Metabolic and orexigenic effects of intracerebroventricular neuropeptide Y are attenuated by food deprivation

Journal of Neuroendocrinology

Volumn 9, Issue 10, 1997, Pages 789-795

  Parikh, Radha ^a   Marks, Jonathan L ^a  

^a WESTMEAD HOSPITAL   (Australia)

Author keywords

Corticosterone; Fasting; Glucagon; Hypothalamus; Insulin; Insulin sensitivity; Neuropeptide Y

Indexed keywords

CARBOHYDRATE; CORTICOSTERONE; GLUCAGON; GLUCOSE; INSULIN; LIPID; NEUROPEPTIDE Y;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARTICLE; BRAIN THIRD VENTRICLE; BRAIN VENTRICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; CORTICOSTERONE RELEASE; DRINKING BEHAVIOR; FEMALE; FOOD DEPRIVATION; FOOD INTAKE; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS; INSULIN INFUSION; INSULIN RELEASE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS GLUCOSE TOLERANCE TEST; LIPID METABOLISM; METABOLISM; NONHUMAN; NUTRITIONAL STATUS; OBESITY; PRIORITY JOURNAL; RAT;

EID: 0030775456     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1997.00648.x     Document Type: Article

References (38)

1. Tatemoto K, Carlquist M, Mutt V. Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 1982; 296: 659-660.
2. Allen YS, Adrian TE, Allen JM, Tatemoto K, Crow TJ, Bloom SR, Polak JM. Neuropeptide Y distribution in the rat brain. Science 1983; 221: 877-879.
3. Beck B, Burlet A, Nicolas JP, Burlet C. Hyperphagia in obesity is associated with a central peptidergic dysregulation in rats. J Nutr 1990; 120: 806-811.
4. Williams G, Gill JS, Lee YC, Carduso HM, Okpere BE, Bloom SR. Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozotocin-induced diabetic rats. Diabetes 1989; 38: 321-327.
5. Clark JT, Kalra PS, Crowley WR, Kalra SP. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behaviour in rats. Endocrinology 1984; 115: 427-429.
6. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. Neuropeptide Y chronically injected into the hypothalamus, a powerful neurochemical inducer of hyperphagia and obesity. Peptides 1986; 7: 1189-1192.
7. Marks JL, Waite K. Intracerebroventricular neuropeptide Y acutely influences glucose metabolism and insulin sensitivity in the rat. J Neuroendocrinol 1997; 9: 99-103.
8. Billington CJ, Briggs JE, Grace M, Levine AS. Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am J Physiol 1991; 260: R321-327.
9. Leibowitz SF, Sladek C, Spencer L, Tempel D. Neuropeptide Y, epinephrine and norepinephrine in the paraventricular nucleus: stimulation of feeding and the release of corticosterone, vasopressin and glucose. Brain Res Bull 1988; 21: 905-912.
10. Wahlstedt C, Skagerberg G, Ekman R, Heilig M, Sundler F, Hakanson R. Neuropeptide Y in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Res 1987; 417: 33-38.
11. Abe M, Saito M, Shimazu T. Neuropeptide Y and norepinephrine injected into the paraventricular nucleus of the hypothalamus activate endocrine pancreas. Biomed Res 1989; 10: 431-436.
12. Marks JL, Waite K. Some acute effects of intracerebroventricular neuropeptide Y on insulin secretion and glucose metabolism in the rat. J Neuroendocrinology 1996; 8: 507-513.
13. Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F, Jeanrenaud B. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 1993; 133: 1753-1758.
14. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. Neuropeptide Y chronically injected into the hypothalamus, a powerful neurochemical inducer of hyperphagia and obesity. Peptides 1986; 7: 1189-1192.
15. Sancora G, Kershaw M, Finkelstein JA, White JD. Increased hypothalamic content of preproneuropeptide Y mRNA in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 1990; 127: 730-737.
16. Wilding JPH, Gilbey SG, Bailey CJ, Batt RAL, Williams G, Ghatei MA, Bloom SR. Increased neuropeptide-Y mRNA and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology 1993; 132: 1939-1944.
17. Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by loss of neuropeptide Y. Science 1996; 274: 1704-1707.
18. Vettor R, Zarjevski N, Cusin I, Rohner-Jeanrenaud F, Jeanrenaud B. Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats. Diabetologia 1994; 37: 1202-1208.
19. Marks JL, Li M, Schwartz M, Porte Jr. D, Baskin DG. Effect of fasting on regional levels of neuropeptide Y mRNA and insulin receptors in the rat hypothalamus. An autoradiographic study. Mol Cell Neurosci 1992; 3: 199-205.
20. Lambert PD, Wilding JPH, Turton MD, Ghatei MA, Bloom SR. Effect of food deprivation and streptozotocin-induced diabetes on hypothalamic neuropeptide Y release as measured by a radioimmunoassay-linked microdialysis procedure. Brain Res 1994; 656: 135-140.
21. Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra PS. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA 1991; 88: 10931-10935.
22. Lewis DE, Shellard L, Koeslag DG, Boer DE, McCarthy HD, McKibbin PE, Russell JC and Williams G. Intense exercise and food restriction cause similar hypothalamic neuropeptide Y increases in rats. Am J Physiol 1993; 264: E279-E284.
23. Marks JL, Waite K, Li M. Effects of streptozotocin-induced diabetes mellitus and insulin treatment on neuropeptide Y mRNA in the rat hypothalamus. Diabetologia 1993; 36: 497-502.
24. McCarthy HD, McKibbin PE, Perkins AV, Linton EA, Williams G. Alterations in hypothalamic NPY and CRF in anorexic tumor-bearing rats. Am J Physiol 1993; 264: E638-643.
25. McArdle WD, Katch FI, Katch VL. In: Exercise Physiology. Energy, Nutrition and Human Performance, 2nd edn, Philadelphia: Lea and Febiger, 1986: 321-342.
26. Guyton AC. In: Textbook of Medical Physiology, 6th edn, Philadelphia, London, Toronto: WB Saunders Company, 1976.
27. Schwartz MW, Dallman MF, Woods SC. Hypothalamic response to starvation: implications for the study of wasting disorders. Am J Physiol 1995; 269: R949-957.
28. Penicaud L, Kande J, Le Magnen J, Girard JR. Insulin action during fasting and refeeding in rats determined by euglycaemic clamp. Am J Physiol 1985; 249: E514-518.
29. Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F, Jeanrenaud B. Intracerebroventricular administration of neuropeptide Y administration to normal rats has divergent effects on glucose utilization by adipose tissue and skeletal muscle. Diabetes 1994; 43: 764-769.
30. Malaisse WJ, Malaisse-Lagae F, Wright PH. Effect of fasting upon insulin secretion in the rat. Am J Physiol 1967; 213: 843-848.
31. Yoshihiro T, Honma S, Honma K. Effects of restricted daily feeding on neuropeptide Y release in the rat paraventricular nucleus. Am J Physiol 1996; 270: E589-595.
32. Marks JL, Davies L, Waite K. Intracerebroventricular neuropeptide Y produces hyperinsulinemia in the presence and absence of food. Physiol Behav 1996; 60: 685-692.
33. van Dijk G, Bottone AE, Strubbe JH, Steffens AB. Hormonal and metabolic effects of paraventricular hypothalamic administration of neuropeptide Y during rest and feeding. Brain Res 1994; 660: 96-103.
34. Dunbar JC, Ergene E, Barraco RA. Neuropeptide-Y stimulation of insulin secretion is mediated via the nucleus tractus solitarius. Horm Metab Res 1992; 24: 103-105.
35. Sainsbury A, Cusin I, Doyle P, Rohner-Jeanrenaud F, Jeanrenaud B. Intracerebroventricular administration of neuropeptide Y to normal rats increases obese gene expression in white adipose tissue. Diabetologia 1996; 39: 353-356.
36. Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 1996, 381: 415-418.
37. Lambert PD, Wilding JP, Dokhayel AL, Bohuon AA, Comoy E, Gilbey SG, Bloom SR. A role of neuropeptide Y-dynorphin, and noradrenaline in the central control of food intake after food deprivation. Endocrinology 1993; 133: 29-32.
38. Stanley BG, Magdalin W, Seirafi A, Nguyen MM, Leibowitz SF. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides 1992; 13: 581-587.