Effects of hypoglycaemia on neurotransmitter and hormone receptor gene expression in laser-dissected arcuate neuropeptide y/agouti-related peptide neurones

Journal of Neuroendocrinology

Volumn 22, Issue 6, 2010, Pages 599-607

  Briski, K P ^a   Nedungadi, T P ^a   Koshy Cherian, A ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Estrogen receptor ; Estrogen receptor ; Glucocorticoid receptor; Insulin receptor; Laser catapult microdissection; Neuropeptide Y; Neutral protamine Hagedorn insulin

Indexed keywords

AGOUTI RELATED PROTEIN; ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; GLUCOKINASE; HORMONE RECEPTOR; INSULIN; ISOPHANE INSULIN; MESSENGER RNA; NEUROPEPTIDE Y; NEUROTRANSMITTER; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYPOGLYCEMIA; LASER; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; CYTOLOGY; GENETICS; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

AGOUTI-RELATED PROTEIN; ANIMALS; ARCUATE NUCLEUS OF HYPOTHALAMUS; BASE SEQUENCE; DNA PRIMERS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HYPOGLYCEMIA; INSULIN, ISOPHANE; LASERS; NEURONS; NEUROPEPTIDE Y; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77954125638     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2010.01992.x     Document Type: Article

References (39)

1. Cone RD, Cowley MA, Butler AA, Fan W, Marks DL, Low MJ. The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int J Obes Relat Metab Disord 2001, 25(Suppl. 5):S63-S67.
2. Morton GJ, Schwartz MW. The NPY/AgRP neuron and energy homeostasis. Int J Obes Relat Metab Disord 2001, 25(Suppl. 5):S56-S62.
3. Beck B. Neuropeptides and obesity. Nutrition 2000, 16:916-923.
4. van den Top M, Spanswick D. Integration of metabolic stimuli in the hypothalamic arcuate nucleus. Prog Brain Res 2006, 153:141-154.
5. Guijarro A, Laviano A, Mequid MM. Hypothalamic integration of immune function and metabolism. Prog Brain Res 2006, 153:367-405.
6. Parikh R, Marks JL. Metabolic and orexigenic effects of intraventricular neuropeptide Y are attenuated by food deprivation. J Neuroendocrinol 1997, 9:789-795.
7. Kalra SP. Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge. Endocr Rev 1993, 14:507-538.
8. Hahn TM, Breninger JF, Baskin DG, Schwartz MW. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1998, 1:271-272.
9. Chen P, Li C, Haskell-Luevanon C, Cone RD, Smith MS. Altered expression of agouti-related protein and its colocalization with neuropeptide Y in the arcuate nucleus of the hypothalamus during lactation. Endocrinology 1999, 140:2645-2650.
10. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997, 278:135-137.
11. Baskin DG, Figlewicz Latteman D, Seeley RJ, Woods SC, Porte D, Schwartz MW. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res 1999, 848:114-123.
12. Sipols AJ, Baskin DG, Schwartz MW. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 1995, 44:147-151.
13. Savontaus E, Conwell IM, Wardlaw SL. Effects of adrenalectomy on AGRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats. Brain Res 2002, 958:130-138.
14. Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats. Endocrinology 2008, 149:4544-4553.
15. Levine JE, Bauer-Dantoin AC, Besecke LM, Conaghan LA, Legan SJ, Meredith JM, Strobl FJ, Urban JH, Vogelsong KM, Wolfe AM. Neuroendocrine regulation of the luteinizing hormone-releasing hormone pulse generator in the rat. Recent Prog Horm Res 1991, 47:97-151.
16. McEwen BS. The molecular and neuroanatomical basis for estrogen effects in the central nervous system. J Clin Endocrinol Metab 1999, 84:1790-1797.
17. Shughrue PJ, Scrimo PJ, Merchentaler I. Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain. Endocrinology 1998, 139:5267-5270.
18. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson J. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997, 138:863-870.
19. Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J. A cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 1996, 93:5925-5930.
20. Paech K, Webb P, Kuiper GGJM, Nilsson S, Gustafsson J, Kushner PJ, Scanlan TS. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 1997, 277:1508-1510.
21. Titolo D, Cai F, Belsham D. Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons. Mol Endocrinol 2006, 20:2080-2092.
22. Cryer PE. Hypoglycemia: still the limiting factor in the glycemic management of diabetes. Endocr Pract 2008, 14:750-756.
23. Nedungadi TP, Briski KP. Effects of estradiol on acute and chronic insulin-induced hypoglycemia-associated patterns of arcuate neuropeptide Y, proopiomelanocortin, and cocaine- and amphetamine related-transcript gene expression in the ovariectomized female rat. Neuroendocrinology 2007, 86:270-276.
24. Briski KP, Parihar M. Effects of orchidectomy on adaptation of arcuate neuropeptide Y, proopiomelanocortin, and cocaine- and amphetamine related-transcript gene profiles to recurring insulin-induced hypoglycemia in the male rat. Neuropeptides 2008, 42:585-591.
25. Matschinsky FM, Magnuson MK, Zelent D, Jettson TL, Doliba N, Han Y, Taub R, Grimsby K. The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes 2006, 55:1-12.
26. Lynch TM, Tomkins LS, Brooks HL, Dunn-Meynell AA, Levin BE. Localization of glucokinase gene expression in rat brain. Diabetes 2000, 49:693-700.
27. Dunn-Meynell AA, Routh VH, Kang L, Gaspers L, Levin BE. Glucokinase is the likely mediator of glucosensing in both glucose excited and glucose inhibited central neurons. Diabetes 2002, 51:2056-2065.
28. Nedungadi TP, Genabai NK, Parihar M, Briski KP. Acclimation of hypothalamic arcuate glucokinase gene and protein expression to recurring insulin-induced hypoglycemia: impact of gender. Neuroendocrinology 2009, 89:377-386.
29. Genabai NK, Briski KP. Adaptation of arcuate insulin receptor, estrogen receptor-alpha, estrogen receptor-beta, and type II glucocorticoid receptor gene profiles to intermediate insulin-induced hypoglycemia in estrogen-treated ovariectomized female rats. J Mol Neurosci 2009, PMID: 19953342
30. Briski KP, Marshall ES, Sylvester PW. Effects of estradiol on glucoprivic transactivation of catecholaminergic neurons in the female rat caudal brainstem. Neuroendocrinology 2001, 73:369-377.
31. Goodman RL. A quantitative analysis of the physiological role of estradiol and progesterone in the control of tonic and surge secretion of luteinizing hormone in the rat. Endocrinology 1987, 102:142-150.
32. Paranjape SA, Briski KP. Recurrent insulin-induced hypoglycemia causes site-specific patterns of habituation or amplification of CNS neuronal genomic activation. Neuroscience 2005, 130:957-970.
33. Nedungadi TP, Goleman WL, Paranjape SA, Kale AY, Briski KP. Effects of estradiol on glycemic and CNS neuronal activational responses to recurrent insulin-induced hypoglycemia in the ovariectomized female rat. Neuroendocrinology 2007, 84:235-243.
34. Tschenett A, Singewald N, Carli M, Balducci C, Salchner P, Vezzani A, Herzog H, Sperk G. Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors. Eur J Neurosci 2003, 18:143-148.
35. Painsipp E, Wultsch T, Edelsbrunner ME, Tasan RO, Singewald N, Herzog H, Holzer P. Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice. Genes Brain Behav 2008, 7:532-542.
36. Karlsson RM, Choe JS, Cameron HA, Thorsell A, Crawley JN, Holmes A, Heilig M. The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice. Psychopharmacology 2008, 195:547-557.
37. Akabayashi A, Zaia CT, Silva I, Chae HJ, Leibowitz SF. Neuropeptide Y in the arcuate nucleus is modulated by alterations in glucose metabolism. Brain Res 1993, 621:343-348.
38. Li C, Chen P, Smith MS. The acute suckling stimulus induces expression of neuropeptide Y (NPY) in cells in the dorsomedial hypothalamus and increases NPY expression in the arcuate nucleus. Endocrinology 1998, 139:1645-1642.
39. Horvath TL, Bechmann I, Naftolin F, Kalra SP, Leranth C. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res 1997, 756:283-286.