et al.: p16 is a major inactivation target in hepatocellular carcinoma. Cancer 89, 60-68 (2000).
-
(2000)
Cancer
, vol.89
, pp. 60-68
-
-
Jin, M.1
Piao, Z.2
Kim, N.G.3
-
44
-
-
18444369018
-
Methylation framework of cell-cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma
-
Roncalli M, Bianchi P, Bruni B et al.: Methylation framework of cell-cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. Hepatology 36, 427-432 (2002).
-
(2002)
Hepatology
, vol.36
, pp. 427-432
-
-
Roncalli, M.1
Bianchi, P.2
Bruni, B.3
-
45
-
-
0141648473
-
Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
-
Lee S, Lee HJ, Kim JH et al.: Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am. J. Pathol. 163, 1371-1378 (2003). (Pubitemid 37175085)
-
(2003)
American Journal of Pathology
, vol.163
, Issue.4
, pp. 1371-1378
-
-
Lee, S.1
Lee, H.J.2
Kim, J.-H.3
Lee, H.-S.4
Jang, J.J.5
Kang, G.H.6
-
46
-
-
33746340651
-
Afatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients
-
Zhang YJ, Rossner P Jr, Chen Y et al.: Afatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients. Int. J. Cancer 119, 985-991 (2006).
-
(2006)
Int. J. Cancer
, vol.119
, pp. 985-991
-
-
Zhang, Y.J.1
Rossner Jr., P.2
Chen, Y.3
-
47
-
-
34247895661
-
Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA
-
Zhang YJ, Wu HC, Shen J et al.: Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. Clin. Cancer Res. 13, 2378-2384 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 2378-2384
-
-
Zhang, Y.J.1
Wu, H.C.2
Shen, J.3
-
48
-
-
41849142290
-
Molecular mechanism underlying the functional loss of cyclin-dependent kinase inhibitors p16 and p27 in hepatocellular carcinoma
-
Matsuda Y: Molecular mechanism underlying the functional loss of cyclin-dependent kinase inhibitors p16 and p27 in hepatocellular carcinoma. World J. Gastroenterol. 14, 1734-1740 (2008).
-
(2008)
World J. Gastroenterol
, vol.14
, pp. 1734-1740
-
-
Matsuda, Y.1
-
50
-
-
0033818628
-
Frequent p 15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients
-
Wong IH, Lo YM, Yeo W, Lau WY, Johnson PJ: Frequent p 15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients. Clin. Cancer Res. 6, 3516-3521 (2000).
-
(2000)
Clin. Cancer Res
, vol.6
, pp. 3516-3521
-
-
Wong, I.H.1
Lo, Y.M.2
Yeo, W.3
Lau, W.Y.4
Johnson, P.J.5
-
51
-
-
69949129964
-
RAS pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
-
Newell P, Toffanin S, Villanueva A et al.: RAS pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J. Hepatol. 51, 725-733 (2009).
-
(2009)
J. Hepatol
, vol.51
, pp. 725-733
-
-
Newell, P.1
Toffanin, S.2
Villanueva, A.3
-
52
-
-
42949176197
-
RAS promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma
-
Yea S, Narla G, Zhao X et al.: RAS promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma. Gastroenterology 134, 1521-1531 (2008).
-
(2008)
Gastroenterology
, vol.134
, pp. 1521-1531
-
-
Yea, S.1
Narla, G.2
Zhao, X.3
-
53
-
-
25844494372
-
Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma
-
Yasuda E, Kumada T, Takai S et al.: Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma. Biochem. Biophys. Res. Commun. 337, 337-342 (2005).
-
(2005)
Biochem. Biophys. Res. Commun
, vol.337
, pp. 337-342
-
-
Yasuda, E.1
Kumada, T.2
Takai, S.3
-
54
-
-
41849111637
-
DNA methylation in hepatocellular carcinoma
-
Tischoff I, Tannapfe A: DNA methylation in hepatocellular carcinoma. World J. Gastroenterol. 14, 1741-1748 (2008).
-
(2008)
World J. Gastroenterol
, vol.14
, pp. 1741-1748
-
-
Tischoff, I.1
Tannapfe, A.2
-
55
-
-
3042707323
-
Methylation profling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
-
Yu J, Ni M, Xu J et al.: Methylation profling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer 2, 29 (2002).
-
(2002)
BMC Cancer
, vol.2
, pp. 29
-
-
Yu, J.1
Ni, M.2
Xu, J.3
-
56
-
-
35648947815
-
Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma
-
Nomoto S, Kinoshita T, Kato K et al.: Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma. Br. J. Cancer 97, 1260-1265 (2007).
-
(2007)
Br. J. Cancer
, vol.97
, pp. 1260-1265
-
-
Nomoto, S.1
Kinoshita, T.2
Kato, K.3
-
57
-
-
43049141867
-
Quantitative promoter methylation ana lysis of hepatocellular carcinoma, cirrhotic and normal liver
-
Harder J, Opitz OG, Brabender J et al.: Quantitative promoter methylation ana lysis of hepatocellular carcinoma, cirrhotic and normal liver. Int. J. Cancer 122, 2800-2804 (2008).
-
(2008)
Int. J. Cancer
, vol.122
, pp. 2800-2804
-
-
Harder, J.1
Opitz, O.G.2
Brabender, J.3
-
58
-
-
18244398914
-
Promoter methylation of E-cadherin in hepatocellular carcinomas and dysplastic nodules
-
Kwon GY, Yoo BC, Koh KC, Cho JW, Park WS, Park CK: Promoter methylation of E-cadherin in hepatocellular carcinomas and dysplastic nodules. J. Korean Med. Sci. 20, 242-247 (2005).
-
(2005)
J. Korean Med. Sci
, vol.20
, pp. 242-247
-
-
Kwon, G.Y.1
Yoo, B.C.2
Koh, K.C.3
Cho, J.W.4
Park, W.S.5
Park, C.K.6
-
59
-
-
33744745285
-
Promoter methylation and response to chemotherapy and radiation in esophageal cancer
-
Hamilton JP, Sato F, Greenwald BD et al.: Promoter methylation and response to chemotherapy and radiation in esophageal cancer. Clin. Gastroenterol. Hepatol. 4, 701-708 (2006).
-
(2006)
Clin. Gastroenterol. Hepatol
, vol.4
, pp. 701-708
-
-
Hamilton, J.P.1
Sato, F.2
Greenwald, B.D.3
-
60
-
-
41149143617
-
Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray
-
Wang Y, Zhang D, Zheng W, Luo J, Bai Y, Lu Z: Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray. Cancer 112, 1325-1336 (2008).
-
(2008)
Cancer
, vol.112
, pp. 1325-1336
-
-
Wang, Y.1
Zhang, D.2
Zheng, W.3
Luo, J.4
Bai, Y.5
Lu, Z.6
-
61
-
-
38849165454
-
Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer
-
Hoque MO, Begum S, Brait M et al.: Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. J. Urol. 179, 743-747 (2008).
-
(2008)
J. Urol
, vol.179
, pp. 743-747
-
-
Hoque, M.O.1
Begum, S.2
Brait, M.3
-
62
-
-
0347325030
-
Relationship between TIMP-3 expression and promoter methylation of TIMP-3 gene in hepatocellular carcinoma
-
Lu GL, Wen JM, Xu JM, Zhang M, Xu RB, Tian BL: [Relationship between TIMP-3 expression and promoter methylation of TIMP-3 gene in hepatocellular carcinoma]. Zhonghua Bing Li Xue Za Zhi 32, 230-233 (2003).
-
(2003)
Zhonghua Bing Li Xue Za Zhi
, vol.32
, pp. 230-233
-
-
Lu, G.L.1
Wen, J.M.2
Xu, J.M.3
Zhang, M.4
Xu, R.B.5
Tian, B.L.6
-
63
-
-
66349102768
-
Methylation of TFPI2 in stool DNA: A potential novel biomarker for the detection of colorectal cancer
-
Glockner SC, Dhir M, Yi JM et al.: Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer. Cancer Res. 69, 4691-4699 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 4691-4699
-
-
Glockner, S.C.1
Dhir, M.2
Yi, J.M.3
-
64
-
-
34248664108
-
Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma
-
Wong CM, Ng YL, Lee JM et al.: Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. Hepatology 45, 1129-1138 (2007).
-
(2007)
Hepatology
, vol.45
, pp. 1129-1138
-
-
Wong, C.M.1
Ng, Y.L.2
Lee, J.M.3
-
65
-
-
41849114326
-
Methylation pattern of DNA repair genes and microsatellite instability in hepatocellular carcinoma
-
Park JH, Cho SB, Lee WS et al.: [Methylation pattern of DNA repair genes and microsatellite instability in hepatocellular carcinoma]. Korean J. Gastroenterol. 48, 327-336 (2006).
-
(2006)
Korean J Gastroenterol
, vol.48
, pp. 327-336
-
-
Park, J.H.1
Cho, S.B.2
Lee, W.S.3
-
66
-
-
0037463277
-
CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection
-
Matsukura S, Soejima H, Nakagawachi T et al.: CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection. Br. J. Cancer 88, 521-529 (2003).
-
(2003)
Br. J. Cancer
, vol.88
, pp. 521-529
-
-
Matsukura, S.1
Soejima, H.2
Nakagawachi, T.3
-
67
-
-
0022931463
-
6 alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues
-
6 alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis 7, 745-749 (1986).
-
(1986)
Carcinogenesis
, vol.7
, pp. 745-749
-
-
Gerson, S.L.1
Trey, J.E.2
Miller, K.3
Berger, N.A.4
-
68
-
-
34548090762
-
Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma
-
Su PF, Lee TC, Lin PJ et al.: Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma. Int. J. Cancer 121, 1257-1264 (2007).
-
(2007)
Int. J. Cancer
, vol.121
, pp. 1257-1264
-
-
Su, P.F.1
Lee, T.C.2
Lin, P.J.3
-
69
-
-
33646091508
-
Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients
-
Wang J, Qin Y, Li B, Sun Z, Yang B: Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients. Clin. Biochem. 39, 344-348 (2006).
-
(2006)
Clin. Biochem
, vol.39
, pp. 344-348
-
-
Wang, J.1
Qin, Y.2
Li, B.3
Sun, Z.4
Yang, B.5
-
70
-
-
40949161396
-
Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
-
Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A: Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 47, 908-918 (2008).
-
(2008)
Hepatology
, vol.47
, pp. 908-918
-
-
Nishida, N.1
Nagasaka, T.2
Nishimura, T.3
Ikai, I.4
Boland, C.R.5
Goel, A.6
-
71
-
-
67651173046
-
Promoter methylation in the genesis of gastrointestinal cancer
-
Boland CR, Shin SK, Goel A: Promoter methylation in the genesis of gastrointestinal cancer. Yonsei Med. J. 50, 309-321 (2009).
-
(2009)
Yonsei Med. J
, vol.50
, pp. 309-321
-
-
Boland, C.R.1
Shin, S.K.2
Goel, A.3
-
72
-
-
69049084616
-
Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation
-
Lee H, Ryu SH, Hong SS et al.: Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation. J. Gastroenterol. Hepatol. 24, 1445-1450 (2009).
-
(2009)
J. Gastroenterol. Hepatol
, vol.24
, pp. 1445-1450
-
-
Lee, H.1
Ryu, S.H.2
Hong, S.S.3
-
73
-
-
33646142159
-
Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl defciency in rats
-
Pogribny IP, Ross SA, Tryndyak V P, Pogribna M, Poirier LA, Karpinets TV: Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl defciency in rats. Carcinogenesis 27, 1180-1186 (2006).
-
(2006)
Carcinogenesis
, vol.27
, pp. 1180-1186
-
-
Pogribny, I.P.1
Ross, S.A.2
Tryndyak, V.P.3
Pogribna, M.4
Poirier, L.A.5
Karpinets, T.V.6
-
74
-
-
20144371437
-
Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors
-
Tischoff I, Markwarth A, Witzigmann H et al.: Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors. Int. J. Cancer 115, 684-689 (2005).
-
(2005)
Int. J. Cancer
, vol.115
, pp. 684-689
-
-
Tischoff, I.1
Markwarth, A.2
Witzigmann, H.3
-
76
-
-
66149110971
-
MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3
-
Selaru FM, Olaru AV, Kan T et al.: MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. Hepatology 49, 1595-1601 (2009).
-
(2009)
Hepatology
, vol.49
, pp. 1595-1601
-
-
Selaru, F.M.1
Olaru, A.V.2
Kan, T.3
-
77
-
-
70649095120
-
Differential methylation of tissue-and cancer-specifc CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fbroblasts
-
Doi A, Park IH, Wen B et al.: Differential methylation of tissue-and cancer-specifc CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fbroblasts. Nat. Genet. 41, 1350-1353 (2009).
-
(2009)
Nat. Genet
, vol.41
, pp. 1350-1353
-
-
Doi, A.1
Park, I.H.2
Wen, B.3
-
78
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V et al.: Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378-390 (2008).
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
79
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
Liu L, Cao Y, Chen C et al.: Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 66, 11851-11858 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
-
80
-
-
57349087153
-
Pivotal role of mTOR signaling in hepatocellular carcinoma
-
1983 E1-E11
-
Villanueva A, Chiang DY, Newell P et al.: Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 135, 1972-1983, 1983 E1-E11 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 1972-1983
-
-
Villanueva, A.1
Chiang, D.Y.2
Newell, P.3
-
81
-
-
33645976174
-
Ubiquitous activation of RAS and JAK/STAT pathways in human HCC
-
Calvisi DF, Ladu S, Gorden A et al.: Ubiquitous activation of RAS and JAK/STAT pathways in human HCC. Gastroenterology 130, 1117-1128 (2006).
-
(2006)
Gastroenterology
, vol.130
, pp. 1117-1128
-
-
Calvisi, D.F.1
Ladu, S.2
Gorden, A.3
|